Article
Medicine, General & Internal
Natasa Gisev, Luke Buizen, Ria E. Hopkins, Andrea L. Schaffer, Benjamin Daniels, Chrianna Bharat, Timothy Dobbins, Sarah Larney, Fiona Blyth, David C. Currow, Andrew Wilson, Sallie-Anne Pearson, Louisa Degenhardt
Summary: The objective of this population-based cohort study was to identify 5-year trajectories of prescription opioid use and examine the characteristics of each trajectory group. The results suggest that most individuals initiating treatment with prescription opioids had relatively low and time-limited exposure over a 5-year period. A small proportion of individuals had sustained or increasing use, and they were typically older with more comorbidities and higher use of psychotropic and other analgesic drugs.
Article
Anesthesiology
Josh Bleicher, Benjamin Sands Brooke, Kimberlee Bayless, Zachary Anderson, Julie Beckstrom, Chong Zhang, Angela P. Presson, Lyen C. Huang, Michael Jacob Buys
Summary: Understanding the patterns of postoperative opioid use among different populations is important for developing opioid stewardship programs. This retrospective study investigated opioid prescribing, use, and pain after general surgery procedures for patients at a veterans administration hospital. The results showed that both non-opioid users and chronic opioid users required very few opioids after surgery, and chronic opioid users quickly returned to their baseline opioid use. There was no difference in pain recovery between the two groups. The study suggests that opioid prescribing guidelines should consider including chronic opioid therapy patients and recommend a more conservative approach.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Urology & Nephrology
Jeffrey Villanueva, Valentina Grajales, Marc Colaco, Omar Ayyash, Rajeev Chaudhry, Francis Schneck, Glenn Cannon, Janelle Fox
Summary: The study found that a state-mandated opioid consent for minors significantly reduced post-urological surgery opioid prescription rates, without increasing rates of readmission or delayed prescriptions.
JOURNAL OF UROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Connie H. Yan, Todd A. Lee, Lisa K. Sharp, Colin C. Hubbard, Charlesnika T. Evans, Gregory S. Calip, Susan A. Rowan, Jessina C. McGregor, Walid F. Gellad, Katie J. Suda
Summary: The study found that the prescribing rates of opioid medications by dentists in the United States have declined over the past few years, following national trends and the implementation of strategies to regulate opioid prescribing.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Deanne E. Jenkin, Justine M. Naylor, Joseph Descallar, Ian A. Harris
Summary: This study found that treatment with strong opioid medication subacutely was not superior to treatment with milder medication for the management of pain in surgically managed orthopedic fracture patients. Therefore, ongoing first-line strong opioid use after discharge from the hospital should not be supported.
Article
Anesthesiology
Mark C. Bicket, Vidhya Gunaseelan, Pooja Lagisetty, Anne C. Fernandez, Amy Bohnert, Elizabeth Assenmacher, Melwyn Sequeira, Michael J. Englesbe, Chad M. Brummett, Jennifer F. Waljee
Summary: This study aimed to determine the effect of prescription opioid use in the year before surgery on opioid consumption after surgery. The results showed that preoperative opioid use is associated with small increases in patient-reported opioid consumption after surgery for most patients, though greater differences exist for patients with chronic use. Existing guidelines may meet the postoperative needs of most patients with preoperative opioid exposure, but may need tailoring for patients with chronic use.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Magdalena Cerda, Katherine Wheeler-Martin, Emilie Bruzelius, William Ponicki, Paul Gruenewald, Christine Mauro, Stephen Crystal, Corey S. Davis, Katherine Keyes, Deborah Hasin, Kara E. Rudolph, Silvia S. Martins
Summary: The study found that pain management clinic laws with criminal penalties were associated with reduced high-dose opioid prescriptions and overdose deaths, but also raised concerns regarding heroin/synthetic overdose deaths.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Anesthesiology
Karim S. Ladha, Kathak Vachhani, Gretchen Gabriel, Rasheeda Darville, Karl Everett, Jodi M. Gatley, Refik Saskin, Dorothy Wong, Praveen Ganty, Rita Katznelson, Alexander Huang, Joseph Fiorellino, Diana Tamir, Maxwell Slepian, Joel Katz, Hance Clarke
Summary: Patients who received Transitional Pain Service showed a faster reduction in opioid use compared to the control group. The difficulty in finding an appropriate control group highlights the need for future randomized controlled trials to determine efficacy.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Anesthesiology
Nafisseh S. Warner, Michelle Mielke, Brandon P. Verdoorn, David S. Knopman, William M. Hooten, Elizabeth B. Habermann, David O. Warner
Summary: This manuscript summarizes the evidence and critical knowledge gaps regarding the relationships between pain, opioid analgesics, and cognition in older adults. It provides a conceptual framework to guide future research in optimizing analgesic outcomes in older adults while minimizing deleterious effects on cognition.
Article
Radiology, Nuclear Medicine & Medical Imaging
Atanas Pachev, Lucas Rauyaud, Luisa Paulatto, Marco Dioguardi Burgio, Vincent Roche, Carmela Garcia Alba, Annie Sibert, Matthieu Lagadec, Juliette Kavafyan-Lasserre, Catherine Paugam-Burtz, Valerie Vilgrain, Maxime Ronot
Summary: Severe abdominal pain was frequent during and after TACE for hepatocellular carcinoma. Young patients without alcoholic liver disease or cirrhosis may benefit from reinforced analgesia.
EUROPEAN RADIOLOGY
(2021)
Article
Anesthesiology
Dario Bugada, Christian Compagnone, Silvia Bettinelli, Stefania Grimaldi, Manuela De Gregori, Carolina Muscoli, Roberto Berretta, Lorenzo Cobianchi, Andrea Peloso, Luca Lorini, Patricia Lavand'homme, Massimo Allegri
Summary: This study investigated the effect of prolonged continuous wound infusion (CWI) on postoperative pain management. The results showed that prolonged CWI with ropivacaine 0.2% and methylprednisolone 1 mg/kg did not reduce opioid consumption in the first seven days after surgery, but it did reduce the use of non-opioid analgesics. The prevalence of chronic post-surgical pain (PPSP) was not different between the CWI group and the placebo group.
MINERVA ANESTESIOLOGICA
(2023)
Review
Anesthesiology
Kevin Gorsky, Nick D. Black, Ayan Niazi, Aparna Saripella, Marina Englesakis, Timothy Leroux, Frances Chung, Ahtsham U. Niazi
Summary: Psychological interventions, including relaxation, psychoeducation, and behavioral modification therapy, have shown promise in reducing postoperative opioid use and pain scores. However, further research is needed to strengthen the evidence for these interventions and determine optimal techniques, timing, and strategies.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2021)
Article
Oncology
Hailey W. Bulls, Lindsay F. Bell, Steven R. Orris, Burel R. Goodin, Jane M. Liebschutz, Antoinette Wozniak, Jessica S. Merlin, Yael Schenker
Summary: The study found that most states recognize the importance of prescription opioids in cancer-related pain management while providing exemptions for cancer patients. However, specific guidance for cancer-related pain prescribing is lacking. Drafting nuanced opioid legislation for a diverse population poses challenges and may unintentionally undermine patient-centered approaches to pain management.
Article
Anesthesiology
Tomoya Kuramochi, Makoto Sano, Ichie Kajiwara, Yukino Oshima, Tomoaki Itaya, Jinsuk Kim, Yoshimi Ichimaru, Osamu Kitajima, Atsushi Masamune, Hideaki Ijichi, Takahiro Suzuki
Summary: This study investigates the effects of tramadol on pancreatic ductal adenocarcinoma and finds that tramadol inhibits proliferation and invasion, increases anti-tumor macrophages, and decreases inflammatory cytokines, suggesting its potential use for pain management in cancer patients.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Review
Anesthesiology
Daniel B. Larach, Jennifer F. Waljee, Mark C. Bicket, Chad M. Brummett, Stephen Bruehl
Summary: This article reviews the connection between perioperative opioid prescribing and postoperative OUD and overdose, and summarizes the existing evidence. The identified risk factors are mainly related to opioid use and demographic attributes.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Anesthesiology
Brooke A. Bell, Ruth Ruscheweyh, Bernard Joseph Kelley, Timothy J. Ness, Thomas R. Vetter, Alethia Baldwin Sellers
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2018)
Article
Anesthesiology
Lubana K. Afreen, Ayesha S. Bryant, Tetsuzo Nakayama, Timothy J. Ness, Keith A. Jones, Charity J. Morgan, Charles M. Wilcox, Mark C. Phillips
ANESTHESIA AND ANALGESIA
(2018)
Article
Neurosciences
Buffie J. Clodfelder-Miller, Hirosato Kanda, Jianguo G. Gu, Judy R. Creighton, Timothy J. Ness, Jennifer J. DeBerry
Article
Neurosciences
Timothy J. Ness, Cary DeWitte, Jennifer J. DeBerry, Alan Randich
Article
Neurosciences
Timothy J. Ness, Cary DeWitte, Jamie McNaught, Buffie Clodfelder-Miller, Xin Su
NEUROSCIENCE LETTERS
(2018)
Article
Anesthesiology
Timothy J. Ness, Jamie McNaught, Buffie Clodfelder-Miller, Dwight E. Nelson, Xin Su
ANESTHESIA AND ANALGESIA
(2020)
Article
Anesthesiology
Timothy John Ness, Jamie McNaught, Buffie Clodfelder-Miller, Dwight E. Nelson, Xin Su
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2019)
Article
Gastroenterology & Hepatology
Anthony C. Johnson, Adam D. Farmer, Timothy J. Ness, Beverley Greenwood-Van Meerveld
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Urology & Nephrology
Timothy J. Ness, Jamie McNaught, Buffie Clodfelder-Miller, Xin Su
NEUROUROLOGY AND URODYNAMICS
(2020)
Article
Neurosciences
Timothy J. Ness, Cary DeWitte, Alan Randich
Summary: This study investigated the role of CRFR2 in bladder hyperalgesia secondary to neonatal bladder inflammation and acute bladder re-inflammation as an adult, suggesting the therapeutic value of CRFR2 antagonists in the treatment of painful bladder disorders.
Article
Multidisciplinary Sciences
Buffie Clodfelder-Miller, Jennifer J. DeBerry, Timothy J. Ness
Summary: This neuroanatomical study quantified the number of bladder primary afferent neurons (bPANs) in female rats and found that Urothelial bPANs were more common at the L6/S1 levels and more likely to be identified as peptidergic compared to bPANs at T13/L1 levels and Non-Urothelial bPANs. These findings provide additional evidence of distinct neuronal populations responsible for bladder sensation, with differing localization, peptide content, and projections to the central nervous system.
Article
Physiology
Xiangrong Cui, Xuan Jing, Susan K. Lutgendorf, Catherine S. Bradley, Andrew Schrepf, Bradley A. Erickson, Vincent A. Magnotta, Timothy J. Ness, Karl J. Kreder, Michael A. O'Donnell, Yi Luo
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Letter
Anesthesiology
Mark C. Phillips, Timothy J. Ness, Ayesha S. Bryant
ANESTHESIA AND ANALGESIA
(2019)
Article
Neurosciences
Alan Randich, Cary DeWitte, Jennifer J. DeBerry, Meredith T. Robbins, Timothy J. Ness
Article
Anesthesiology
Michael A. Frolich, Catiffaney Banks, Timothy J. Ness
ANESTHESIA AND ANALGESIA
(2017)