Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wan-Ru Yu, Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study found significantly higher levels of urinary cytokines and chemokines in patients with IC/BPS, which were closely associated with bladder conditions and treatment outcomes.
Article
Medicine, Research & Experimental
Zhenming Zheng, Jintao Hu, Wenshuang Li, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Yousheng Yao
Summary: This study used 16S rRNA sequencing and untargeted metabolomics techniques to analyze the urinary microbial and metabolite profiles of IC/BPS patients and healthy controls. The results showed differential genera and metabolites associated with the inflammatory response of IC/BPS, including Lactobacillus as a protective bacterium and Sphingomonas as a pathogenic factor. The metabolite theophylline may also play a role in downregulating the inflammatory response of IC/BPS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Hung-Yu Lin, Jian-He Lu, Shu-Mien Chuang, Kuang-Shun Chueh, Tai-Jui Juan, Yi-Chang Liu, Yung-Shun Juan
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic bladder disorder characterized by suprapubic pain and discomfort during bladder filling, accompanied by lower urinary tract symptoms. The diagnosis of IC/BPS is still not standardized, but cystoscopy and bladder biopsy can determine the presence of ulcers. The pathophysiology of IC/BPS may involve chronic inflammation, autoimmune disorders, and other factors. Biomarkers in urine and serum specimens could be useful for the diagnosis of IC/BPS.
Article
Medicine, General & Internal
Pedro Abreu-Mendes, Beatriz Araujo-Silva, Ana Charrua, Francisco Cruz, Rui Pinto
Summary: This study suggests that daily silodosin can be an effective and well-tolerated treatment for refractory BPS/IC female patients. Additionally, stress coping levels may be associated with symptom improvement.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jin Li, Xianyanling Yi, Jianzhong Ai
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease with a negative impact on quality of life. Diagnoses and treatments are still unsatisfactory, calling for new approaches. This study aims to provide a comprehensive overview of IC/BPS research, promoting progress in diagnosis, treatment, and prognosis. The complexity of IC/BPS and emerging evidence call for further studies to optimize management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yuan-Hong Jiang, Jia-Fong Jhang, Hann-Chorng Kuo
Summary: This study analyzed the differences in urinary cytokines and chemokines between different subtypes of interstitial cystitis/bladder pain syndrome (IC/BPS), particularly ulcer (HIC) and non-ulcer subtypes. The results showed that elevated urine levels of IL-8, CXCL10, BDNF, IL-6, and RANTES may indicate the presence of HIC. These findings suggest that urinary biomarkers may be useful for discriminating HIC patients from controls.
Article
Pharmacology & Pharmacy
Chin-Li Chen, Chien-Chang Kao, Ming-Hsin Yang, Gang-Yi Fan, Juin-Hong Cherng, Chih-Wei Tsao, Sheng-Tang Wu, Tai-Lung Cha, En Meng
Summary: The study demonstrated that dextrose prolotherapy shows promising treatment results for IC/BPS, reducing bladder instability, frequent urination, improving glycosaminoglycan layer regeneration and bladder wall thickness, along with significantly enhancing CD44 receptor expression. Additionally, it reduced treatment frequency over time and improved EGF levels while reducing HGF, PIGF-1, and VEGF-D levels in patients with IC/BPS. The modulation of growth factors and cytokines suggests potential tissue remodeling effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Lori A. A. Birder, Hann-Chorng Kuo
Summary: The aim of this study was to investigate the expression levels of sensory receptors, inflammatory proteins, and pro-apoptotic proteins in the urothelium of non-Hunner's interstitial cystitis (NHIC) bladders of patients with different clinical and cystoscopic phenotypes. The study concluded that IC/BPS patients with frequency and bladder pain complaints have higher levels of urothelial sensory receptors, and inflammatory and pro-apoptotic proteins. The expression levels of these sensory receptors, inflammatory proteins, and pro-apoptotic proteins are not significantly different among IC/BPS bladders with different conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Tadeja Kuret, Dominika Peskar, Mateja Erdani Kreft, Andreja Erman, Peter Veranic
Summary: Urothelial cells in IC/BPS show upregulation of proinflammatory mediators after TNF alpha stimulation, suggesting their active role in shaping the local immune response of the bladder. Our study provides insights into the phenotype and function of urothelial cells in an inflammatory environment and confirms the role of TNF alpha signaling in IC/BPS pathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Irfan Anjum, Daanyaal Ali, Mohammed Bourhia, Mueen Ahmad Chaudhry, Farhan Siddique, Mehvish Bibi, Abdel-Rhman Z. Gaafar, Touriya Zair, Farid Khallouki
Summary: The study found that Cuminum cyminum has antioxidant and anti-inflammatory effects, and can protect against bladder toxicity induced by cyclophosphamide. The plant extract can reduce oxidative stress, inflammation, and bladder overactivity.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Dominika Peskar, Tadeja Kuret, Katja Lakota, Andreja Erman
Summary: Animal models were used to study the pathophysiology of IC/BPS. The mouse model induced with low-dose CYP treatment showed upregulation of inflammatory transcripts and activation of the JAK3/STAT3 pathway in bladder cells. Gender differences were observed in cell proliferation and immune responses. This study provides valuable insights into IC/BPS research and the sex-specific mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Jayoung Kim, Amanda De Hoedt, Emily Wiggins, Kelsey Haywood, Peng Jin, Bennett Greenwood, Niven R. Narain, Vladimir Tolstikov, Valerie Bussberg, Kamil E. Barbour, Michael A. Kiebish, Stephen J. Freedland, Jennifer T. Anger
Summary: The study aimed to identify potential biomarkers of interstitial cystitis/painful bladder syndrome (IC) by analyzing urine and serum metabolomes of IC patients and non-disease controls. The analysis revealed distinct metabolomic profiles in IC patients, with specific markers identified in urine samples. Integrated analyses of key metabolites showed promising biomarkers for the pathophysiology of IC.
Article
Biology
Jing-Dung Shen, Szu-Ju Chen, Huey-Yi Chen, Kun-Yuan Chiu, Yung-Hsiang Chen, Wen-Chi Chen
Summary: The treatment of urinary bladder dysfunction requires an understanding of bladder function, involving physiology, pathology, and psychology. Various animal models are available for studying bladder disorders, ranging from rodents to non-human primates. These models can help in studying different bladder disorders, such as overactive bladder or incontinence, according to facility, priority, and disease.
Article
Immunology
Masaru Yoshizumi, Naoya Tazawa, Chizuko Watanabe, Hirokazu Mizoguchi
Summary: Activation of TRPV4 can negatively regulate bladder inflammation induced by LPS and alleviate bladder hypersensitivity. This finding may provide new therapeutic targets for refractory bladder pain syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)