Article
Biochemistry & Molecular Biology
Colin F. Davenport, Tobias Scheithauer, Alessia Dunst, Frauke Sophie Bahr, Marie Dorda, Lutz Wiehlmann, Doan Duy Hai Tran
Summary: Downregulation of multiple tumor suppressor genes is crucial in cancer formation, with epigenetic modifications playing a significant role. Using nanopore sequencing technology, the study identified potential TSGs in HCC and demonstrated the tumor suppressor function of GCK in inhibiting HCC cell proliferation through lactate accumulation-induced energy crisis. These findings offer valuable insights for further understanding tumorigenesis in human cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Prince Verma, Court K. M. Waterbury, Elizabeth M. Duncan
Summary: By analyzing the H3K4me3 signal on the planarian genome, it was found that Set1 plays a key role in creating this mark, with its depletion leading to abnormal stem cell phenotypes suggesting dysfunction of TSGs.
Article
Oncology
Dmitry Chernyakov, Alexander Gross, Annika Fischer, Nicola Bornkessel, Christoph Schultheiss, Dennis Gerloff, Bayram Edemir
Summary: This study reveals that NFAT5 directly regulates the expression of Ranbp3l by binding its promoter, leading to tumor-like phenotype and altered cell behavior and gene expression in RANBP3L-deficient cells. Loss of RANBP3L may promote the development and progression of renal cell carcinoma.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Jinpeng Wang, Wei Zhang, Wenbin Hou, Enyang Zhao, Xuedong Li
Summary: DNA methylation plays a crucial role in the development of renal cell carcinoma (RCC). This study establishes molecular clusters and a prognostic model based on DNA methylation-driven genes, providing insights and tools for predicting and managing the prognosis of RCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Liping Tang, Shasha Zhu, Weiyan Peng, Xuedong Yin, Cui Tan, Yaying Yang
Summary: The protein expression of MAPK10 is significantly downregulated in HCC patients compared to normal tissues, and its negative expression is correlated with advanced tumor stage, more microsatellite nodules, higher serum AFP, and shorter overall survival time in HCC patients. MAPK10 is frequently methylated in HCC, and its methylation is associated with silenced or downregulated expression.
Article
Immunology
Ahreum Kim, Sun Min Lim, Joo-Hang Kim, Jeong-Sun Seo
Summary: This study found that mutations in tumor suppressor genes can affect the tumor immune microenvironment, particularly in lung squamous cell carcinoma, where these gene mutations can suppress infiltrating immune and stromal cells, leading to a decrease in immune gene expression. Patients with non-mutated tumor suppressor genes are more likely to have inflamed tumors and respond positively to immune checkpoint blockade therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hanyu Rao, Xiaoxue Li, Min Liu, Jing Liu, Wenxin Feng, Huayuan Tang, Jin Xu, Wei-Qiang Gao, Li Li
Summary: This study reveals that SETD2 inhibits beta-catenin activity during the transition from polycystic kidney disease (PKD) to renal cell carcinoma (RCC) by competing with beta-catenin for binding promoters of target genes, ultimately enhancing Wnt/beta-catenin signaling and promoting epithelial-to-mesenchymal transition and tumorigenesis.
Article
Genetics & Heredity
Brian M. Ortmann, Natalie Burrows, Ian T. Lobb, Esther Arnaiz, Niek Wit, Peter S. J. Bailey, Louise H. Jordon, Olivia Lombardi, Ana Penalver, James McCaffrey, Rachel Seear, David R. Mole, Peter J. Ratcliffe, Patrick H. Maxwell, James A. Nathan
Summary: The histone H3K4 methyltransferase SET1B plays a crucial role in the transcriptional activity of HIF target genes, and its loss results in impaired cell growth and tumor formation. Experimental findings demonstrate that SET1B accumulates on chromatin in hypoxia and is recruited to HIF target genes by the HIF complex.
Article
Environmental Sciences
Xingjie Zhang, Lin Ma, Yue Tang, Jiangyuan Han, Yongmei Qi, Dejun Huang
Summary: The study revealed that Cd-induced promoter hypermethylation of RASSF1A and DAPK1, decreasing their expression and leading to higher level of cell proliferation. Furthermore, Cd at low concentrations could influence DNA methylation, which may serve as the proliferative mechanism of Cd.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Jing-min Zheng, Mei-fu Gan, Hong-yuan Yu, Lu-xia Ye, Qing-xin Yu, Yu-hui Xia, Han-xi Zhou, Jia-qian Bao, Yi-qing Guo
Summary: KDF1 has been identified as a key regulator of epidermal proliferation and differentiation, but its involvement in malignancy remains unknown. This study explored the role of KDF1 in clear cell renal cell carcinoma (ccRCC) through analyzing its expression levels and functions. The results suggest that KDF1 may act as a tumor suppressor in ccRCC by inhibiting proliferation and invasion of cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Renbo Guo, Yiran Liang, Benkui Zou, Danyang Li, Zhen Wu, Fei Xie, Xu Zhang, Xiangzhi Li
Summary: MOF, a histone acetyltransferase, is downregulated in renal cell carcinoma (RCC), and its downregulation is associated with advanced histological grade, pathologic stage, and distant metastasis of RCC. Ectopic expression of MOF inhibits cell proliferation and promotes cell apoptosis, and suppresses cell migration through inhibiting epithelial-mesenchymal transition. Mechanistically, MOF transcriptionally upregulates the expression of SIRT1, leading to attenuated STAT3 signaling. Silencing SIRT1 restores the biological functions induced by MOF overexpression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xin Tong, Lu Xu, Rong Rong, Xianwei Su, Tingxiu Xiang, Weiyan Peng, Taoping Shi
Summary: ZBTB28 is frequently silenced by promoter methylation in RCC, and its overexpression can inhibit cell proliferation and migration, as well as induce apoptosis. It functions as a novel tumor suppressive gene and may be a potential target for RCC therapeutic strategies.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhangjie Wang, Na Shen, Ziao Wang, Lei Yu, Song Yang, Yang Wang, Yu Liu, Gaohua Han, Qi Zhang
Summary: This study reveals that TRIM3 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by promoting cell death and inhibiting tumorigenesis. TRIM3 directly interacts with SLC7A11/xCT, leading to its degradation and inhibition of NSCLC development. Low TRIM3 expression is associated with a worse prognosis in NSCLC.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Chih-Ming Ho, Ting-Lin Yen, Tsai -Yen Chien, Shih-Hung Huang
Summary: CpG-island methylation plays a role in ovarian cancer progression and is associated with survival outcomes. Differential promoter methylation of tumor suppressor genes (TSGs) was observed, with RASSF1A hypomethylation and increased aggressiveness in mesenchymal-like OCSPCs. Overexpression of CCND2 and CDKN2B reduced the aggressiveness of mesenchymal-like OCSPCs and may serve as potential therapeutic targets for EOC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Endocrinology & Metabolism
Andrew H. Nguyen, Michael P. O'Leary, James P. De Andrade, Philip H. G. Ituarte, Jonathan Kessler, Daneng Li, Gagandeep Singh, Sue Chang
Summary: Renal neuroendocrine neoplasms are rare and their natural history is poorly understood. The study found that patients with earlier stage and favorable histologies had increased survival rates.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Hui Min Lee, Alice Pei Eal Sia, Lili Li, Hans Prakash Sathasivam, Melissa Sue Ann Chan, Pathmanathan Rajadurai, Chi Man Tsang, Sai Wah Tsao, Paul G. Murray, Qian Tao, Ian C. Paterson, Lee Fah Yap
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao, Tingxiu Xiang
CLINICAL EPIGENETICS
(2020)
Review
Oncology
Kenneth C. W. Wong, Edwin P. Hui, Kwok-Wai Lo, Wai Kei Jacky Lam, David Johnson, Lili Li, Qian Tao, Kwan Chee Allen Chan, Ka-Fai To, Ann D. King, Brigette B. Y. Ma, Anthony T. C. Chan
Summary: Over the past three decades, significant progress has been made in understanding the molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated cancer. Technological advances have led to the introduction of proton therapy and other contemporary radiotherapy approaches, with continued efforts to determine the optimal sequencing of chemotherapy with radiotherapy through decades of clinical trials.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Tang, Weiyan Peng, Yixiao Feng, Xin Le, Kang Wang, Qin Xiang, Lili Li, Yan Wang, Can Xu, Junhao Mu, Ke Xu, Ping Ji, Qian Tao, Ailong Huang, Chu-Xia Deng, Yong Lin, Tingxiu Xiang
Summary: This study discusses the importance of inactivation of tumor-suppressor genes in oncogenesis, as well as the role of a novel epigenetic regulatory mechanism in p53 inactivation.
Article
Biochemistry & Molecular Biology
Ke Ying, Chan Wang, Shuiping Liu, Yeye Kuang, Qian Tao, Xiaotong Hu
Summary: This study identified the crucial roles of DIRAS2 in colorectal cancer, suggesting its potential as a tumor-suppressor gene and revealing a distinct mechanism in CRC tumorigenesis. Downregulation of DIRAS2 expression is associated with poor prognosis in CRC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Correction
Medicine, Research & Experimental
Lili Li, Juan Xu, Guohua Qiu, Jianming Ying, Zhenfang Du, Tingxiu Xiang, Kai Yau Wong, Gopesh Srivastava, Xiao-Feng Zhu, Tony S. Mok, Anthony T. C. Chan, Francis K. L. Chan, Richard F. Ambinder, Qian Tao
Article
Multidisciplinary Sciences
Ying Ying, Maolin Wang, Yongheng Chen, Meiqi Li, Canjie Ma, Junbao Zhang, Xiaoyan Huang, Min Jia, Junhui Zeng, Yejun Wang, Lili Li, Xiaomei Wang, Qian Tao, Xing-Sheng Shu
Summary: This study unveiled the role of zinc finger protein 280C (ZNF280C) in colorectal cancer (CRC) and its significance in colitis-associated carcinogenesis and intestinal tumorigenesis. Silencing ZNF280C in human CRC cells inhibited cell proliferation and migration, and predicted worse prognosis in patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yeye Kuang, Zhanglian He, Lili Li, Chan Wang, Xiaoqing Cheng, Qinglan Shi, Guoxiang Fu, Jianming Ying, Qian Tao, Xiaotong Hu
Summary: This study reveals that HAND1 is frequently downregulated in gastric cancer due to promoter methylation, and its low expression is correlated with tumor progression and poor prognosis. High expression of HAND1 is associated with higher 5-year overall survival rates in gastric cancer patients. HAND1 inhibits gastric cancer cell growth and migration through induction of endoplasmic reticulum (ER) stress and apoptosis. The methylation status of HAND1 promoter could be a potential biomarker for gastric cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Virology
Joanna W. Y. Ho, Lili Li, Kai Yau Wong, Gopesh Srivastava, Qian Tao
Summary: The expression pattern of EBV genes in PTCL was mainly latency II, but occasionally fully lytic infection could also be detected. These findings have implications for the future development of EBV-targeting therapeutics for this cancer.
Article
Biochemistry & Molecular Biology
Lili Li, Xing-sheng Shu, Hua Geng, Jianming Ying, Lei Guo, Jie Luo, Tingxiu Xiang, Longtao Wu, Brigette B. Y. Ma, Anthony T. C. Chan, Xiaofeng Zhu, Richard F. Ambinder, Qian Tao
Summary: Peptides/small proteins encoded by noncanonical open reading frames (ORF) of previously claimed non-coding RNAs have important biological functions but are largely uncharacterized. In this study, we identified and validated a small protein SP0495 as a novel tumor suppressor, frequently inactivated by promoter methylation in multiple tumors. SP0495 functions as a phosphoinositide-binding protein, regulating AKT signaling activation and autophagy. It inhibits tumor cell growth and induces apoptosis, cell cycle arrest, senescence, and autophagy through multiple mechanisms, including the modulation of phosphoinositides turnover and autophagic/proteasomal degradation of autophagy regulators. SP0495 has the potential to be a biomarker for cancer diagnosis and prognosis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Lok Seng Chan, Johnson Liu, Molly S. C. Li, Lili Li, Qian Tao, Tony S. K. Mok
Summary: Selenite is found to induce both apoptosis and ferroptosis in lung cancer cells, especially those with EGFR and KRAS mutations. It activates the p38-ATF4-DDIT3 pathway for ferroptosis induction and influences DNA methylation machinery. Combining selenite with osimertinib or adagrasib enhances the therapeutic effect.
CLINICAL EPIGENETICS
(2023)
Meeting Abstract
Oncology
Yingjun Zhang, Connie Hui, Chi Hang Wong, Chi Tung Choy, Teresa Tse, Teresa Tan, Sampson Kwan, Qian Tao, Herbert Loong
Meeting Abstract
Oncology
Junyu Zhu, Lili Li, Connie W. Hui, Joanna H. Tong, Raymond Chan, Chi Hang Wong, Qiyong Ai, Edwin P. Hui, Anthony T. Chan, Kwok Wai Lo, Qian Tao, Brigette B. Ma
Article
Oncology
Junyu Zhu, Lili Li, Joanna Tong, Connie Hui, Chi Hang Wong, Kwok Wai Lo, Raymond Chan, Qi Yong Ai, Edwin P. Hui, Anthony T. C. Chan, Ka F. To, Qian Tao, Brigette B. Y. Ma
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)
Article
Medicine, Research & Experimental
Xin Le, Junhao Mu, Weiyan Peng, Jun Tang, Qin Xiang, Shaorong Tian, Yixiao Feng, Sanxiu He, Zhu Qiu, Guosheng Ren, Ailong Huang, Yong Lin, Qian Tao, Tingxiu Xiang
