Article
Multidisciplinary Sciences
Marwan Moussa, Md. Raihan Chowdhury, David Mwin, Mohamed Fatih, Gokul Selveraj, Ahmed Abdelmonem, Mohamed Farghaly, Qianhui Dou, Nina Filipczak, Tatyana Levchenko, Vladimir P. Torchilin, Vassiliki Boussiotis, S. Nahum Goldberg, Muneeb Ahmed
Summary: The study demonstrates that the combination of liposomal GM-CSF and RFA improves intratumoral immune cell trafficking and increases the populations of DCs and M1 cells, among others. Additionally, liposomes can influence synchronous untreated metastases by increasing infiltration of Th1, CTL, and DCs.
Article
Acoustics
Alessandro Beleu, Alessandro Drudi, Alvise Giaretta, Riccardo De Robertis, Ilaria Fedrigo, Enrico Martone, Conci Simone, Chiara Bovo, Mirko D'Onofrio
Summary: The study showed that ultrasound fusion imaging significantly improves the detection of target tumors, increases operator confidence, and saves time in the percutaneous ablation of hepatic malignancies, particularly in the treatment of local recurrences.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Frank Hao, Navid Eghbalieh, Alexandra So, Edward Wolfgang Lee
Summary: This study demonstrates that hepatic nerve plexus block can effectively control pain during microwave ablation of hepatic tumors, with relatively low pain scores, and only a minority of patients requiring additional sedation.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kevin S. He, Rukshan Fernando, Tatiana Cabrera, David Valenti, Abdulaziz Algharras, Nicolas Martinez, David M. Liu, Geoffroy Noel, Karl Muchantef, Ali Bessissow, Louis-Martin Boucher
Summary: The study developed a safe and technically simple liver-specific nerve block method to effectively reduce pain during liver disease treatment and reduce the risk of oversedation. Among the 12 patients who received hepatic hilar nerve block, the pain level was significantly lower compared to the control group, and the intraoperative fentanyl requirement was also reduced.
Article
Oncology
Kun Qian, Minjiang Chen, Feng Zhang, Jeffrey Forris Beecham Chick, Hongxiu Ji, Chuansheng Zheng, Xiaoming Yang
Summary: Radiofrequency-induced hyperthermia (RFH) combined with intra-tumoral chemotherapy showed a promising treatment effect for rabbit VX2 liver tumors by enhancing the uptake of Doxorubicin and increasing the expression of HSP70, resulting in apoptosis of tumor cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Youlan Shang, Ge Li, Bin Zhang, Yuzhi Wu, Yanjing Chen, Chang Li, Wei Zhao, Jun Liu
Summary: Image-guided percutaneous lung ablation is an alternative and effective strategy for the treatment of lung cancer and other lung malignancies. Radiofrequency ablation, microwave ablation, and cryoablation are widely used modalities that can be performed alone or in combination with other treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Joslin R. Musick, Prejesh Philips, Charles R. Scoggins, Michael E. Egger, Kelly M. McMasters, Robert CG. Martin II
Summary: This study compared laparoscopic microwave ablation with percutaneous microwave ablation in terms of efficacy and recurrence-free survival outcomes in patients with hepatic malignancies. The results showed that the laparoscopic group had lower rates of local recurrence and same-lobe recurrence, as well as longer median recurrence-free survival. Additionally, the laparoscopic group had lower complications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew M. Chiu, Rohan Savoor, Andrew C. Gordon, Ahsun Riaz, Kent T. Sato, Elias Hohlastos, Riad Salem, Robert J. Lewandowski
Summary: A retrospective study found that yttrium-90 radiation segmentectomy is a safe and effective treatment for oligo-metastatic secondary hepatic malignancies, achieving high disease control rate.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xuan Yu, Jiandong Chang, Dezhi Zhang, Qiang Lu, Songsong Wu, Kai Li
Summary: This study retrospectively analyzed the clinical data of patients who underwent ultrasound-guided percutaneous thermal ablation for FNH in China. The results showed that this treatment method is safe and effective, with a high technical success rate and a low incidence of complications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Hong-Tao Hu, Xiao-Hui Zhao, Chen-Yang Guo, Quan-Jun Yao, Xiang Geng, Wen-Bo Zhu, Hong-Le Li, Wei-Jun Fan, Hai-Liang Li
Summary: Local ablation treatment is effective and safe for adjacent pleural lung tumors, achieving complete tumor ablation. However, there are potential adverse events and complications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dennis Parhar, Richard A. Baum, Rebecca Spouge, Tyler Yan, Stephen Ho, Anastasia Hadjivassiliou, Lindsay Machan, Gerald Legiehn, Darren Klass, Ravjot Dhatt, Louis-Martin Boucher, David M. Liu
Summary: The purpose of this study was to determine whether hepatic hilar nerve block techniques reduce analgesic and sedation requirements during percutaneous image-guided thermal ablation of hepatic tumors. The results showed that the group receiving hepatic hilar nerve blocks had a longer procedure duration but no significant differences in technical success or adverse event rates compared to the unblocked group. After adjustment, hilar nerve blocks were associated with lower fentanyl and midazolam dosages.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Scott C. Mauch, Annie M. Zlevor, Emily A. Knott, Allison B. Couillard, Sarvesh Periyasamy, Eliot C. Williams, John F. Swietlik, Paul F. Laeseke, Xiaofei Zhang, Zhen Xu, E. Jason Abel, Fred T. Lee, Timothy J. Ziemlewicz
Summary: Liver and kidney histotripsy appears to be safe with no elevated bleeding risk in this anticoagulated animal model, supporting the possibility of histotripsy treatments in patients on anticoagulation.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Eun Ko, Min Woo Lee, Soohyun Ahn, Hyunchul Rhim, Tae Wook Kang, Kyoung Doo Song, Jong Man Kim, Gyu-Seong Choi, Dong Ik Cha, Ji Hye Min, Dong Hyun Sinn, Moon Seok Choi, Hyo Keun Lim
Summary: This study compared the therapeutic outcomes of laparoscopic hepatic resection (LHR) and laparoscopic radiofrequency ablation (LRFA) for single subcapsular hepatocellular carcinoma (HCC) measuring 1-3 cm. The results showed no significant difference in therapeutic outcomes between the two methods.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Medicine, General & Internal
Tsung-Hsing Hung, Chih-Chun Tsai, Hsing-Feng Lee
Summary: This study evaluated the impact of liver reserve on mortality after RFA for early stage HCC among cirrhotic patients, finding that cirrhotic-related complications significantly increased mortality, with patients having 3 complications having a 4-fold increased risk of death.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Ik Cha, Min Woo Lee, Woo Kyoung Jeong, Soo Hyun Ahn, Tae Wook Kang, Kyoung Doo Song, Ji Hye Min, Hyunchul Rhim, Hyo Keun Lim
Summary: Primary hepatic malignant tumors with arterial rim enhancement (RE) after RFA, especially RE tumors with other targetoid appearances (REoT), have higher risks of local tumor progression (LTP), intrahepatic distant metastasis (IDR), and extrahepatic metastasis (EM) compared to non-RE tumors within 2 years.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Syed M. S. Reza, Winston T. Chu, Fatemeh Homayounieh, Maxim Blain, Fatemeh D. Firouzabadi, Pouria Y. Anari, Ji Hyun Lee, Gabriella Worwa, Courtney L. Finch, Jens H. Kuhn, Ashkan Malayeri, Ian Crozier, Bradford J. Wood, Irwin M. Feuerstein, Jeffrey Solomon
Summary: This study employs deep-learning techniques to quantitatively analyze the CT scans of nonhuman primates exposed to SARS-CoV-2, specifically focusing on whole-lung and lung-lesion segmentation. Through the use of a novel multi-model ensemble technique, the automated segmentation of lung lesions is improved, demonstrating superior performance compared to other methods. The application of automated segmentation methods provides a standardized and automated approach for disease detection and quantification.
ACADEMIC RADIOLOGY
(2023)
Article
Engineering, Biomedical
Hengtao Guo, Hanqing Chao, Sheng Xu, Bradford J. Wood, Jing Wang, Pingkun Yan
Summary: This paper presents a novel deep learning approach, named deep contextual-contrastive network (DC2-Net), for sensorless ultrasound volume reconstruction from freehand 2D ultrasound scans without tracking information. The proposed method efficiently exploits content correspondence between ultrasound frames to estimate spatial movement and contrastive features and achieves superior performance compared with other methods, with a drift rate of 9.64% and a prostate Dice of 0.89. The promising results demonstrate the capability of deep neural networks for universal ultrasound volume reconstruction.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Xi Fang, Xuanang Xu, James J. Xia, Thomas Sanford, Baris Turkbey, Sheng Xu, Bradford J. Wood, Pingkun Yan
Summary: In this paper, a set of shape description losses is proposed to supervise the training of segmentation networks. These losses extract and quantify geometric features of the targets, such as volume, surface area, center of mass, and bounding box. The results demonstrate that using these shape losses alone for weakly supervised learning can achieve promising performance.
MACHINE VISION AND APPLICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Enis C. Yilmaz, Joanna H. Shih, Mason J. Belue, Stephanie A. Harmon, Tim E. Phelps, Charisse Garcia, Lindsey A. Hazen, Antoun Toubaji, Maria J. Merino, Sandeep Gurram, Peter L. Choyke, Bradford J. Wood, Peter A. Pinto, Baris Turkbey
Summary: This study aimed to evaluate the performance of PI-RADS version 2.1 in prostate cancer detection and identify MRI features for improving csPCa detection. A total of 454 men who were suspected or known to have prostate cancer participated in this study. The results showed that csPCa rates varied among different PI-RADS categories, and MRI features including lesion volume, shape, and EPE scores could predict csPCa.
Correction
Multidisciplinary Sciences
Ayele H. Negussie, Andrew S. Mikhail, Joshua W. Owen, Natalie Hong, Camella J. Carlson, Yiqing Tang, Kendal Paige Carrow, Michal Mauda-Havakuk, Andrew L. Lewis, John W. Karanian, William F. Pritchard, Bradford J. Wood
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Cecilia Monge, Changqing Xie, Yuta Myojin, Kelley Coffman, Donna Mabry Hrones, Sophie Wang, Jonathan M. Hernandez, Bradford J. Wood, Elliot B. Levy, Israa Juburi, Stephen M. Hewitt, David E. Kleiner, Seth M. Steinberg, William D. Figg, Bernadette Redd, Philip Homan, Maggie Cam, Benjamin Ruf, Austin G. Duffy, Tim F. Greten
Summary: This study evaluated the safety and efficacy of the combination of PexaVec, durvalumab, and tremelimumab in patients with refractory pMMR mCRC. The results showed that the combination therapy has potential clinical activity without unexpected toxicities.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Claudia Wing-Kwan Wu, Rashid Nok-Shun Lui, Vincent Wai-Sun Wong, Tsz-Fai Yam, Terry Cheuk-Fung Yip, Ken Liu, Jimmy Che-To Lai, Yee-Kit Tse, Tony Shu-Kam Mok, Henry Lik-Yuen Chan, Kelvin Kwok-Chai Ng, Grace Lai-Hung Wong, Stephen Lam Chan
Summary: The study successfully validated the efficacy of the Baveno VII criteria in predicting high-risk varices in patients with hepatocellular carcinoma, providing a non-invasive method for assessing the risk of variceal bleeding and hepatic decompensation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ming Li, Sherif Mehralivand, Sheng Xu, Nicole Varble, Ivane Bakhutashvili, Sandeep Gurram, Peter A. Pinto, Peter L. Choyke, Bradford J. Wood, Baris Turkbey
Summary: An augmented reality (AR) system was developed to facilitate real-time needle guidance for transperineal prostate (TP) procedures. The system uses preprocedural volumetric images to superimpose annotated anatomy onto a patient, providing real-time needle tip localization and visualization. The accuracy of the system was evaluated on a phantom, and the feasibility was further demonstrated by implanting soft tissue markers into a pelvic phantom. The results showed accurate needle guidance and the potential for more flexibility in TP procedures.
JOURNAL OF MEDICAL IMAGING
(2023)
Article
Acoustics
Hengtao Guo, Xuanang Xu, Xinrui Song, Sheng Xu, Hanqing Chao, Joshua Myers, Baris Turkbey, Peter A. Pinto, Bradford J. Wood, Pingkun Yan
Summary: In this study, a novel method for fusing ultrasound and magnetic resonance images using deep neural networks is proposed. The method is validated on a clinical dataset of 618 subjects and shows promising results in real-time navigation tasks.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Multidisciplinary Sciences
Nicole A. Varble, Ivane Bakhutashvili, Sheridan L. Reed, Jose Delgado, Zoi Tokoutsi, Bruno Frackowiak, Marco Baragona, John W. Karanian, Bradford J. Wood, William F. Pritchard
Summary: Heat-induced destruction of cancer cells via microwave ablation (MWA) is an effective treatment for liver cancer. Predicting the impacted zone of cell death is challenging, especially in the presence of vasculature. In order to improve thermal MWA for cancer treatment, an in vivo method and experimental dataset were created to assess biophysical models that can predict ablation zone parameters.
Article
Medicine, General & Internal
Kelvin K. C. Ng
JOURNAL OF CLINICAL MEDICINE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Xinrui Song, Xuanang Xu, Sheng Xu, Baris Turkbey, Thomas Sanford, Bradford J. Wood, Pingkun Yan
MEDICAL IMAGING 2023
(2023)
Meeting Abstract
Urology & Nephrology
Anjali Pillai, Zoe Blake, Daniel R. Nemirovsky, Jacob J. Enders, Neil Mendhiratta, Alexander P. Kenigsberg, Michael B. Rothberg, Jibriel Noun, Daniel Nethala, Sandeep Gurram, Bradford J. Wood, Baris Turkbey, Peter A. Pinto
JOURNAL OF UROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tim E. E. Phelps, Enis C. C. Yilmaz, Stephanie A. A. Harmon, Mason J. J. Belue, Joanna H. H. Shih, Charisse Garcia, Lindsey A. A. Hazen, Antoun Toubaji, Maria J. J. Merino, Sandeep Gurram, Peter L. L. Choyke, Bradford J. J. Wood, Peter A. A. Pinto, Baris Turkbey
Summary: This study evaluates the cancer detection rates of reduced-core biopsy schemes in patients with unilateral mpMRI-visible intraprostatic lesions and finds that the combined strategy of targeted biopsy and systematic biopsy maximizes the detection of clinically significant prostate cancer.
ABDOMINAL RADIOLOGY
(2023)
Article
Engineering, Biomedical
Neil Glossop, Reto Bale, Sheng Xu, William F. Pritchard, John W. Karanian, Bradford J. Wood
Summary: This study aimed to evaluate the feasibility of using personalized needle guidance grid templates for implementing in vivo ablation treatment plans with multiple needles. The personalized templates were fabricated using intraprocedural CT images, and multiple needle trajectories were planned. A numerical-controlled milling machine was used to drill the corresponding holes, and the needles were inserted to the calculated depth. The needle placement accuracy was high, and the procedure was performed rapidly.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)