Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

The ONIOM Method and Its Applications

(2015) Lung Wa Chung et al.   CHEMICAL REVIEWS

Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography

(2015) Rajan Vyas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Mechanism of DNA Polymerase β

(2014) William A. Beard et al.   BIOCHEMISTRY

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

(2014) Bret D. Freudenthal et al.   NATURE

Observing a DNA Polymerase Choose Right from Wrong

(2013) Bret D. Freudenthal et al.   CELL

Structural Comparison of DNA Polymerase Architecture Suggests a Nucleotide Gateway to the Polymerase Active Site

(2013) Sangwook Wu et al.   CHEMICAL REVIEWS

Effect of Geometry Optimizations on QM-Cluster and QM/MM Studies of Reaction Energies in Proteins

(2013) Sophie Sumner et al.   Journal of Chemical Theory and Computation

Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

(2013) Vinod K. Batra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer

(2012) Jason L. Parsons et al.   ANTIOXIDANTS & REDOX SIGNALING

Charge Model 5: An Extension of Hirshfeld Population Analysis for the Accurate Description of Molecular Interactions in Gaseous and Condensed Phases

(2012) Aleksandr V. Marenich et al.   Journal of Chemical Theory and Computation

Watching DNA polymerase η make a phosphodiester bond

(2012) Teruya Nakamura et al.   NATURE

Human Mitochondrial RNA Polymerase: Evaluation of the Single-Nucleotide-Addition Cycle on Synthetic RNA/DNA Scaffolds

(2011) Eric D. Smidansky et al.   BIOCHEMISTRY

A new proofreading mechanism for lesion bypass by DNA polymerase-λ

(2011) Emmanuele Crespan et al.   EMBO REPORTS

Modifications to the dNTP triphosphate moiety: From mechanistic probes for DNA polymerases to antiviral and anti-cancer drug design

(2010) Charles E. McKenna et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Nucleoside analogs: molecular mechanisms signaling cell death

(2008) B Ewald et al.   ONCOGENE

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase  

(2008) P. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA