Article
Cardiac & Cardiovascular Systems
Dunpeng Cai, Chenming Sun, Gui Zhang, Xingyi Que, Ken Fujise, Neal L. Weintraub, Shi-You Chen
Summary: The study identified ADAR1 as a novel regulator of AAA development, showing its interaction with HuR to regulate the stability of MMP2 and MMP9 mRNA, leading to increased MMP levels and activities that may represent a potential new therapeutic target to hinder AAA growth and rupture.
CIRCULATION RESEARCH
(2021)
Article
Genetics & Heredity
Lin Yang, Hong-Gang Sui, Meng-Meng Wang, Jia-Yin Li, Xiao-Feng He, Jing-Yuan Li, Xiao-Zeng Wang
Summary: Plasma levels of miR-30c-1-3p and MMP-9 may serve as candidate biomarkers for AAA progression.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemistry & Molecular Biology
Aida Javidan, Weihua Jiang, Lihua Yang, Ana Clara Frony, Venkateswaran Subramanian
Summary: The aim of this study is to investigate the effect of Celastrol on angiotensin II-induced abdominal aortic aneurysms (AAA) in hypercholesterolemic mice. The results showed that Celastrol supplementation significantly increased the dilation of abdominal aorta and incidence of AAA induced by AngII.
Article
Cardiac & Cardiovascular Systems
Kohei Karasaki, Hiroki Kokubo, Batmunkh Bumdelger, Nobuchika Kaji, Chiemi Sakai, Mari Ishida, Masao Yoshizumi
Summary: This study found that Angiotensin II type 1 receptor blockers (ARBs) can prevent the progression of abdominal aortic aneurysm (AAA) by upregulating angiotensin (1-7), suggesting that angiotensin (1-7) may play a key role in mediating the protective effect of ARBs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Chongyang Zhang, Hongmei Zhao, Yujun Cai, Jian Xiong, Amy Mohan, Danfei Lou, Hangchuan Shi, Yishuai Zhang, Xiaochun Long, Jing Wang, Chen Yan
Summary: Abdominal aortic aneurysm (AAA) is a common vascular pathology in elderly males characterized by aorta dilation, with cyclic nucleotide phosphodiesterase 1C (PDE1C) playing a critical role in its development. PDE1C elevation contributes to SMC senescence and AAA progression, potentially serving as a therapeutic target against aortic aneurysms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Chung-Huang Chen, Hua-Hui Ho, Wei-Cheng Jiang, Wai-Sam Ao-Ieong, Jane Wang, Alexander N. Orekhov, Igor A. Sobenin, Matthew D. Layne, Shaw-Fang Yet
Summary: This study found that the lack of Cysteine-rich protein 2 (CRP2) can alleviate the occurrence and severity of abdominal aortic aneurysm (AAA) induced by angiotensin II (Ang II), by maintaining the density of aortic vascular smooth muscle cells (VSMCs), extracellular matrix protein homeostasis, and structural integrity of the aorta. In addition, CRP2 deficiency can also reduce elastin degradation, collagen deposition, and abnormal blood pressure, and exert its effects through the Erk1/2-Col III and MMP2 signaling pathways.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Hematology
Michele Silvestro, Cristobal F. Rivera, Dornazsadat Alebrahim, John Vlahos, Muhammad Yogi Pratama, Cuijie Lu, Claudia Tang, Zander Harpel, Rayan Sleiman Tellaoui, Ariadne L. Zias, Delphina J. Maldonado, Devon Byrd, Mukundan Attur, Paolo Mignatti, Bhama Ramkhelawon
Summary: The cytoplasmic domain of MT1-MMP protects against the development of AAA and atherosclerotic plaques through a nonproteolytic signaling mechanism. This finding reveals a novel mechanism of synchronous onset of AAA and atherogenesis and highlights the importance of MT1-MMP in the control of vascular wall homeostasis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Xia Guo, Dunpeng Cai, Kun Dong, Chenxiao Li, Zaiyan Xu, Shi-You Chen
Summary: DOCK2 is identified as a novel regulator for AAA formation, playing a role in promoting vascular inflammation and elastin degradation by upregulating MCP-1 and MMP2 expression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jen-Chun Wang, Shih-Hung Tsai, Hsiao-Ya Tsai, Shing-Jong Lin, Po-Hsun Huang
Summary: This study aimed to elucidate the relationship between hyperuricemia and abdominal aortic aneurysm (AAA). Retrospective study and mouse model revealed that hyperuricemia exacerbates AAA formation and activates the URAT1/ERK1/2/ROS/MMP-9 pathway in human aortic smooth muscle cells (HASMCs).
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Haruhito A. Uchida, Tetsuharu Takatsuka, Yoshiko Hada, Ryoko Umebayashi, Hidemi Takeuchi, Kenichi Shikata, Venkateswaran Subramanian, Alan Daugherty, Jun Wada
Summary: The study found that edaravone can attenuate angiotensin II-induced abdominal aortic aneurysms and atherosclerosis through its antioxidant and anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Andrea Herrero-Cervera, Carla Espinos-Estevez, Susana Martin-Vano, Alida Taberner-Cortes, Maria Aguilar-Ballester, Angela Vinue, Laura Piqueras, Sergio Martinez-Hervas, Herminia Gonzalez-Navarro
Summary: The study suggests a protective role of LIGHT in preventing VSMC trans-differentiation and maintaining their contractile characteristics. Loss of LIGHT exacerbates AAA severity and affects the gene expression of VSMCs.
Article
Hematology
Paul Loick, Goran Hamid Mohammad, Ismail Cassimjee, Anirudh Chandrashekar, Pierfrancesco Lapolla, Alison Carrington, Mayra Vera-Aviles, Ashok Handa, Regent Lee, Samira Lakhal-Littleton
Summary: In patients with abdominal aortic aneurysm (AAA), hepcidin is induced in smooth muscle cells (SMCs) of the aneurysm wall and inversely correlated with the expression of LNC2. The study suggests that hepcidin has a protective role in AAA.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Naofumi Amioka, Toru Miyoshi, Tomoko Yonezawa, Megumi Kondo, Satoshi Akagi, Masashi Yoshida, Yukihiro Saito, Kazufumi Nakamura, Hiroshi Ito
Summary: This study found that Pemafibrate has a preventive effect on AAA rupture, reducing ROS, inflammation, and extracellular matrix degradation. The protective effect against AAA rupture is partly mediated by the antioxidative effect of catalase induced by Pemafibrate.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hannah A. Cooper, Stephanie Cicalese, Kyle J. Preston, Tatsuo Kawai, Keisuke Okuno, Eric T. Choi, Shingo Kasahara, Haruhito A. Uchida, Nozomu Otaka, Rosario Scalia, Victor Rizzo, Satoru Eguchi
Summary: AngII-induced mitochondrial fission via Drp1 plays a crucial role in the development of AAA, likely involving mitochondrial dysfunction and inflammatory activation of VSMCs. Mitochondrial fission inhibition with mdivi1 attenuated AAA development and associated pathology in mouse models, suggesting a potential therapeutic target for AAA.
CARDIOVASCULAR RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Jianing Gao, Yanghui Chen, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S. Lu, Ying H. Shen, Yong Liu, Jifeng Zhang, Y. Eugene Chen, Alan Daugherty, Dao Wen Wang, Lemin Zheng
Summary: This study investigates the role of GSDMD in vascular smooth muscle cell phenotypic alteration and abdominal aortic aneurysm (AAA) formation. Gsdmd is found to be upregulated in aortic VSMCs in Ang II-induced AAA. VSMC-specific Gsdmd deletion ameliorates AAA formation. Untargeted metabolomic analysis reveals a significant reduction of putrescine in GSDMD-deficient mice.