Article
Health Care Sciences & Services
Erik Wiberg, Andres Vega, Victoria Eriksson, Viqar Banday, Johan Svensson, Elisabeth Eriksson, Staffan Jahnson, Amir Sherif
Summary: This study aimed to validate the registered clinical tumour categories (cT-categories) in the Swedish National Register for Urinary Bladder Cancer (SNRUBC) for Norrland University Hospital, Sweden, from 2009 to 2020. The study found significant incorrect registration of cT-categories, with a major part of the misclassifications related to tumour-associated hydronephrosis (TAH) and tumour in bladder diverticulum (TIBD). The inclusion of these variables in SNRUBC is recommended to improve correct cT-classification.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cui Feng, Yanchun Wang, Guangyu Dan, Zheng Zhong, M. Muge Karaman, Zhen Li, Daoyu Hu, Xiaohong Joe Zhou
Summary: The combination of high b-value DWI with a FROC model is effective in distinguishing between NMIBC and MIBC, as well as in grading bladder tumors.
EUROPEAN RADIOLOGY
(2022)
Article
Urology & Nephrology
Kelly K. Bree, Andrea Kokorovic, Mary E. Westerman, Patrick J. Hensley, Nathan A. Brooks, Wei Qiao, Yu Shen, Ashish M. Kamat, Colin P. Dinney, Neema Navai
Summary: This study evaluated the impact of repeat transurethral resection of bladder tumor prior to radical cystectomy on oncologic outcomes. The results showed that repeat transurethral resection of bladder tumor was not associated with improved survival outcomes, but patients without residual tumor had better survival outcomes.
JOURNAL OF UROLOGY
(2023)
Review
Medicine, General & Internal
Pau Sarrio-Sanz, Laura Martinez-Cayuelas, Blanca Lumberas, Laura Sanchez-Caballero, Antonio Palazon-Bru, Vicente F. Gil-Guillen, Luis Gomez-Perez
Summary: This study aimed to identify risk-predictive models for bladder-specific cancer mortality in patients undergoing radical cystectomy and assess their clinical utility and risk of bias. The findings showed that clinical predictors can be used to assess the risk of bladder-specific cancer mortality, but the studies had a high risk of bias and their applicability is uncertain.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Przemyslaw Adamczyk, Pawel Poblocki, Mateusz Kadlubowski, Adam Ostrowski, Andrzej Wrobel, Witold Mikolajczak, Jan Adamowicz, Tomasz Drewa, Kajetan Juszczak
Summary: This study found that clinical staging of bladder cancer is often inaccurate, with a significant number of patients being under- or over-staged. The authors recommend a multimodal approach combining histopathological evaluation with imaging studies to improve the accuracy of staging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Liang-Liang Hu, Zhong-Qiang Guo, Peng Dai, Gang Chen, Tao Tian
Summary: Pheochromocytomas are rare neuroendocrine tumors that produce catecholamines. Bladder involvement is uncommon, and common symptoms include hypertension, headache, hematuria, and syncope. While transurethral resection may be performed in some patients, most require partial or radical cystectomy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Urology & Nephrology
Francesco Soria, Peter C. Black, Adrian S. Fairey, Michael S. Cookson, Evan Y. Yu, Wassim Kassouf, Marc A. Dall'Era, Srikala S. Sridhar, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Siamak Daneshmand, Jeff M. Holzbeierlein, Trinity J. Bivalacqua, Scott North, Daniel A. Barocas, Yair Lotan, Petros Grivas, Andrew J. Stephenson, Jay B. Shah, Bas W. van Rhijn, Philippe E. Spiess, Shahrokh F. Shariat, Paolo Gontero
Summary: In patients with cT2N0 bladder cancer and no preoperative hydronephrosis, neoadjuvant chemotherapy (NAC) increased the rate of pathological complete response and downstaging, showing a positive impact on overall survival.
Article
Oncology
Huapyong Kang, Seung-seob Kim, Min Je Sung, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Mi-Suk Park, Seungmin Bang
Summary: The suitability of the 8th edition AJCC staging system for clinical staging of pancreatic cancer remains uncertain. This study validated the prognostic performance and suitability of the current staging system and found that it is not validated for clinical staging. Separate criteria more suitable for clinical staging should be considered.
Article
Oncology
Alexander B. J. Borgstein, Kammy Keywani, Wietse J. Eshuis, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz
Summary: This study determined the value of staging laparoscopy in patients with advanced gastric cancer in a Western population, showing high accuracy in detecting non-curable disease and avoiding futile treatment.
Article
Urology & Nephrology
Toshiaki Tanaka, Tetsuya Shindo, Kohei Hashimoto, Ko Kobayashi, Naoya Masumori
Summary: The objective of this study was to clarify the incidence of postoperative hydronephrosis and assess the effectiveness of diagnostic and therapeutic approaches for hydronephrosis after cystectomy and urinary diversion. The results showed that postoperative hydronephrosis may be associated with recurrent disease and accurate differential diagnosis is challenging. Open surgical revision is highly effective in treating benign strictures.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucia Manganaro, Yulia Lakhman, Nishat Bharwani, Benedetta Gui, Silvia Gigli, Valeria Vinci, Stefania Rizzo, Aki Kido, Teresa Margarida Cunha, Evis Sala, Andrea Rockall, Rosemarie Forstner, Stephanie Nougaret
Summary: The ESUR female pelvic imaging working group updated their recommendations in 2019 based on >= 80% consensus among experts, highlighting the main role of MRI in initial staging, response monitoring, and evaluation of disease recurrence, while emphasizing the importance of whole-body FDG-PET in detecting lymph nodes and distant metastases.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Alexander B. J. Borgstein, Mark I. van Berge Henegouwen, Wytze Lameris, Wietse J. Eshuis, Suzanne S. Gisbertz
Summary: This study found that staging laparoscopy in gastric cancer patients does not completely avoid surgery, indicating a low sensitivity for detecting metastases or locoregional non-resectability.
Article
Urology & Nephrology
Ahmed S. Elsayed, Sean Gibson, Zhe Jing, Carl Wijburg, Andrew A. Wagner, Alexandre Mottrie, Prokar Dasgupta, James Peabody, Ahmed A. Hussein, Khurshid A. Guru
Summary: This study reported and analyzed disease relapse following robot-assisted radical cystectomy using a multinational database, finding a 25% relapse rate among patients and various patterns of relapse. The multivariate regression models identified that node positive status and higher disease stage (pT3 or greater) were significantly associated with relapse and survival rates.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Kuo-Wei Kao, Weiming Cheng, Yi-Chin Chang
Summary: Bladder chondroma is a rare benign tumor that mainly affects older patients. It manifests as urinary symptoms and abdominal pain, and transurethral resection is the preferred treatment.
Article
Surgery
Nadia Russolillo, Alessandro Borello, Serena Langella, Michele Casella, Roberto Lo Tesoriere, Alessandro Ferrero
Summary: The study showed that preoperative MRI in CRLMs patients undergoing LLR can predict liver metastases, while LUS can additionally detect new nodules, helping adjust surgical strategy and improve accuracy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Cell Biology
Andrew J. Spieker, Jennifer B. Gordetsky, Alexander S. Maris, Lauren M. Dehan, James E. Denney, Shanna A. Arnold Egloff, Kristen Scarpato, Daniel A. Barocas, Giovanna A. Giannico
Summary: This study investigated the association between PTEN expression and morphological patterns in prostate cancer, revealing that PTEN loss within glomeruloid morphology was associated with biochemical recurrence. Despite PTEN loss not being significantly associated with invasive cribriform carcinoma, the presence of any cribriform pattern was linked to biochemical recurrence.
Editorial Material
Urology & Nephrology
Lauren Folgosa Cooley, Adaeze A. Emeka, Travis J. Meyers
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
David D'Andrea, Peter C. Black, Homayoun Zargar, Colin P. Dinney, Francesco Soria, Michael S. Cookson, Jeffrey S. Montgomery, Wassim Kassouf, Marc A. Dall'Era, Srikala S. Sridhar, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Jeff M. Holzbeierlein, Diego M. Carrion, Ettore Di Trapani, Trinity J. Bivalacqua, Scott North, Daniel A. Barocas, Yair Lotan, Petros Grivas, Andrew J. Stephenson, Bas W. van Rhijn, Siamak Daneshmand, Philippe E. Spiess, Shahrokh F. Shariat, Kamran Zargar-Shoshtar, Laura S. Mertens, Adrian S. Fairey, Maria C. Mir, Laura-Maria Krabbe, Niels-Erik Jacobsen, Nikhil Vasdev, Evan Y. Yu, Evanguelos Xylinas, Benjamin Pradere, Renate Pichler, Nicholas J. Campain, Jo-An Seah, Cesar E. Ercole, Simon Horenblas, Jonathan Aning, Todd M. Morgan, Jay B. Shah, Marco Moschini
Summary: This study investigated the pathological response rates and survival outcomes of patients with cT2-4N0M0 muscle invasive bladder cancer who received 3 vs 4 cycles of cisplatin-based neoadjuvant chemotherapy (NAC). The results showed that patients treated with 4 cycles of NAC achieved better pathological response and overall survival compared to those treated with 3 cycles. These findings provide valuable information for clinicians and serve as a benchmark for prospective trials.
JOURNAL OF UROLOGY
(2022)
Article
Oncology
Daniel D. Joyce, Christopher J. D. Wallis, Amy N. Luckenbaugh, Heather L. Huelster, Zhiguo Zhao, Karen E. Hoffman, Li-Ching Huang, Tatsuki Koyama, Ralph Conwill, Michael Goodman, Ann S. Hamilton, Xiao-Cheng Wu, Lisa E. Paddock, Antoinette Stroup, Matthew R. Cooperberg, Mia Hashibe, Brock B. O'Neil, Sherrie H. Kaplan, Sheldon Greenfield, David F. Penson, Daniel A. Barocas
Summary: The addition of androgen deprivation therapy in combination with radiation treatment is associated with worse sexual function through 3 years in men with high-risk prostate cancer compared to radiation alone. However, adding androgen deprivation therapy in the treatment of intermediate-risk disease does not lead to worse sexual function at 3 or 5-year follow-up compared to radiation alone.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Christopher J. D. Wallis, Li-Ching Huang, Zhiguo Zhao, David F. Penson, Tatsuki Koyama, Ralph Conwill, Jacob E. Tallman, Michael Goodman, Ann S. Hamilton, Xiao-Cheng Wu, Lisa E. Paddock, Antoinette Stroup, Matthew R. Cooperberg, Mia Hashibe, Brock B. O'Neil, Sherrie H. Kaplan, Sheldon Greenfield, Daniel A. Barocas, Karen E. Hoffman
Summary: This population-based cohort study compared the functional outcomes of men receiving prostate and pelvic radiotherapy versus prostate-only radiotherapy over a 5-year period. The results showed that men receiving prostate and pelvic radiotherapy reported worse sexual, hormonal, and physical function compared to those receiving prostate-only radiotherapy. However, there were no statistically or clinically significant differences in bowel function, urinary incontinence, irritative voiding symptoms, or sexual function between the two groups.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Urology & Nephrology
David D'Andrea, Peter C. Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Francesco Soria, Adrian S. Fairey, Laura S. Mertens, Colin P. Dinney, Maria C. Mir, Laura-Maria Krabbe, Michael S. Cookson, Niels-Erik Jacobsen, Jeffrey S. Montgomery, Nikhil Vasdev, Evan Y. Yu, Evanguelos Xylinas, Nicholas J. Campain, Wassim Kassouf, Marc A. Dall'Era, Jo-An Seah, Cesar E. Ercole, Simon Horenblas, Srikala S. Sridhar, John S. McGrath, Jonathan Aning, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Jeff M. Holzbeierlein, Trinity J. Bivalacqua, Scott North, Daniel A. Barocas, Yair Lotan, Petros Grivas, Andrew J. Stephenson, Jay B. Shah, Bas W. van Rhijn, Siamak Daneshmand, Philippe E. Spiess, Shahrokh F. Shariat
Summary: The study evaluated the association of patient age with response to preoperative chemotherapy in MIBC patients. Younger patients showed slightly lower DDR gene mutations but no significant difference in treatment response or survival outcomes based on age. The findings suggest that preoperative chemotherapy should be considered regardless of patient age.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Amy N. Luckenbaugh, Christopher J. D. Wallis, Li-Ching Huang, Daniela Wittmann, Zachary Klaassen, Zighuo Zhao, Tatsuki Koyama, Aaron A. Laviana, Ralph Conwill, Michael Goodman, Ann S. Hamilton, Xiao-Cheng Wu, Lisa E. Paddock, Antoinette Stroup, Matthew R. Cooperberg, Mia Hashibe, Brock B. O'Neil, Sherrie H. Kaplan, Sheldon Greenfield, Karen E. Hoffman, David F. Penson, Daniel A. Barocas
Summary: The study aimed to compare the patient-reported mental health outcomes for men undergoing treatment for localized prostate cancer over a 5-year period. The results showed that there were no clinically significant differences in mental health outcomes, including depressive symptoms, emotional well-being, and energy/fatigue, based on the treatment received (surgery, radiotherapy, or surveillance). However, certain factors like older age, poorer health, being unmarried, and baseline depressive symptoms were associated with worse mental health outcomes.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Wilson Sui, Mary E. Hall, Daniel A. Barocas, Sam S. Chang, Amy N. Luckenbaugh, Kelvin A. Moses, David F. Penson, Christopher J. D. Wallis, Aaron A. Laviana
Summary: The study reveals that the management of bladder cancer variant histology at high-volume centers is associated with improved overall survival. Hospital volume and/or surgeon volume are related to the management of rare or complex diseases, and can affect treatment patterns.
Article
Oncology
Christopher J. D. Wallis, Zhiguo Zhao, Li-Ching Huang, David F. Penson, Tatsuki Koyama, Sherrie H. Kaplan, Sheldon Greenfield, Amy N. Luckenbaugh, Zachary Klaassen, Ralph Conwill, Michael Goodman, Ann S. Hamilton, Xiao-Cheng Wu, Lisa E. Paddock, Antoinette Stroup, Matthew R. Cooperberg, Mia Hashibe, Brock B. O'Neil, Karen E. Hoffman, Daniel A. Barocas
Summary: Treatment-related regret is a common experience for localized prostate cancer patients, with rates differing depending on treatment approach, functional outcomes, and patient expectations. Patient-perceived treatment efficacy and adverse effects, along with functional outcomes like sexual dysfunction, were significant factors associated with regret. Shared decision-making tools, social support, and age also played a role in predicting treatment-related regret.
Article
Medicine, General & Internal
Vivek Venkatramani, Isildinha M. Reis, Mark L. Gonzalgo, Erik P. Castle, Michael E. Woods, Robert S. Svatek, Alon Z. Weizer, Badrinath R. Konety, Mathew Tollefson, Tracey L. Krupski, Norm D. Smith, Ahmad Shabsigh, Daniel A. Barocas, Marcus L. Quek, Atreya Dash, Dipen J. Parekh
Summary: This study aimed to determine the recovery of functional independence after radical cystectomy and compare the differences between robot-assisted radical cystectomy (RARC) and open procedures. The results showed that patients require 3 to 6 months to recover baseline levels, regardless of the surgical approach. Hand grip strength and activities of daily living tend to recover earlier after RARC, but there was no difference in the percentage of patients recovering compared to open procedures. These findings are important for patient counseling and preparation.
Correction
Urology & Nephrology
Maria Carmen Mir, Michele Marchionic, Homi Zargard, K. Zargar-Shoshtari, A. S. Fairey, Laura S. Mertens, C. P. Dinney, L. M. Krabbei, M. S. Cookson, N. E. Jacobsen, J. Griffin, J. S. Montgomery, N. Vasdev, E. Y. Yu, E. Xylinas, J. S. McGrathr, W. Kassoufs, M. A. Dall'Era, S. S. Sridhar, J. Aningn, S. F. Shariat, J. L. Wright, A. C. Thorpe, T. M. Morganm, J. M. Holzbeierlein, T. J. Bivalacquax, S. North, D. A. Barocas, Y. Lotan, P. Grivaso, A. J. Stephenson, J. B. Shah, B. W. van Rhijng, P. E. Spiess, S. Daneshmand, P. C. Blackd
EUROPEAN UROLOGY FOCUS
(2022)
Article
Oncology
Jacob E. Tallman, Christopher J. D. Wallis, Li-Ching Huang, Zhiguo Zhao, David F. Penson, Tatsuki Koyama, Ralph Conwill, Michael Goodman, Ann S. Hamilton, Xiao-Cheng Wu, Lisa E. Paddock, Antoinette Stroup, Matthew R. Cooperberg, Mia Hashibe, Brock B. O'Neil, Sherrie H. Kaplan, Sheldon Greenfield, Daniel A. Barocas, Karen E. Hoffman
Summary: Compliance with nationally recognized radiation therapy quality measures was not significantly associated with patient-reported health-related quality of life outcomes after prostate cancer treatment.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Brian D. Cortese, Stacie B. Dusetzina, Amy N. Luckenbaugh, Bashir Al Hussein Al Awamlh, C. J. Stimson, Daniel A. Barocas, David F. Penson, Sam S. Chang, Ruchika Talwar
Summary: This study estimated the potential savings of using Mark Cuban Cost Plus Drug Company (MCCPDC) prices for seven generic oncology drugs in Medicare Part D plans. The findings suggest significant cost savings could be achieved by replacing current Part D formulary prices with MCCPDC pricing.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Yu Jiang, Travis J. Meyers, Adaeze A. Emeka, Lauren Folgosa Cooley, Phillip R. Cooper, Nicola Lancki, Irene Helenowski, Linda Kachuri, Daniel W. Lin, Janet L. Stanford, Lisa F. Newcomb, Suzanne Kolb, Antonio Finelli, Neil E. Fleshner, Maria Komisarenko, James A. Eastham, Behfar Ehdaie, Nicole Benfante, Christopher J. Logothetis, Justin R. Gregg, Cherie A. Perez, Sergio Garza, Jeri Kim, Leonard S. Marks, Merdie Delfin, Danielle Barsa, Danny Vesprini, Laurence H. Klotz, Andrew Loblaw, Alexandre Mamedov, S. Larry Goldenberg, Celestia S. Higano, Maria Spillane, Eugenia Wu, H. Ballentine Carter, Christian P. Pavlovich, Mufaddal Mamawala, Tricia Landis, Peter R. Carroll, June M. Chan, Matthew R. Cooperberg, Janet E. Cowan, Todd M. Morgan, Javed Siddiqui, Rabia Martin, Eric A. Klein, Karen Brittain, Paige Gotwald, Daniel A. Barocas, Jeremiah R. Dallmer, Jennifer B. Gordetsky, Pam Steele, Shilajit D. Kundu, Jazmine Stockdale, Monique J. Roobol, Lionne D. F. Venderbos, Martin G. Sanda, Rebecca Arnold, Dattatraya Patil, Christopher P. Evans, Marc A. Dall'Era, Anjali Vij, Anthony J. Costello, Ken Chow, Niall M. Corcoran, Soroush Rais-Bahrami, Courtney Phares, Douglas S. Scherr, Thomas Flynn, R. Jeffrey Karnes, Michael Koch, Courtney Rose Dhondt, Joel B. Nelson, Dawn McBride, Michael S. Cookson, Kelly L. Stratton, Stephen Farriester, Erin Hemken, Walter M. Stadler, Tuula Pera, Deimante Banionyte, Fernando J. Bianco, Isabel H. Lopez, Stacy Loeb, Samir S. Taneja, Nataliya Byrne, Christopher L. Amling, Ann Martinez, Luc Boileau, Franklin D. Gaylis, Jacqueline Petkewicz, Nicholas Kirwen, Brian T. Helfand, Jianfeng Xu, Denise M. Scholtens, William J. Catalona, John S. Witte
Summary: Men diagnosed with low-risk prostate cancer who initially choose active surveillance may eventually convert to active treatment due to genetic factors that predispose to aggressive tumors. This study identified genetic variants associated with conversion from active surveillance to active treatment, suggesting that germline genetics may help individualize management decisions for low-risk prostate cancer.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)
Article
Oncology
Melih Balci, Zachary A. Glaser, Sam S. Chang, S. Duke Herrell, Daniel A. Barocas, Kirk A. Keegan, Kelvin A. Moses, Matthew J. Resnick, Joseph A. Smith, David F. Penson, Kristen Scarpato, Peter E. Clark
Summary: The study investigated the relationship between gender, BMI, and prognosis in renal cell carcinoma patients. Higher BMI was associated with better overall survival and recurrence-free survival, especially in male patients. Female patients did not show a significant relationship between BMI and oncologic outcomes.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)