Review
Medicine, General & Internal
Carli E. Calderone, Eric M. Turner, Omar E. Hayek, David Summerlin, Janelle T. West, Soroush Rais-Bahrami, Samuel J. Galgano
Summary: Tissue changes and enlargement of the prostate, both benign and malignant, are common diseases that have significant impacts on men's length and quality of life. Benign prostatic hyperplasia (BPH) is highly prevalent with age, affecting almost all older men. Prostate cancer, except for skin cancer, is the most common cancer among men in the US. Imaging plays a crucial role in diagnosing and managing these conditions, with various modalities available, including novel imaging techniques that have revolutionized prostate imaging. This review covers standard-of-care prostate imaging modalities, advancements in newer technologies, and emerging standards impacting prostate gland imaging.
Article
Biochemistry & Molecular Biology
Kai-Yen Tsai, Deng-Chyang Wu, Wen-Jeng Wu, Jiunn-Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Hsiang-Ying Lee
Summary: This study investigates the potential relationship between human microbiota and prostatic disease by analyzing stool and urine samples from patients. The results suggest that the microbiota composition in urine samples is different among different patient populations, indicating a potential link between microbiota and prostatic disease.
Article
Andrology
Rohit Reddy, Natoli Farber, Eliyahu Kresch, Deepa Seetharam, Parris Diaz, Ranjith Ramasamy
Summary: This paper investigates the presence of SARS-CoV-2 in prostate tissue and suggests that the virus can enter and persist in the prostate, even after the initial infection period. The findings provide a basis for future research on histopathological changes in prostate tissue associated with SARS-CoV-2 viral infection.
WORLD JOURNAL OF MENS HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Samara V. Silver, Petra Popovics, Giuseppe Cappellano
Summary: The prostate gland is crucial for reproductive physiology and sexual health in men, but it is susceptible to pathologies such as prostatitis, benign prostatic hyperplasia, and prostate cancer. Osteopontin (OPN), a versatile protein involved in wound healing and inflammatory responses, has been implicated in all three conditions. OPN is expressed at higher levels in prostate cancer, promoting tumor progression and aggressiveness, while in benign conditions, it provokes inflammation and fibrosis. This review discusses the role and cellular sources of OPN in prostate diseases, as well as potential future investigations.
Article
Urology & Nephrology
Nicholas L. Kavoussi, Naren Nimmagadda, Jennifer Robles, Connor Forbes, Alice Wang, Benjamin Stone, Nicole L. Miller
Summary: Holmium laser enucleation of the prostate using MOSES technology improves operative time and reduces blood loss compared to traditional holmium laser enucleation of the prostate, with similar functional outcomes and complications at follow-up.
JOURNAL OF UROLOGY
(2021)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Cell Biology
Xing-Jie Wang, Xiao-Qing Ni, Sheng Zhao, Rui-Zhe Zhao, Xiao-Hai Wang, Shu-Jie Xia, Xiao-Wen Sun, Jian Zhuo
Summary: The study focused on the role of ROS-NLRP3 signaling pathway in sterile inflammation (SI) after TmLRP, showing that HSP70-induced inflammation may be mediated through this pathway and could be reduced by NAC. Inhibition of NLRP3 or Caspase-1 could suppress the expression of IL-1 beta and IL-18.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Andrea Fuschi, Yazan Al Salhi, Gennaro Velotti, Lorenzo Capone, Alessia Martoccia, Paolo P. Suraci, Silvio Scalzo, Filippo Annino, Saba Khorrami, Anastasios Asimakopoulos, Giorgio Bozzini, Mario Falsaperla, Antonio Carbone, Antonio L. Pastore
Summary: This study compared the perioperative and functional outcomes of laparoscopic and robot-assisted simple prostatectomy with Holmium laser enucleation of the prostate in patients with prostate volumes >= 120mL. Despite significant improvements, there were no significant differences in functional and perioperative outcomes between the groups. The only statistically significant difference was longer catheterization time in the LSP group compared to RASP and HoLEP groups.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Oncology
Yung-Ting Cheng, Jian-Hua Hong, Yu-Chuan Lu, Yi-Kai Chang, Shih-Chun Hung, Kuo-Kang Feng, Shih-Ping Liu, Po-Ming Chow, Chung-Hsin Chen, Hong-Chiang Chang, Yeong-Shiau Pu
Summary: This study aimed to investigate the association between post-transurethral enucleation of the prostate nadir prostate-specific antigen level and prostate cancer. The findings suggest that a post-operative nadir prostate-specific antigen level of >= 1.7 ng/ml predicts significant residual cancer, while patients with low post-operative levels can be managed conservatively.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biology
Che-Hsueh Yang, Yen-Chuan Ou, Chi-Chien Lin, Yi-Sheng Lin, Min-Che Tung, Chia-Cheng Yu, Jen-Tai Lin, Chen-Yueh Wen
Summary: Phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, shows promising effects in treating BPH and PCa, based on animal and in-vitro studies. Further research is needed regarding its safety and effective dosages in human clinical trials.
Article
Green & Sustainable Science & Technology
R. Zhong, R. Chu, J. Zhu, J. Ling, L. Zhang, Y. Zhou, M. Yin, Z. Hao, C. Liang, S. Cao, T. Xu, S. Ye, S. Fan
Summary: Prostate diseases are common in males, and nanomedicine provides opportunities for the biomedical field by designing and manufacturing biomaterials. Gels have various applications in drug delivery, anti-inflammation, tissue regeneration, and wound healing. This review focuses on the current research on gels-based nanocomposites in the diagnostics and therapy of prostate diseases, pointing out their shortcomings and suggesting a broader prospect for future clinical application.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Oncology
Ritaparna Ahmed, Leyder Elena Lozano, Amandine Anastasio, Sebastien Lofek, Beatris Mastelic-Gavillet, Blanca Navarro Rodrigo, Sylvain Nguyen, Florence Dartiguenave, Sonia-Cristina Rodrigues-Dias, Valerie Cesson, Massimo Valerio, Beat Roth, Lana Elias Kandalaft, Irina Redchenko, Adrian Vivian Sinton Hill, Alexandre Harari, Pedro Romero, Laurent Derre, Selena Vigano
Summary: Lymphocytes expanded from BPH tissue samples can recognize tumor antigens and autologous tissue independently from the presence of tumor lesions. These findings support the connection between BPH and prostate cancer and may lead to personalized preventive vaccination strategies for patients with BPH.
Review
Biochemistry & Molecular Biology
Weronika Ratajczak, Michal Lubkowski, Anna Lubkowska
Summary: This review article discusses the role of heat shock proteins (HSPs) in prostate diseases and their potential as therapeutic targets. HSPs are overexpressed in benign prostatic hyperplasia (BPH) and prostate cancer (PCa), and play roles in maintaining cell homeostasis, protein folding and repair, as well as immune response and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kentaro Takezawa, Kazutoshi Fujita, Makoto Matsushita, Daisuke Motooka, Koji Hatano, Eri Banno, Nobutaka Shimizu, Tetsuya Takao, Shingo Takada, Koichi Okada, Shinichiro Fukuhara, Hiroshi Kiuchi, Hirotsugu Uemura, Shota Nakamura, Yoshiyuki Kojima, Norio Nonomura
Summary: This study found a higher proportion of Firmicutes and Actinobacteria in the gut microbiota of patients with prostate enlargement, while patients without enlargement had a higher proportion of Bacteroidetes. The Firmicutes/Bacteroidetes (F/B) ratio of the gut microbiota was associated with prostate enlargement.
Article
Urology & Nephrology
Christian A. Ericson, Bryce A. Baird, David J. Mauler, Timothy D. Lyon, Colleen T. Ball, Chandler D. Dora
Summary: The study compared the outcomes of Holmium laser enucleation of the prostate (HOLEP) using the early apical release (EAR) technique and the En-bloc no touch (EBNT) technique. The results showed that the EAR technique may result in longer operative times but significantly reduced the need for open cystotomy. There were no significant differences in perioperative complications between the two techniques.
WORLD JOURNAL OF UROLOGY
(2023)
Review
Oncology
E. J. Bass, A. Pantovic, M. J. Connor, S. Loeb, A. R. Rastinehad, M. Winkler, Rhian Gabe, H. U. Ahmed
Summary: Using MRI-guided biopsy offers superior detection rates of clinically significant PCa and reduces the detection of insignificant PCa compared to TRUS-GB in patients with suspected prostate cancer. However, no individual MRI-GB technique was found to be better in detecting csPCa. Prospective adequately powered randomized controlled trials are needed for further validation.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Nutrition & Dietetics
Stacy Loeb, Benjamin C. Fu, Scott R. Bauer, Claire H. Pernar, June M. Chan, Erin L. Van Blarigan, Edward L. Giovannucci, Stacey A. Kenfield, Lorelei A. Mucci
Summary: This study suggests that consuming a greater amount of healthful plant-based foods is associated with a reduced risk of aggressive forms of prostate cancer, with a stronger effect observed among men under 65 years of age.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Oncology
Alex J. Xu, Akya Myrie, Jacob Taylor, Richard Matulewicz, Tian Gao, Veronica Perez-Rosas, Rada Mihalcea, Stacy Loeb
Summary: The study found that content related to prostate cancer on Instagram mainly focuses on raising awareness or sharing patient stories, with a small percentage created by physicians. Most content is of low to moderate quality, understandable, but poorly actionable. Some content contains significant misinformation, but most posts have comments offering social support.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Urology & Nephrology
Brett J. Friedman, Irene Chen, Kwesi Asantey, Stacy Loeb, Simon P. Kim, Rena D. Malik, Patrick Karabon, Tracy Wunderlich-Barillas, Thenappan Chandrasekar
Summary: This study aimed to determine the impact of medical students' Twitter engagement on the urology residency match and their overall perception of Twitter. The study used a mixed methods approach, including Twitter metrics data, online student surveys, and qualitative semi-structured interviews.
Article
Urology & Nephrology
Heiko Yang, Benjamin N. Breyer, Eric B. Rimm, Edward Giovannucci, Stacy Loeb, Stacey A. Kenfield, Scott R. Bauer
Summary: The study found that a healthy plant-based diet is inversely associated with incident ED in men aged 60 to <70 years, while an unhealthy plant-based diet is positively associated with ED in men aged <60 years.
Article
Nutrition & Dietetics
James F. Borin, John Knight, Ross P. Holmes, Shivam Joshi, David S. Goldfarb, Stacy Loeb
Summary: This study compared the concentrations of important ingredients for kidney stones and chronic kidney disease in popular brands of milk alternatives. Oat, macadamia, rice, and soy milk had similar parameters to dairy milk in terms of kidney stone risk factors, while almond and cashew milk had more potential stone risk factors. Coconut milk may be a favorable dairy substitute for patients with chronic kidney disease.
JOURNAL OF RENAL NUTRITION
(2022)
Editorial Material
Oncology
Stacy Loeb, Rena Malik
JCO ONCOLOGY PRACTICE
(2022)
Review
Oncology
Eleonora Teplinsky, Sara Beltran Ponce, Emily K. Drake, Ann Meredith Garcia, Stacy Loeb, G. J. van Londen, Deanna Teoh, Michael Thompson, Lidia Schapira
Summary: The Internet has democratized access to medical information, but has also led to an increase in health misinformation. Despite this, healthcare professionals remain among the most trusted sources of information. Therefore, clinicians need to actively combat misinformation in oncology.
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Amber S. Herbert, Naeemul Hassan, Rena Malik, Stacy Loeb, Akya Myrie
Summary: This study evaluates the quality, understandability, and actionability of genitourinary malignancy content on Pinterest and finds that the majority of the content is of low quality and lacks diversity. The findings highlight the need for disseminating diverse, high-quality, and accurate healthcare information on Pinterest and other social media platforms.
Article
Oncology
Stacy Loeb, Tatiana Sanchez Nolasco, Katherine Siu, Nataliya Byrne, Veda N. Giri
Summary: Researchers created a series of podcasts about PCa genetics and found that they were perceived as useful and associated with high levels of knowledge among patients with PCa and the general public. This suggests that podcasts are a promising new educational tool for raising awareness about PCa genetic evaluation.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Fred Gong, Stacy Loeb, Katherine Siu, Akya Myrie, Stephanie Orstad, Stacey A. A. Kenfield, Alicia Morgans, Sameer Thakker, Rebecca Robbins, Patricia Carter, Girardin Jean-Louis, Tatiana Sanchez Nolasco, Nataliya Byrne, Natasha Gupta
Summary: This study investigated the prevalence of sleep disturbances among prostate cancer survivors and the involvement of urologists in sleep care. The results showed that most prostate cancer survivors experienced sleep disturbances, including poor sleep quality, clinical/severe insomnia, and high-risk for sleep apnea. However, few urologists routinely screened for sleep disturbances as recommended in national cancer survivorship guidelines.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Editorial Material
Oncology
Michael S. Leapman, Stacy Loeb, Matthew R. Cooperberg, William J. Catalona, Franklin D. Gaylis
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Colin Scott, Peter Campbell, Amy Nemirovsky, Stacy Loeb, Rena Malik
Summary: Podcasts are a new information source, but their quality has not been evaluated. Based on the DISCERN criteria for quality, the Patient Education Materials Assessment Tool for understandability and actionability, and evaluating misinformation and commercial bias, it is concluded that podcasts are currently not good information sources for lay health consumers.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Urology & Nephrology
Jenna Kanner, Suneet Waghmarae, Amy Nemirovsky, Shu Wang, Stacy Loeb, Rena Malik
Summary: This study assessed the quality, understandability, actionability, and diversity of speakers in TikTok and YouTube videos on overactive bladder. The findings revealed poor actionability, understandability, and quality in these videos, with evidence of misinformation and commercial bias.
Article
Oncology
Zhiyu Qian, Edoardo Beatrici, Quoc-Dien Trinh, Adam S. Kibel, Stacy Loeb, Hari S. Iyer, Alexander P. Cole
Summary: As the climate crisis worsens, its impact on human health, including cancer pathogenesis and treatment, becomes increasingly evident. This study found a significant association between individuals' recognition of climate change as a personal health threat and their interest in cancer screening. These findings suggest a promising avenue for future research on the intersection of climate and cancer risk, and support the integration of environmental health literacy into public health interventions for cancer screening.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)