Article
Hematology
Zhongying Mo, Scott Wood, Shawn Namiranian, Reina Mizukoshi, Stephanie Weng, In Sock Jang, Celia Fontanillo, Joshua M. Baughman, Arianna Silva-Torres, Michelle Slade, Marwa Khater, Kai Wang, Mark Rolfe, Gang Lu
Summary: The study conducted genome-wide CRISPR/Cas9 screening and mechanistic characterization of CC-122 in DLBCL cell lines, identifying genes that regulate the response to CC-122, including both known and novel genetic factors.
Article
Pharmacology & Pharmacy
Tae Hyun Kim, Jong Hyeok Park, Jooyeon Park, Dong Min Son, Ji-Young Baek, Hee Jun Jang, Won Ki Jung, Youngjoo Byun, Sang Kyum Kim, Song-Kyu Park
Summary: (R)-crizotinib can induce changes in cancer cells and cancer stem cells properties by inhibiting AMPK, resulting in alterations in cellular morphology and characteristics.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Pengfei Xue, Xiaowei Liu, Hao Jia, Haiyue Yuan, Bingjie Liu, Jingran Zhang, Zeying He
Summary: This study investigates the environmental behavior of epoxiconazole in an earthworm-soil system. It reveals the enantioselectivity and chemically specific enantiomer fraction of its chiral transformation products in different matrices. The activation of CYP450 monooxygenase in earthworms is observed, which provides further insights into the biotransformation mechanism of epoxiconazole.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Biochemistry & Molecular Biology
Kathleen Gallo, Andrean Goede, Oliver-Andreas Eckert, Bjoern-Oliver Gohlke, Robert Preissner
Summary: A challenge in drug development is the interaction with off-targets, which can cause unintended side-effects and withdrawal of drugs. These off-targets also provide opportunities for repositioning withdrawn drugs for new indications. To gain further insights, the Withdrawn database was updated with additional data and improved accessibility.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Oncology
Jia-Jia Zhang, Wei Liu, Guo-Zhen Xing, Li Xiang, Wen-Ming Zheng, Zhen-Ling Ma
Summary: Gynecological cancer is a severe disease that poses a threat to women's lives and health worldwide. CCL2 plays a significant role in the occurrence and development of gynecological cancers and may serve as a diagnostic biomarker and prognostic predictor. This review focuses on the role of CCL2 in breast cancer, ovarian cancer, cervical cancer, and endometrial cancer, as well as potential therapeutic strategies.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Mohammadhassan Foroughbakhshfasaei, Mate Dobo, Francisc Boda, Zoltan-Istvan Szabo, Gergo Toth
Summary: The study investigated the enantioseparation of four phthalimide derivatives using different polysaccharide-type stationary phases and polar organic mobile phases. It found that only Chiralcel OJ-H column with MeOH was successful for baseline-separation of all investigated drugs, and observed that enantioselectivity depends on the direction from which the composition of the eluent is approached, regardless of the eluent pair used.
Article
Multidisciplinary Sciences
M. Kopec, K. Beton, K. Jarczewska, H. Abramczyk
Summary: Raman spectroscopy and Raman imaging were used to identify the biochemical and structural features of human cancer lung cells (CCL-185). The study found that high levels of glucose decrease oxidative phosphorylation and shift the metabolism to glycolysis in cancer cells, which may contribute to a more malignant phenotype.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Yiming Cheng, Jian Chen, Michael Pourdehnad, Simon Zhou, Yan Li
Summary: The population pharmacokinetics of CC-122 was adequately described by a two-compartment model with first-order absorption and elimination in 298 patients from 3 clinical studies. Tumor types were significantly correlated with apparent clearance and apparent volume of distribution of the central compartment, while creatinine clearance was identified as a statistically significant covariate of clearance. Sex and body weight were statistically but not clinically relevant on volume of distribution.
CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS
(2021)
Review
Immunology
Kimia Ghasemi, Kosar Ghasemi
Summary: Chemokines and their receptors play crucial roles in immune responses. CXCR4, a GPCR, interacts with SDF-1 to regulate multiple signaling pathways and has potential therapeutic value in cancer treatment. MSX-122, an orally available CXCR4 antagonist, shows promising anti-cancer properties, especially in treating metastatic cancers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Fatma A. Abouelnazar, Xiaoxin Zhang, Jiahui Zhang, Maoye Wang, Dan Yu, Xueyan Zang, Jiayin Zhang, Yixin Li, Jing Xu, Qiurong Yang, Yue Zhou, Haozhou Tang, Yanzheng Wang, Jianmei Gu, Xu Zhang
Summary: This study reveals that SALL4 is overexpressed in stomach adenocarcinoma and is associated with tumor progression and poor prognosis. SALL4 regulates VEGF expression at the transcriptional level, thus promoting angiogenesis. Co-delivery of si-SALL4-B and thalidomide using engineered exosomes shows potential in inhibiting cancer angiogenesis.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Wei Yan, Minghui Cao, Xianhui Ruan, Li Jiang, Sylvia Lee, Adriana Lemanek, Majid Ghassemian, Donald P. Pizzo, Yuhao Wan, Yueqing Qiao, Andrew R. Chin, Erika Duggan, Dong Wang, John P. Nolan, Jeffrey D. Esko, Simon Schenk, Shizhen Emily Wang
Summary: Breast cancer suppresses O-GlcNAc protein modification in muscle through miR-122, leading to dysregulated skeletal muscle proteolysis with aberrant Ca2+ levels and calpain protease activation.
NATURE CELL BIOLOGY
(2022)
Article
Chemistry, Organic
Jianbo Tang, Junhua Kong, Hui Xu, Zhi-Jiang Jiang, Yifan She, Jianfei Bai, Bencan Tang, Jia Chen, Zhanghua Gao, Kun Gao
Summary: Silver-catalyzed deuteration of nitroaromatics was achieved using D2O as the deuterium source. Unlike traditional directing group-guided hydrogen-isotope exchange, this protocol exhibited an interesting deuteration pattern, with significant deuterium accumulation around the aromatic rings. Additional experiments suggested that the deuteration was initiated by silver-promoted C-H activation. Therefore, a tentative two-stage deuteration mechanism involving aryl-silver species was proposed to explain the deuteration at meta- and para-positions.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Oncology
Miran Jeong, Yi-Yue Wang, Ju-Yeon Choi, Myong Cheol Lim, Jung-Hye Choi
Summary: This study highlights the interaction between macrophages and ovarian cancer cells in metastasis. CCL7 in macrophages promotes ovarian cancer cell invasion, contributing to the development and metastasis of ovarian cancer. The CCL7/CCR3 axis may play a crucial role in the effect of tumor-associated macrophages on human ovarian cancer metastasis.
Article
Biochemical Research Methods
Christopher Heim, Marcus D. Hartmann
Summary: This study investigated the binding modes of next-generation IMiDs drugs on Cereblon using a crystal-soaking system, providing important insights for the development of future cereblon effectors.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2022)
Editorial Material
Chemistry, Medicinal
Sheila DeWitt, Anthony W. Czarnik, Vincent Jacques
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Carole Thang, Sebastien Bolze, Sheila Dewitt, Sophie Hallakou-Bozec, Julie Dubourg, Pierre Bedossa, Kenneth Cusi, Vlad Ratziu, Jean-Marie Grouin, David E. Moller, Pascale Fouqueray
Summary: The study aimed to evaluate the efficacy and safety of PXL065 in NASH patients. The results showed that PXL065 had similar efficacy as Pio in reducing liver fat content and improving liver histology, but with reduced potential for side effects. These findings suggest that PXL065 may be a safer treatment option for NASH.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Vincent Jacques, Sebastien Bolze, Sophie Hallakou-Bozec, Anthony W. Czarnik, Ajit S. Divakaruni, Pascale Fouqueray, Anne N. Murphy, Lex H. T. van der Ploeg, Sheila DeWitt
Summary: Pioglitazone is a potent drug for treating NASH in non-diabetic or diabetic patients, but its side effects include weight gain and edema. Stabilized stereoisomers of pioglitazone showed that (R)-pioglitazone retains efficacy in NASH without the PPAR γ activity associated with weight gain observed in (S)-pioglitazone.
HEPATOLOGY COMMUNICATIONS
(2021)