Article
Cardiac & Cardiovascular Systems
Marc P. Bonaca, Naomi M. Hamburg, Mark A. Creager
Summary: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis with modifiable risk factors including smoking, dyslipidemia, and diabetes. Medical therapies can reduce the risk of major adverse cardiovascular events and major adverse limb events, and improve function. Diagnosis and treatment should consider the individual risk profile of the patient.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Viviana Onofrei, Cristina Andreea Adam, Dragos Traian Marius Marcu, Maria-Magdalena Leon, Carmen Cumpat, Florin Mitu, Doina-Clementina Cojocaru
Summary: This retrospective study analyzed the clinical and therapeutic characteristics of 652 patients with peripheral artery disease (PAD) based on gender. It found that men tended to be younger, have higher BMI, and higher smoking rates, while women had a higher prevalence of hypercholesterolemia, obesity, concomitant cerebrovascular disease, and chronic kidney disease. Smoking, uric acid, and inflammatory markers were positively correlated with the number of stenotic lesions and ankle-brachial index (ABI). In the subgroup of men, the number of stenotic and thrombosed lesions positively correlated with ABI value. The presence of more than three cardiovascular risk factors and serum triglyceride levels were significantly correlated with the number of angiographically detected lesions.
Article
Cardiac & Cardiovascular Systems
John W. Eikelboom, Deepak L. Bhatt, Keith A. A. Fox, Jacqueline Bosch, Stuart J. Connolly, Sonia S. Anand, Alvaro Avezum, Scott D. Berkowitz, Kelley R. H. Branch, Gilles R. Dagenais, Camilo Felix, Tomasz J. Guzik, Robert G. Hart, Aldo P. Maggioni, Eva Muehlhofer, Mukul Sharma, Olga Shestakovska, Salim Yusuf
Summary: The combination of rivaroxaban and aspirin reduces overall cardiovascular mortality and specific cause-specific cardiovascular mortality in patients with chronic CAD or PAD. The mortality benefits increase with higher baseline risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Saman L. Parvar, Linh Ngo, Joseph Dawson, Stephen J. Nicholls, Robert Fitridge, Peter J. Psaltis, Isuru Ranasinghe
Summary: This retrospective cohort study compared the long-term outcomes of endovascular and surgical revascularization in PAD patients and found that although endovascular revascularization can reduce the risk of MALE, it is associated with higher mortality. Surgical revascularization has lower long-term mortality, which contradicts previous studies and highlights the controversy in this field.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Martin Ursli, Bernhard Zierfuss, Thomas Grigassy, Gerfried Pesau, Renate Koppensteiner, Gerit-Holger Schernthaner, Clemens Hobaus
Summary: This study is the first to show an association between uGal-3/cr and long-term mortality in patients with PAD. Gal-3 was not predictive of long-term mortality but seems to be a marker of PAD severity in patients without critical limb ischemia.
Article
Cardiac & Cardiovascular Systems
Cheng-Yueh Hsu, Wayne Huey-Herng Sheu, I-Te Lee
Summary: This study found a synergistic effect between low serum BDNF levels and CKD in predicting all-cause mortality in patients with CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biology
Lilla Horvath, Noemi Nemeth, Gergely Feher, Zsuzsanna Kives, Dora Endrei, Imre Boncz
Summary: The past decades have seen a significant increase in atherosclerotic cardiovascular diseases (CVDs), particularly in low-income and middle-income countries (LMICs). Peripheral artery disease (PAD), which is strongly age-related, is estimated to become more prevalent in the future. PAD shares risk factors with coronary and cerebrovascular diseases and is associated with significant morbidity and mortality. Despite advances in treatment, the prevalence of PAD continues to rise, and data from LMICs are scarce.
Article
Gastroenterology & Hepatology
Ronit Patnaik, Mustafa Tamim Alam Khan, Ince Spencer, Hassan Aziz
Summary: This study investigated the impact of chronic kidney disease (CKD) on patients undergoing pancreaticoduodenectomy. The results demonstrated that the severity of CKD was associated with overall complications and outcomes after the surgery. Therefore, the classification of CKD should be strongly considered in preoperative risk stratification for these patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Medicine, General & Internal
Raffaele Serra, Umberto Marcello Bracale, Nicola Ielapi, Luca Del Guercio, Maria Donata Di Taranto, Maurizio Sodo, Ashour Michael, Teresa Faga, Egidio Bevacqua, Federica Jiritano, Giuseppe Fliberto Serraino, Pasquale Mastroroberto, Michele Provenzano, Michele Andreucci
Summary: Chronic kidney disease (CKD) and peripheral artery disease (PAD) are closely associated, with revascularization procedures benefiting PAD patients but posing higher risks for CKD patients, necessitating caution.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Immunology
Xiaohan Huang, Liangliang Chen, Lan Lan, Pingping Ren, Anqi Ni, Yanhong Ma, Yaomin Wang, Yilin Zhu, Ying Xu, Jianghua Chen, Fei Han
Summary: The study aimed to analyze the clinical characteristics of kidney involvement in AAV patients and identify risk factors for poor outcomes. The research found that KDIGO AKI stage 3 is a major risk factor for ESRD, while poor recovery of kidney function at 90 days and BVAS score are independent risk factors for both ESRD and all-cause death.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Daniel B. C. Dos Santos, Luis Henrique W. Gowdak, Elias David-Neto, Felizardo A. Nataniel, Jose J. G. De Lima, Luiz A. Bortolotto
Summary: There is a need for a simple, inexpensive, and reliable noninvasive testing method to predict coronary artery disease in patients with chronic kidney disease. Peripheral artery disease (PAD) can be diagnosed using both palpation and ultrasound (USD). Palpation-diagnosed PAD is a better predictor of combined cardiovascular events and death, as well as being associated with CAD severity and likelihood of intervention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Andy T. Tran, John A. Spertus, Carlos Mena-Hurtado, Philip G. Jones, Herbert D. Aronow, David M. Safley, Ali O. Malik, Poghni A. Peri-Okonny, Mehdi H. Shishehbor, Clementine Labrosciano, Kim G. Smolderen
Summary: This study shows that PAD-specific health status is independently associated with 5-year survival in patients with new or worsening PAD symptoms, with the most recent assessment being the most prognostic.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Surgery
Goren Saenz-Pipaon, Susana Ravassa, Katrine L. Larsen, Esther Martinez-Aguilar, Josune Orbe, Jose A. Rodriguez, Leopoldo Fernandez-Alonso, Arantxa Gonzalez, Jose L. Martin-Ventura, Jose A. Paramo, Jes S. Lindholt, Carmen Roncal
Summary: The study aimed to determine the prognostic value of LCN2 and calprotectin in cardiovascular risk assessment for PAD patients. The results confirmed the association of these two inflammatory biomarkers with increased risks of CV death and MALE through examination of their expression in human femoral plaques and measurement of their levels in serum and plasma of PAD patients.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Review
Cell Biology
Hailing Zhang, Yu Jie, Pei Wang, Yimeng Sun, Xiaoyan Wang, Yu Fan
Summary: Frailty can predict the risk of mortality in patients with lower extremity PAD, but its impact on major amputation remains unclear.
AGEING RESEARCH REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Christiane Engelbertz, Hans O. Pinnschmidt, Eva Freisinger, Holger Reinecke, Boris Schmitz, Manfred Fobker, Roland E. Schmieder, Karl Wegscheider, Guenter Breithardt, Hermann Pavenstaedt, Eva Brand
Summary: This study found that in patients with coronary artery disease and chronic kidney disease, sex did not have a significant impact on long-term outcomes, while factors such as age and disease severity were more crucial in predicting mortality.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lucia Mazzolai, Victor Aboyans, Walter Ageno, Giancarlo Agnelli, Adriano Alatri, Rupert Bauersachs, Marjolein P. A. Brekelmans, Harry R. Buller, Antoine Elias, Dominique Farge, Stavros Konstantinides, Gualtiero Palareti, Paolo Prandoni, Marc Righini, Adam Torbicki, Charalambos Vlachopoulos, Marianne Brodmann
EUROPEAN HEART JOURNAL
(2018)
Review
Peripheral Vascular Disease
Guillaume Mahe, Carine Boulon, Ileana Desormais, Philippe Lacroix, Luc Bressollette, Jean-Louis Guilmot, Claire Le Hello, Marie-Antoinette Sevestre, Gilles Pernod, Joel Constans, Christian Boissier, Alessandra Bura-Riviere
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2017)
Article
Medicine, General & Internal
Samir Henni, Guillaume Mahe, Christophe Lamotte, Remi Laurent, Alessandra Bura Riviere, Marion Aubourg, Gabrielle Sarlon, Damien Laneelle, Anne Long, Isabelle Signolet, Jean Picquet, Mathieu Feuilloy, Pierre Abraham
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2018)
Article
Hematology
Elvira Grandone, Pier Paolo Di Micco, Michela Villani, Donatella Colaizzo, Carmen Fernandez-Capitan, Jorge Del Toro, Vladimir Rosa, Alessandra Bura-Riviere, Isabelle Quere, Angeles Blanco-Molina, Maurizio Margaglione, Manuel Monreal
THROMBOSIS AND HAEMOSTASIS
(2018)
Review
Immunology
Louis Journeau, Marc-Antoine Pistorius, Ulrique Michon-Pasturel, Marc Lambert, Francois-Xavier Lapebie, Alessandra Bura-Riviere, Philippe de Faucal, Patrick Jego, Quentin Didier, Cecile Durant, Geoffrey Urbanski, Baptiste Hervier, Claire Toquet, Christian Agard, Olivier Espitia
AUTOIMMUNITY REVIEWS
(2019)
Article
Endocrinology & Metabolism
Amal Shahwan Jamee, Victor Aboyans, Julien Magne, Pierre Marie Preux, Philippe Lacroix
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2019)
Review
Cardiac & Cardiovascular Systems
Lucia Mazzolai, Adriano Alatri, Alessandra Bura Riviere, Marco De Carlo, Christian Heiss, Christine Espinola-Klein, Oliver Schlager, Henrik Sillesen, Daniel Staub, Jose F. Rodriguez-Palomares, Aline Verstraeten, Victor Aboyans
Summary: This review article summarizes key research on vascular diseases published in 2020, including studies on aortic aneurysm, fibromuscular dysplasia (FMD), the role of NADPH oxidases in vascular physiology, imaging of vulnerable plaque, and clinical trials on lower extremity peripheral artery disease.
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Peripheral Vascular Disease
Victor Aboyans, Maria Teresa B. Abola
Editorial Material
Cardiac & Cardiovascular Systems
Marouane Boukhris, Victor Aboyans
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marco De Carlo, Oliver Schlager, Lucia Mazzolai, Marianne Brodmann, Christine Espinola-Klein, Daniel Staub, Victor Aboyans, Henrik Sillesen, Sebastian Debus, Maarit Venermo, Jill Belch, Mauro Ferrari, Raffaele De Caterina
Summary: This study investigated the use of antithrombotic therapy by European physicians after lower extremity revascularization surgeries. The results showed variations in the choice of therapy among different countries and specialties, with a minority of physicians having dedicated protocols for treatment.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Letter
Pharmacology & Pharmacy
Jean-Louis Montastruc, Francois Montastruc, Alessandra Bura-Riviere
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Victor Aboyans, Lucie Chastaingt
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Mamadou Adama Sow, Guillaume Treiber, Emmanuel Cosson, Yves Mutunzi, Julien Magne, Cyrille Boulogne, Laurence Salle, Marouane Boukhris, Estelle Nobecourt, Victor Aboyans
Summary: This study identified the determinants of high coronary artery calcium score (CACS) in CVD-free patients with Type-2 diabetes (T2D). The risk factors for high CACS include age, sex, diabetes duration, non-CV end-organ damage, and presence of other cardiovascular disease (CVD) risk factors. The French-CAC100 score allows for the identification of patients at higher risk of elevated CACS and can help reduce unnecessary CT scans.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Ramon Luengo-Fernandez, Marjan Walli-Attaei, Alastair Gray, Aleksandra Torbica, Aldo P. Maggioni, Radu Huculeci, Firoozeh Bairami, Victor Aboyans, Adam D. Timmis, Panos Vardas, Jose Leal
Summary: The study found that cardiovascular disease costs the EU 282 billion annually, with 55% allocated to health and long-term care, accounting for 11% of EU health expenditure. This provides important evidence for policymaking to address the economic burden of CVD.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Julien Magne, Baptiste Salerno, Dania Mohty, Claire Serena, Florence Rolle, Alessandro Piccardo, Najmeddine Echahidi, Alexandre Le Guyader, Victor Aboyans
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2019)