Review
Physiology
Dongqing Pang, Yi Gao, Limin Liao
Summary: This article reviews previous studies and combines the latest findings to discuss brain regions, networks, and changes in brain function related to bladder control in various diseases. The study found that these regions form subnetworks through functional connections to achieve bladder control and identified changes in brain functional connectivity networks related to bladder control.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Magdalena Kolak, Izabela Herman-Sucharska, Malgorzata Radon-Pokracka, Malgorzata Stolarek, Anna Horbaczewska, Hubert Huras
Summary: The study showed that prenatal MRI had low accuracy in diagnosing complex brain defects, and was not suitable for replacing postnatal tests. Therefore, the possibility of replacing postnatal studies with pMRI was not supported.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Ma, Liang Zhou, Wei Li, Xiujuan Li, Yan Huang, Sijie Gao, Jie Yu, Yuan Fang, Ye Xu
Summary: This study retrospectively analyzed the clinical and brain MRI data of 114 children with CNS-HLH. The results showed that brain MRI features have an independent predictive value for mortality in these children. Restricted diffusion of the lesion and the count of affected brain regions were identified as independent risk factors for death.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Carlos Perez-Serrano, Alvaro Bartolome, Nuria Bargallo, Carmen Sebastia, Alfons Nadal, Olga Gomez, Laura Oleaga
Summary: This article discusses the evaluation of the CNS system using post-mortem MRI, including protocol description, normal and abnormal results, and correlation with histopathological results, aiming to guide radiologists in their role in perinatal deaths.
INSIGHTS INTO IMAGING
(2021)
Article
Clinical Neurology
Yushi Kawazoe, Shigeo Ohba, Kazuhiro Murayama, Shunsuke Nakae, Yuya Nishiyama, Masato Abe, Mitsuhiro Hasegawa, Yuichi Hirose
Summary: Contrast-enhanced MRI, perfusion MRI, and quantitative analysis of H-1-MRS are valuable techniques for distinguishing PCNSV from glioblastoma before surgery.
WORLD NEUROSURGERY
(2022)
Article
Rehabilitation
Yoo Jin Choo, Mathieu Boudier-Reveret, Min Cheol Chang
Summary: Detailed knowledge of brain anatomy is essential for treating patients with brain disorders. This study reviewed essential parts of human brain anatomy using magnetic resonance imaging, focusing on structures in each brain lobe, limbic system, language-related structures, and important neural tracts related to motor and sensory functions. This review aims to assist physiatrists in accurately identifying functional damage from brain disorders and planning appropriate rehabilitative treatment.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Review
Clinical Neurology
Nathan Arnett, Athanasios Pavlou, Morgan P. Burke, Brett L. Cucchiara, Rennie L. Rhee, Jae W. Song
Summary: This study reviewed the vessel wall magnetic resonance imaging features of vasculitis affecting the central nervous system, comparing inflammatory and infectious vasculitides and intracranial versus extracranial arteries of the head and neck. Commonly reported features included vessel wall enhancement, thickening, edema, and perivascular enhancement, with differences noted between inflammatory vasculitides affecting intracranial versus extracranial arteries.
Article
Rheumatology
T. Shimoyama, K. Uchino, L. H. Calabrese, R. A. Hajj-Ali
Summary: This study aimed to determine the diagnostic accuracy of high-resolution vessel wall image (HR-VWI) and brain biopsy according to angiographical classification in patients with primary central nervous system vasculitis (PCNSV). The results showed that HR-VWI is useful for diagnosing PCNSV with large-medium vessel variant (LMVV), while brain biopsy is more accurate for diagnosing PCNSV with small vessel variant (SVV).
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Pediatrics
Usha D. Nagaraj, Charu Venkatesan, Karin S. Bierbrauer, Beth M. Kline-Fath
Summary: Fetal MRI and neonatal CNS MRI are complementary tools that play a vital role in accurately diagnosing and treating congenital anomalies. By allowing for real-time monitoring and guiding treatment direction, both imaging techniques are essential in patient management.
PEDIATRIC RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shalendra Kumar Misser, Jan Willem Lotz, Stefan-Dan Zaharie, Nobuhle Mchunu, Moherndran Archary, Anthony James Barkovich
Summary: This study describes the spectrum of parasagittal injury on MRI scans of children following severe perinatal term hypoxia-ischaemia. It proposes a novel MRI grading system and introduces a previously undescribed pattern of injury, the most severe form in this spectrum.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lenhard Pennig, Ulrike Cornelia Isabel Hoyer, Lukas Goertz, Rahil Shahzad, Thorsten Persigehl, Frank Thiele, Michael Perkuhn, Maximilian Ruge, Christoph Kabbasch, Jan Borggrefe, Liliana Caldeira, Kai Roman Laukamp
Summary: This study investigated the performance of a deep-learning model in automatically detecting and segmenting primary central nervous system lymphoma on clinical MRI. The results showed that the automated segmentations had good spatial overlap with manual segmentations for total tumor volume and tumor core, and the performance was comparable between initial and follow-up scans.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Xia, Bin Hu, Haiqing Li, Wei Shi, Ying Tang, Yang Yu, Chen Geng, Qiuwen Wu, Liqin Yang, Zekuan Yu, Daoying Geng, Yuxin Li
Summary: The study investigated the use of a convolutional neural network (CNN) model for differentiation of primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) without tumor delineation. The results showed that the CNN model can effectively differentiate between PCNSL and GBM, comparable to radiomics models and radiologists in terms of diagnostic accuracy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Acoustics
D. Di Mascio, A. Khalil, G. Rizzo, G. Kasprian, M. Caulo, L. Manganaro, A. O. Odibo, M. E. Flacco, A. Giancotti, D. Buca, M. Liberati, I. E. Timor-Tritsch, F. D'Antonio
Summary: This study evaluated the methodology of 15 studies reporting reference ranges for fetal brain structures on MRI, finding that most of them had low-to-moderate quality and high risk of bias. Issues were identified in study design, statistical and reporting methods, and specific aspects relevant to MRI. The findings were similar to those reported for ultrasound studies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul D. Griffiths, Mariasavina Severino, Deborah Jarvis, Laura Mandefield, Cecilia Parazzini, Lorenzo Pinelli, Marco Di Maurizio, Fabio Triulzi, Elisa Scola, Giorgio Conte, Giovanni Palumbo, Maurilio Genovese, Andrea Rossi, Renzo Guerrini, Andrea Righini
Summary: The study included 64 foetuses with cortical formation abnormalities (CFA) who underwent two in utero magnetic resonance (iuMR) exams, with 62% showing consistent CFA description between the two studies. In 38% of cases, there was a category change, including cases without CFA initially detected, changes in laterality/symmetry, and re-classification within the same group. Brain abnormalities other than CFA were present in around half of the cases on both first and second studies. Prognosis was predicted to have changed in 8% of cases based on the second study, with all indicating a worse prognosis.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fan Fu, Xuefei Sun, Yingying Li, Yuanbo Liu, Yi Shan, Nan Ji, Xiaochen Wang, Jie Lu, Shengjun Sun
Summary: The study found that K(trans) and changes in K(trans) measured by DCE-MRI were reliable biomarkers for predicting chemotherapy responses in PCNSL patients. These factors may also influence patients' progression-free survival.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Robert A. Scranton, Saeed Sadrameli, Edward Brian Butler, Andrew Farach, Hui-Chuan Wang, Bin S. Teh, Ivo W. Tremont-Lukats, Steve H. Fung, Paolo Zanotti-Fregonara, Robert C. Rostomily
PRACTICAL RADIATION ONCOLOGY
(2020)
Article
Computer Science, Interdisciplinary Applications
Xu Chen, Chunfeng Lian, Li Wang, Hannah Deng, Steve H. Fung, Dong Nie, Kim-Han Thung, Pew-Thian Yap, Jaime Gateno, James J. Xia, Dinggang Shen
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Editorial Material
Clinical Neurology
Meryim Poursheykhi, Farhan Mithani, Tanu Garg, Christian Cajavilca, Siraya Jaijakul, Steve Fung, Richard Klucznik, Rajan Gadhia
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2020)
Article
Clinical Neurology
Sindhu Ramchandren, Tong Tong Wu, Richard S. Finkel, Carly E. Siskind, Shawna M. E. Feely, Joshua Burns, Mary M. Reilly, Timothy Estilow Ot, Michael E. Shy
Summary: The study identified 6 domains relevant to quality of life in children with CMT through systematic literature reviews and analysis of generic QOL measures. A total of 60 items corresponding to those domains were developed and underwent rigorous psychometric testing to develop a reliable and valid pediatric CMT-specific quality of life outcome measure.
ANNALS OF NEUROLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Xu Chen, Chunfeng Lian, Li Wang, Hannah Deng, Tianshu Kuang, Steve Fung, Jaime Gateno, Pew-Thian Yap, James J. Xia, Dinggang Shen
Summary: An anatomy-regularized representation learning approach is proposed for segmentation-oriented cross-modality image synthesis, showing superiority in comparison with state-of-the-art cross-modality medical image segmentation methods.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Clinical Neurology
Paige Howard, Shawna M. E. Feely, Tiffany Grider, Alexa Bacha, Marina Scarlato, Raffaella Fazio, Angelo Quattrini, Michael E. Shy, Stefano C. Previtali
Summary: Mutations in the Myelin Protein Zero (MPZ) gene lead to CMT1B, with toxic gain of function from the mutant protein causing neuropathy, while some patients have haploinsufficiency in the MPZ gene, mainly presenting with sensory neuropathy.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Tiziana Cavallaro, Matteo Tagliapietra, Gian Maria Fabrizi, Yunhong Bai, Michael E. Shy, Jean-Michel Vallat
Summary: Hereditary neuropathies can be caused by mutations in genes expressed by Schwann cells or neurons, and may involve the central nervous system and other organs and tissues, with diagnostic methods revolutionizing due to advances in molecular genetics; skin biopsy has emerged as a minimally invasive method to provide clues to the pathophysiology and molecular pathology of inherited neuropathies.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2021)
Article
Computer Science, Artificial Intelligence
Xu Chen, Chunfeng Lian, Li Wang, Hannah Deng, Tianshu Kuang, Steve H. Fung, Jaime Gateno, Dinggang Shen, James J. Xia, Pew-Thian Yap
Summary: The lack of annotated data is a major challenge in building reliable image segmentation models. In this paper, a diverse data augmentation generative adversarial network (DDA-GAN) is introduced to train a segmentation model for an unannotated target image domain by borrowing information from an annotated source image domain. The method effectively combines features from different domains to improve segmentation quality through data augmentation and model training.
MEDICAL IMAGE ANALYSIS
(2021)
Editorial Material
Clinical Neurology
Tiziana Cavallaro, Matteo Tagliapietra, Gian Maria Fabrizi, Yunhong Bai, Michael E. Shy, Jean-Michel Vallat
Summary: The cover image is based on the Special Issue HEREDITARY NEUROPATHIES: A PATHOLOGICAL PERSPECTIVE by Tiziana Cavallaro et al., focusing on hereditary neuropathies from a pathological perspective.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2021)
Article
Computer Science, Interdisciplinary Applications
Xu Chen, Tianshu Kuang, Hannah Deng, Steve H. Fung, Jaime Gateno, James J. Xia, Pew-Thian Yap
Summary: This paper introduces a dual-attention domain-adaptative segmentation network for cross-modality medical image segmentation, which shows superior performance in challenging tasks.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Review
Clinical Neurology
Mary M. Reilly, David N. Herrmann, Davide Pareyson, Steven S. Scherer, Richard S. Finkel, Stephan Zuechner, Joshua Burns, Michael E. Shy
Summary: Heritable neurological disorders provide insights into disease mechanisms, facilitating the development of novel therapeutic approaches. The challenges of measuring disease progression in rare and slowly progressive neurogenetic diseases are addressed through the development of clinical outcome assessments and disease biomarkers in inherited peripheral neuropathies. It is proposed that carefully developed biomarkers from imaging, plasma, or skin can predict meaningful progression in functional and patient-reported outcome assessments, enabling feasible clinical trials within a shorter duration for these rare and ultra-rare disorders.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Tong Tong Wu, Richard S. S. Finkel, Carly E. E. Siskind, Shawna M. E. Feely, Joshua Burns, Mary M. M. Reilly, Francesco Muntoni, Timothy Estilow, Michael E. E. Shy, Sindhu Ramchandren
Summary: This study developed and validated the parent-proxy version of the pCMT-QOL outcome measure for children aged 8 to 18 with CMT, which is a reliable and valid measure of health-related QOL.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Tong Tong Wu, Richard Finkel, Carly E. Siskind, Shawna M. E. Feely, Joshua Burns, Mary M. Reilly, Francesco Muntoni, Evelin Milev, Timothy Estilow, Michael E. Shy, Sindhu Ramchandren
Summary: The objective of this study was to evaluate the parent-proxy version of the pediatric Charcot Marie Tooth specific quality of life (pCMT-QOL) outcome instrument for children aged 7 or younger with CMT. The parent-proxy version of the pCMT-QOL outcome measure, known as the pCMT-QOL (0-7 years parent-proxy), was validated as a valid and sensitive proxy measure of health-related quality of life for children aged 0-7 years with CMT.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Christopher P. Ptak, Tabitha A. Peterson, Jesse B. Hopkins, Christopher A. Ahern, Michael E. Shy, Robert C. Piper
Summary: Mutations in MPZ can cause various neurological disorders, and the study focuses on understanding how MPZ functions and forms oligomeric assemblies.
Proceedings Paper
Materials Science, Multidisciplinary
Hemant Sarin, Steve H. Fung, Ariel S. Kanevsky, Haitao Wu, Colin M. Wilson, Howard Vo, Sungyoung Auh, Daniel Glen, Richard Reynolds
Summary: This study investigates the use of dendritic conjugates for dynamic magnetic resonance imaging, providing insights into solid tumor barriers and contrast agent pharmacodynamics. The neutralization of nanoparticle exterior surface charge enables effective delivery across abnormal barrier endothelium pores.
MATERIALS TODAY-PROCEEDINGS
(2021)