Article
Genetics & Heredity
Enyang Zhao, Xuedong Li, Bosen You, Jinpeng Wang, Wenbin Hou, Qiong Wu
Summary: The study aims to identify kidney renal clear cell carcinoma using miRNAs as biomarkers. By employing a feature selection strategy and Gaussian mixture model, five miRNAs were identified as a signature for diagnosis.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Jianrong Bai, Axiu Zheng, Yanping Ha, Xiaoqing Xu, Yaping Yu, Yanda Lu, Shaojiang Zheng, Zhihua Shen, Botao Luo, Wei Jie
Summary: LAMC1 expression is associated with prognosis in kidney cancer, high expression indicates poor prognosis in KIRP and better prognosis in KIRC. LAMC1 expression is correlated with immune cell infiltration and signaling pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Analytical
Oliver Schiffmann, Ben Hicks, Aydin Nassehi, James Gopsill, Maria Valero
Summary: This research investigates the use of simulation for predicting the benefits and costs of digitalizing cold distribution chains. It focuses on the distribution of refrigerated beef in the UK and compares simulations of digitalized and non-digitalized supply chains. The study finds that digitalization can reduce beef waste and decrease miles driven per successful delivery, leading to potential cost savings. It suggests that simulation plays a crucial role in informed decision-making about the implementation of digital technologies in the food supply chain.
Review
Biochemistry & Molecular Biology
Husayn Ahmed Pallikonda, Samra Turajlic
Summary: This article reviews current approaches for evaluating the evolutionary features of cancer and discusses the impact of tumor sampling methods and experimental design. Using clear-cell renal cell carcinoma (ccRCC) as an example, the study explores the understanding and prediction of cancer evolutionary dynamics. Finally, the authors discuss the benefits of understanding cancer evolution for patients.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Microbiology
Josep Ferrer, Estela Gimenez, Diego Carretero, Javier Buesa, Francisco Morillas, Rafael Granell, Amadeo Fuenmayor, David Navarro, Eliseo Albert
Summary: The implementation of multiplex molecular panels allows microbiological laboratories to quickly, sensitively, and accurately diagnose acute infectious gastroenteritis. This methodology therefore allows faster decisions regarding treatment and infection control measures.
MICROBIOLOGY SPECTRUM
(2022)
Review
Oncology
Yuqing Wu, Saisai Chen, Minhao Zhang, Kuangzheng Liu, Jibo Jing, Kehao Pan, Lihua Zhang, Bin Xu, Xiaoming Lu, Ming Chen
Summary: This study aimed to comprehensively characterize Xp11.2 tRCC patients and identify risk factors associated with overall survival (OS) and progression-free survival (PFS). T stage at presentation was found to be significantly associated with both PFS and OS, while age, T stage, and metastasis status were also identified as predictors of OS. Patients with higher T stage, older age, or metastases were shown to have poorer outcomes.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Liliana Eleonora Semenescu, Ligia Gabriela Tataranu, Anica Dricu, Gheorghe Vasile Ciubotaru, Mugurel Petrinel Radoi, Silvia Mara Baez Rodriguez, Amira Kamel
Summary: Despite the era of targeted therapies, neurosurgery still plays an important role in the treatment of brain metastases from renal cell carcinoma (BM RCC). This study found that nephrectomy, systemic therapy, and a single brain metastasis were associated with improved survival rates. Additionally, higher levels of hemoglobin were correlated with an increased number of brain metastases.
Article
Biochemistry & Molecular Biology
Kathleen M. McClain, Joshua N. Sampson, Jessica L. Petrick, Kaitlyn M. Mazzilli, Robert E. Gerszten, Clary B. Clish, Mark P. Purdue, Loren Lipworth, Steven C. Moore
Summary: This study found that six serum metabolites were associated with the risk of kidney cancer, and three of these metabolites had independent associations in the mutually adjusted model. These metabolites may point to new biological pathways relevant to kidney malignancy.
Review
Oncology
Yu-Wei Chen, Brian Rini, Kathryn E. Beckermann
Summary: This review summarizes ongoing efforts in drug development in clear cell renal cell carcinoma (ccRCC), focusing on novel targets and treatment methods. While immunotherapy-based combinations have shown significant efficacy improvement in frontline treatment, there is still a need for new therapies to address non-responsive or resistant patients.
Article
Surgery
Amelia J. Hessheimer, Ana Magdalena Vargas-Martinez, Marta Trapero-Bertran, Miquel Navasa, Constantino Fondevila
Summary: This study evaluated the cost-effectiveness and utility of posttransplant hepatocellular carcinoma (HCC) surveillance compared to standard follow-up. Although surveillance slightly improves survival and quality of life, it also increases costs and does not appear to be cost-effective in this setting.
Article
Public, Environmental & Occupational Health
Qianru Zhu, Benjamin D. Leibowicz
Summary: This article introduces a novel Markov decision process model for cost-benefit analysis of infrastructure resilience upgrades. By applying this model to two case studies of electric utility infrastructure hardening, the study demonstrates the practical applicability of the model. Results from the case studies show that factors such as the value of lost load during power outages and the distribution of customer types significantly impact decisions on whether to implement resilience upgrades.
Review
Urology & Nephrology
Laura Bukavina, Karim Bensalah, Freddie Bray, Maria Carlo, Ben Challacombe, Jose A. Karam, Wassim Kassouf, Thomas Mitchell, Rodolfo Montironi, Tim O'Brien, Valeria Panebianco, Ghislaine Scelo, Brian Shuch, Hein van Poppel, Christopher D. Blosser, Sarah P. Psutka
Summary: The incidence and mortality rates of kidney cancer vary significantly globally, with variations across time, geography, and sex. Hypertension, obesity, and smoking are the most well-established risk factors. Recent advances in genetic characterization have improved our understanding of the mutations that predispose individuals to kidney cancer.
Article
Biochemistry & Molecular Biology
Samuel Swearson, Aseel O. Rataan, Steven Eliason, Brad A. Amendt, Yousef Zakharia, Aliasger K. Salem, Thai Ho, Youcef M. Rustum
Summary: This study quantitated the expression levels of miR-17, -19a, -34a, -155, and -210 in different types of renal cell carcinoma cell lines and primary kidney tumors. The results showed that miR-17 and -19a were expressed at lower levels, while miR-34a, miR-155, and miR-210 were expressed at higher levels. In ccRCC cell lines with sarcomatoid differentiation, miR-34a was expressed higher than miR-210, -155, -17, and -19a. More samples are needed to confirm the statistical significance of the differences in miR expression levels in tumor biopsies. Previous studies have shown that miR-210, miR-155, and HIFs are druggable targets, and downregulation of these miRs may be a novel strategy for the treatment of advanced ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Aisheng Dong, Qing Yang, Meimian Hua, Chao Cheng, Changjing Zuo
Summary: This study describes the findings of FAPI PET/CT in renal tumors, including a case of lipid-poor renal angiomyolipoma and a case of high-grade clear cell renal cell carcinoma. Both tumors showed intense FAPI uptake, indicating that lipid-poor renal angiomyolipoma should be considered in the differential diagnosis of FAPI-avid renal tumors.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aron Bartha, Zsuzsanna Darula, Gyoengyi Munkacsy, Eva Klement, Peter Nyirady, Balazs Gyorffy
Summary: This research used a proteotranscriptomic approach to differentiate normal and tumor tissues in clear cell renal cell carcinoma (ccRCC). Top genes over-expressed in ccRCC were identified using transcriptomic data of patients with malignant and normal tissue samples. Protein level analysis and mass spectrometry further validated the differential protein abundance of these genes. A minimal panel of proteins highly specific for ccRCC tissues was identified using transcriptomic and proteomic data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Kristina J. Nicholson, Kenneth J. Smith, Kelly L. McCoy, Sally E. Carty, Linwah Yip
Article
Nutrition & Dietetics
Vikram K. Raghu, David G. Binion, Kenneth J. Smith
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Article
Geriatrics & Gerontology
Angela R. Wateska, Mary Patricia Nowalk, Chyongchiou J. Lin, Lee H. Harrison, William Schaffner, Richard K. Zimmerman, Kenneth J. Smith
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2020)
Article
Surgery
Chethan M. Puttarajappa, Rajil B. Mehta, Mark S. Roberts, Kenneth J. Smith, Sundaram Hariharan
Summary: The study found that screening for subclinical rejection more than once during the first year after kidney transplantation is not economically reasonable, with a one-time screening at peak incidence being the preferred option. Screening with protocol biopsy was favored over using biomarkers.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Angela R. Wateska, Mary Patricia Nowalk, Hawre Jalal, Chyongchiou J. Lin, Lee H. Harrison, William Schaffner, Richard K. Zimmerman, Kenneth J. Smith
Summary: The study indicates that further research on parameters of pneumococcal vaccine uptake programs is not supported at commonly cited US cost-effectiveness benchmarks in adults. It is justifiable to conduct further research to reduce uncertainty in other aspects of adult pneumococcal vaccination.
Article
Immunology
Kenneth J. Smith, Angela R. Wateska, Mary Patricia Nowalk, Chyongchiou J. Lin, Lee H. Harrison, William Schaffner, Richard K. Zimmerman
Summary: The COVID-19 pandemic has led to declines in childhood PCV13 vaccination rates, which could result in increased pneumococcal disease rates in seniors, impacting the economic favorability of PCV13 vaccination in older adults. Absolute decreases of over 50% in pediatric PCV13 vaccination over a two-year period would be needed to make intensified PCV13 use economically favorable in non-immunocompromised seniors.
Article
Clinical Neurology
Clark A. Veet, Stephen Capone, David Panczykowski, Natasha Parekh, Kenneth J. Smith, Dong H. Kim, H. Alex Choi, Spiros L. Blackburn
Summary: The study found that immediate surgical treatment is the most cost-effective strategy for small unruptured anterior circulation aneurysms, particularly in patients under 70 years of age. The cost-effectiveness of immediate surgery is highly sensitive to factors such as diagnosis age, rupture rate, and surgical complication risk.
CEREBROVASCULAR DISEASES
(2022)
Article
Health Care Sciences & Services
Margaret F. Zupa, Ronald A. Codario, Kenneth J. Smith
Summary: The study found that for patients with Type 2 diabetes and cardiovascular disease, semaglutide is likely to be more cost-effective than empagliflozin added to usual treatment.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2021)
Article
Oncology
Lauren E. Sigler, Andrew D. Althouse, Teresa H. Thomas, Robert M. Arnold, Douglas White, Thomas J. Smith, Edward Chu, Margaret Rosenzweig, Kenneth J. Smith, Yael Schenker
Summary: This study assessed the effect of an oncology nurse-led primary palliative care intervention on illness expectations among patients with advanced cancer. The results showed little difference in realistic illness expectations at 3 months between the intervention and standard care groups. The study suggests that illness expectations are difficult to change among patients with advanced cancer.
JCO ONCOLOGY PRACTICE
(2022)
Article
Nutrition & Dietetics
Vikram K. Raghu, Wednesday M. A. Sevilla, Dale E. King, Feras Alissa, Scott Rothenberger, Kenneth J. Smith, Simon P. Horslen, Jeffrey A. Rudolph
Summary: Centers for intestinal rehabilitation and transplantation commonly use alternative intravenous lipid emulsions (ILEs), which is significant for decision support in specific clinical scenarios.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Oncology
Scott A. Greenberg, Janet E. Cowan, Peter E. Lonergan, Samuel L. I. I. I. I. I. I. Washington, Hao G. Nguyen, Ronald J. Zagoria, Peter R. Carroll
Summary: This study assessed the association between preoperative membranous urethral length (MUL) and the risk of persistent postoperative urinary incontinence after robot-assisted radical prostatectomy (RARP). The results showed that preoperative MUL measurements had no impact on urinary incontinence after 12 months post-RARP. There was poor agreement between radiologists' and urologists' measurements of MUL.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Infectious Diseases
Kenneth J. Smith, Angela R. Wateska, Mary Patricia Nowalk, Chyongchiou J. Lin, Lee H. Harrison, William Schaffner, Richard K. Zimmerman
Summary: The general population recommendations for PCV20 use are more economically reasonable for both Black and non-Black older adult populations compared to PCV15/PPSV23. If a single vaccine can increase the uptake, especially in underserved populations, the use of PCV20 becomes even more favorable.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Immunology
Angela R. Wateska, Mary Patricia Nowalk, Chyongchiou J. Lin, Lee H. Harrison, William Schaffner, Richard K. Zimmerman, Kenneth J. Smith
Summary: The introduction summarizes the CDC's recommendations for pneumococcal vaccination in older adults and the potential benefits of an in-development 21-valent vaccine (PCV21) compared to current recommendations. A decision model was used to compare the cost-effectiveness of PCV21 to current vaccines in Black and non-Black cohorts. The results indicate that PCV21 is likely to be economically and clinically favorable in older adults.
Article
Economics
Shoroq M. Altawalbeh, Angela R. Wateska, Mary Patricia Nowalk, Chyongchiou J. Lin, Lee H. Harrison, William Schaffner, Richard K. Zimmerman, Kenneth J. Smith
Summary: This study estimated the societal cost of racial disparities in pneumococcal disease among US adults aged >= 50 years. The findings suggest that the racial disparities in costs are substantial and implementing policies and interventions could reduce these costs and improve health.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)
Article
Health Policy & Services
Angela R. Wateska, Mary Patricia Nowalk, Chyongchiou J. Lin, Lee H. Harrison, William Schaffner, Richard K. Zimmerman, Kenneth J. Smith
JOURNAL OF COMMUNITY HEALTH
(2020)