Review
Infectious Diseases
Darragh G. G. Kennedy, Aoife M. M. O'Mahony, Eamonn P. P. Culligan, Caitriona M. M. O'Driscoll, Katie B. B. Ryan
Summary: Orthopaedic device implants are crucial in treating musculoskeletal diseases and injuries, but carry a risk of infection. This review examines the pathogenesis of implant infections and the challenges they pose, highlighting advancements in next-generation devices to mitigate against infections.
Article
Biotechnology & Applied Microbiology
Franziska Woitschach, Marlen Kloss, Karsten Schlodder, Anne Rabes, Caroline Moerke, Stefan Oschatz, Volkmar Senz, Alexander Borck, Niels Grabow, Emil Christian Reisinger, Martina Sombetzki
Summary: Biofilm-associated infections have become a major problem in the medical field in recent decades, leading to the need for modified anti-microbial implant materials. This study compared modified liquid silicone rubber surfaces with two commonly used TPUs, showing reduced bacterial adhesion and biofilm formation on the new materials, suggesting their potential as promising candidates for implant manufacturing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Panxin Li, Rui Yin, Juanli Cheng, Jinshui Lin
Summary: Bacterial biofilms can cause widespread infections and have strong resistance to antibiotics. This article summarizes the formation processes, resistance mechanisms, and main characteristics of clinically persistent infections caused by biofilms. Additionally, two main methods for preventing and treating biofilm-related infections on biomaterials are introduced: antibacterial coatings and surface modification of biomaterials. The advantages of each strategy in terms of antibacterial effect, biocompatibility, limitations, and application prospects are analyzed, providing ideas and research directions for the development of novel biofilm infection strategies related to therapeutic materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Kelly Moore, Niraj Gupta, Tripti Thapa Gupta, Khushi Patel, Jacob R. Brooks, Anne Sullivan, Alan S. Litsky, Paul Stoodley
Summary: Implant-associated infection is a major complication of orthopedic surgery, with Staphylococcus aureus being a common pathogen. The surface features of orthopedic implants, such as roughness and edges, may influence biofilm formation and attachment.
Article
Orthopedics
Alexander W. Grimberg, Thomas M. Grupp, Johanna Elliott, Oliver Melsheimer, Volkmar Jansson, Arnd Steinbrueck
Summary: A registry-based study in Germany followed up on 117,660 cemented primary TKAs for up to 3 years and found that ceramic coating did not reduce the risk of PJI, but showed a higher revision rate for TKAs with ceramic coating for reasons other than PJI.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Engineering, Biomedical
Kai Yu, Amal Alzahrani, Sara Khoddami, Demian Ferreira, Kymora B. Scotland, John T. J. Cheng, Hossein Yazdani-Ahmadabadi, Yan Mei, Arshdeep Gill, Lily E. Takeuchi, Edbert Yeung, Dana Grecov, Robert E. W. Hancock, Ben H. Chew, Dirk Lange, Jayachandran N. Kizhakkedathu
Summary: This study reports a highly effective non-fouling coating for catheters that can prevent biofilm formation long-term, is applicable to diverse materials, and shows high efficiency in preventing bacterial adhesion.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Materials Science, Multidisciplinary
Abhishek Tiwari, Prince Sharma, Bhagyashree Vishwamitra, Gaurav Singh
Summary: Surface treatment of metallic implants is crucial in orthopedics and orthodontics to prevent bacterial infections, and using coating processes can reduce bacterial and biofilm adhesion, lowering the risk of infection and providing a solution to reduce medical expenses.
Review
Chemistry, Physical
Daniele Pressato, Angela Battista, Marco Govoni, Leonardo Vivarelli, Dante Dallari, Antonio Pellegrini
Summary: Periprosthetic joint infections (PJIs) and osteosynthesis-associated infections (OAIs) are challenging complications in orthopaedics and traumatology. Preventing these infections through local antibiotic treatment using coating-release systems is becoming a smart approach.
Article
Microbiology
Olguta Lungu, Ioana Grigoras, Olivia Simona Dorneanu, Catalina Lunca, Teodora Vremera, Stefania Brandusa Copacianu, Iuliu Ivanov, Luminita Smaranda Iancu
Summary: Health care-associated infections are a major cause of inpatient complications, with rapid pathogen detection and identification being a key challenge in sepsis management. Current microbiological identification methods rely on bacterial culture, but have limitations. Gene sequencing research has developed culture-independent techniques for improved etiological diagnosis and outcomes in sepsis.
Article
Polymer Science
Sookyung Choi, Hyeonjoon Lee, Ran Hong, Byungwook Jo, Suenghwan Jo
Summary: Infection associated with biomedical implants is a major cause of failure in orthopedic surgery, characterized by microbial biofilm formation. A potential method to prevent and treat these complications is to coat the implant with a temperature-responsive polymer brush that releases antibiotics at the onset of infection.
Review
Materials Science, Multidisciplinary
Xin Li, Luyao Sun, Peng Zhang, Yang Wang
Summary: Biofilms are formed by microorganisms as a protective survival state to resist antimicrobial agents and host immune responses. They pose a serious threat to human health, especially in medical device-associated infections, and traditional antimicrobial agents are ineffective. New treatment strategies are urgently needed to address biofilm infections.
Article
Materials Science, Multidisciplinary
Shukufe Amukarimi, Iman Mobasherpour, Sorosh Abdollahi, Peiman Brouki Milan, Masoud Mozafari
Summary: Thanks to prophylactic antibiotics, the risk of wound infection in orthopedic surgeries has significantly decreased. This study focuses on the effectiveness of a new biodegradable antibiotic-loaded coating on the surface of a magnesium implant. The results show that the coating is biocompatible, antibacterial, and has improved corrosion resistance, making it potentially suitable for bone regeneration applications.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Review
Orthopedics
Konstantinos Tsikopoulos, Konstantinos Sidiropoulos, Dimitrios Kitridis, Anas Hassan, Lorenzo Drago, Andreas Mavrogenis, Donald McBride
Summary: The study evaluated the effects of various coating methods on titanium implants against MRSA and MSSA biofilm development. Active coating with antibiotics was found to be effective, as well as a combination of active and traditional non-degradable passive coatings. Future research should focus on combined coating modalities for S. aureus biofilm infections in the presence of titanium implants.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Chemistry, Multidisciplinary
Cintia M. G. Nobre, Belinda Konig, Norbert Putz, Matthias Hannig
Summary: The study found that using hydroxyapatite solution as a mouthwash can effectively reduce biofilm coverage, showing comparable results to chlorhexidine treated samples, without altering the viability of microorganisms.
Article
Chemistry, Physical
Akiko Ogawa, Akane Tahori, Mayumi Yano, Shunma Hirobe, Satoshi Terada, Hideyuki Kanematsu
Summary: This study investigated the antibiofilm properties and biocompatibility of siloxane-based polymer coatings. The results showed that the amount of biofilm formed on the polymer-coated titanium and SUS316L plates was higher, resulting in lower viability of U937 cells. The siloxane-based polymer coatings require additional treatment to enhance antibiofilm properties and are sensitive to autoclave treatment, leading to cytotoxicity.
Article
Biophysics
Suphatra Hiranphinyophat, Akihisa Otaka, Yuta Asaumi, Syuji Fujii, Yasuhiko Iwasaki
Summary: A stable oil-in-water emulsion loaded with a lipophilic drug and stabilized by nanocrystals was developed to enhance drug permeation in transdermal drug delivery. The emulsion showed promising results in terms of stability, drug release capacity, skin permeation, and histopathology studies.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Analytical
Koji Toma, Masato Tsujii, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
Summary: VOCs in breath and skin gas are promising samples for disease screening and metabolism assessment, with simultaneous measurement of multiple VOCs improving examination quality. A dual-target gas-phase biosensor was developed to measure IPA and acetone vapours, relevant to lipid metabolisms, showing dynamic ranges that encompass those in the breath of healthy people. The biosensor was applied for measurement of IPA and acetone in the breath of healthy people, demonstrating intermittent and repeated measurement of both VOCs.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Taku Okoshi, Takeshi Iwasaki, Shimon Takahashi, Yasuhiko Iwasaki, Keiki Kishikawa, Michinari Kohri
Summary: Natural melanin plays a crucial role in creating bright structural colors in nature. In this study, core-shell particles were prepared using a melanin precursor polymer and light irradiation was found to enhance the visibility of structural colors of the pellet samples.
Review
Materials Science, Multidisciplinary
Suphatra Hiranphinyophat, Yasuhiko Iwasaki
Summary: Phosphorus is a common element in living organisms, with versatile and important functions in forming genetic code, cell membrane, and mineral components. Materials inspired by phosphorus-containing biomolecules have unique properties at biointerfaces, but host responses must be considered. Biomimetic phosphorus-containing polymers improve material reliability and biocompatibility in biological systems.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pasiree Thongthai, Haruaki Kitagawa, Susita Noree, Yasuhiko Iwasaki, Yuhan Liu, Gabriela Laranjeira Abe, Satoshi Yamaguchi, Satoshi Imazato
Summary: The copolymer combining protein-repellent and antibacterial agents showed long-lasting effects in terms of protein repulsion, antibacterial activity, and anti-biofilm formation.
DENTAL MATERIALS JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Shin-ichi Yusa, Daishiro Oka, Yasuhiko Iwasaki, Kazuhiko Ishihara
Summary: Well-defined pH-responsive biocompatible random copolymers were synthesized and their pH-responsive association and dissociation behavior were studied using various techniques. The copolymers exhibited different microstructures and solubility properties under acidic and basic conditions.
Article
Chemistry, Multidisciplinary
Ryota Komatsu, Yasushi Tanimoto, Koji Ando, Kazuma Yasuhara, Yasuhiko Iwasaki, Fumio Hayashi, Kenichi Morigaki
Summary: Studying membrane proteins in a controlled model membrane environment can provide clear and quantitative information, but reconstituting membrane proteins in a model system poses challenges. The developed micropatterned lipid membrane platform allows highly sensitive observation of membrane proteins, providing a novel research platform.
Article
Chemistry, Multidisciplinary
Yichen Cheng, Masato Ueda, Yasuhiko Iwasak
Summary: Adhesive coacervates composed of water soluble polyphosphoester (PPE) and tannic acid (TA) were prepared and showed potential as adhesive for titanium plates with an average maximum shear bond strength of 1.6 MPa.
Article
Chemistry, Multidisciplinary
Hoang Nam Nguyen, Thi Lan Huong Ngo, Yasuhiko Iwasaki, Chun-Jen Huang
Summary: This study reports the development of biodegradable and biocompatible hydrogels using an innovative zwitterionic cross-linker, MPCSS. The hydrogels exhibit stronger mechanical properties and higher water content compared to conventional hydrogels. The biocompatibility and fouling characteristics of the hydrogels are systematically investigated, and the degradation of the hydrogels is evaluated. The results show that the MPC/MPCSS hydrogel has potential as a tissue scaffold.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Engineering, Biomedical
Kenjiro Kiyono, Shun Mabuchi, Akihisa Otaka, Yasuhiko Iwasaki
Summary: This article reports the potential of polyphosphodiesters (PPDEs) to enhance osteoblastic differentiation and target bone tissues in vivo. Two types of PPDEs, poly (ethylene sodium phosphate) (PEP center dot Na) and poly (propylene sodium phosphate) (PPP center dot Na), have been synthesized and shown to upregulate the gene expression of osteoblast-specific transcription factors in mouse osteoblastic-like cells. The mineralization of these cells is also enhanced by PPDEs with beta-glycerophosphate.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Chemistry, Medicinal
Yota Okuno, Yasuhiko Iwasaki
Summary: Peptoids, a type of polymer with biocompatibility and easily adjustable side chains, have shown great potential in biomedical applications. In the past decade, researchers have created well-defined self-assemblies such as vesicles, micelles, sheets, and tubes using peptoids, and have analyzed them at the atomic level. This review focuses on the recent advancements in peptoid synthesis strategies and the development of anisotropic self-assemblies, specifically nanotubes and nanosheets, which exhibit ordered molecular arrangements. The protease resistance of peptoids has also been leveraged for various biomedical applications, including phototherapy, enzymatic mimetics, bio-imaging, and biosensing.
Article
Engineering, Biomedical
Sota Fukaura, Yasuhiko Iwasaki
Summary: Osteoporosis is characterized by reduced bone density and increased risk of fractures. Polyphosphoesters (PPEs) have shown potential in inhibiting osteoclastic differentiation, but the effect of their chemical structure on this process remains largely unexplored.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Chemistry, Multidisciplinary
Yasuhiko Iwasaki
Summary: This article discusses the methods and applications of surface modification using MPC polymers. Particularly, it focuses on the use of photoreactions, specifically photoinduced graft polymerization, to modify surfaces. In addition to antifouling materials, it summarizes micromanipulated, long-lasting hydrophilic, and super antiwear surfaces. Furthermore, it introduces several photoreactive MPC polymers that can control interactions between biomolecules and materials, and discusses their potential to form selective recognition surfaces for biosensors and diagnostic devices.
Article
Chemistry, Analytical
Kenta Iitani, Hidehisa Mori, Kenta Ichikawa, Koji Toma, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
Summary: In this study, liquid- and gas-phase biosensors were developed to facilitate the continuous measurement of trans-2-nonenal vapor. The ALDH biosensor showed reactivity to a variety of aldehydes, while the ER1 biosensor exhibited high selectivity for trans-2-nonenal. Based on the findings, age-related differences were observed in the signals collected from study participants, indicating the potential for measuring trans-2-nonenal vapor.
Article
Materials Science, Biomaterials
Aldona Mzyk, Gabriela Imbir, Yuri Noguchi, Marek Sanak, Roman Major, Justyna Wiecek, Przemyslaw Kurtyka, Hanna Plutecka, Klaudia Trembecka-Wojciga, Yasuhiko Iwasaki, Masato Ueda, Sachiro Kakinoki
Summary: The blood compatibility of self-assembled monolayers (SAMs) of oligoproline was studied and found to strongly suppress the adsorption of blood components and the adhesion of blood cells, especially the activation of platelets.
BIOMATERIALS SCIENCE
(2022)
