Article
Immunology
Geneva M. Wilson, Katie J. Suda, Margaret A. Fitzpatrick, Brian Bartle, Christopher D. Pfeiffer, Makoto Jones, Michael A. Rubin, Eli Perencevich, Martin Evans, Charlesnika T. Evans
Summary: Among US veterans with CP-CRE, African Americans, patients with congestive heart failure, and those with gastroesophageal reflux disease were more likely to have CP-CRE cultures. Roughly one in four patients with CP-CRE had no known antibiotic exposure in the year before their positive culture.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Schola K. Peter, Joshua M. Mutiso, Mercy Ngetich, Cecilia Mbae, Samuel Kariuki
Summary: Non-typhoidal Salmonella (NTS) infections are a public health challenge in sub-Saharan Africa, particularly in Kenya. A study was conducted to determine the proportion of children exposed to Salmonella Enteritidis or Salmonella Typhimurium and associated factors in Mukuru, Kenya. The study found a high exposure to NTS among children below five years of age and identified water treatment methods and animal keeping as factors associated with exposure.
Article
Public, Environmental & Occupational Health
L. M. O'Hara, M. H. Nguyen, D. P. Calfee, L. G. Miller, L. Pineles, L. S. Magder, J. K. Johnson, D. J. Morgan, D. A. Rasko, A. D. Harris
Summary: The study found that HCP gloves and gowns were frequently contaminated with CRE, with the highest contamination rate being among respiratory therapists. Additionally, factors such as being in the intensive care unit, having a positive clinical culture, and increasing bacterial burden on the patient were associated with CRE transmission to HCP gloves or gown.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Microbiology
Marwan Osman, Craig Altier, Casey Cazer
Summary: This study investigated the antimicrobial susceptibility patterns of canine clinical enterococci in the northeastern United States and identified the emergence of multidrug resistance, particularly in Enterococcus faecium. The study found high levels of antimicrobial resistance among enterococci, with the lowest resistance to vancomycin and chloramphenicol. The emergence of vancomycin-resistant enterococci in the canine population is of great concern to both human and animal health.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Enrico Maria Trecarichi, Gabriele Giuliano, Chiara Cattaneo, Stelvio Ballanti, Marianna Criscuolo, Anna Candoni, Francesco Marchesi, Marica Laurino, Michelina Dargenio, Rosa Fanci, Mariagiovanna Cefalo, Mario Delia, Angelica Spolzino, Laura Maracci, Valentina Bonuomo, Alessandro Busca, Maria Ilaria Del Principe, Rosa Daffini, Edoardo Simonetti, Giulia Dragonetti, Maria Elena Zannier, Livio Pagano, Mario Tumbarello
Summary: Bloodstream infections caused by antibiotic-resistant Gram-negative bacteria in patients with hematological malignancies are associated with high mortality rates. A multicenter cohort study found a reduction in fluoroquinolone prophylaxis and increased susceptibility rates to ciprofloxacin among Pseudomonas aeruginosa, Escherichia coli, and Enterobacter cloacae isolates compared to a previous survey. There was also an increased susceptibility of P. aeruginosa isolates to ceftazidime, meropenem, and gentamicin.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Multidisciplinary Sciences
Mariachiara Carestia, Massimo Andreoni, Ersilia Buonomo, Fausto Ciccacci, Luigi De Angelis, Gerardo De Carolis, Patrizia De Filippis, Daniele Di Giovanni, Leonardo Emberti Gialloreti, Carla Fontana, Luca Guarente, Andrea Magrini, Marco Mattei, Stefania Moramarco, Laura Morciano, Claudia Mosconi, Stefano Orlando, Giuseppe Quintavalle, Fabio Riccardi, Viviana Santoro, Leonardo Palombi
Summary: In Italy, the integration of microbiology laboratory data with electronic health records (EHRs) has provided a valuable tool for evaluating healthcare-associated infections (HAIs) and antimicrobial resistance (AMR). This study successfully established a management system that accurately assessed the burden of HAIs and the impact of AMR. Despite a low percentage of HAIs caused by antimicrobial resistant bacteria, the contribution of AMR to increased mortality risk was significant.
Article
Immunology
Pranita D. Tamma, Stephan Beisken, Yehudit Bergman, Andreas E. Posch, Edina Avdic, Sima L. Sharara, Sara E. Cosgrove, Patricia J. Simner
Summary: The study investigates the emergence of ceftolozane-tazobactam (TOL-TAZ) resistance in patients infected with Pseudomonas aeruginosa. Results suggest that inadequate source control and lack of extended TOL-TAZ infusions may increase the risk of developing TOL-TAZ resistance.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
Jennifer Lord, Nick Millis, Rebekah Duckett Jones, Brian Johnson, Stephen A. Kania, Agricola Odoi
Summary: This study investigated antimicrobial, multidrug, and methicillin resistance patterns among four common Staphylococcus species isolated from canine clinical specimens. The results showed significant levels of resistance, particularly in MRSP and MRESA, with increasing temporal trends. Detection methods such as oxacillin and cefoxitin disk diffusion tests were found to be effective in identifying resistance genes. Continued surveillance and guided treatment decisions are recommended for managing this concerning issue.
BMC VETERINARY RESEARCH
(2022)
Article
Veterinary Sciences
Marwan Osman, Belen Albarracin, Craig Altier, Yrjo T. Grohn, Casey Cazer
Summary: This study assessed the antimicrobial resistance of clinical Escherichia coli isolates in dogs and identified interesting trends and associations. The results showed that dogs are still a source of drug-resistant strains, but some resistance patterns are decreasing. The study also found a link between resistance and drug use.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Infectious Diseases
Mayu Horie, Dongsheng Yang, Philip Joosten, Patrick Munk, Katharina Wadepohl, Claire Chauvin, Gabriel Moyano, Magdalena Skarzynska, Jeroen Dewulf, Frank M. Aarestrup, Thomas Blaha, Pascal Sanders, Bruno Gonzalez-Zorn, Dariusz Wasyl, Jaap A. Wagenaar, Dick Heederik, Dik Mevius, Heike Schmitt, Lidwien A. M. Smit, Liese Van Gompel
Summary: This study identified significant positive associations between antimicrobial resistance (AMR) and antimicrobial usage (AMU) in turkey farms, particularly for specific antimicrobial classes. However, no evidence was found that lower biosecurity increases the abundance of AMR. Using multiple complementary AMR detection methods provided insights into the associations between AMU and AMR at turkey farms.
Article
Environmental Sciences
Derek T. Elsby, Ruth N. Zadoks, Kenneth Boyd, Nuno Silva, Margo Chase-Topping, Mairi C. Mitchel, Carol Currie, Mark A. Taggart
Summary: Antimicrobial resistance (AMR) is a recognized threat to global health. This study examined the prevalence of AMR Escherichia coli in fecal samples from deer in Scotland and investigated potential risk factors associated with AMR occurrence. The results showed that resistant E. coli strains were present in wild deer populations, with different risk factors influencing resistance phenotypes and deer species. However, overall, resistance to critically important antimicrobials was found to be low, suggesting no immediate cause for concern regarding human health. Therefore, wild deer in Scotland could serve as a sentinel species for AMR surveillance in the Scottish environment.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Fabio Campioni, Felipe Pinheiro Vilela, Guojie Cao, George Kastanis, Dalia dos Prazeres Rodrigues, Renata Garcia Costa, Monique Ribeiro Tiba-Casas, Lanlan Yin, Marc Allard, Juliana Pfrimer Falcao
Summary: Salmonella Dublin strains isolated in Brazil exhibited some unique genes not found in strains from other countries and were allocated into two distinct clades, highlighting the zoonotic potential.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Jordan E. Sealey, Ashley Hammond, Oliver Mounsey, Virginia C. Gould, Kristen K. Reyher, Matthew B. Avison
Summary: This study compares faecal third-generation cephalosporin-resistant (3GC-R) Escherichia coli isolates from dogs living in a city and a rural area, and also compares isolates from dogs, cattle, and humans in these regions. Risk factors associated with 3GC-R E. coli carriage in dogs were determined. The results indicate that in rural dogs, carriage of 3GC-R E. coli, particularly CTX-M producers, is phylogenetically associated with interaction with local cattle and epidemiologically associated with feeding raw meat. In urban dogs, sources of 3GC-R E. coli appear to be more varied and include environments such as rivers.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Genetics & Heredity
Benjamin M. Hetman, David L. Pearl, Dillon O. R. Barker, James Robertson, John H. E. Nash, Richard Reid-Smith, Agnes Agunos, Catherine Carrillo, Edward Topp, Gary Van Domselaar, E. Jane Parmley, Amrita Bharat, Michael Mulvey, Vanessa Allen, Eduardo N. Taboada
Summary: Antimicrobial resistance (AMR) is a major threat to global public health. The use of antimicrobials in poultry production is believed to contribute to the dissemination of antibiotic resistant bacteria (ARB) and the genes and plasmids that confer resistance (ARG). However, more research is needed to understand the dynamics of ARB and ARG in food production and the factors involved in the increased risk of transmission in order to determine their relative contribution to the emergence and transmission of resistant pathogens in poultry production and human infections.
MICROBIAL GENOMICS
(2022)
Article
Microbiology
Fabrizio Bertelloni, Giulia Cagnoli, Valentina Virginia Ebani
Summary: Dogs can harbor different species of Staphylococcus and can develop various clinical forms caused by these bacteria. Most of the clinical Staphylococcus isolates cultured from sick dogs were Staphylococcus pseudointermedius, with common characteristics including gelatinase, biofilm, and slime production, as well as high levels of multi-drug resistance.
Article
Veterinary Sciences
J. R. Fletcher, K. Y. Yuen, A. J. Stewart, A. C. Young, J. S. Gibson, O. A. James, C. E. Medina-Torres, B. M. Forde, A. Sole-Guitart
Summary: Chronic oroantral fistulae (OAF) with secondary sinusitis can occur in horses following repulsion of cheek teeth. This case report describes the successful treatment of a complicated OAF with concurrent MDR Escherichia coli infection using various therapeutic strategies. Whole-genome sequencing may be beneficial in guiding antimicrobial selection for MDR or XDR infections in the future.
AUSTRALIAN VETERINARY JOURNAL
(2022)
Article
Veterinary Sciences
Cleide H. Sprohnle-Barrera, Justine S. Gibson, Rochelle Price, Rikki M. Graham, Amy Jennison, Madeline R. Ricca, Rachel E. Allavena
Summary: This study reports a case of severe subcutaneous emphysema and multi-organ failure in a Siberian Husky dog. Pathological and genetic analysis revealed Clostridium perfringens type A as the causative pathogen with multiple virulence-related genes.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2022)
Article
Infectious Diseases
Nicole Jacqueline Kalnins, Catriona Croton, Mark Haworth, Justine Gibson, Sarah Leonie Purcell, Allison Jean Stewart
Summary: This study investigated the antimicrobial prescribing habits of Australian veterinary clinics for dog-to-dog bite wounds. The results showed that antimicrobials were commonly prescribed for these wounds, with underdosing of a commonly used drug. The use of high-importance antimicrobials was associated with wound severity, year, and surgery.
Article
Veterinary Sciences
L. Awawdeh, C. Turni, J. L. Mollinger, J. Henning, R. N. Cobbold, D. J. Trott, J. S. Gibson
Summary: Avian colibacillosis is a major disease in poultry worldwide, causing significant mortality and economic losses. This study found a small reservoir of resistant E. coli in Australian commercial meat chickens, despite the absence of antibiotic use in the industry. Some of these resistant isolates carried resistance genes and signature mutations.
Article
Veterinary Sciences
Hester Rynhoud, Catriona Croton, Grace Henry, Erika Meler, Justine S. Gibson, Ricardo J. Soares Magalhaes
Summary: The study showed that dogs treated with oclacitinib required fewer courses of antimicrobials compared to dogs receiving other anti-pruritic treatments, indicating a potential sparing effect of oclacitinib on the prescription of antimicrobials for allergic skin diseases in dogs.
BMC VETERINARY RESEARCH
(2022)
Article
Urology & Nephrology
Priskila Christy, Hanna Evelina Sidjabat, Anggia Augustasia Lumban Toruan, Emmanuel Jairaj Moses, Narazah Mohd Yussof, Yessy Puspitasari, Muhammad Robiul Fuadi, Ferdy Royland Marpaung
Summary: This study compared the diagnostic value of the Shih-Yung conventional microscopic and urine flow cytometry methods in the detection of leukocyte and bacterial parameters of patients with urinary tract infections (UTIs). The results showed consistent agreement between the two methods, and urine flow cytometry demonstrated good performance in detecting acquired symptomatic UTIs.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ferdy Royland Marpaung, Victoria Mayasari, Hanna Sidjabat, Sidarti Soehita, Bambang Pujo Semedi, Ida Parwati, Titin Andri Wihastuti, Agustin Iskandar, Aryati
Summary: This study investigated the relationship between ACTH and cortisol levels and ARDS in COVID-19 patients. The results showed a moderate correlation between ACTH and cortisol levels, particularly in patients who survived.
Article
Veterinary Sciences
Nicole J. J. Kalnins, Justine S. Gibson, Allison J. J. Stewart, Catriona Croton, Sarah L. L. Purcell, Bandula Rajapaksha, Mark Haworth
Summary: Dog-to-dog bite wounds are common, but studies on antimicrobial usage patterns are limited. This retrospective study evaluated 1526 dog bite events from 1999 to 2019 in three Australian university clinics and found that amoxicillin-clavulanic acid was the most commonly prescribed antimicrobial. The study also found an association between wound severity and the use of high-importance antimicrobials. Routine susceptibility testing is recommended to optimize antimicrobial stewardship.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tasneem Imam, Justine S. Gibson, Suman Das Gupta, Mohammad Foysal, Shetu B. Das, Md Ahasanul Hoque, Guillaume Fournie, Joerg Henning
Summary: Adapting the Social Cognitive Theory framework, a cross-sectional study was conducted on 137 commercial chicken farms in Bangladesh to investigate factors influencing farmers' behavior towards the application of antimicrobials. The study found that almost all farmers used antimicrobials for treating poultry diseases, with a significant percentage also using them for healthy growth and increased production. The inappropriate usage of antimicrobials was primarily driven by short-term goals, while farmers' perception of control over antimicrobial administration had a marginal influence. The study suggests the need for targeted education programs to reduce antimicrobial application in poultry flocks.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Suzanne Suk Kwan Tso, Ellie Leister, Claire Rebecca Sharp, Jane Heller, Justine S. Gibson
Summary: This study describes the clinical course, culture and susceptibility profiles of dogs and cats mechanically ventilated for tick paralysis. The majority of these cases had concurrent evidence of aspiration pneumonia. Appropriate use of antimicrobials improved outcome. Clinicians should be aware of the development of bacterial pneumonia and select antimicrobials based on culture and susceptibility testing.
Article
Veterinary Sciences
Helen Owen, Emily Jones, Carla Kowald, Sebastian Hand, Michael McGowan, Rowland Cobbold, Tamsin S. Barnes, Justine S. Gibson, Shahab Ranjbar, Chiara Palmieri, Rachel Allavena
Summary: This study aimed to create a post-mortem data collection tool for evaluating liver diseases in Australian beef cattle and to analyze the pathological findings in both normal and condemned livers. The study developed an efficient tool for rapid assessment of large numbers of cattle livers, allowing thorough investigation into the impact of liver disease on beef production.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Sara Horsman, Erika Meler, Deirdre Mikkelsen, John Mallyon, Hong Yao, Ricardo J. Soares Magalhaes, Justine S. S. Gibson
Summary: This study investigates the associations between Staphylococcus spp. infections and nasal microbiota in a canine animal shelter population. It reveals that shelter dogs with dermatological conditions have different nasal microbial communities compared to those without dermatological conditions, with decreased diversity and abundance. The study emphasizes the importance of exploring decolonization and probiotic therapies for restoring the nasal microbiota.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
Jinnat Ferdous, Md Helal Uddin, Rashed Mahmud, Mathew Hennessey, Abdullah Al Sattar, Suman Das Gupta, Justine S. Gibson, Robyn Alders, Joerg Henning, Guillaume Fournie, Md. Ahasanul Hoque
Summary: Bangladesh's commercial poultry production is rapidly growing, primarily due to the perception that processed poultry provides safer food than traditional live bird markets. However, this study found a lack of consistency in quality control and meat traceability within the dressed and processed poultry production and distribution network (PDN). This raises concerns about the safety of dressed poultry products and the potential increase in food-borne disease risks.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Correction
Veterinary Sciences
Jinnat Ferdous, Helal Uddin, Rashed Mahmud, Mathew Hennessey, Abdullah Al Sattar, Suman Das Gupta, Justine S. Gibson, Robyn Alders, Joerg Henning, Guillaume Fournie, Ahasanul Hoque
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Marine & Freshwater Biology
Alexandra M. McGowan, Jennifer M. Seddon, Janet M. Lanyon, Nicholas Clark, Justine S. Gibson
Summary: Bacterial isolates cultured from the fresh faeces of dugongs in Queensland, Australia, showed resistance to antibiotics such as penicillin and trimethoprim, and contained various resistance and virulence genes. This highlights the role that dugongs can play as a sentinel species for antimicrobial resistance in coastal waters.