Article
Physiology
Xiaochen Yu, Ziyu Meng, Ting Fang, Xiaohuan Liu, Ying Cheng, Linxin Xu, Xiangyang Liu, Xiaoyu Li, Mei Xue, Ting Li, Bei Sun, Liming Chen
Summary: This study investigated the effects and mechanisms of Empagliflozin on hepatic gluconeogenesis and glycogenesis, and found that Empagliflozin could reduce gluconeogenesis and increase glycogenesis through the AMPK/CREB/GSK3 beta signaling pathway, thus maintaining glucose homeostasis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Ting Cao, Qian Chen, BiKui Zhang, XiangXin Wu, CuiRong Zeng, ShuangYang Zhang, HuaLin Cai
Summary: The study revealed that CLZ promoted gluconeogenesis and repressed glycogenesis in rat liver through the PGRMC1-EGFR/GLP1R pathway, leading to worsening of glucose metabolism disorder. Silencing or inhibiting PGRMC1 mimicked this process, while its overexpression alleviated CLZ-induced glucose disturbances.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Helen Ziqing Liao, Yanting Liang, Ye Wang, Chun Liang
Summary: This article discusses various factors involved in the development of diabetes, including genetic and environmental factors, as well as abnormal factors and medications that may play a role in diabetes development. The commonly used anti-diabetic drugs are also reviewed.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Endocrinology & Metabolism
Emmanuel Quaye, Shaji Chacko, Stephanie T. Chung, Robert J. Brychta, Kong Y. Chen, Rebecca J. Brown
Summary: This study demonstrates that gluconeogenesis accounts for a significant portion of energy expenditure in patients with insulin resistance, potentially one-third of resting energy expenditure. Prediction equations may underestimate caloric needs in these individuals.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Toxicology
Kennedy M. Walls, Kyung U. Hong, David W. Hein
Summary: Heterocyclic amines (HCAs) are mutagenic substances that can be consumed through cooked meat, and recent studies have found a significant association between dietary HCA exposure and insulin resistance and type II diabetes. This study investigated the effects of three HCAs commonly found in cooked meat on insulin signaling and glucose production in human hepatocytes, and found that HCA exposure decreases insulin signaling and promotes hepatic glucose production.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Coen C. Paulusma, Wouter H. Lamers, Stefan Broer, Stan F. J. van de Graaf
Summary: The liver controls the exposure of amino acids entering via the gastrointestinal tract, but it is still unclear which transporters are involved in hepatocellular amino acid transport.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biophysics
Margarida Coelho, Rohit Mahar, Getachew D. Belew, Alejandra Torres, Cristina Barosa, Fernando Cabral, Ivan Viegas, Amalia Gastaldelli, Vera M. Mendes, Bruno Manadas, John G. Jones, Matthew E. Merritt
Summary: Deuterated water ((H2O)-H-2) is commonly used to trace carbohydrate biosynthesis, but it can distort metabolic information and mediate toxicity. O-18-water ((H2O)-O-18) can be incorporated into specific carbohydrates but has not been evaluated in animal models.
NMR IN BIOMEDICINE
(2023)
Review
Pharmacology & Pharmacy
Motonobu Nakamura, Nobuhiko Satoh, Shoko Horita, Masaomi Nangaku
Summary: This review provides an overview of the relationship between mTOR and renal gluconeogenesis, emphasizing the importance of mTOR in regulating glucose metabolism, while also suggesting that mTOR signaling defects may lead to various pathological conditions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Ferrol I. Rome, Gregory L. Shobert, William C. Voigt, David B. Stagg, Patrycja Puchalska, Shawn C. Burgess, Peter A. Crawford, Curtis C. Hughey
Summary: Acute exercise increases liver gluconeogenesis, but it is not necessary for exercise training to lower liver lipids.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Food Science & Technology
Mengting Wang, Haiguang Mao, Jianchu Chen, Qiang Li, Wei Ma, Nan Zhu, Lili Qi, Jinbo Wang
Summary: Chinese bayberry leaves proanthocyanidins (BLPs) have significant effects on hepatic glucose metabolism, promoting glycogen synthesis and reducing gluconeogenesis. These effects may be achieved through the activation of the PI3K/AKT signaling pathway. Additionally, BLPs can also regulate the expression of specific miRNAs, further influencing hepatic glucose metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Plant Sciences
Ming-Yue Wang, Meng-Fei An, Mao-Si Fan, Shao-Shi Zhang, Ze-Rui Sun, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng
Summary: Ferulic acid ethyl ester (FAEE) can inhibit osteoclastogenesis and relieve ovariectomy-induced osteoporosis through the MAPK signaling pathway. In vitro experiments showed that FAEE suppressed RANKL-induced osteoclast formation by reducing the expression of osteoclast-specific genes, proteins, and MAPK pathway-related proteins. In ovariectomized rats, FAEE maintained normal calcium balance, increased estradiol levels, and reduced bone density and mineral content.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Semim Akhtar Ahmed, Pranamika Sarma, Sagar Ramrao Barge, Deepsikha Swargiary, Gurumayum Shalini Devi, Jagat C. Borah
Summary: This study investigated the beneficial effects of Tribulus terrestris (TT) and its active constituent, Xanthosine, on gluconeogenesis and glycogenesis in hepatic insulin resistance. Xanthosine enhanced glucose uptake and decreased glucose production in hepatocytes. It also improved insulin sensitivity, reduced fasting blood glucose levels, and improved glucose homeostasis in diabetic rats.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Di Zhang, Bei Jing, Zhenni Chen, Xin Li, Huimei Shi, Yachun Zheng, Shiquan Chang, Guoping Zhao
Summary: Ferulic acid has therapeutic effects on sciatica by inhibiting peripheral sensitization through reducing inflammatory factors, TRPA1, and TRPV1 levels via the RhoA/p38 MAPK pathway.
Article
Medicine, Research & Experimental
Yan Zhang, Jun Lu, Yu-juan Zhong, Cheng-fang Yang, Li Chen, Dan Wu, Meng-wei Song, Lin Shi, Zu-heng Ma, Li Li, Yong-wen Li
Summary: The study found that MFA enhances insulin sensitivity by decreasing miR-378b levels and increasing IR and p110α expression, thereby combating ALD. Experimental evidence suggests that MFA partially activates the insulin signaling pathway to alleviate alcohol-induced hepatic insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Dai Ying, Shan Mengya, Li Peilin, Zhao Lingong, Ma Huan, Xu Jing, Zhang Le, Zhang Kebin, Chen Bin, Yan Jun, Guo Shaodong, Xu Zihui
Summary: Mibefradil has been shown to decrease cytoplasmic calcium levels, increase phosphorylation of Akt and FoxO1, and contribute to the cytoplasmic localization of FoxO1, ultimately alleviating insulin resistance and glucose output. Additionally, it decreases the expression of key gluconeogenesis enzymes, thus helping to control blood sugar levels and reduce insulin resistance through the Ca2+-CaMKII dependent Akt/FoxO1 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Akilavalli Narasimhan, Mayilvanan Chinnaiyan, Balasubramanian Karundevi
EUROPEAN JOURNAL OF PHARMACOLOGY
(2015)
Article
Pharmacology & Pharmacy
Mangala Priya Viswanathan, Vigneswari Mullainadhan, Mayilvanan Chinnaiyan, Balasubramanian Karundevi
Article
Cardiac & Cardiovascular Systems
Viswanathan Mangala Priya, Chinnaiyan Mayilvanan, Narasimhan Akilavalli, Parsanathan Rajesh, Karundevi Balasubramanian
CARDIOVASCULAR TOXICOLOGY
(2014)
Article
Endocrinology & Metabolism
Akilavalli Narasimhan, Sathish Sampath, Selvaraj Jayaraman, Balasubramanian Karundevi
ENDOCRINE RESEARCH
(2013)
Article
Environmental Sciences
Shankar Jayashree, Dhananjayan Indumathi, Narasimhan Akilavalli, Sampath Sathish, Jayaraman Selvaraj, Karundevi Balasubramanian
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2013)
Article
Integrative & Complementary Medicine
Sathish Sampath, Akilavalli Narasimhan, Raveendar Chinta, K. R. Janardanan Nair, Anil Khurana, Debadatta Nayak, Alok Kumar, Balasubramanian Karundevi
Article
Toxicology
D. Indumathi, S. Jayashree, J. Selvaraj, S. Sathish, C. Mayilvanan, N. Akilavalli, K. Balasubramanian
HUMAN & EXPERIMENTAL TOXICOLOGY
(2013)
Review
Endocrinology & Metabolism
Akilavalli Narasimhan, Rafael R. Flores, Paul D. Robbins, Laura J. Niedernhofer
Summary: Cellular senescence is a cell fate that can either promote tissue repair or drive inflammation, depending on the context. Aging and obesity increase the burden of senescent cells in multiple organs, leading to various diabetic complications.
Editorial Material
Geriatrics & Gerontology
Michaela E. Murphy, Akilavalli Narasimhan, Alexis Adrian, Ankur Kumar, Cara L. Green, Carolina Soto-Palma, Chathurika Henpita, Christina Camell, Christopher S. Morrow, Chung-Yang Yeh, Claire E. Richardson, Cristal M. Hill, Darcie L. Moore, Dudley W. Lamming, Eric R. McGregor, Heather A. Simmons, Heidi H. Pak, Hua Bai, John M. Denu, Josef Clark, Judith Simcox, Kishore Chittimalli, Korbyn Dahlquist, Kyoo-a Lee, Mariah Calubag, Mark Bouska, Matthew J. Yousefzadeh, Michelle Sonsalla, Reji Babygirija, Rong Yuan, Tadataka Tsuji, Timothy Rhoads, Vinal Menon, Yagna PR. Jarajapu, Yun Zhu
Review
Endocrinology & Metabolism
Akilavalli Narasimhan, Rafael R. Flores, Christina D. Camell, David A. Bernlohr, Paul D. Robbins, Laura J. Niedernhofer
Summary: Obesity is associated with the accumulation of senescent cells in various organs, which can lead to multiple complications. These senescent cells produce secretory factors that affect other cells and tissues, resulting in organ dysfunction. Reducing the burden of senescent cells can improve the complications associated with obesity, indicating the potential therapeutic option of senotherapeutic drugs.
CURRENT DIABETES REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Navaneethabalakrishnan Shobana, Mariajoseph Michael Aruldhas, Lalmuankimi Tochhawng, Ayyalu Loganathan, Sadhasivam Balaji, Mani Kathiresh Kumar, Liaquat Alikhan Sheerin Banu, Ajit Kumar Navin, Chinnaiyan Mayilvanan, Ramachandran Ilangovan, Karundevi Balasubramanian
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)