Article
Pharmacology & Pharmacy
Mei Chen, Zhenyu Nie, Yuanhui Gao, Hui Cao, Linlin Zheng, Na Guo, Yanling Peng, Shufang Zhang
Summary: This study revealed the role of m7G RNA methylation in the tumor immune microenvironment of KIRC and developed an m7G score that can predict patient prognosis. Experimental evidence showed that knocking down WDR4 can inhibit KIRC cell proliferation, migration, invasion, and increase sensitivity to specific drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xi Xiong, Chen Chen, Jun Yang, Li Ma, Xiong Wang, Wei Zhang, Yuan Yuan, Min Peng, Lili Li, Pengcheng Luo
Summary: This study established a prognostic model based on BMGs for KIRC, assessing survival status, tumor microenvironment, pathological features, and chemotherapeutic resistance. Results indicated that FREM2 could be a potential candidate for KIRC prognosis prediction.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Kangsan Kim, Qinbo Zhou, Alana Christie, Christina Stevens, Yuanqing Ma, Oreoluwa Onabolu, Suneetha Chintalapati, Tiffani Mckenzie, Vanina Toffessi Tcheuyap, Layton Woolford, He Zhang, Nirmish Singla, Pravat Kumar Parida, Mauricio Marquez-Palencia, Ivan Pedrosa, Vitaly Margulis, Arthur Sagalowsky, Zhiqun Xie, Tao Wang, Steffen Durinck, Zora Modrusan, Somasekar Seshagiri, Payal Kapur, James Brugarolas, Srinivas Malladi
Summary: In this study, the authors explore the determinants of vascular invasion and metastasis in RCC patients with tumor thrombi (TT). They found that tumor thrombi associated with metastases are characterized by higher grade, mTOR activation, and a particular immune contexture. TT grade is a better predictor of metastasis than overall tumor grade.
NATURE COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Wentao Yao, Hanyuan Liu, Feng Xu, Zhenyu Cai, Lijing Hang, Mingya Lu, Yuan Zhao, Chendi Yang, Yang Zong
Summary: The high expression of C1QC is associated with clinical and prognostic features in KIRC. C1QC is specifically upregulated in tumor-infiltrating immune cells and shows a significant correlation with various immune cell types in KIRC. Targeting C1QC may provide a new treatment approach for KIRC.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Jing-min Zheng, Mei-fu Gan, Hong-yuan Yu, Lu-xia Ye, Qing-xin Yu, Yu-hui Xia, Han-xi Zhou, Jia-qian Bao, Yi-qing Guo
Summary: KDF1 has been identified as a key regulator of epidermal proliferation and differentiation, but its involvement in malignancy remains unknown. This study explored the role of KDF1 in clear cell renal cell carcinoma (ccRCC) through analyzing its expression levels and functions. The results suggest that KDF1 may act as a tumor suppressor in ccRCC by inhibiting proliferation and invasion of cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Chen Lyu, Lili Wang, Birgit Stadlbauer, Elfriede Noessner, Alexander Buchner, Heike Pohla
Summary: Cancer stem cells play a crucial role in renal cell carcinoma, and a potential treatment strategy to suppress these cells has been identified, along with the identification of related markers.
Article
Medicine, Research & Experimental
Liu-xun Chen, Shen-jie Zeng, Xv-dong Liu, Hai-bin Tang, Jia-wu Wang, Qing Jiang
Summary: This study characterizes the intercellular communications within the ccRCC microenvironment and shows their impact on prognosis and immunotherapy efficacy. It reveals a potential relationship between the VHL phenotype and the landscape of cell-cell communication. Moreover, these communication molecules also influence the development and infiltration of T cells and myeloid cells. Different clusters of intercellular communications have significant predictive value for prognosis and distinguish immunotherapy efficiency.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Nicholas H. Chakiryan, Youngchul Kim, Anders Berglund, Andrew Chang, Gregory J. Kimmel, Ali Hajiran, Jonathan Nguyen, Carlos Moran-Segura, Daryoush Saeed-Vafa, Esther N. Katende, Neale Lopez-Blanco, Jad Chahoud, Phillip Rappold, Philippe E. Spiess, Michelle Fournier, Daniel Jeong, Liang Wang, Jamie K. Teer, Jasreman Dhillon, Fengshen Kuo, Abraham Ari Hakimi, Philipp M. Altrock, James J. Mule, Brandon J. Manley
Summary: In clear cell renal cell carcinoma (ccRCC), the clustering of CD163+M2 like TAMs into the stromal compartment at the tumor-stroma interface is associated with poor clinical outcomes and CD8+T cell terminal exhaustion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell Biology
Haiting Zhou, Yi He, Yongbiao Huang, Rui Li, Hao Zhang, Xiaohui Xia, Huihua Xiong
Summary: Elevated expression of CPNE1 in clear cell renal cell carcinoma (ccRCC) is associated with tumor progression and poor prognosis. CPNE1 regulates cancer-related and immune-related pathways and is significantly correlated with immune infiltration in ccRCC. In vitro experiments showed that CPNE1 promotes ccRCC cell proliferation and migration through the EGFR/STAT3 pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Dongchen Pei, Chaojie Xu, Dong Wang, Xiaoxue Shi, Yurui Zhang, Yi Liu, Jianhua Guo, Nan Liu, Haipeng Zhu
Summary: A prognostic signature related to the tumor microenvironment in kidney renal clear cell carcinoma (KIRC) was constructed, which can accurately predict the prognosis of patients and provide new ideas for treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Chengdong Qin, Siyuan Liu, Shiqi Zhou, Qibo Wang, Xianghou Xia, Jiejie Hu, Xiaohong Yuan, Zongping Wang, Yang Yu, Dening Ma
Summary: PIK3C2A expression is decreased in various tumors, particularly in renal clear cell carcinoma (KIRC). It is significantly correlated with tumor stage, grade, and other clinicopathological features in KIRC. PIK3C2A serves as a potential biomarker for tumor progression and is associated with immune infiltration in KIRC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Yuqing Wu, Saisai Chen, Minhao Zhang, Kuangzheng Liu, Jibo Jing, Kehao Pan, Lihua Zhang, Bin Xu, Xiaoming Lu, Ming Chen
Summary: This study aimed to comprehensively characterize Xp11.2 tRCC patients and identify risk factors associated with overall survival (OS) and progression-free survival (PFS). T stage at presentation was found to be significantly associated with both PFS and OS, while age, T stage, and metastasis status were also identified as predictors of OS. Patients with higher T stage, older age, or metastases were shown to have poorer outcomes.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Bin Zheng, Fang Xie, Fajuan Cheng, Jianwei Wang, Zhongshun Yao, Wei He, Zhihong Niu
Summary: This study comprehensively assessed the tumor microenvironment of kidney cancer, identified two immune-related hub genes - IGLL5 and IL2RA, and validated their clinical application value in ccRCC and pRCC. Drug response was also predicted based on selected genes, revealing novel drug candidates for RCC treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Endocrinology & Metabolism
Jiasheng Yan, Yunqiu Gao
Summary: This study aimed to investigate the role of tissue inhibitor of metalloproteinase-1 (TIMP1) in kidney renal clear cell carcinoma (KIRC). Analysis of data from the TCGA database revealed that TIMP1 expression was associated with patient prognosis and may play a crucial role in the development and spread of KIRC. TIMP1 could serve as a prognostic marker for KIRC.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Xinqiang Gan, Ruiji Liu, Hong Cheng, Weipu Mao, Ninghan Feng, Ming Chen
Summary: The study revealed that ASNS expression is significantly increased in ccRCC and is associated with advanced clinicopathological characteristics. ASNS may play a significant role in the development and immune cell infiltration of ccRCC and can serve as a valuable clinical prognostic biomarker.
FRONTIERS IN ONCOLOGY
(2022)
Review
Urology & Nephrology
Izak Faiena, Christopher Koprowski, Hari Tunuguntla
JOURNAL OF UROLOGY
(2016)
Meeting Abstract
Urology & Nephrology
Angelo Gousse, Lee J. Milas, Hari Tunuguntla
JOURNAL OF UROLOGY
(2017)
Review
Urology & Nephrology
Kushan D. Radadia, Nicholas J. Farber, Brian Shinder, Charles F. Polotti, Lee J. Milas, Hari S. G. R. Tunuguntla
Editorial Material
Urology & Nephrology
Brian Shinder, Jayme Sack, Evita Sadimin, Hari Tunuguntla
Article
Environmental Sciences
Renuka Tunuguntla, Hari Siva Gurunadha Rao Tunuguntla, Himanshu Kathuria, Sadhna Verma
Summary: The study demonstrates that app-based intervention (YOI) during the COVID-19 pandemic can effectively improve insomnia symptoms, with significant improvements in various categories of insomnia severity across all age groups and genders.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Psychiatry
Sadhna Verma, James Donovan, Hari S. Tunuguntla, Renuka Tunuguntla, Babu V. Gupta, Ayon Nandi, Ishan Shivanand
Summary: During the COVID-19 pandemic, participants who used the Yoga of Immortals (YOI) intervention for 8 weeks reported significant decreases in symptoms of depression and anxiety, as well as alleviation of insomnia.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Urology & Nephrology
Kevin J. Chua, Mark Mikhail, Hiren Patel, Alexandra L. Tabakin, Sai Krishnaraya Doppalapudi, Joshua Sterling, Hari S. G. R. Tunuguntla
Summary: Female urethral strictures are rare but can cause voiding dysfunction and are best managed with open reconstruction. Considerations when selecting the type of repair include etiology, type of stricture, and local vascularity. Multiple different techniques have been described with theoretical advantages to each one.
RESEARCH AND REPORTS IN UROLOGY
(2021)
Article
Urology & Nephrology
Kevin J. Chua, Hiren Patel, Alexandra Tabakin, Arnav Srivastava, Sai Krishnaraya Doppalapudi, Elias Hyams, Hari S. G. R. Tunuguntla
Summary: Anticholinergics like oxybutynin continue to be the most prescribed OAB medication each year, while the utilization of mirabegron has been steadily increasing. Agents with fewer cognitive adverse effects, such as trospium, darifenacin, and fesoterodine, are among the least prescribed in the study.
Article
Urology & Nephrology
Hari Siva Gurunadha Rao Tunuguntla, Renuka Tunuguntla, Himanshu Kathuria, Abhinav Sidana, Nidhiben Chaudhari, Sadhna Verma, Ishan Shivanand
Summary: The study investigated the effectiveness of Yoga of Immortals intervention in participants with urinary incontinence, showing significant improvement in symptoms and quality of life.
Meeting Abstract
Urology & Nephrology
Hari Siva G. R. Tunuguntla, Renuka Tunuguntla, Arnav Srivastava
NEUROUROLOGY AND URODYNAMICS
(2021)
Meeting Abstract
Urology & Nephrology
Kevin Chua, Hiren Patel, Alexandra Tabakin, Saikrishnaraya Doppalapudi, Charles Polotti, Elias Hyams, Hari Tunuguntla
JOURNAL OF UROLOGY
(2020)
Meeting Abstract
Urology & Nephrology
Kevin Chua, Hiren V. Patel, Alexandra Tabakin, Saikrishnaraya Doppalapudi, Elias Hyams, Hari Tunuguntla
NEUROUROLOGY AND URODYNAMICS
(2020)
Meeting Abstract
Urology & Nephrology
Jeffrey Sack, Jayme Sack, Hari Tunuguntla
JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Urology & Nephrology
Angelo E. Gousse, Jan-Michael Pohudka, Hari Tunuguntla
JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Urology & Nephrology
Angelo Gousse, Kushan Radadia, Hari Tunuguntla
NEUROUROLOGY AND URODYNAMICS
(2018)
