期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 71, 期 5, 页码 621-630出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.71.621
关键词
alimentary tract; histology; lymphoid organ; microbiological monitoring; rat
资金
- Japan Society for the Promotion of Science [19580339]
- Grants-in-Aid for Scientific Research [19580339] Funding Source: KAKEN
The spatial relationship between the distribution of indigenous bacteria (IB) and the Situation of mucosal lymphatic follicles (LF) is histoplanimetrically studied in the rat alimentary tract. From the oral cavity to the nonglandular part of the stomach, IB adhered to the corneal layer of the most luminal mucosa. In the glandular part of the stomach, IB adhered only to the most luminal mucosa but not in the gastric pits. In the small intestine, IB consistently adhered around the apices of both intestinal villi and the doilies, and their amounts decreased toward their basal portions. No IB entered the intestinal crypts. In the large intestine, IB consistently adhered to the most luminal mucosa. Numerous IB were Suspended in the intestinal crypts of both the cecum and the proximal colon, whereas there were no IB in the crypts of the distal colon and the rectum. When IB spread over the basal portions of the intestinal villi, IB with the same morphology were detected on the neighboring LF, whereas no bacteria were detected on the neighboring LF, when IB were located in the apical to middle portions of the intestinal villi. This close relationship between the distribution of IB and mucosal LF was also observed in the large intestine. These results Suggest that the most luminal mucosae are a fundamental settlement site of IB throughout the alimentary tract and that the hyperproliferation of IB's colonies might be detected by neighboring LF in the rat intestine.
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