Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates

New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2

(2013) Victoria Magrioti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insertion of the Ca2+-Independent Phospholipase A2 into a Phospholipid Bilayer via Coarse-Grained and Atomistic Molecular Dynamics Simulations

(2013) Denis Bucher et al.   PLoS Computational Biology

Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review

(2012) Andrew J. Percy et al.   ANALYTICA CHIMICA ACTA

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

Phospholipase A2 enzymes and the risk of atherosclerosis

(2012) R. S. Rosenson et al.   EUROPEAN HEART JOURNAL

Using Hydrogen/Deuterium Exchange Mass Spectrometry to Define the Specific Interactions of the Phospholipase A2Superfamily with Lipid Substrates, Inhibitors, and Membranes

(2012) Jian Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluoroketone Inhibition of Ca2+-Independent Phospholipase A2 through Binding Pocket Association Defined by Hydrogen/Deuterium Exchange and Molecular Dynamics

(2012) Yuan-Hao Hsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Applications of Mass Spectrometry to Lipids and Membranes

(2011) Richard Harkewicz et al.   Annual Review of Biochemistry

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

The Application of Rational Design on Phospholipase A2 Inhibitors

(2011) V. D. Mouchlis et al.   CURRENT MEDICINAL CHEMISTRY

Binding Conformation of 2-Oxoamide Inhibitors to Group IVA Cytosolic Phospholipase A2 Determined by Molecular Docking Combined with Molecular Dynamics

(2011) Varnavas D. Mouchlis et al.   Journal of Chemical Information and Modeling

POVME: An algorithm for measuring binding-pocket volumes

(2010) Jacob D. Durrant et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Localizing the Membrane Binding Region of Group VIA Ca2+-independent Phospholipase A2Using Peptide Amide Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Yuan-Hao Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic Review Series: Proteomics.An integrated omics analysis of eicosanoid biology,

(2009) Matthew W. Buczynski et al.   JOURNAL OF LIPID RESEARCH

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

(2009) Fabio Zuccotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Location of Inhibitors Bound to Group IVA Phospholipase A2Determined by Molecular Dynamics and Deuterium Exchange Mass Spectrometry

(2009) John E. Burke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome

(2009) A. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Phospholipid Substrate Molecule Residing in the Membrane Surface Mediates Opening of the Lid Region in Group IVA Cytosolic Phospholipase A2

(2008) John E. Burke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY