Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lenka Turner, Paulina J. Stanczyk, Sonja Khemiri, Julie C. Chamberlain, Wei Yang, Tom R. Webb, Christopher P. Nelson, Nilesh J. Samani, Shu Ye
Summary: This comprehensive analysis shows that a large percentage of CAD loci can modulate gene expression in VSMCs and influence VSMC behavior. Several candidate causal genes identified are likely to be druggable and thus represent potential therapeutic targets.
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Carmen Gutierrez-Munoz, Luis Miguel Blanco-Colio
Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Megumi Miyabe, Nobuhisa Nakamura, Tomokazu Saiki, Satoru Miyabe, Mizuho Ito, Sachiko Sasajima, Tomomi Minato, Tatsuaki Matsubara, Keiko Naruse
Summary: Atherosclerosis is a leading cause of death globally, and there is a correlation between periodontal disease and atherosclerosis. This study used Porphyromonas gingivalis-derived LPS (Pg-LPS) to investigate the proliferation and migration of human aortic smooth muscle cells (HASMCs). The results suggest that Pg-LPS promotes atherosclerosis through the activation of the TLR4-MAPK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Cell Biology
Hua-Li Qin, Jing-Hui Bao, Jian-Jun Tang, Dan-Yan Xu, Li Shen
Summary: Arterial remodeling is a common pathological process in cardiovascular diseases, and vascular smooth muscle cells play a key role in this process. Mitochondrial dysfunction and oxidative stress contribute to the phenotypic transformation of vascular smooth muscle cells, leading to the onset and progression of arterial remodeling. Improving mitochondrial function may be a new intervention strategy to prevent arterial remodeling and treat related cardiovascular diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Raquel Roldan-Montero, Juan M. Perez-Saez, Isabel Cerro-Pardo, Jorge Oller, Diego Martinez-Lopez, Estefania Nunez, Sebastian M. Maller, Carmen Gutierrez-Munoz, Nerea Mendez-Barbero, Joan C. Escola-Gil, Jean-Baptiste Michel, Maria Mittelbrunn, Jesus Vazquez, Luis M. Blanco-Colio, Gabriel A. Rabinovich, Jose L. Martin-Ventura
Summary: Galectin-1 (Gal-1) plays a significant role as a therapeutic target for atherosclerosis and abdominal aortic aneurysm (AAA). Lack of Gal-1 leads to severe atherosclerosis and VSMC phenotypic switch, while treatment with recombinant Gal-1 prevents these effects and alleviates the conditions of atherosclerosis and AAA.
Article
Biochemistry & Molecular Biology
Holly E. Szczepanski, Kyle L. Flannigan, Barbara Mainoli, Laurie Alston, Grace M. Baruta, Joshua W. Lee, Vivek Krishna Pulakazhi Venu, Jane Shearer, Antoine Dufour, Simon A. Hirota
Summary: Stricture formation is a common complication of Crohn's disease, and the orphan nuclear receptor NR4A1 plays a role in regulating intestinal smooth muscle cell proliferation and muscle thickening. Loss of NR4A1 leads to increased proliferation and alterations in cellular metabolism, while activation of NR4A1 attenuates proliferation. By targeting NR4A1, it may be possible to regulate intestinal smooth muscle phenotype and limit excessive proliferation contributing to stricture development in Crohn's disease.
Review
Cell Biology
France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud
Summary: This review summarizes the importance of cellular processes and dysfunction in the development of pulmonary arterial hypertension, as well as the roles of circulating and resident vascular cells in pulmonary vascular remodeling.
Article
Biochemistry & Molecular Biology
Maria Francesca Greco, Alessandra Stefania Rizzuto, Marta Zara, Marco Cafora, Chiara Favero, Giulia Solazzo, Ilaria Giusti, Maria Pia Adorni, Francesca Zimetti, Vincenza Dolo, Cristina Banfi, Nicola Ferri, Cesare R. Sirtori, Alberto Corsini, Silvia Stella Barbieri, Anna Pistocchi, Valentina Bollati, Chiara Macchi, Massimiliano Ruscica
Summary: This study reveals that PCSK9 plays an inflammatory role through EVs released by vascular smooth muscle cells, affecting the function and content of neighboring cells, and may have a significant role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xi-zhenzi Fan, Ying-Ying Wang, Zi-Yang Cui, Zi-Hao Cheng, Hai-Lin Zhang, Nikita Gamper, Fan Zhang, Mei Han
Summary: In this study, the researchers found that Kv7.4 channel is involved in vascular inflammation response, which affects neointimal hyperplasia and abdominal aortic aneurysm formation by regulating inflammation-related genes, matrix metalloproteinases, and intercellular adhesion molecules.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jaqueline Herrmann, Mengdi Xia, Manasa Reddy Gummi, Anna Greco, Annika Schacke, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Vessel wall calcification is a structural pathology of aged vessels associated with high cardiovascular mortality in elderly patients. Chronic inflammation and oxidative stress in aging lead to activation of PRRs in vascular cells, contributing to VSMC calcification. Inhibition of PRR activation may be a potential target for reducing vascular calcification and subsequent cardiovascular mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jie Huang, Yongpeng Xie, Bing Chen, Yu Xia, Yanjiao Jiang, Yun Liu
Summary: This study investigated the role of GPR146 in pulmonary arterial hypertension (PAH) and found that GPR146 is highly expressed in the pulmonary vessels. It was discovered that GPR146 promotes pulmonary vascular remodeling by promoting the proliferation of pulmonary artery smooth muscle cells (PASMCs) through the upregulation of 5-lipoxygenase (5-LO) expression. This finding suggests that GPR146 may serve as a possible target for the prevention and treatment of PAH.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiaopei Cui, Guopin Pan, Ye Chen, Xiaosun Guo, Tengfei Liu, Jing Zhang, Xiaofan Yang, Mei Cheng, Haiqing Gao, Fan Jiang
Summary: Pathological vascular remodeling plays a critical role in various vascular diseases, and activation of p53 may help counteract vascular remodeling and reduce inflammation. Currently, targeting the p53 pathway through pharmacological interventions could be a novel strategy to prevent the development of vascular remodeling.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
M. B. Cicekdal, B. T. Kazan, B. G. Tuna, U. Ozorhan, I. D. Ekici, F. Zhu, O. Suakar, A. Kuskucu, O. F. Bayrak, K. Arcaro, M. P. Cleary, S. Dogan, O. Atasayan, B. Yilmaz
Summary: The study found that energy restriction affects the methylation levels of the AdipoR1 and Leprot genes. Different types of restrictions have different regulatory effects on these genes, with chronic energy restriction having a greater impact on both.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Umit Ozorhan, Bilge G. Tuna, Munevver B. Cicekdal, Aysegul Kuskucu, Omer F. Bayrak, Bayram Yilmaz, Pinar B. Demirel, Margot P. Cleary, Soner Dogan
Summary: The study aims to explore differentially expressed miRNAs and altered gene pathways in the brain of mice under long-term calorie restriction, suggesting that specific miRNAs may play important roles in the preventive effects of calorie restriction on neurodegenerative and ageing-related diseases.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Neuroimaging
Nerea Arrarte Terreros, Agnetha A. E. Bruggeman, Isabella S. J. Swijnenburg, Laura C. C. van Meenen, Adrien E. Groot, Jonathan M. Coutinho, Yvo B. W. E. M. Roos, Bart J. Emmer, Ludo F. M. Beenen, Ed van Bavel, Henk A. Marquering, Charles B. L. M. Majoie
Summary: Early recanalization in transferred EVT patients with LVO stroke is associated with clinical improvement, more distal occlusions, and shorter thrombi at baseline imaging.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neurosciences
Daphne M. P. Naessens, Johannes G. G. Dobbe, Judith de Vos, Ed VanBavel, Erik N. T. P. Bakker
Summary: This study mapped the clearance pathways from the mouse brain and found that tracers spread through the hippocampus to adjacent brain structures, with an important clearance pathway along the ventral part of the hippocampus.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Analytical
Bilge Guvenc Tuna, Dilara Buse Durdabak, Meltem Kazak Ercan, Soner Dogan, Murat Kavruk, Ali Dogan Dursun, Serap Demir Tekol, Caner Celik, Veli Cengiz Ozalp
Summary: This study presents a direct and fast detection method for the CoV-2 genome in nose-throat swab samples, without the need for further processing. The method utilizes fluorescein-loaded mesoporous silica nanoparticles with specific gene sequence probes on their surface, which are released upon hybridization with the target viral genome.
Article
Biochemical Research Methods
Yidan Xue, Theodosia Georgakopoulou, Anne-Eva Van der Wijk, Tamas Jozsa, Ed van Bavel, Stephen J. Payne
Summary: The microvasculature is crucial for oxygen transport in the mammalian brain. Occlusions in cerebral penetrating arteriole trees can lead to unexpected distant tissue hypoxia and infarction. In vivo experiments and in silico simulations were used to investigate the spatial correlation between hypoxic regions and occlusion sites. Results showed that hypoxic regions were present in both experiments and simulations, mainly due to hypoperfusion downstream of the occlusion site. The spatial correlation between hypoxic regions and occlusion sites was reasonably consistent between experiments and simulations.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Oncology
Ertug Avci, Hulya Yilmaz, Nurettin Sahiner, Bilge Guvenc Tuna, Munevver Burcu Cicekdal, Mehmet Eser, Kayhan Basak, Fatih Altintoprak, Ismail Zengin, Soner Dogan, Mustafa Culha
Summary: This study investigates the reliability of surface-enhanced Raman scattering (SERS) for cancer diagnosis by varying several parameters. The results demonstrate the potential of this technique to accurately differentiate blood samples from cancer patients, healthy individuals, and patients with chronic diseases.
Article
Chemistry, Analytical
Simge Balaban Hanoglu, Ezgi Man, Duygu Harmanci, Serife Tozan Ruzgar, Serdar Sanli, Nazim Arda Keles, Atakan Ayden, Bilge Guvenc Tuna, Ozgul Duzgun, Omer Faruk Ozkan, Soner Dogan, Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Serap Evran, Suna Timur
Summary: An electrochemical sensing system based on magnetic nanoparticles enables quantitative and selective analysis of the methylated septin9 gene, a diagnostic marker for early stage colorectal cancer. The system has the potential for translational applications in early cancer detection.
Article
Cell Biology
Yavuz Yavuz, Gamze Yesilay, Bilge Guvenc Tuna, Akif Maharramov, Mustafa Culha, Cihan Suleyman Erdogan, Gunseli Ayse Garip, Bayram Yilmaz
Summary: Gold nanoparticles (GNPs) are widely used in medicine for their multifunctional properties. In this study, the effects of transferrin-conjugated GNPs (Tf-GNPs) on anxiety and locomotor behavior, as well as hippocampal neuronal activity, were investigated. The results showed that Tf-GNP induced anxiety-like behavior without altering the firing rate of hippocampal neurons. These findings highlight the need to evaluate the neurobiological effects of Tf-GNP before their medical applications. Overall, a rating of 7.5 out of 10 is given for the importance of this article.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Haryadi Prasetya, Manon L. Tolhuisen, Miou S. Koopman, Manon Kappelhof, Frederick J. A. Meijer, Lonneke S. F. Yo, Geert J. Lycklama Nijeholt, Wim H. van Zwam, Aad van der Lugt, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Ed T. van Bavel, Henk A. Marquering
Summary: Good collateral status in acute ischemic stroke patients is an important indicator for good outcomes. Perfusion imaging allows for simultaneous assessment of local perfusion and collateral status. We developed a CTP-based collateral score that is significantly associated with functional outcomes and may serve as an alternative collateral measure in settings where MR imaging is not feasible.
Article
Multidisciplinary Sciences
Daphne M. P. Naessens, Judith de Vos, Edo Richard, Micha M. M. Wilhelmus, Cornelis A. M. Jongenelen, Edwin R. R. Scholl, Nicole N. N. van der Wel, Johannes A. A. Heijst, Charlotte E. E. Teunissen, Gustav J. J. Strijkers, Bram F. F. Coolen, Ed Van Bavel, Erik N. T. P. Bakker
Summary: Midlife hypertension is a significant risk factor for cognitive impairment and dementia. The effects of long-term treatment with two different classes of antihypertensive drugs on the brain were investigated. The study found that while both drugs lowered blood pressure, they had different impacts on the hemodynamics of the brain.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Dilara Buse Durdabak, Soner Dogan, Serap Demir Tekol, Caner Celik, Veli Cengiz Ozalp, Bilge Guvenc Tuna
Summary: Universal-modifiable probe-gated silica nanoparticles (SNPs) based lateral flow assay (LFA) has been developed for rapid and early detection of viral infections. The assay can detect various aspects of the virus directly from human swab samples and is adaptable to different types of viruses.
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrianus J. Bakermans, Merel Kouwenhoven, Judith De Vos, Dylan K. De Vries, Yolan J. Reckman, Emile S. Farag, David R. Koolbergen, Jolanda Kluin, Aart J. Nederveen, Gustav J. Strijkers, S. Matthijs Boekholdt
Summary: This study aimed to validate MRI measurements of extracellular volume fraction (ECV) against ex vivo histology of myocardial tissue samples. The results showed a strong correlation between ECV and myocardial collagen content. However, there was no correlation between native T-1 values of the myocardium and ECV or myocardial collagen content.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Analytical
Ali Dogan Dursun, Soner Dogan, Murat Kavruk, B. Busra Tasbasi, Mert Sudagidan, M. Deniz Yilmaz, Bayram Yilmaz, Veli C. Ozalp, Bilge G. Tuna
Summary: A labelless biosensor based on surface plasmon resonance was developed to measure the concentration of Intercellular Adhesion Molecule-1 (ICAM-1) in blood samples. The sensor showed high specificity and low detection limit, providing real-time information on ICAM-1 protein concentration.
Meeting Abstract
Endocrinology & Metabolism
Bilge Guvenc Tuna, Umit Ozorhan, Munevver Burcu Cicekdal, Aysegul Kuskucu, Omer Faruk Bayrak, Bayram Yilmaz, Pinar Buket Demirel, Soner Dogan
NEUROENDOCRINOLOGY
(2021)