Review
Biochemistry & Molecular Biology
Li-Jen Liao, Wan-Lun Hsu, Chi-Ju Chen, Yen-Ling Chiu
Summary: Nasopharyngeal carcinoma is endemic in southern Asia and this article describes the molecular abnormalities in NPC and potential molecular mechanisms for future therapy. It provides an up-to-date review on the molecular pathways of NPC, improving our understanding of the disease and highlighting areas for further research.
Review
Oncology
Ramon Yarza, Mateo Bover, Maria Teresa Agullo-Ortuno, Lara Carmen Iglesias-Docampo
Summary: Nasopharyngeal carcinoma (NPC) is a molecularly paradigmatic tumor with complex environmental and host dependent factors, where Epstein Barr Virus (EBV) plays a key role in malignant transformation. The dysregulation of proteasome signaling is central in NPC pathogenesis and could be a potential therapeutic target. Studies have shown the efficacy of immunotherapy in NPC, with novel strategies aiming to reverse immune resistance and favor tumor recognition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Article
Cell Biology
Xiandong Lin, Steven Wang, Keyu Lin, Jingfeng Zong, Qianlan Zheng, Ying Su, Tao Huang
Summary: This study investigated the roles of microRNAs and circular RNAs in Nasopharyngeal Carcinoma (NPC) by constructing a circRNA-miRNA-mRNA co-expression network and performing differential expression analysis. The Epstein-Barr virus (EBV) infection was found to be an important risk factor for NPC, with potential pathological differences between EBV+ and EBV- subtypes. The study identified differentially expressed coding and non-coding RNAs across different comparison groups, helping to elucidate genetic and epigenetic changes central to NPC progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiao-Hui Zheng, Chang-Mi Deng, Ting Zhou, Xi-Zhao Li, Cao-Li Tang, Cheng-Tao Jiang, Ying Liao, Tong-Min Wang, Yong-Qiao He, Wei-Hua Jia
Summary: Saliva sampling is a non-invasive method that can be done by individuals themselves. This study used saliva samples to explore the use of EBV methylation as a biomarker in the diagnosis of NPC. The results showed that EBV methylation was significantly increased in NPC patients compared to controls, and detection of specific CpG sites showed good diagnostic performance. The study suggests that non-invasive detection of NPC through saliva sampling could be a promising alternative for future large-scale screening.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Li Yuan, Shibing Li, Qiuyan Chen, Tianliang Xia, Donghua Luo, Liangji Li, Sailan Liu, Shanshan Guo, Liting Liu, Chaochao Du, Guodong Jia, Xiaoyun Li, Zijian Lu, Zhenchong Yang, Huanliang Liu, Haiqiang Mai, Linquan Tang
Summary: This study found that Epstein-Barr virus (EBV) infection reduces the sensitivity of nasopharyngeal carcinoma (NPC) cells to ferroptosis by activating the p62-Keap1-NRF2 signaling pathway and upregulating SLC7A11 and GPX4 expression. Inhibition of GPX4 enhances the chemosensitivity of EBV-infected NPC cells. High GPX4 expression is associated with poor clinical outcomes in NPC and other cancer types.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Environmental Sciences
Mengmeng Li, Wen-Jie Chen, Jun Yang, Hadrien Charvat, Shang-Hang Xie, Tong Li, Wei Ling, Yu-Qiang Lu, Qing Liu, Ming-Huang Hong, Su-Mei Cao
Summary: This study investigated the association between solid fuel use and Epstein-Barr virus (EBV) seropositivity, as well as EBV activation related to nasopharyngeal carcinoma (NPC). The results showed that solid fuel use was associated with a higher risk of EBV seropositivity and NPC-related EBV activation. The findings have important implications for understanding the etiology of NPC and public health, particularly in low resource settings.
ENVIRONMENTAL POLLUTION
(2022)
Review
Cell Biology
Chin-King Looi, Lian-Chee Foong, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Ee-Mun Loo, Chee-Onn Leong, Chun-Wai Mai
Summary: This review provides updated understanding of the roles of epigenetic factors in regulating EBV latent gene expression and promoting NPC progression. The crosstalk between epigenetic mechanisms and immune evasion in NPC is explored, along with the potential roles of DNMT and HDAC inhibitors in reversing immune suppression and augmenting antitumour immunity. Furthermore, the advantages of combining epigenetic therapy and immune checkpoint inhibitor to reverse immune resistance and improve clinical outcomes are highlighted.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Microbiology
Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah
Summary: Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy associated with Epstein-Barr virus (EBV). Despite global EBV infection, NPC incidences are higher in certain ethnic groups and endemic regions. Research has revealed the molecular mechanisms of NPC pathogenesis due to EBV infection and environmental/genetic factors. EBV-associated biomarkers can be used for mass population screening and EBV products may act as therapeutic targets. This review discusses the role of EBV in NPC and efforts to utilize EBV-associated molecules as biomarkers and therapeutic targets.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Oncology
Wei Shi, Mackenzie Fijardo, Jeff P. Bruce, Jie Su, Wei Xu, Rachel Bell, Pierre-Antoine Bissey, Angela B. Y. Hui, John Waldron, Trevor J. Pugh, Kenneth W. Yip, Fei-Fei Liu
Summary: This study reveals the prognostic significance of CD8+ tumor-infiltrating lymphocytes (TILs) in naso-pharyngeal cancer (NPC) and suggests the potential of utilizing CD8+ lymphocytes for immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah
Summary: Nasopharyngeal carcinoma microenvironment is a complex niche with important clinical value, which can serve as a rich field for the discovery of potential predictive or diagnostic biomarkers and the development of therapeutic strategies. Studying this environment can provide a better understanding of tumor biology mechanisms and guide clinical practice.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xiaohan Zhou, Yanling Lin, Yuting Chen, Lingzhi Wang, Xiaohong Peng, Jinrong Liao, Hanyi Zeng, Wenxiao Luo, Dehua Wu, Longmei Cai
Summary: Research has shown that the upregulation of EBV-miR-BART8-3p in nasopharyngeal carcinoma patients is associated with radioresistance and metastasis. This miRNA promotes invasion and metastasis of NPC cells, suggesting it could be a potential therapeutic target.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Wenting Li, Xiaobing Duan, Xingxing Chen, Meixiao Zhan, Haichuan Peng, Ya Meng, Xiaobin Li, Xian-Yang Li, Guofu Pang, Xiaohui Dou
Summary: Epstein-Barr virus (EBV) is the first tumor virus in humans, and nasopharyngeal carcinoma (NPC) accounts for 60% of new tumor cases caused by EBV worldwide annually. Over 90% of patients with undifferentiated NPC are infected with EBV. Immunotherapy has shown significant breakthroughs in the treatment of recurrent or metastatic NPC, providing a broad prospect for NPC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Virology
Raja Pramanik, Shalabh Arora, Preity Sharma, Ahitagni Biswas, Baibaswata Nayak, Alok Thakar, Atul Sharma, Sampa Ghose
Summary: Nasopharyngeal carcinoma is not endemic in India but shows higher incidences in its North-Eastern regions. Detecting NPC early is challenging, and assessing plasma Epstein-Barr virus DNA load can help monitor disease status, treatment response, and future relapse risk in nonendemic NPC patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Gongwei Tian, Yan Liu, Mei Yu, Cuiyuan Liang, Dan Yang, Jianping Huang, Qinyi Zhao, Wei Zhang, Jianhui Chen, Yu Wang, Ping Xu, Zhiyuan Liu, Dianpeng Qi
Summary: This study fabricates a strong electrostatic adhesive and applies it to stretchable neural microelectrodes to solve the problem of drift or fall of electrodes from the surface of wet and dynamic tissues. The adhesive exhibits high conformability and stretchability, and successfully records the electrophysiological signals of animals.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yingzhang Yan, Yonghao Yu, Yumin Zhang, Tai Yao, Ping Xu, Bo Song
Summary: This study demonstrates a Cu-PMMA porous hybrid catalyst with rich triple-phase boundaries, which enhances gas diffusion and electron transfer, facilitating CO electrolysis kinetics. The catalyst achieves high C-2(+) faradaic efficiency and partial current density, showing promising potential for designing electrochemical CO reduction catalysts.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jing Wang, Jing Hu, Siqi Niu, Siwei Li, Yunchen Du, Ping Xu
Summary: This article reports an efficient bifunctional electrocatalyst for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in alkaline solution. The catalyst exhibits good performance at both low and overpotentials, and demonstrates outstanding long-term durability. Spectroscopic studies reveal the importance of in situ surface reconstruction for the enhanced catalytic activity in both HER and OER processes.
Article
Chemistry, Physical
Yuanyuan Zhang, Ping Guo, Siwei Li, Jianmin Sun, Wei Wang, Bo Song, Xiaoxuan Yang, Xianjie Wang, Zaixing Jiang, Gang Wu, Ping Xu
Summary: The study reveals that the magnetoresistance effect caused by spin electron scattering dominates the apparent electrocatalytic activity in the magnetic field-assisted oxygen evolution reaction process. Additionally, the magnetic field-induced spin-polarized kinetics are more distinct when the first electron transfer step is the rate-determining step of the OER, especially for nickel. These findings provide insights into the role of magnetic effects in electrochemical reactions and may aid in the rational design of magnetic effect catalysts.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Review
Biochemistry & Molecular Biology
Jing Hu, Adel Al-Salihy, Bin Zhang, Siwei Li, Ping Xu
Summary: This review discusses the role and development of the d-band center of materials based on iron-series metals in electrocatalytic water splitting, focusing on the impact of different composites of iron-based materials on electrocatalytic performance. The information presented can be helpful for adjusting the active centers of catalysts and improving electrochemical efficiencies in future works.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Jie Wu, Xuetao Qin, Yu Xia, Yuanyuan Zhang, Bin Zhang, Yunchen Du, Hsing-Lin Wang, Siwei Li, Ping Xu
Summary: This study demonstrates an effective strategy for reducing the surface oxidation of CoS2 and improving its catalytic performance for hydrogen evolution by introducing glued V2O5 nanoclusters.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Physical
Xiaoyu Chen, Zhi Han, Zonghao Lu, Tingting Qu, Ce Liang, Yu Wang, Bin Zhang, Xijiang Han, Ping Xu
Summary: Novel 2D-2D SnS2/CdS heterostructures are demonstrated by loading SnS2 nanosheets onto CdS nanosheets, exhibiting excellent photocatalytic hydrogen evolution activity under visible light. The highest hydrogen evolution rate is achieved on SnS2/CdS heterostructures with 35 wt% SnS2, which is approximately 6-fold higher than that of pure CdS NSs.
SUSTAINABLE ENERGY & FUELS
(2023)
Article
Engineering, Environmental
Shu-Chao Sun, Fei-Xiang Ma, Hao Jiang, Meng-Xin Chen, Ping Xu, Liang Zhen, Bo Song, Cheng-Yan Xu
Summary: Dual-phase WC-W2C nanocrystals embedded into hollow carbon dodecahedrons (WC-W2C/HCDs) exhibit competitive HER activities and durability in a wide pH range.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Ranran Liang, Bin Zhang, Yunchen Du, Xijiang Han, Siwei Li, Ping Xu
Summary: A series of Co(OH)(x)(A)(y) materials with different acidic anions were synthesized and their catalytic activity for the OER was determined. Surface oxidation and the content of highly active Co(IV) were found to be crucial parameters for the OER performance. Furthermore, the leaching ability of anions in Co(OH)(x)(A)(y) was directly related to the Co(IV) content and the catalytic activity, which can be summarized as an anion leaching-metal oxidation model. This study provides deep insights into the anion effect of metal basic salt-based OER catalysts and the activation process of pre-catalysts for the OER.
Review
Chemistry, Physical
Yuanyuan Zhang, Jie Wu, Bingrong Guo, Haohao Huo, Siqi Niu, Siwei Li, Ping Xu
Summary: Transition-metal metaphosphates (TMMPs) have been recognized as highly efficient catalysts for both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in water splitting. This review summarizes the recent advances in the synthesis and applications of TMMPs, discusses the strategies for improving their catalytic activity, and explores the future opportunities and challenges in the field of electrocatalysis.
Article
Chemistry, Physical
Jianying Zhao, Yuanyuan Zhang, Yu Xia, Bin Zhang, Yunchen Du, Bo Song, Hsing-Lin Wang, Siwei Li, Ping Xu
Summary: In this study, a novel strong phosphide-metaphosphate interaction (SPmPI) was discovered in the RuP/CoNiP4O12 catalyst for efficient electrocatalytic overall water splitting. The SPmPI facilitates electron transfer and coordination environment, enabling the catalyst to achieve a low overpotential of 27 mV for hydrogen evolution reaction (HER) and effective oxygen evolution reaction (OER) for overall water splitting.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Immunology
Elif Cakan, Marie Dominique Ah Kioon, Yolanda Garcia-Carmona, Salome Glauzy, David Oliver, Natsuko Yamakawa, Andrea Vega Loza, Yong Du, Jean-Nicolas Schickel, Joshua M. Boeckers, Chao Yang, Alessia Baldo, Lionel B. Ivashkiv, Ryan M. Young, Louis M. Staudt, Krishna L. Moody, Kerstin Nundel, Ann Marshak-Rothstein, Caspar I. van der Made, Alexander Hoischen, Anthony Hayward, Marzia Rossato, Timothy R. D. J. Radstake, Charlotte Cunningham-Rundles, Changwan Ryu, Erica L. Herzog, Franck J. Barrat, Eric Meffre
Summary: TLR9 and CXCL4 play important roles in central B cell tolerance, with TLR9 regulating the removal of autoreactive clones and CXCL4 inhibiting TLR9 function by sequestering its ligands. The findings suggest that correcting defective TLR9 function may be a potential therapeutic strategy for restoring B cell tolerance in SSc patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Ce Liang, Kexin Sun, Mengxin Chen, Ping Xu
Summary: This perspective introduces the promising role of two-dimensional transition-metal dichalcogenides (TMDs) in surface-enhanced Raman scattering (SERS) and discusses their fundamental properties, crystal-phase configurations, and phase transition strategies. It emphasizes the importance of crystal phase in determining the SERS effect of TMDs and highlights recent advances in phase-engineering approaches for remarkable SERS performance. By addressing current challenges and future directions in improving the crystal-phase engineering of TMDs in SERS, new insights are provided for the design and synthesis of more promising TMD-based SERS substrates.
Article
Chemistry, Applied
Mengxin Chen, Yuanyuan Zhang, Ran Wang, Bin Zhang, Bo Song, Yanchao Guan, Siwei Li, Ping Xu
Summary: Surface reconstruction of NiS2, NiSe2, and Se-NiS2 during the OER process is studied through in-situ Raman spectroscopy and ex-situ X-ray photoelectron spectroscopy. Se-NiS2 exhibits outstanding OER activity and stability in alkaline conditions, requiring an overpotential of 343 mV at a current density of 50 mA cm-2. The research provides a novel insight into the surface reconstruction and electrocatalytic mechanism of Ni-based chalcogenides.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Mengxin Chen, Chuqiao Song, Ce Liang, Bin Zhang, Yanchun Sun, Siwei Li, Lili Lin, Ping Xu
Summary: In this study, we demonstrate the crystalline phase induced Raman enhancement on molybdenum carbide materials (beta-Mo2C and alpha-MoC), with the Raman enhancement on beta-Mo2C being 2-4 times higher than that on alpha-MoC. Spectroscopic and theoretical calculations reveal that beta-Mo2C has a lower electron work function and a higher density of states near the Fermi level than alpha-MoC, promoting charge transfer and photo induced charge transfer processes between probe molecules and the substrate.
INORGANIC CHEMISTRY FRONTIERS
(2022)
