期刊
JOURNAL OF VASCULAR RESEARCH
卷 49, 期 3, 页码 185-197出版社
KARGER
DOI: 10.1159/000335123
关键词
Vessel tortuosity; Artery tortuosity; Mechanical buckling; Wall remodeling; Mechanical instability
资金
- National Science Foundation [0644646]
- National Institute of Health [R01HL095852]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL095852] Funding Source: NIH RePORTER
Tortuous arteries and veins are commonly observed in humans and animals. While mild tortuosity is asymptomatic, severe tortuosity can lead to ischemic attack in distal organs. Clinical observations have linked tortuous arteries and veins with aging, atherosclerosis, hypertension, genetic defects and diabetes mellitus. However, the mechanisms of their formation and development are poorly understood. This review summarizes the current clinical and biomechanical studies on the initiation, development and treatment of tortuous blood vessels. We submit a new hypothesis that mechanical instability and remodeling could be mechanisms for the initiation and development of these tortuous vessels. Copyright (C) 2012 S. Karger AG, Basel
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