Dual allosteric activation mechanisms in monomeric human glucokinase

Kinetic Cooperativity in Human Pancreatic Glucokinase Originates from Millisecond Dynamics of the Small Domain

(2015) Mioara Larion et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme

(2014) Lee Freiburger et al.   Nature Chemical Biology

A Unified View of “How Allostery Works”

(2014) Chung-Jung Tsai et al.   PLoS Computational Biology

Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein

(2013) Tobias Beck et al.   BIOCHEMISTRY

Microscopic Insights into the NMR Relaxation-Based Protein Conformational Entropy Meter

(2013) Vignesh Kasinath et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulation of allostery by protein intrinsic disorder

(2013) Allan Chris M. Ferreon et al.   NATURE

50 years of allosteric interactions: the twists and turns of the models

(2013) Jean-Pierre Changeux   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A decade and a half of protein intrinsic disorder: Biology still waits for physics

(2013) Vladimir N. Uversky   PROTEIN SCIENCE

Small-Molecule Allosteric Activation of Human Glucokinase in the Absence of Glucose

(2013) Joseph M. Bowler et al.   ACS Medicinal Chemistry Letters

Structural and Energetic Basis of Allostery

(2012) Vincent J. Hilser et al.   Annual Review of Biophysics

The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation

(2012) A Joshua Wand   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein activity regulation by conformational entropy

(2012) Shiou-Ru Tzeng et al.   NATURE

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase

(2012) Mioara Larion et al.   PLOS BIOLOGY

Homotropic allosteric regulation in monomeric mammalian glucokinase

(2011) Mioara Larion et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cooperativity in monomeric enzymes with single ligand-binding sites

(2011) Carol M. Porter et al.   BIOORGANIC CHEMISTRY

Direct Evidence of Conformational Heterogeneity in Human Pancreatic Glucokinase from High-Resolution Nuclear Magnetic Resonance

(2010) Mioara Larion et al.   BIOCHEMISTRY

Global Fit Analysis of Glucose Binding Curves Reveals a Minimal Model for Kinetic Cooperativity in Human Glucokinase

(2010) Mioara Larion et al.   BIOCHEMISTRY

23-Residue C-Terminal α-Helix Governs Kinetic Cooperativity in Monomeric Human Glucokinase

(2009) Mioara Larion et al.   BIOCHEMISTRY

Activating Mutations in the Human Glucokinase Gene Revealed by Genetic Selection

(2009) Priya Pal et al.   BIOCHEMISTRY

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

(2009) Kara K. Osbak et al.   HUMAN MUTATION

Mapping Transient Partial Unfolding by Protein Engineering and Native-State Proteolysis

(2009) Youngil Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

(2009) T. P. Schrank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation.

(2008) Henrik B T Christesen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Catalytic activation of human glucokinase by substrate binding - residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions

(2008) Janne Molnes et al.   FEBS Journal

Allosteric cooperativity in protein kinase A

(2008) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery and cooperativity revisited

(2008) Qiang Cui et al.   PROTEIN SCIENCE