Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance

Spatial Heterogeneity in Drug Concentrations Can Facilitate the Emergence of Resistance to Cancer Therapy

(2015) Feng Fu et al.   PLoS Computational Biology

Antagonism between Bacteriostatic and Bactericidal Antibiotics Is Prevalent

(2014) Paolo S. Ocampo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells

(2014) Véronique Dartois   NATURE REVIEWS MICROBIOLOGY

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The path of least resistance: aggressive or moderate treatment?

(2014) R. D. Kouyos et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Loss and Recovery of Genetic Diversity in Adapting Populations of HIV

(2014) Pleuni S. Pennings et al.   PLoS Genetics

Cycling Empirical Antibiotic Therapy in Hospitals: Meta-Analysis and Models

(2014) Pia Abel zur Wiesch et al.   PLoS Pathogens

Evolutionary Rescue in Structured Populations

(2013) Hildegard Uecker et al.   AMERICAN NATURALIST

Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis

(2013) Jansy Sarathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Pharmaco –, Population and Evolutionary Dynamics of Multi-drug Therapy: Experiments with S. aureus and E. coli and Computer Simulations

(2013) Peter Ankomah et al.   PLoS Pathogens

Evolutionary dynamics of cancer in response to targeted combination therapy

(2013) Ivana Bozic et al.   eLife

Drug-Resistant Tuberculosis—Current Dilemmas, Unanswered Questions, Challenges, and Priority Needs

(2012) Alimuddin Zumla et al.   JOURNAL OF INFECTIOUS DISEASES

Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis

(2012) Ravindra K Gupta et al.   LANCET

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome

(2012) Daniel I S Rosenbloom et al.   NATURE MEDICINE

A quantitative basis for antiretroviral therapy for HIV-1 infection

(2012) Benjamin L Jilek et al.   NATURE MEDICINE

Mutational Pathway Determines Whether Drug Gradients Accelerate Evolution of Drug-Resistant Cells

(2012) Philip Greulich et al.   PHYSICAL REVIEW LETTERS

On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient

(2012) R. Hermsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-existence and emergence of drug resistance in a generalized model of intra-host viral dynamics

(2012) Helen K. Alexander et al.   Epidemics

Standing Genetic Variation and the Evolution of Drug Resistance in HIV

(2012) Pleuni Simone Pennings   PLoS Computational Biology

Two-Drug Antimicrobial Chemotherapy: A Mathematical Model and Experiments with Mycobacterium marinum

(2012) Peter Ankomah et al.   PLoS Pathogens

Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract

(2011) Laura J Else et al.   ANTIVIRAL THERAPY

Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus

(2011) Jean-Michel Pawlotsky   HEPATOLOGY

Multidrug-Resistant Tuberculosis Not Due to Noncompliance but to Between-Patient Pharmacokinetic Variability

(2011) Shashikant Srivastava et al.   JOURNAL OF INFECTIOUS DISEASES

Hepatitis B virus resistance to antiviral drugs: where are we going?

(2011) Fabien Zoulim   LIVER INTERNATIONAL

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

(2011) Erdal Toprak et al.   NATURE GENETICS

The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy

(2011) A. F. Read et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acceleration of Emergence of Bacterial Antibiotic Resistance in Connected Microenvironments

(2011) Q. Zhang et al.   SCIENCE

Long‐Term Probability of Detecting Drug‐Resistant HIV in Treatment‐Naive Patients Initiating Combination Antiretroviral Therapy

(2010)   CLINICAL INFECTIOUS DISEASES

Therapy Failure following Selection of Enfuvirtide‐Resistant HIV‐1 in Cerebrospinal Fluid

(2010) S. F. L. van Lelyveld et al.   CLINICAL INFECTIOUS DISEASES

Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms

(2010) R. Singh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

HIV‐1 Viral Escape in Cerebrospinal Fluid of Subjects on Suppressive Antiretroviral Treatment

(2010) Arvid Edén et al.   JOURNAL OF INFECTIOUS DISEASES

The transport of anti-HIV drugs across blood–CNS interfaces: Summary of current knowledge and recommendations for further research

(2009) Lavanya Varatharajan et al.   ANTIVIRAL RESEARCH

Vancomycin in Combination with Other Antibiotics for the Treatment of Serious Methicillin‐ResistantStaphylococcus aureusInfections

(2009) Stan Deresinski   CLINICAL INFECTIOUS DISEASES

Effect of vancomycin plus rifampicin in the treatment of nosocomial methicillin-resistant Staphylococcus aureus pneumonia*

(2009) Young Ju Jung et al.   CRITICAL CARE MEDICINE

The rate at which asexual populations cross fitness valleys

(2009) Daniel B. Weissman et al.   THEORETICAL POPULATION BIOLOGY

Population Extinction and the Genetics of Adaptation

(2008) H. Allen Orr et al.   AMERICAN NATURALIST

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outbreak of Resistant Pseudomonas aeruginosa Infections during a Quarterly Cycling Antibiotic Regimen

(2008) Traci L. Hedrick et al.   Surgical Infections