Article
Biochemistry & Molecular Biology
Ethan L. Morgan, James A. Scarth, Molly R. Patterson, Christopher W. Wasson, Georgia C. Hemingway, Diego Barba-Moreno, Andrew Macdonald
Summary: The study identified activation of the JNK signaling pathway in cervical disease and cancer, with the HPV E6 oncogene inducing JNK1/2 phosphorylation. Blocking JNK signaling reduced cell proliferation and induced apoptosis, while promoting EGFR signaling. This positive feedback loop between EGFR signaling and HPV E6/E7 expression may offer a novel therapeutic target for cervical cancer treatment.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Tzu-Ching Shih, Chung-Min Yeh, Tso-Fu Wang, Ray-Jade Chen, Yu-Chun Chang, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study aimed to explore a tumor suppressive compound that can enhance the efficacy of Gefitinib treatment in lung cancer. Through in vitro and in vivo experiments, it was found that the combination of Daidzein and Gefitinib synergistically induced apoptosis and cell cycle arrest, effectively inhibiting lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sung Shin Ahn, Hyunjin Yeo, Euitaek Jung, Yoongho Lim, Young Han Lee, Soon Young Shin
Summary: This study identified the molecular mechanisms by which inflammatory cytokines inhibit the expression of FLG in the skin. It was found that the formation of the FRA1:c-JUN:HDAC1 complex is promoted under TNFa + IFNγ stimulation, leading to the downregulation of FLG expression. This insight into the regulatory pathways of FLG expression provides potential therapeutic strategies for restoring skin barrier function in chronic skin inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Xiang Yin, Peng Zhang, Ning Xia, Shaoqiu Wu, Bingyan Liu, Li Weng, Mingyi Shang
Summary: In this study, the role of GPx8 in esophageal squamous cell carcinoma (ESCC) and its molecular mechanism were investigated. GPx8 was found to be overexpressed in ESCC cell lines and tumor tissue. Knockdown of GPx8 suppressed ESCC proliferation and induced autophagy and apoptosis, while overexpression of GPx8 increased proliferation and inhibited apoptosis. GPx8-mediated inhibition of apoptosis was associated with the IRE1/JNK pathway in response to endoplasmic reticulum (ER) stress. Knockdown of GPx8 in xenograft models of ESCC resulted in a significant reduction in tumor weight and volume, which was further reduced with IRE1 or JNK inhibitors.
CELLULAR SIGNALLING
(2022)
Article
Medicine, Research & Experimental
Tianxiang Yu, Jiachen Xu, Qinyan Wang, Xue Han, Yu Tu, Yi Wang, Wu Luo, Mengyang Wang, Guang Liang
Summary: This study found that 20(S)-Rh2 alleviates cardiac damage induced by Ang-II through inhibition of the JNK/AP-1 pathway, reducing myocardial fibrosis, hypertrophy, and inflammation. These findings provide evidence for the use of 20(S)-Rh2 as an effective regimen for HHF.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Kristin Frensemeier, Angela Holzer, Karin Hoppe-Seyler, Felix Hoppe-Seyler
Summary: This study reveals that the expression of tumor suppressor protein Dkk1 is strongly restrained in HPV-positive cervical cancer cells through the continuous expression of the viral E6 oncogene, leading to increased resistance to Cisplatin-induced apoptosis. The repression of Dkk1 is not linked to Wnt pathway activation but rather the diminished stimulation of JNK signaling, which is required for efficient apoptosis induction by Cisplatin.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cell Biology
Wenhao Zhang, Dongmei Wang, Jingjing Si, Lihua Jin, Yangguang Hao
Summary: The Drosophila lymph gland is a valuable model for studying hematopoiesis and understanding the pathogenesis of human hematopoietic malignancies. The study focuses on the role of Glass bottom boat (Gbb) and Screw (Scw), two TGF-beta family ligands, in Drosophila hematopoiesis. The results reveal that the loss of Gbb induces lamellocyte differentiation and excessive differentiation of plasmatocytes through overactivation of the EGFR and JNK pathways, while Gbb is also important for preventing lymph gland hyperproliferation by inhibiting the overactivation of the EGFR and JNK pathways.
Article
Genetics & Heredity
Jielian Wu, Rong Lv, Linhan Qiu, Shuangping Zhang, He Jiao, Yanrui Wang, Shanshan Luo, Haihong Fang, Chungen Wen
Summary: In response to stress, cells activate the Nrf2/Keap1 pathway to protect against oxidative damage. JNK regulates the Nrf2/ARE signaling pathway and NQO1 plays a vital role in removing peroxide and providing resistance to oxidative injury.
Article
Biochemistry & Molecular Biology
Phuong Linh Nguyen, Bich Phuong Bui, Men Thi Hoai Duong, Kyeong Lee, Hee-Chul Ahn, Jungsook Cho
Summary: The study found that azelastine can exert anti-inflammatory and anti-migratory effects in BV2 cells by inhibiting the JNK/NF-κB pathway, making it a potential candidate for drug repurposing to mitigate neuroinflammation in various neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Yuyan Wang, Jinfeng Wang, Anqi Zhao, Xin Huang, Xin Zhang
Summary: KIF2A plays a key role in the motility and metastasis of cervical cancer, and HPV16 E6/E7 up-regulates the transcriptional expression of KIF2A by activating JNK signaling pathway.
Article
Urology & Nephrology
Sheng Chen, Yi Gao, Fei Chen, Tian-Bao Wang
Summary: This study found that ANLN may be an oncogene of bladder urothelial carcinoma (BLCA) and is associated with the activation of the JNK signal pathway. Inhibiting ANLN can suppress the proliferation, invasion, and migration of BLCA cells while promoting apoptosis.
UROLOGIA INTERNATIONALIS
(2023)
Article
Environmental Sciences
Tzu-Chao Chuang, Kuohui Wu, Ying-Yu Lin, Han-Peng Kuo, Ming-Ching Kao, Vinchi Wang, Shih-Chung Hsu, Shou-Lun Lee
Summary: Berberine reduces the motility and invasiveness of ovarian cancer cells by depleting EGFR and ErbB2, and down-regulating their downstream targets through the EGFR-ErbB2/PI3K/Akt signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Zongcai Liu, Fen Ning, Yanna Cai, Huiying Sheng, Ruidan Zheng, Xi Yin, Zhikun Lu, Ling Su, Xiaodan Chen, Chunhua Zeng, Haifang Wang, Li Liu
Summary: This study aimed to explore the impact of EGFR signaling on PD-L1 and HLA-I expression in HCC cells and revealed a novel signaling network involving the EGFR-P38 MAPK axis, miR-675-5p, and HK2 that may contribute to immune suppression in HCC, suggesting EGFR signaling as a potential target for HCC immunotherapy.
CANCER COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Lina Yang, Changhong Qu, Jiaxi Jin, Hong Yang, Lipeng Pei
Summary: Syringic acid (SRA) exhibits proapoptotic activities on ovarian cancer cells, suppressing cell proliferation and migration through regulation of cell cycle and apoptosis-related proteins.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jing Shan, Meng-Yu Wu, Ying-Chi Zhang, Yu-Jia Lin, Bin Cheng, Yan-Rong Gao, Zhi-Hong Liu, Hai -Ming Xu
Summary: This study screened and identified miRNAs that could regulate the human CTGF gene and downstream cascade reaction Rac1/MLK3/JNK/AP-1/Collagen I through bioinformatics and experimental methods. A total of 9 differentially expressed miRNAs were predicted, and hsa-miR-379-3p was found to directly target and down-regulate the human CTGF gene. Overexpression of hsa-miR-379-3p affected the expression levels of key genes and proteins in the Rac1/MLK3/JNK/AP1/Collagen I cascade reaction.
