Article
Biochemistry & Molecular Biology
Hang Xu, Xiaonan Zheng, Shiyu Zhang, Xianyanling Yi, Tianyi Zhang, Qiang Wei, Hong Li, Jianzhong Ai
Summary: The study identified TOP2A, NCF4, FMNL1, and DOK3 as potential effective neoantigens for KIRC mRNA vaccine development and characterized two immune subtypes, RIS1 and RIS2, in KIRC. Patients with RIS2 tumors may benefit more from mRNA vaccination, indicating potential for personalized cancer therapy.
Article
Biochemistry & Molecular Biology
Yange Wang, Chenyang Li, Xinlei Qi, Yafei Yao, Lu Zhang, Guosen Zhang, Longxiang Xie, Qiang Wang, Wan Zhu, Xiangqian Guo
Summary: This study investigated the expression of 33 blood group antigen genes in 31,870 tumor tissue samples and found that these antigens are abnormally expressed in various cancers. The high expression of seven antigen genes was associated with good overall survival (OS) in six types of cancers, while ten genes were associated with poor OS in three types of cancers. Kidney renal clear cell carcinoma showed the largest number of prognostic antigen genes, and high expression of SEMA7A gene was significantly correlated with poor prognosis in this type of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Urology & Nephrology
Laura Bukavina, Karim Bensalah, Freddie Bray, Maria Carlo, Ben Challacombe, Jose A. Karam, Wassim Kassouf, Thomas Mitchell, Rodolfo Montironi, Tim O'Brien, Valeria Panebianco, Ghislaine Scelo, Brian Shuch, Hein van Poppel, Christopher D. Blosser, Sarah P. Psutka
Summary: The incidence and mortality rates of kidney cancer vary significantly globally, with variations across time, geography, and sex. Hypertension, obesity, and smoking are the most well-established risk factors. Recent advances in genetic characterization have improved our understanding of the mutations that predispose individuals to kidney cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Evgenia Efthymiou, Georgios Velonakis, Georgios Charalampopoulos, Argyro Mazioti, Elias Brountzos, Nikolaos Kelekis, Dimitrios Filippiadis
Summary: This study evaluates the performance of RENAL and mRENAL scores in predicting oncological outcomes in patients with T1 renal cell carcinomas treated with microwave ablation. The results show that both RENAL and mRENAL scores have significant prognostic ability in predicting progression in renal cancer.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Biochemistry & Molecular Biology
Jun Wang, Hongyuan Wan, Yuanyuan Mi, Sheng Wu, Jie Li, Lijie Zhu
Summary: This study investigated the specific mechanism by which TROAP functions in kidney renal clear cell carcinoma (KIRC). It was found that TROAP was significantly overexpressed in KIRC tissues and was associated with higher T and pathological stages, and a poor prognosis. Inhibition of TROAP expression reduced KIRC proliferation, affected cell cycle, promoted cell apoptosis, and reduced cell migration and invasion. Further analysis revealed that TROAP may regulate KIRC progression by binding to STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Yaoxian Xu, Christoph Kuppe, Javier Perales-Paton, Sikander Hayat, Jennifer Kranz, Ali T. Abdallah, James Nagai, Zhijian Li, Fabian Peisker, Turgay Saritas, Maurice Halder, Sylvia Menzel, Konrad Hoeft, Annegien Kenter, Hyojin Kim, Claudia R. C. van Roeyen, Michael Lehrke, Julia Moellmann, Thimoteus Speer, Eva M. Buhl, Remco Hoogenboezem, Peter Boor, Jitske Jansen, Cordula Knopp, Ingo Kurth, Bart Smeets, Eric Bindels, Marlies E. J. Reinders, Carla Baan, Joost Gribnau, Ewout J. Hoorn, Joachim Steffens, Tobias B. Huber, Ivan Costa, Jurgen Floege, Rebekka K. Schneider, Julio Saez-Rodriguez, Benjamin S. Freedman, Rafael Kramann
Summary: Adult kidney organoids, known as tubuloids, are derived from a distinct CD24(+) epithelial subpopulation and can be used to model autosomal dominant polycystic kidney disease (ADPKD) and study drug response. The study found similarities in gene expression between gene-edited tubuloids and ADPKD patients' tissue, demonstrating the potential of tubuloids in ADPKD disease modeling. Additionally, the approved drug for ADPKD, tolvaptan, was found to have a significant effect on cyst size in tubuloids but not in pluripotent stem cell-derived models.
Article
Biochemistry & Molecular Biology
Jianrong Bai, Axiu Zheng, Yanping Ha, Xiaoqing Xu, Yaping Yu, Yanda Lu, Shaojiang Zheng, Zhihua Shen, Botao Luo, Wei Jie
Summary: LAMC1 expression is associated with prognosis in kidney cancer, high expression indicates poor prognosis in KIRP and better prognosis in KIRC. LAMC1 expression is correlated with immune cell infiltration and signaling pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Marcus Lowe, Antony Payton, Arpana Verma, Judith Worthington, Isla Gemmell, Patrick Hamilton, William Ollier, Titus Augustine, Kay Poulton
Summary: This study found 22 HLA types associated with increased renal function, and 11 types associated with decreased renal function. Many of these HLA types commonly inherit together in established haplotypes, which could have important applications for the diagnosis and treatment of renal disease.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Bin Li, Xue-dong Shi
Summary: This study investigated the significance of LAPTM5 in kidney renal clear cell carcinoma (KIRC). The results showed that high expression of LAPTM5 was associated with poor overall survival of KIRC patients. Additionally, LAPTM5 was found to be involved in immune-related pathways and associated with tumor immune infiltrates. Therefore, LAPTM5 may serve as an independent prognostic factor and potential biomarker for KIRC patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Oncology
Xuedan He, Shiqi Zhou, Melissa Dolan, Yuhao Shi, Jianxin Wang, Breandan Quinn, Dushyant Jahagirdar, Wei-Chiao Huang, Moriya Tsuji, Roberto Pili, Fumito Ito, Joaquin Ortega, Scott Abrams, John M. L. Ebos, Jonathan F. Lovell
Summary: The study successfully predicted and screened MHC-I restricted neoepitopes in a murine renal adenocarcinoma model, converting them into immunogenic nanoparticles which induced antitumor responses. One candidate neoepitope, Nesprin-2 L4492R (Nes2LR), not only induced functional responses within 20-plex or 60-plex particles, but also prevented tumor growth.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Jasmeet Kaur, Goutham Patil, Daniel M. Geynisman, Pooja Ghatalia
Summary: Immunotherapy has shown effectiveness in treating metastatic renal cell carcinoma. For localized RCC, partial or complete nephrectomy is the standard treatment. However, there is a high recurrence rate and varied survival rates after surgery. Due to the positive response to immunotherapies in metastatic RCC, these treatments are being tested in the (neo)adjuvant setting as monotherapy or in combination with tyrosine kinase inhibitors. This article describes the current landscape of these treatments in localized RCC.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kathleen M. McClain, Joshua N. Sampson, Jessica L. Petrick, Kaitlyn M. Mazzilli, Robert E. Gerszten, Clary B. Clish, Mark P. Purdue, Loren Lipworth, Steven C. Moore
Summary: This study found that six serum metabolites were associated with the risk of kidney cancer, and three of these metabolites had independent associations in the mutually adjusted model. These metabolites may point to new biological pathways relevant to kidney malignancy.
Article
Oncology
Shruti Gupta, Shamsher Singh Kanwar
Summary: Kidney stone is a common urological condition with increasing prevalence, associated with dietary habits, obesity, and diabetes mellitus. Patients with kidney stones are more prone to kidney tumors, and dysbiosis of the gut and urinary tract microbiome may contribute to the development of kidney stone disease. The variation in microbiome in human gut and urinary tract is linked to chronic kidney stone diseases and increased risks of papillary RCC.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Zhi Chen, Zuan Li, Chunlin Li, Bingcai Li, Haojian Wang, Deyong Nong, Ximing Li, Guihai Huang, Junhao Lin, Wei Li
Summary: The overexpression of SPOP in RCC cells suppresses cell proliferation, migration, and invasion while increasing cell apoptosis. Additionally, the use of sunitinib and IFN-alpha 2b enhances the inhibitory effects on proliferation and apoptosis in SPOP-overexpressing cells. In RCC tissues, SPOP protein expression is significantly decreased in clear cell RCC (ccRCC) tissues compared to adjacent normal tissues.
Article
Oncology
Savio Domenico Pandolfo, Davide Loizzo, Alp T. Beksac, Ithaar Derweesh, Antonio Celia, Lorenzo Bianchi, Jeffrey Elbich, Giovanni Costa, Umberto Carbonara, Giuseppe Lucarelli, Clara Cerrato, Margaret Meagher, Pasquale Ditonno, Lance J. Hampton, Giuseppe Basile, Fernando J. Kim, Riccardo Schiavina, Umberto Capitanio, Jihad Kaouk, Riccardo Autorino
Summary: This study compared the outcomes of robot-assisted partial nephrectomy (RAPN) and percutaneous thermal ablation (PTA) in the treatment of renal tumors cT1 in solitary kidney. The results showed that there were no significant differences in surgical, functional, and oncological outcomes between the two methods, but PTA may carry a higher risk of recurrence and may require retreatment.
Article
Biochemistry & Molecular Biology
Sofia De Marco, Barbara Torsello, Emanuela Minutiello, Ivana Morabito, Chiara Grasselli, Silvia Bombelli, Nicola Zucchini, Giuseppe Lucarelli, Guido Strada, Roberto A. Perego, Cristina Bianchi
Summary: In this study, it was found that TGF-beta 1/Smad signaling is more activated in high-grade ccRCC and inversely correlated with Abl2 protein expression. TGF-beta 1 treatment increased the degradation of Abl2 protein and promoted tumor invasion and metastasis markers in ccRCC cells.
Review
Biochemistry & Molecular Biology
Francesco Lasorsa, Nicola Antonio di Meo, Monica Rutigliano, Matteo Ferro, Daniela Terracciano, Octavian Sabin Tataru, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli
Summary: Prostate cancer is a common malignancy in men and a leading cause of cancer death. The cancer cells have specific metabolic characteristics, including increased lipogenesis, cholesterogenesis, and reliance on glutamine. The tumor microenvironment also plays a role in cancer progression through interactions between cancer and stromal cells. The use of multi-omic approaches can provide a comprehensive understanding of the metabolic changes in prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Savio Domenico Pandolfo, Alp T. Beksac, Ithaar Derweesh, Antonio Celia, Riccardo Schiavina, Lorenzo Bianchi, Giovanni Costa, Umberto Carbonara, Davide Loizzo, Giuseppe Lucarelli, Clara Cerrato, Ciro Imbimbo, Vicenzo Mirone, Jeffrey Elbich, Giuseppe Basile, Lance J. Hampton, Fernando J. Kim, Umberto Capitanio, Jihad Kaouk, Riccardo Autorino
Summary: This study compared the outcomes of RAPN and PTA in treating completely endophytic renal masses. The results show that PTA treatment has low complications and good mid-term functional and oncologic outcomes. RAPN is more suitable for younger patients with fewer comorbidities.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nicoletta De Vietro, Antonella Maria Aresta, Arcangelo Picciariello, Donato Francesco Altomare, Giuseppe Lucarelli, Alessia Di Gilio, Jolanda Palmisani, Gianluigi De Gennaro, Carlo Zambonin
Summary: Chronic kidney disease (CKD) can lead to end-stage renal disease and increased mortality. Kidney transplantation is the only definitive treatment, but organ rejection is a risk in the short-medium term. This preclinic study proposes the optimization of a non-invasive and cheap TD-GC-MS protocol to monitor CKD patients before and after surgery, with the aim of predicting kidney rejection. Using the ReCIVA((R)) device, the breath of healthy and pathological subjects was analyzed, identifying 67 molecules and quantifying 13 compounds with high prognostic values.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Biagio Barone, Benito Fabio Mirto, Alfonso Falcone, Francesco Del Giudice, Achille Aveta, Luigi Napolitano, Dario Del Biondo, Matteo Ferro, Gian Maria Busetto, Celeste Manfredi, Daniela Terracciano, Raffaele Gambardella, Savio Domenico Pandolfo, Francesco Trama, Ciro De Luca, Raffaele Martino, Federico Capone, Gaetano Giampaglia, Enrico Sicignano, Octavian Sabin Tataru, Giuseppe Lucarelli, Felice Crocetto
Summary: Bacterial prostatitis is a common prostatic infection that significantly affects quality of life. The combination of appropriate antibiotics and nutraceutical products can enhance treatment efficacy. This study found that the combination therapy of Flogofilm (R) and fluoroquinolones demonstrated significant improvement in pain, urinary symptoms, and quality of life in patients with chronic bacterial prostatitis, as indicated by IPSS and NIH-CPSI scores, compared to fluoroquinolones alone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Francesco Lasorsa, Monica Rutigliano, Martina Milella, Matteo Ferro, Savio Domenico Pandolfo, Felice Crocetto, Octavian Sabin Tataru, Riccardo Autorino, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli
Summary: Globally, clear-cell renal cell carcinoma (ccRCC) is the most prevalent type of kidney cancer. Surgery is key in treatment, but a significant number of patients have metastatic ccRCC or experience recurrence. Molecular-target-based agents like TKIs and ICIs are recommended for advanced cancer treatment. The tumor microenvironment (TME) plays an essential role in cancer development and can be targeted for therapy. Understanding immune cell interactions with cancer and other TME elements is crucial for enhancing immunotherapies and reducing resistance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Antonio Tufano, Costantino Leonardo, Chiara Di Bella, Giuseppe Lucarelli, Vincenzo Dolcetti, Piervito Dipinto, Flavia Proietti, Rocco Simone Flammia, Umberto Anceschi, Sisto Perdona, Giorgio Franco, Alessandro Sciarra, Giovanni Battista Di Pierro, Vito Cantisani
Summary: Contrast-enhanced ultrasound (CEUS) can differentiate clear cell renal cell carcinoma (ccRCC) from renal oncocytoma (RO). Heterogeneous enhancement and rim-like enhancement are independent predictors of ccRCC. These features can be clearly visualized on CEUS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Roberto Contieri, Rodolfo Hurle, Marco Paciotti, Paolo Casale, Alberto Saita, Francesco Porpiglia, Cristian Fiori, Biagio Barone, Felice Crocetto, Giuseppe Lucarelli, Gian M. Busetto, Francesco Del Giudice, Martina Maggi, Francesco Cantiello, Rocco Damiano, Marco Borghesi, Pierluigi Bove, Riccardo Bertolo, Rocco Papalia, Andrea Mari, Stefano Luzzago, Francesco A. Mistretta, Francesco Soria, Paolo Gontero, Michele Marchioni, Evelina La Civita, Daniela Terracciano, Giorgio I. Russo, Luigi Schips, Sisto Perdona, Vincenzo Mirone, Octavian S. Tataru, Gennaro Musi, Mihai D. Vartolomei, Riccardo Autorino, Emanuele Montanari, Ottavio De Cobelli, Matteo Ferro
Summary: The European Association of Urology has updated the prognostic factor risk groups model for NMIBC and introduced a new group of patients at very high risk (VHR). They also proposed three additional clinical risk factors. However, the new scoring model was created without considering patients who received BCG intravesical therapy.
MINERVA UROLOGY AND NEPHROLOGY
(2023)
Article
Thermodynamics
Giuseppe Lucarelli, Matteo Genovese, Gaetano Florio, Petronilla Fragiacomo
Summary: The article discusses the use of a novel multi-objective optimization model for tri-generative energy systems, considering technical, economic, and environmental objectives. The model was employed to simulate the daily operation of various system configurations and evaluate the data. A comparison was made among 22 technology sets, resulting in the identification of an optimal tri-generation plant for a large industrial user.
Review
Nutrition & Dietetics
Felice Crocetto, Raffaele Balsamo, Ugo Amicuzi, Luigi De Luca, Alfonso Falcone, Benito Fabio Mirto, Gaetano Giampaglia, Gianpiero Ferretti, Federico Capone, Fabio Machiella, Domenico Varriale, Enrico Sicignano, Giovanni Pagano, Alessandro Lombardi, Giuseppe Lucarelli, Francesco Lasorsa, Gian Maria Busetto, Francesco Del Giudice, Matteo Ferro, Ciro Imbimbo, Biagio Barone
Summary: Urinary tract infections are a common and significant global health concern, with high recurrence rates and increasing antibiotic resistance. However, novel compounds such as D-mannose, chondroitin sulphate, hyaluronic acid, and N-acetylcysteine could provide important alternatives or adjuncts to existing prevention and treatment strategies. Numerous studies have evaluated the efficacy and potential use of these compounds in urinary tract health, particularly for urinary tract infections.
Article
Urology & Nephrology
Simona Simone, Francesco Pesce, Giulia Fonto, Virginia Pronzo, Paola Pontrelli, Francesca Conserva, Annalisa Schirinzi, Annalisa Casanova, Pasquale Gallo, Michele Rossini, Giuseppe Lucarelli, Marco Spilotros, Maria Rendina, Giovanni Stallone, Francesca Di Serio, Alfredo Di Leo, Silvio Tafuri, Pasquale Ditonno, Loreto Gesualdo
Summary: This study aimed to evaluate the seroconversion rate after BNT162b2 vaccine in kidney transplant recipients, factors associated with humoral response, and clinical outcome of COVID-19 in these patients. The results showed that after three doses of the vaccine, kidney transplant patients exhibited a late but effective immune response against SARS-CoV-2, reducing morbidity and mortality.
JOURNAL OF NEPHROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Michele Marchioni, Annamaria Porreca, Marta Di Nicola, Giuseppe Lucarelli, Vartolomei Mihai Dorin, Francesco Soria, Daniela Tarracciano, Francesco Alessandro Mistretta, Carlo Buonerba, Francesco Cantiello, Andrea Mari, Andrea Minervini, Alessandro Veccia, Alessandro Antonelli, Gennaro Musi, Rodolfo Hurle, Gian Maria Busetto, Francesco Del Giudice, Benjamin I. Chung, Francesco Berardinelli, Sisto Perdona, Paola Del Prete, Vincenzo Mirone, Marco Borghesi, Angelo Porreca, Pierluigi Bove, Riccardo Autorino, Nicolae Crisan, Michele Battaglia, Pasquale Ditonno, Giorgio Ivan Russo, Matteo Muto, Rocco Damiano, Francesco Porpiglia, Ottavio De Cobelli, Luigi Schips, Matteo Ferro
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
M. Marchioni, A. Porreca, M. Di Nicola, G. Lucarelli, V. M. Dorin, F. Soria, D. Terracciano, F. A. Mistretta, C. Buonerba, F. Cantiello, A. Mari, A. Minervini, A. Veccia, A. Antonelli, G. Musi, R. Hurle, G. M. Busetto, F. Del Giudice, B. I. Chung, F. Berardinelli, S. Berdona, P. Del Prete, F. Porpiglia, L. Schips
Review
Urology & Nephrology
Matteo Ferro, Felice Crocetto, Biagio Barone, Francesco del Giudice, Martina Maggi, Giuseppe Lucarelli, Gian Maria Busetto, Riccardo Autorino, Michele Marchioni, Francesco Cantiello, Fabio Crocerossa, Stefano Luzzago, Mattia Piccinelli, Francesco Alessandro Mistretta, Marco Tozzi, Luigi Schips, Ugo Giovanni Falagario, Alessandro Veccia, Mihai Dorin Vartolomei, Gennaro Musi, Ottavio de Cobelli, Emanuele Montanari, Octavian Sabin Tataru
Summary: Radiomics and artificial intelligence (AI) have the potential to improve the differentiation and characterization of various renal lesions, including distinguishing benign from malignant lesions, differentiating different subtypes of renal cell carcinoma, and predicting clinical outcomes such as Fuhrman grade and treatment response. By analyzing imaging data using neural networks, quantitative features related to contour, heterogeneity, and gray zone can be extracted, providing valuable information for diagnosis and prognosis. Standardization of scanner protocols is crucial for enhancing the diagnostic ability of imaging tools and improving the accuracy in differentiating between benign and clinically significant renal cancers.
THERAPEUTIC ADVANCES IN UROLOGY
(2023)
