期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 16, 页码 5195-5200出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1503550112
关键词
reward value; associative learning; ventromedial prefrontal cortex; olfaction; multivoxel pattern analysis
资金
- National Institute on Deafness and Other Communication Disorders [1F31DC013500, R01DC010014]
- National Institute of Neurological Disorders and Stroke [T32NS047987]
- Swiss National Science Foundation [PP00P1_128574, PP00P1_150739, CRSII3_141965]
Nervous systems must encode information about the identity of expected outcomes to make adaptive decisions. However, the neural mechanisms underlying identity-specific value signaling remain poorly understood. By manipulating the value and identity of appetizing food odors in a pattern-based imaging paradigm of human classical conditioning, we were able to identify dissociable predictive representations of identity-specific reward in orbitofrontal cortex (OFC) and identity-general reward in ventromedial prefrontal cortex (vmPFC). Reward-related functional coupling between OFC and olfactory (piriform) cortex and between vmPFC and amygdala revealed parallel pathways that support identity-specific and -general predictive signaling. The demonstration of identity-specific value representations in OFC highlights a role for this region in model-based behavior and reveals mechanisms by which appetitive behavior can go awry.
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