Editorial Material
Biochemistry & Molecular Biology
Moriah J. Deimeke, Christopher B. Sturdy
Summary: Animals have cognitive skills that enable them to form concepts, as shown by laboratory tasks. A new study explores the role of abstract concept formation in the wild.
Article
Neurosciences
Darryl C. Gidyk, Robert J. McDonald, Robert J. Sutherland
Summary: Results from experiments suggest that rats can maintain normal memory in adversarial learning and discrimination tasks even in the absence of the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Stefano Recanatesi, Matthew Farrell, Guillaume Lajoie, Sophie Deneve, Mattia Rigotti, Eric Shea-Brown
Summary: Recent research has shown that artificial neural networks can produce representations with low-dimensional latent structure by learning to predict observations about the world. These representations can recover the underlying latent structure in the data, as demonstrated by a network trained on a spatial navigation task generating neural activations related to place similar to those observed in the hippocampus.
NATURE COMMUNICATIONS
(2021)
Article
Psychology, Developmental
Attila Keresztes, Laurel Raffington, Andrew R. Bender, Katharina Boegl, Christine Heim, Yee Lee Shing
Summary: Cross-sectional findings suggest that hippocampal subfield volumes increase in middle childhood and early adolescence, but a small number of longitudinal studies reported decreased volumes in most subfields over this age range. It remains unknown whether structural changes are associated with gains in children's memory.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Article
Biology
Stephen J. Gotts, Shawn C. Milleville, Alex Martin
Summary: In the study, Gotts et al. tested different theoretical model predictions for repetition-associated alterations in functional and/or effective brain connectivity using fMRI. They found that the data was most consistent with a Synchrony model-based prediction, leading to refinements of all tested models. While some support for the Facilitation and Sharpening models was found, the data primarily supported the Synchrony model with increased coupling between specific brain regions.
COMMUNICATIONS BIOLOGY
(2021)
Editorial Material
Neurosciences
Bruce L. McNaughton, Rajat Saxena
Summary: In a complex maze with changing barrier configurations, rat hippocampal neurons maintain their location-specific firing, learn to generate activity sequences representing possible routes to rewards that respect the locations of barriers, and rapidly adapt to barrier reconfiguration.
Article
Multidisciplinary Sciences
Renzhi Qian, Yuan Yan, Yu Pei, Yixuan Zhang, Yuanwei Chi, Yuxuan Chen, Kun Hao, Zhen Xu, Guang Yang, Zilun Shao, Yuhao Wang, Xinran Li, Chenxu Lu, Xuan Zhang, Kehan Chen, Wenqiang Zhang, Baoqing Wang, Zhengxin Ying, Kaiyuan Huang
Summary: Through a light maze experiment, researchers have demonstrated that planarian worms have spatial localization ability, as they can navigate to a previously recognized place in the maze. This finding reveals the spatial learning ability of planarians for the first time, providing insights into the evolution of spatial learning. Furthermore, this experiment can serve as a simplified model for studying spatial learning due to the planarians' simple brain structure.
Article
Neurosciences
Tyler Bonnen, L. K. Daniel Yamins, D. Anthony Wagner
Summary: The medial temporal lobe (MTL) is involved in memory-related behaviors, while its role in perceptual processing, particularly the involvement of the perirhinal cortex (PRC), has been a subject of debate. By utilizing a deep learning framework to simulate visual behaviors supported by the ventral visual stream (VVS) without PRC, the study found similarities between VVS-modeled and PRC-lesioned behaviors, but both were outperformed by participants with an intact PRC. This research resolves decades of inconsistent findings by situating lesion, electrophysiological, and behavioral results within a shared computational framework.
Article
Biology
Xiaoxuan Jia, Ha Hong, James J. DiCarlo
Summary: The study investigates whether plasticity of individual IT neurons underlies human core object recognition behavioral changes induced with unsupervised visual experience. The results suggest that a model combining a single-neuron plasticity model with an IT population-to-recognition-behavior-linking model, constrained by neurophysiological data, largely predicts human learning effects.
Article
Multidisciplinary Sciences
Lynn Nadel
Summary: The article discusses why our conceptions of space and time are intertwined with memory in the hippocampal formation, pointing out that animals bridge spatial and temporal gaps through the creation of internal models. The hippocampal formation plays a critical role in this process by constructing cognitive maps, creating neural trajectories, and simulating possible futures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Samy-Adrien Foudil, Claire Pleche, Emiliano Macaluso
Summary: Episodic memory involves storage of events with their spatio-temporal context and retrieval of the link between the person and the episode. Mobile-phone encoding, virtual town exploration, and standard laboratory paradigm were used to examine memory. Accurate context-memory increased remember responses, and participants were tested on temporal-order judgement.Temporal similarity model showed scale-invariant properties of order-retrieval with contribution of non-chronological factors.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Behavioral Sciences
Leonardo Munari, Vishwendra Patel, Nicholas Johnson, Chiara Mariottini, Som Prabha, Robert D. Blitzer, Ravi Iyengar
Summary: This study identifies the transcriptional repressor WT1 as an important regulator of synaptic plasticity in the hippocampus, affecting memory discrimination. WT1 deletion in dentate gyrus granule cells disrupts memory discrimination and alters synaptic transmission. Further experiments establish a causal link between granule cell hyperexcitability and impaired memory discrimination.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Ramon Nogueira, Chris C. C. Rodgers, Randy M. M. Bruno, Stefano Fusi
Summary: Neurons encode non-linear functions of multiple task variables, but the somatosensory cortex of mice reflects a linear integration of whisker contacts. However, there is a structure in the representational geometry where different whisker contacts are represented as disentangled variables in approximately orthogonal subspaces. This geometry allows linear readouts to perform various tasks without compromising the ability to generalize.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jessica D. Creery, David J. Brang, Jason D. Arndt, Adrianna Bassard, Vernon L. Towle, James X. Tao, Shasha Wu, Sandra Rose, Peter C. Warnke, Naoum P. Issa, Ken A. Paller
Summary: This study investigates the impact of sleep on memory by measuring electrical activity in the hippocampus, and finds that the presentation of sounds during sleep enhances corresponding spatial memories, which is associated with increased specific brainwave activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Taylor Kuhn, Tobias Kaufmann, Nhat Trung Doan, Lars T. Westlye, Jacob Jones, Rodolfo A. Nunez, Susan Y. Bookheimer, Elyse J. Singer, Charles H. Hinkin, April D. Thames
HUMAN BRAIN MAPPING
(2018)
Article
Neurosciences
Prabha Siddarth, Berna Rahi, Natacha D. Emerson, Alison C. Burggren, Karen J. Miller, Susan Bookheimer, Helen Lavretsky, Bruce Dobkin, Gary Small, David A. Merrill
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Correction
Multidisciplinary Sciences
Neelroop N. Parikshak, Vivek Swarup, T. Grant Belgard, Manuel Irimia, Gokul Ramaswami, Michael J. Gandal, Christopher Hartl, Virpi Leppa, Luis de la Torre Ubieta, Jerry Huang, Jennifer K. Lowe, Benjamin J. Blencowe, Steve Horvath, Daniel H. Geschwind
Article
Multidisciplinary Sciences
Alberto Parras, Hector Anta, Maria Santos-Galindo, Vivek Swarup, Ainara Elorza, Jose L. Nieto-Gonzalez, Sara Pico, Ivo H. Hernandez, Juan I. Diaz-Hernandez, Eulalia Belloc, Annie Rodolosse, Neelroop N. Parikshak, Olga Penagarikano, Rafael Fernandez-Chacon, Manuel Irimia, Pilar Navarro, Daniel H. Geschwind, Raul Mendez, Jose J. Lucas
Article
Neurosciences
Juan E. Kamienkowski, Alexander Varatharajah, Mariano Sigman, Matias J. Ison
Article
Psychology, Developmental
Ryo Kimura, Vivek Swarup, Kiyotaka Tomiwa, Michael J. Gandal, Neelroop N. Parikshak, Yasuko Funabiki, Masatoshi Nakata, Tomonari Awaya, Takeo Kato, Kei Iida, Shin Okazaki, Kanae Matsushima, Toshihiro Kato, Toshiya Mural, Toshio Heike, Daniel H. Geschwind, Masatoshi Hagiwara
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2019)
Article
Neurosciences
Christoph Pokorny, Matias J. Ison, Arjun Rao, Robert Legenstein, Christos Papadimitriou, Wolfgang Maass
Review
Neurosciences
Dean Mobbs, Toby Wise, Nanthia Suthana, Noah Guzman, Nikolaus Kriegeskorte, Joel Z. Leibo
Summary: The principle of using movements to understand internal states and motives has been applied successfully in computational ethology for animal behavioral neuroscience. Now, new technologies for capturing and analyzing complex behaviors may similarly drive progress in human neuroscience and psychology. By extending behavioral measurements and providing novel insights into human brain function, these methods aim to reduce the gap between human and animal neuroscience.
Letter
Behavioral Sciences
Nanthia Suthana, Arne D. Ekstrom, Michael A. Yassa, Craig Stark
Summary: The article argues that there is no pattern separation in the human hippocampus, and memories are coded by coactivation of invariant and context-independent engrams. However, it is believed that pattern separation and completion are both important components of human memory, and overlooked empirical studies and theoretical considerations fundamentally challenge the arguments made.
TRENDS IN COGNITIVE SCIENCES
(2021)
Article
Neurosciences
Damian Care, Maria da Fonseca, Matias J. J. Ison, Juan E. E. Kamienkowski
Summary: Tasks that seem simple in our everyday lives, such as reading or searching for objects, actually involve multiple cognitive processes. This study aimed to investigate the brain activity involved in free-viewing visual search and how category information and the task performed affect it. Participants observed/searched for faces and objects in random noise while their electroencephalogram and eye movements were recorded. The results showed distinct effects of category and task on brain activity, providing valuable insight into the neural mechanisms underlying real-world tasks.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Veera R. Rajagopal, Kyoko Watanabe, Joelle Mbatchou, Ariane M. Ayer, Peter Quon, Deepika A. Sharma, Michael Kessler, Kavita Praveen, Sahar Gelfman, Neelroop Parikshak, Jacqueline Otto, Suying Bao, Shek Man Chim, Elias Pavlopoulos, Andreja Avbersek, Manav Kapoor, Esteban Chen, Marcus Jones, Michelle Leblanc, Jonathan Emberson, Rory Collins, Jason Torres, Pablo Kuri Morales, Roberto Tapia-Conyer, Jesus Alegre, Jaime Berumen, Alan Shuldiner, GHS REGN DiscovEHR Collaboration, Regeneron Genetics Ctr, Suganthi Balasubramanian, Goncalo R. Abecasis, Hyun Kang, Jonathan Marchini, Eli Stahl, Eric Jorgenson, Robert Sanchez, Wolfang Liedtke, Matthew Anderson, Michael Cantor, David Lederer, Aris Baras, Giovanni Coppola
Summary: Human genetic studies have found a protective association between rare variants in CHRNB2 and decreased odds of heavy smoking. This aligns with experimental observations in mice indicating that loss of the beta 2 subunit of the alpha 4 beta 2 nicotine acetylcholine receptor abolishes nicotine-mediated neuronal responses and attenuates nicotine self-administration. These findings inspire future drug designs targeting CHRNB2 for the treatment of nicotine addiction.
Review
Neurosciences
Matthias Stangl, Sabrina L. Maoz, Nanthia Suthana
Summary: Cognitive neuroscience studies in humans have been limited to laboratory settings, but recent advances in neuroimaging technologies have allowed for recordings of brain activity during real-world behaviors. These mobile neuroimaging methods provide unique insights into human cognition and have the potential to develop new treatments for neurological and psychiatric disorders. However, studying naturalistic human behaviors in complex real-world settings poses challenges, which can be overcome with appropriate strategies.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Psychology, Multidisciplinary
Dan Hu, Matias Ison, Alan Johnston
Summary: Human vision has a common processing rate for motion-based visual prediction across diverse motion phenomena. Motion Induced Spatial Conflict (MISC) frequency correlates significantly with the accrual rate of the Motion Induced Position Shift (MIPS) effect, suggesting a shared perceptual rate between them.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
Christina Ralph-Nearman, Armen C. Arevian, Maria Puhl, Rajay Kumar, Diane Villaroman, Nanthia Suthana, Jamie D. Feusner, Sahib S. Khalsa
JMIR MENTAL HEALTH
(2019)