Article
Food Science & Technology
Shufen Han, Ruijuan Song, Yifei Cao, Xiao Yan, Hui Gao, Fuzhi Lian
Summary: This study found that crocin can reduce the progression of atherosclerosis by enhancing hepatic antioxidant capacity, inhibiting NLRP3 inflammasome and TLR4 signal, and improving gut microbiota composition.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Jingwen Xie, Lin Liu, Hongyan Li, Hongxia Che, Wancui Xie
Summary: Oral administration of MSI significantly alleviated DSS-induced colitis by modulating inflammatory cytokines and oxidation stress, maintaining the mucosal barrier, and reverting microbiota changes.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Environmental Sciences
Yunping Li, Heidi Qunhui Xie, Yin Liu, Li Xu, Liping Zheng, Shuyuan Yu, Guomin Chen, Jiajia Ji, Shuai Jiang, Tai L. Guo, Bin Zhao
Summary: This study revealed the effects of chlorinated flame retardant Dechlorane 602 (Dec 602) on the intestinal microbiota and metabolites. The results showed that Dec 602 altered the composition of intestinal microbiota towards a pro-inflammatory state, up-regulated oxidative and pro-inflammatory metabolites, and down-regulated antioxidative and anti-inflammatory metabolites.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Priyankar Dey, Saumya Ray Chaudhuri, Thomas Efferth, Sirshendu Pal
Summary: The role of the intestine in human health and disease is crucial, and studies on intestinal microbiota and metabolites have enhanced our understanding of their relationship. Research on the effects of dietary phytochemicals on microbial metabolites in the gut is also a key focus.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Linglian Kong, Zhenhua Wang, Chuanpi Xiao, Qidong Zhu, Zhigang Song
Summary: The study demonstrated that appropriate doses of glycerol monolaurate (GML) enhanced growth performance and immunity, improved intestinal morphology and barrier function in broiler chicks, and modulated the composition of cecal microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Xulu Chang, Meiru Kang, Yihao Shen, Lili Yun, Guokun Yang, Lei Zhu, Xiaolin Meng, Jianxin Zhang, Xi Su
Summary: The research explores the effects of B. coagulans on Cd2+ bioaccumulation, gut barrier function, oxidative stress, and gut microbiota in common carp. B. coagulans can maintain gut barrier function by reducing Cd2+ bioaccumulation, increasing tight junction protein gene mRNA levels, and decreasing diamine oxidase and D-lactic acid levels in Cd2+-exposed fish. Additionally, B. coagulans can relieve oxidative stress and reverse altered intestinal microbiota diversity and composition in common carp exposed to Cd2+.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Zhenxin Wang, Dan Shao, Shu Wu, Zhigang Song, Shourong Shi
Summary: This study demonstrates the beneficial effects of dietary dimethylglycine (DMG) in reducing heat stress-induced intestine injury. DMG supplementation improves growth performance and repairs gut barrier integrity, while modulating the composition of gut microbiota and enhancing microbiota-gut-brain axis metabolism function. These findings provide insights into a novel mechanism by which gut microbiota can improve host health.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Agriculture, Dairy & Animal Science
Weilei Yao, Tongxin Wang, Lu Huang, Zhengxi Bao, Shu Wen, Feiruo Huang
Summary: The study demonstrated that embelin exerts protective effects against intestinal inflammation in weaned pigs by suppressing the PCAF/NF-kappa B signaling pathway, as evidenced by decreased serum D-lactate and diamine oxidase levels, increased expression of ZO-1, occludin and claudin-1 proteins in the jejunum and ileum, and downregulation of critical inflammatory molecules in the jejunal and ileal mucosa. Additionally, embelin also downregulated PCAF activity and attenuated the acetylation and activities of NF-kappa B in IPEC-1 cells with overexpression of PCAF.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Marine & Freshwater Biology
Lei Wang, Cong Hu, Bin Wang, Heng Wang, Chenyang Wang, Yilin Shu, Chang Gao, Yunzhi Yan
Summary: The study found that chronic exposure to environmentally relevant concentrations of Cu2+ had adverse effects on the intestinal health of freshwater grouper, including inducing oxidative stress, inflammation, prevalence of pathogens, and inhibition of probiotic bacteria, as well as damaging intestinal integrity.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Xiaowen Zhang, Manli Shen, Cui Wang, Miaomiao Gao, Liuen Wang, Zeyu Jin, Xiaohua Xia
Summary: This study evaluated the effects of aluminum exposure on crayfish. The results showed that aluminum induced biochemical, histological, gut microbial, and immune changes in the crayfish. Therefore, excessive aluminum exposure may have adverse effects on various biological processes of crayfish, posing a potential threat to crayfish culture.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Mulin Liu, Hexin Wen, Lugen Zuo, Xue Song, Zhijun Geng, Sitang Ge, Yuanyuan Ge, Rong Wu, Shiyuan Chen, Chaowen Yu, Yong Gao
Summary: This study investigated the effects of Bryo-1 on intestinal ischemia/reperfusion (I/R) injury and its mechanism. The results showed that Bryo-1 improved the intestinal barrier dysfunction caused by I/R, reduced oxidative stress damages and inflammation, and activated Nrf2/HO-1 signaling. These findings suggest that Bryo-1 protects intestines against I/R-induced injury through intestinal barrier protection and inhibition of inflammation and oxidative stress partly via Nrf2/HO-1 signaling.
Article
Immunology
Grace T. Patterson, Elvia Y. Osorio, Alex Peniche, Sara M. Dann, Erika Cordova, Geoffrey A. Preidis, Ji Ho Suh, Ichiaki Ito, Omar A. Saldarriaga, Michael Loeffelholz, Nadim J. Ajami, Bruno L. Travi, Peter C. Melby
Summary: Acute malnutrition is associated with abnormal development of the intestinal microbiota and dysfunction of the intestinal barrier, resulting in systemic inflammation and endotoxemia.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xiaopeng Tang, Kangning Xiong, Rejun Fang, Meijun Li
Summary: Weaning is a critical period in pig production, but it often causes stress for piglets due to separation from the sow, changes in diet and living environment, and social challenges. This stress leads to changes in the piglets' small intestine, disrupting digestion and absorption, damaging intestinal barrier function, and resulting in reduced feed intake, increased diarrhea rate, and growth retardation. Understanding the effects of weaning stress on intestinal health is important for developing nutritional strategies to alleviate weaning stress.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xuan Li, Guowen Huang, Yanan Zhang, Yuting Ren, Ruofan Zhang, Weiyun Zhu, Kaifan Yu
Summary: This study found that the interaction between SUCNR1 receptor and succinate has a protective effect on obesity-induced intestinal barrier dysfunction. Supplementation of succinate under high-fat diet conditions can regulate intestinal immune response, promote mucus production, suppress intestinal inflammation, restore intestinal barrier function, and ultimately exert anti-obesity effects.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Food Science & Technology
Tao Wang, Panpan Wang, Wupeng Ge, Chao Shi, Gongnian Xiao, Xin Wang, Xin Lu
Summary: This study found that a multi-strain probiotics mixture could significantly inhibit tumorigenesis and inflammatory response, improve intestinal barrier function, and alleviate oxidative stress in azoxymethane/dextran sulfate sodium-induced CRC mice by mediating gut microbiota.