期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 112, 期 4, 页码 1149-1154出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1417064112
关键词
colon cancer; African American; next-generation sequencing; mutation; Caucasian
资金
- Public Health Service [Case GI SPORE P50 CA150964, KO8 CA148980]
- Career Development Program of Case GI SPORE Awards [P50 CA150964, R21 CA149349, P30 CA043703]
We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.
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