Article
Nutrition & Dietetics
Xin Dai, Si Liu, Lokyu Cheng, Ting Huang, Honghui Guo, Dongliang Wang, Min Xia, Wenhua Ling, Yunjun Xiao
Summary: Betaine supplementation reduces plasma SAH levels and protects against SAHH-deficiency-promoted atherosclerosis by inhibiting inflammation and smooth muscle cell proliferation and migration.
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
YongPeng Fang, JinShuang Li, XuDong Niu, NingShun Ma, Jia Zhao
Summary: This study found that hypomethylation of the promoter of Rnase6 led to upregulated Rnase6 expression in AS patients, affecting cell proliferation, migration, ROS content, and inflammatory factor secretion, and activating the PI3K/Akt signaling pathway.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cell Biology
Alex P. Rickel, Hanna J. Sanyour, Courtney Kinser, Nisha Khatiwada, Hayley Vogel, Zhongkui Hong
Summary: Atherosclerosis-related cardiovascular diseases are a leading cause of mortality worldwide. Research has found that the mechanical properties of vascular smooth muscle cells are altered during atherosclerosis, contributing to the development of the disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jessica Pauli, Tessa Reisenauer, Greg Winski, Nadja Sachs, Ekaterina Chernogubova, Hannah Freytag, Christoph Otto, Christian Reeps, Hans-Henning Eckstein, Claus-Juergen Scholz, Lars Maegdefessel, Albert Busch
Summary: This study aims to investigate the cellular mechanisms involved in the progression of popliteal artery aneurysm (PAA). Through analysis of samples from PAA patients using various techniques, it was found that VSMCs in PAA lose their contractile phenotype and exhibit increased cell proliferation. APOE, which is specifically higher expressed in PAA tissue, was found to reduce cell proliferation and upregulate contractile VSMC markers when stimulated. The findings suggest similarities between PAA and AAA pathogenesis but with potential differences in the mechanisms involved.
Article
Cardiac & Cardiovascular Systems
Ruyi Zhang, Fan Bu, Yubing Wang, Mei Huang, Xiaomin Lin, Changmeng Wu, Juanjiang Chen, Yiyi Huang, Haifang Wang, Shu Ye, Xiumei Hu, Qian Wang, Lei Zheng
Summary: The study found that long noncoding RNA RP4-639F20.1 is downregulated in atherosclerosis. RP4-639F20.1 interacts with THRAP3 and downregulates c-FOS expression, thereby inhibiting the proliferation and migration of vascular smooth muscle cells. In vivo experiments also revealed that RP4-639F20.1 can deter the development of atherosclerosis. Therefore, RP4-639F20.1 and c-FOS could serve as potential therapeutic targets for atherosclerosis-related diseases.
Article
Cardiac & Cardiovascular Systems
Ning Yang, Bo Dong, Yanqiu Song, Yang Li, Lu Kou, Qin Qin
Summary: This research investigated the role of CLU in regulating VSMC proliferation and migration in vascular restenosis. The findings showed that CLU was highly expressed in vascular restenosis and over-expression of CLU promoted VSMC autophagy, thus attenuating intimal hyperplasia and vascular restenosis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Cell Biology
Wenhua Su, Liwen Liang, Liang Zhou, Yu Cao, Xiuli Zhou, Shiqi Liu, Qian Wang, Hong Zhang
Summary: This study identified a crucial gene, LILRB2, associated with the progression of peripheral atherosclerotic disease (PAD) through bioinformatics analysis. The role of this gene in PAD was validated using a mouse model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Karim J. Brandt, Kapka Miteva
Summary: The study demonstrated that oxLDL-activated monocytes can directly affect VSMCs in a co-culture system, leading to reduced expression of certain markers and upregulation of others, as well as activation of caspase 1, secretion of IL-1 beta, and pyroptosis in VSMCs. The activation of VSMC NLRP3 inflammasome by monocytes may play a detrimental role in atherosclerotic plaque stability in human atherosclerosis, as evidenced by findings in both mice and human atherosclerotic plaques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xu Li, Yong Ding, Min Zhou, Zhenyu Zhou, Tianchen Xie, Yonggang Wang, Zhenjie Liu, Yi Si, Zhenyu Shi
Summary: This study found that Tsp2 is involved in the pathogenesis of intimal hyperplasia (IH) by regulating the proliferation and migration of vascular smooth muscle cells. Inhibition of Tsp2 can mitigate the progression of IH, suggesting that it may serve as a therapeutic target for this disorder.
Review
Chemistry, Medicinal
Diem Thi Ngoc Huynh, Kyung-Sun Heo
Summary: Mitochondrial dynamics and mitophagy play crucial roles in regulating VSMC proliferation and migration through different mechanisms, with dynamin-related protein-1 and mitofusion-2 being key molecules in this process.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dai Sik Ko, Junho Kang, Hye Jin Heo, Eun Kyoung Kim, Kihun Kim, Jin Mo Kang, YunJae Jung, Seung Eun Baek, Yun Hak Kim
Summary: Vascular smooth muscle cell (VSMC) proliferation plays a crucial role in atherosclerosis and restenosis. This study identified PCK2 as a key regulator of VSMC proliferation and suggested targeting PCK2 as a novel therapeutic approach for atherosclerosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hui-Hsuan Lin, Ming-Chang Hsieh, Chi-Ping Wang, Pei-Rong Yu, Ming-Shih Lee, Jing-Hsien Chen
Summary: In this study, GTIN was found to inhibit VSMCs proliferation and migration, reduce ROS generation, and potentially play a role in controlling atherosclerosis and other cardiovascular diseases.
Article
Cardiac & Cardiovascular Systems
Joseph M. Miano, Edward A. Fisher, Mark W. Majesky
Summary: Studying the phenotypic modulation of vascular smooth muscle cells is crucial for understanding the pathogenesis of atherosclerosis and developing new therapies. Recent technological and conceptual advances shed light on the multifunctionality and plasticity of VSMCs.
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Oncology
Francesca Benedetti, Sabrina Curreli, Robert C. Gallo, Davide Zella
Summary: DNA damages caused by factors like viral and bacterial infections increase mutations and genomic instability, raising the risk of cancer development. Reduced ability to repair DNA is associated with various human diseases and elevated likelihood of cellular transformation and cancer development.
Article
Endocrinology & Metabolism
Stella Bernardi, Fabiola Giudici, Vincenzo Barbato, Lorenzo Zanatta, Andrea Grillo, Bruno Fabris
Summary: Current data on cardiovascular manifestations in patients with mild primary hyperparathyroidism (pHPT) show conflicting results. This study found that aortic stiffness is increased in patients with mild pHPT, but parathyroidectomy (PTX) significantly reduced arterial stiffness in these patients. Further research is needed to fully understand the impact of PTX on cardiovascular outcomes in mild pHPT.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Francesca Benedetti, Sabrina Curreli, Robert C. Gallo, Davide Zella
Summary: Studies on tumor cell signaling mechanisms have highlighted the crucial role of kinases in carcinogenesis and cancer progression. Mycoplasmas, components of the normal human microbiota, have been associated with certain cancers and are found in the tumor microenvironment. Research indicates that Mycoplasmas can impact kinase activity, leading to dysregulation of signaling pathways involved in cancer progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Maria-Bernadette Madel, He Fu, Dominique D. Pierroz, Mariano Schiffrin, Carine Winkler, Anne Wilson, Cecile Pochon, Barbara Toffoli, Mahdia Taieb, Jean-Yves Jouzeau, Federica Gilardi, Serge Ferrari, Nicolas Bonnet, Claudine Blin-Wakkach, Beatrice Desvergne, David Moulin
Summary: The study investigated the impact of adipocyte deficiency on bone homeostasis in mice, revealing that adiponectin can inhibit osteoclastogenesis and block mature osteoclast activity by activating AMPK. This research provides potential new approaches to treat osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Roberto Cesareo, Gaia Tabacco, Anda Mihaela Naciu, Anna Crescenzi, Stella Bernardi, Francesco Romanelli, Maurilio Deandrea, Pierpaolo Trimboli, Andrea Palermo, Marco Castellana
Summary: This study systematically reviewed the long-term efficacy and safety of PEI in treating benign cystic thyroid nodules, showing significant reduction in nodule volume, improvement in compressive symptoms and cosmetic concerns, with no permanent complications observed.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Federica Tonon, Riccardo Candido, Barbara Toffoli, Elisabetta Tommasi, Thomas Cortello, Bruno Fabris, Stella Bernardi
Summary: The study found that patients with type 1 diabetes have higher expression of ACE and AngII, and lower expression of ACE2, which may contribute to increased cardiovascular risk and sensitivity to tissue damage caused by SARS-CoV2. Gender has an impact on ACE2 expression, with higher levels in female patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Letter
Endocrinology & Metabolism
V. Calabro, S. Lovriha, L. Zandona, F. Sirianni, B. Fabris, S. Bernardi
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Medicine, General & Internal
Stella Bernardi, Veronica Calabro, Marco Cavallaro, Sara Lovriha, Rita Eramo, Bruno Fabris, Nicolo de Manzini, Chiara Dobrinja
Summary: Adrenal incidentalomas are common, with most being benign and not requiring surgery. However, some are functionally active, including hormone-secreting adenomas and malignant nodules. All patients should undergo screening and confirmatory tests to exclude the presence of a functionally active mass. Multidisciplinary meetings are advocated to improve perioperative management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Barbara Toffoli, Federica Tonon, Fabiola Giudici, Tommaso Ferretti, Elena Ghirigato, Matilde Contessa, Morena Francica, Riccardo Candido, Massimo Puato, Andrea Grillo, Bruno Fabris, Stella Bernardi
Summary: Night shift work is associated with an increased risk of cardiovascular and cerebrovascular disease, possibly due to the promotion of hypertension. This study conducted an analysis comparing blood pressure and clock gene expression in internists working day and night shifts. The results showed that night shift work significantly increased night blood pressure and heart rate and disrupted circadian rhythm. The findings suggest that night shifts contribute to higher blood pressure and circadian rhythm misalignment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Stella Bernardi, Silvia Taccogna, Martina D'Angelo, Fabiola Giudici, Giovanni Mauri, Bruno Raggiunti, Doris Tina, Fabrizio Zanconati, Enrico Papini, Roberto Negro
Summary: The purpose of this study was to evaluate the immunocytochemistry profile of thyroid nodules with poor response to thermal ablation (TA) in order to identify potential predictors of treatment response. The absence of CK-19 was associated with resistance to TA, while the presence of CK-19 was predictive of response to TA. Therefore, the expression of CK-19 could provide rapid and low-cost information about the potential outcome of TA on thyroid nodules.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2023)
Letter
Endocrinology & Metabolism
S. Bernardi, F. Zorat, V. Calabro, M. Faustini Fustini, B. Fabris
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Riccardo Candido, Sara Gaiotti, Fabiola Giudici, Barbara Toffoli, Federica De Luca, Valerio Velardi, Alessandra Petrucco, Chiara Gottardi, Elena Manca, Iris Buda, Bruno Fabris, Stella Bernardi
Summary: This study demonstrates the effectiveness and safety of oral semaglutide as a switch or add-on therapy for patients with type 2 diabetes mellitus in a real-world setting, showing significant reductions in HbA1c and BMI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Stella Bernardi, Andrea Grillo, Roberta Maria Antonello, Marco Fabio Cola, Chiara Dobrinja, Bruno Fabris, Fabiola Giudici
Summary: This study found that both subclinical and overt hypothyroidism, as well as thyrotoxicosis, were associated with an increase in aortic stiffness. The impact of treatment on aortic stiffness should be evaluated in clinical trials.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Letter
Oncology
Stella Bernardi, Fabiola Giudici, Giacomo Colombin, Marco Cavallaro, Fulvio Stacul, Bruno Fabris
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)