Article
Oncology
Caroline Touloupas, Matthieu Faron, Julien Hadoux, Frederic Deschamps, Charles Roux, Maxime Ronot, Steven Yevich, Julien Joskin, Maximiliano Gelli, Remy Barbe, Livia Lamartina, Hubert Tissot, Jean-Yves Scoazec, David Malka, Michel Ducreux, Eric Baudin, Thierry de Baere, Lambros Tselikas
Summary: Treating NET liver metastases with TACE has shown long-term efficacy and survival rates, with imaging responses correlating significantly with overall survival. This study confirms the effectiveness of TACE and the importance of imaging evaluation in tailoring patient treatment.
Article
Oncology
Shuguang Ju, Chen Zhou, Junwen Hu, Yingliang Wang, Chaoyang Wang, Jiacheng Liu, Chongtu Yang, Songjiang Huang, Tongqiang Li, Yang Chen, Yaowei Bai, Wei Yao, Bin Xiong
Summary: This study aimed to explore the efficacy and safety of TACE combined with apatinib and camrelizumab for unresectable HCC, as well as the impact of the timing of the combination. The results showed that the combination therapy had promising antitumor activity and a manageable safety profile. Late combination therapy provided better overall survival and progression-free survival compared to early combination.
Article
Engineering, Biomedical
Guorong Jia, Tao Wang, Rou Li, Xiao Li, Gaofeng Sun, Wei Chen, Ye Peng, Chao Cheng, Jijin Yang, Changjing Zuo
Summary: In interventional treatment, the combination therapy of transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) using multifunctional nanoparticles shows promise in overcoming drug resistance and improving therapeutic effect in hepatocellular carcinoma (HCC).
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Yingliang Wang, Xuelian He, Chen Zhou, Yaowei Bai, Tongqiang Li, Jiacheng Liu, Shuguang Ju, Chaoyang Wang, Guangya Xiang, Bin Xiong
Summary: Transcatheter arterial chemoembolization (TACE) is commonly used for hepatocellular carcinoma (HCC) treatment, but its efficacy is limited by tumor hypoxia and the abnormal tumor microenvironment (TME). In this study, CaO2 nanoparticles were synthesized and combined with TACE to enhance the antitumor effect. CaO2 NPs relieved tumor hypoxia, neutralized the acidic TME, and induced Ca2+ overloading, resulting in improved efficacy of TACE in the rabbit liver cancer model.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Audrey Fohlen, Remi Beaudouin, Arnaud Alves, Karine Bouhier-Leporrier, Christophe Pasik, Jean-Pierre Pelage
Summary: This study evaluated the tolerability and clinical, biological and radiological tumor response and survival rates in patients with unresectable neuroendocrine liver metastases treated by trans-catheter arterial embolization with conventional chemoembolization, using streptozocin, Lipiodol, and embolization microspheres. The results showed that this procedure using streptozocin is an effective and well-tolerated palliative option for patients with unresectable neuroendocrine liver metastases, with a high objective response rate and non-progressive disease rate. The overall survival rate at different time points was also encouraging.
Article
Medicine, Research & Experimental
Tamas Benkoe, Julia Koenig, Jens M. Theysohn, Clemens Schotten, Fuat H. Saner, Juergen Treckmann, Sonia Radunz
Summary: This study compared the recurrence of HCC after liver transplantation following TACE or radioembolization bridging treatment. The results showed no significant difference in HCC recurrence and overall survival between the radioembolization group and TACE group. Multivariable analysis found recipient age, gender, tumor necrosis, and microvascular invasion to be associated with HCC recurrence.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Oncology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Jia- Liao, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: Tumor burden score (TBS), estimated by the diameter and number of tumor nodules, is a feasible prognostic marker for HCC patients within the Milan criteria. Among patients with low TBS, radiofrequency ablation (RFA) should be considered the priority treatment modality.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuri Cho, Jin Woo Choi, Hoon Kwon, Kun Yung Kim, Byung Chan Lee, Hee Ho Chu, Dong Hyeon Lee, Han Ah Lee, Gyoung Min Kim, Jung Suk Oh, Dongho Hyun, In Joon Lee, Hyunchul Rhim, Korean Liver Cancer Association
Summary: Transarterial chemoembolization (TACE) is a commonly used and important non-surgical treatment for hepatocellular carcinoma (HCC). A group of 12 experts convened by the Korean Liver Cancer Association has developed expert consensus-based practical recommendations in TACE to enhance therapeutic efficacy and safety. These recommendations have been endorsed by the Korean Society of Interventional Radiology and provide useful information and direction in performing TACE procedure as well as pre-and post-procedural patient care.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Health Care Sciences & Services
Evgenia Kotsifa, Chrysovalantis Vergadis, Michael Vailas, Nikolaos Machairas, Stylianos Kykalos, Christos Damaskos, Nikolaos Garmpis, Georgios D. Lianos, Dimitrios Schizas
Summary: HCC is the most common primary liver malignancy associated with liver cirrhosis and chronic liver disease. Key risk factors for HCC development include viral infections, alcoholic liver disease, and nonalcoholic fatty liver disease. Treatment options for HCC depend on tumor burden, liver function, and patient's health status, with surgical resection, transplantation, ablation, TACE, and systemic therapy being potential strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Yunan Wang, Zhihui Chang, Jiahe Zheng, Zhaoyu Liu, Jun Zhang
Summary: Liver abscess formation following TACE in patients with malignant liver tumors is rare but can lead to prolonged drainage tube removal time and contribute to a poor prognosis in these patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Monika Hajkova, Tomas Andrasina, Petra Ovesna, Tomas Rohan, Marek Dostal, Vlastimil Valek, Lenka Ostrizkova, Stepan Tucek, Jiri Sedo, Igor Kiss
Summary: This study evaluates the prognostic value of RECIST, modified RECIST, and volumetric analysis in HCC patients treated with TACE. The results show that volumetric analysis is superior to RECIST and mRECIST in predicting overall survival and progression-free survival, with minimal interobserver variability.
Article
Infectious Diseases
Shingo Yoshihara, Hayato Yamana, Manabu Akahane, Miwa Kishimoto, Yuichi Nishioka, Tatsuya Noda, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Kei Kasahara, Tomoaki Imamura
Summary: This study analyzed the association between prophylactic antibiotic use for TACE and the occurrence of liver abscess, finding that antibiotic use was associated with a reduced occurrence of liver abscess requiring procedural intervention. There was no significant difference in 30-day in-hospital mortality between the groups, but the length of stay was longer in the antibiotics group.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Gastroenterology & Hepatology
Yuri Cho, Jin Woo Choi, Hoon Kwon, Kun Yung Kim, Byung Chan Lee, Hee Ho Chu, Dong Hyeon Lee, Han Ah Lee, Gyoung Min Kim, Jung Suk Oh, Dongho Hyun, In Joon Lee, Hyunchul Rhim, Res Comm Korean Liver Canc Assoc
Summary: Transarterial chemoembolization (TACE) was introduced in 1977 as a treatment for hepatocellular carcinoma (HCC) and has evolved over the years. Currently, TACE is widely used for HCC patients who cannot undergo curative treatment. The development of expert consensus-based practical recommendations has provided valuable guidance for performing TACE and ensuring proper patient care. Rating: 8/10
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Oncology
Natsuhiko Saito, Hideyuki Nishiofuku, Takeshi Sato, Shinsaku Maeda, Kiyoyuki Minamiguchi, Ryosuke Taiji, Takeshi Matsumoto, Yuto Chanoki, Tetsuya Tachiiri, Hideki Kunichika, Nagaaki Marugami, Toshihiro Tanaka
Summary: This study aimed to clarify the prognosis and identify predictors for obtaining a complete response (CR) by transarterial chemoembolization (TACE) in intermediate stage HCC beyond up-to-7 criteria. Overall, 56.9% of patients obtained CR, which contributed to prolonging survival. The treatment strategy based on the 7-11 criteria is suggested for intermediate stage HCC.
Article
Medicine, General & Internal
Sun Young Choi, Kyung Ah Kim, Woosun Choi, Yohan Kwon, Soo Buem Cho
Summary: The study investigated the utility of CBCT-based liver perfusion mapping in assessing treatment response and predicting outcomes in HCC patients undergoing TACE. Results showed that CBCT-based liver perfusion mapping and PBV values were significant in the analysis and demonstrated high sensitivity and specificity in predicting residual tumors. The study highlights the importance of these imaging techniques in enhancing the efficacy of TACE in HCC patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Mahmud Mossa-Basha, Thien J. Huynh, Daniel S. Hippe, Peter Fata, Ryan P. Morton, Michael R. Levitt
JOURNAL OF NEUROSURGERY
(2019)
Article
Clinical Neurology
Justin E. Vranic, Thien J. Huynh, Peter Fata, Jason Barber, Robert H. Bonow, Michael R. Levitt, Nancy Temkin, Ryan Morton, Cory Kelly, Dean K. Shibata, Mahmud Mossa-Basha
JOURNAL OF NEURORADIOLOGY
(2020)
Article
Clinical Neurology
Charlie Chia-Tsong Hsu, Suradech Suthiphosuwan, Thien Huynh, Amanda Murphy, Yangmei Li, Aditya Bharatha
CLINICAL NEURORADIOLOGY
(2020)
Article
Medicine, General & Internal
Michael D. Hill, Mayank Goyal, Bijoy K. Menon, Raul G. Nogueira, Ryan A. McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian H. Buck, Thalia S. Field, Dar Dowlatshahi, Brian A. van Adel, Richard H. Swartz, Ruchir A. Shah, Eric Sauvageau, Charlotte Zerna, Johanna M. Ospel, Manish Joshi, Mohammed A. Almekhlafi, Karla J. Ryckborst, Mark W. Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M. Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy L. Rempel, Axel C. R. Rohr, Daniela Lancu, Demetrios J. Sahlas, Amy Y. X. Yu, Thomas G. Devlin, Ricardo A. Hanel, Volker Puetz, Frank L. Silver, Bruce C. Campbell, Rene Chapot, Jeanne Teitelbaum, Jennifer L. Mandzia, Timothy J. Kleinig, David Turkel-Parrella, Donald Heck, Michael E. Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F. Frei, Jason W. Tarpley, Cameron G. McDougall, Staffan Holman, Joung-Ho Rha, Ajit S. Puri, Marie-Christine Camden, Gotz Thomalla, Hana Choe, Stephen J. Phillips, Joseph L. Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung- Sohn, Marios-Nikos Psychogios, Ronald F. Budzik, Sidney Starkman, Coleman O. Martin, Paul A. Burns, Sean Murphy, George A. Lopez, Joey English, Michael Tymianski
Article
Computer Science, Interdisciplinary Applications
Allister Mason, James Rioux, Sharon E. Clarke, Andreu Costa, Matthias Schmidt, Valerie Keough, Thien Huynh, Steven Beyea
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Neuroimaging
Mark Alexander MacLean, Thien J. Huynh, Matthias Helge Schmidt, Vitor M. Pereira, Adrienne Weeks
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2020)
Reprint
Neuroimaging
Thien J. Huynh, Ryan P. Morton, Michael R. Levitt, Basavaraj V. Ghodke, Onno Wink, Danial K. Hallam
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2020)
Review
Surgery
Young Erben, Camila Franco-Mesa, David Miller, Giuseppe Lanzino, Bernard R. Bendok, Yupeng Li, Sukhwinder J. S. Sandhu, Kevin M. Barrett, William D. Freeman, Michelle Lin, Josephine F. Huang, Thien Huynh, Houssam Farres, Thomas G. Brott, Albert G. Hakaim, Tara J. Brigham, Nathan D. Todnem, Rabih G. Tawk, James F. Meschia
Summary: This study compared short- and long-term outcomes of carotid artery stenting in patients with radiation-induced internal carotid artery stenosis and atherosclerotic stenosis. Patients with radiation-induced stenosis had a higher rate of restenosis and reintervention compared to those with atherosclerotic stenosis. Although carotid artery stenting is safe and effective for radiation-induced stenosis, further research is needed to reduce restenosis risk, and close patient monitoring is necessary.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Clinical Neurology
Alexander D. Wong, Rufus Alubankudi, Judith Jarrett, Thien J. Huynh, Adam A. Dmytriw, Gwynedd E. Pickett
Summary: This study examines the outcomes of treating aneurysmal subarachnoid haemorrhage (aSAH) with endovascular coiling or surgical clipping at a Canadian quaternary centre over a 15-year period post-ISAT. The study found no significant difference in clinical outcomes between the two techniques. These findings provide valuable insights for clinical decision-making and understanding the natural recovery progression of aSAH.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
James L. West, Gaetano De Biase, Kingsley Abode-Iyamah, Eric W. Nottmeier, H. Gordon Deen, Selby G. Chen, Thien Huynh, W. Christopher Fox, Mohamad Bydon, David A. Miller, Steven R. Clendenen
Summary: This study retrospectively reviewed patients who underwent US-EBP for symptomatic postoperative pseudomeningocele, and found that the success rate was high with few complications. The routine utilization of US-guided EBP may allow for targeted treatment of pseudomeningoceles, avoiding prolonged hospitalization, risks of general anesthesia, and impaired wound healing associated with surgical revision.
WORLD NEUROSURGERY
(2021)
Review
Clinical Neurology
N. Borg, J. Cutsforth-Gregory, S. Oushy, T. Huynh, L. E. Savastano, H. J. Cloft, G. Lanzino, W. Brinjikji
Summary: This article summarizes the treatment experience and anatomical knowledge of CSF-venous fistulas, providing a practical guide for doctors performing transvenous spinal procedures.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Andrew L. Callen, Lalani Carlton Jones, Vincent M. Timpone, Jack Pattee, Daniel J. Scoffings, David Butteriss, Thien Huynh, Peter Y. Shen, Mark D. Mamlouk
Summary: This study retrospectively evaluated the application of CT-guided fibrin glue occlusion in patients with CSF-to-venous fistulas, and the results showed a correlation between cure rates and injectate spread and drainage patterns.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Ashkan Shoamanesh, M. Patrice Lindsay, Lana A. Castellucci, Anne Cayley, Mark Crowther, Kerstin de Wit, Shane W. English, Sharon Hoosein, Thien Huynh, Michael Kelly, Cian J. O'Kelly, Jeanne Teitelbaum, Samuel Yip, Dar Dowlatshahi, Eric E. Smith, Norine Foley, Aleksandra Pikula, Anita Mountain, Gord Gubitz, Laura C. Gioia
Summary: Spontaneous intracerebral hemorrhage is a severe type of stroke with high mortality rate, and the latest update of the Canadian Stroke Best Practice Recommendations introduces a standalone module focusing on all aspects of care for intracerebral hemorrhage. It covers topics from initial clinical management to inpatient complications, addressing a comprehensive range of issues related to stroke management.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeet Patel, Thien J. Huynh, Dinesh Rao, Grzegorz Brzezicki
JOURNAL OF CLINICAL IMAGING SCIENCE
(2020)
Article
Medicine, General & Internal
Mark Alexander MacLean, Thien J. Huynh, Matthias Helge Schmidt, Vitor M. Pereira, Adrienne Weeks