Article
Radiology, Nuclear Medicine & Medical Imaging
Anna S. Morr, Helge Herthum, Felix Schrank, Steffen Goerner, Matthias S. Anders, Markus Lerchbaumer, Hans-Peter Mueller, Thomas Fischer, Klaus-Vitold Jenderka, Hendrik H. G. Hansen, Paul A. Janmey, Juergen Braun, Ingolf Sack, Heiko Tzschatzsch
Summary: This study introduces a phantom that mimics the stiffness dispersion of the human liver, allowing for improved standardization of liver elastography across ultrasound and MRI devices. The phantom shows good reproducibility and low variability, making it useful for establishing standard liver stiffness measurements.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Medicine, General & Internal
Jon Nielsen, Mette Skalshoi Kjaer, Allan Rasmussen, Deepthi Chiranth, Gro Linno Willemoe, Birthe Merete Henriksen, Lotte Borgwardt, Mia Klinten Grand, Lise Borgwardt, Vibeke Brix Christensen
Summary: USe, TE and MRe have good discriminatory ability for assessing advanced liver fibrosis in pediatric liver disease, with TE and MRe performing best. For most children, TE is a reliable and easily applicable measure.
Article
Computer Science, Interdisciplinary Applications
Qi Zeng, Mohammad Honarvar, Caitlin Schneider, Shahed Khan Mohammad, Julio Lobo, Emily H. T. Pang, Kirby T. Lau, Changhong Hu, James Jago, Siegfried R. Erb, Robert Rohling, Septimiu E. Salcudean
Summary: The study presents a novel ultrasound matrix array implementation of S-WAVE that can sample axial multi-frequency steady-state tissue motion over a volume and shows correlation with MRE results. This approach has the potential to deliver a similar assessment of liver fibrosis as MRE in a more accessible and cost-effective way.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Review
Gastroenterology & Hepatology
Elton Dajti, Federico Ravaioli, Romanas Zykus, Pierre-Emmanuel Rautou, Laure Elkrief, Ivica Grgurevic, Horia Stefanescu, Masashi Hirooka, Mirella Fraquelli, Matteo Rosselli, Pik Eu Jason Chang, Fabio Piscaglia, Thomas Reiberger, Elba Llop, Sebastian Mueller, Giovanni Marasco, Annalisa Berzigotti, Agostino Colli, Davide Festi, Antonio Colecchia
Summary: The combination of spleen stiffness measurement (SSM) with the Baveno VII criteria improves the accuracy of diagnosing clinically significant portal hypertension and reduces the diagnostic grey zone.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Mattia Paratore, Matteo Garcovich, Maria Elena Ainora, Livio Enrico Del Vecchio, Giuseppe Cuccia, Laura Riccardi, Maurizio Pompili, Antonio Gasbarrini, Maria Assunta Zocco
Summary: Ultrasound imaging is the preferred method for investigating abdominal symptoms and can diagnose various pathological conditions in the gastrointestinal tract. Ultrasound elastography, a recent technological advancement, allows the evaluation of tissue characteristics like neoplastic transformation or inflammation. It has been extensively used in studying liver diseases and other clinical settings, including gastrointestinal diseases. This paper summarizes the evidence of different ultrasound elastography modalities in non-liver gastrointestinal diseases.
Article
Pediatrics
Steven Levitte, Lori W. Lee, Jared Isaacson, Evan J. Zucker, Carlos Milla, Richard A. Barth, Zachary M. Sellers
Summary: The study introduced SWE technology to aid in detecting liver fibrosis in children with CF, finding that 6-MHz point SWE correlated with MR elastography, and SWE at 1.84 m/s could effectively differentiate the severity of liver stiffness, providing a tool for predicting liver fibrosis.
PEDIATRIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun Wang, Dong Yu, Gaofeng Li, Li Wen, Shuchen Zhang
Summary: This prospective study compared the diagnostic accuracy of shear wave elastography (SWE) and shear wave dispersion (SWD) in evaluating hepatic fibrosis in patients with hepatocellular carcinoma (HCC). The results showed that both SWE and SWD values were highly correlated with liver fibrosis stage and necroinflammatory activity, and SWE had better diagnostic performance in predicting severe fibrosis and cirrhosis.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vinicius P. V. Alves, Jonathan R. Dillman, Jean A. Tkach, Paula S. Bennett, Stavra A. Xanthakos, Andrew T. Trout
Summary: This study found moderate to high correlation between quantitative US shear-wave speed (SWS) and MRI elastography-derived stiffness in children, adolescents, and young adults with liver disease. US SWS was able to predict abnormal liver stiffness with high accuracy.
Article
Biotechnology & Applied Microbiology
Martina Caruso, Carlo Ricciardi, Gregorio Delli Paoli, Fabiola Di Dato, Leandro Donisi, Valeria Romeo, Mario Petretta, Raffaele Iorio, Giuseppe Cesarelli, Arturo Brunetti, Simone Maurea
Summary: This study utilized machine learning algorithms to extract quantitative parameters from laboratory tests, US imaging, and MR imaging to predict the long-term medical outcome in native liver survivor BA patients after KP. The results suggest that TB and DB values play a crucial role in predicting disease progression, and physicians should pay attention to changes in these values.
BIOENGINEERING-BASEL
(2021)
Review
Oncology
Lucia Cerrito, Irene Mignini, Maria Elena Ainora, Carolina Mosoni, Antonio Gasbarrini, Maria Assunta Zocco
Summary: Hepatocellular carcinoma (HCC) risk is increased in nonalcoholic fatty liver disease (NAFLD), even without cirrhosis. New noninvasive tests have been proposed to predict HCC risk, and imaging techniques evaluating liver stiffness have gained increasing importance in this context.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas J. Vogl, Max P. Dosch, Yannick Haas
Summary: This study investigates the response of hepatic tissue to percutaneous microwave ablation (MWA) of liver tumors using MRI and MR elastography in a clinical setting. The results demonstrate that total liver stiffness and healthy parenchyma stiffness increase after MWA. The response to MWA is influenced by the duration and energy dose of the treatment session, as well as the baseline tumor stiffness. Successful ablation is associated with increased ablation margin stiffness and higher ablation intensity.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Acoustics
Cheng Fang, Vasileios Rafailidis, Eleni Konstantatou, Gibran T. Yusuf, Ian Barrow, Eirini Pagkalidou, Odyssefs Romanos, Kosh Agarwal, Alberto Quaglia, Paul S. Sidhu
Summary: This study evaluates the utility of 2-D shear wave elastography (SWE) in assessing liver fibrosis in patients with chronic liver disease. It compared the performance of 2-D SWE with point shear wave elastography (pSWE), using liver histological staging as the reference standard. The results showed that 2-D SWE provides feasible and accurate assessment of liver fibrosis, comparable to that of pSWE.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Tong Chen, Feng-Shan Jin, Le-Hang Guo, Xiao-Long Li, Qiao Wang, Hui Zhao, Li-Ping Sun, Hui-Xiong Xu
Summary: This study assessed muscle mass and function in elderly patients with type 2 diabetes using ultrasound and shear wave elastography. Various clinical indicators were measured, and the thickness, cross-sectional area, and shear wave elastography values of the rectus femoris muscle were also measured. The study found independent predictors for sarcopenia and established a diagnostic model with high accuracy.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Catherine Paverd, Sivert Kupfer, Iara Nascimento Kirchner, Sherin Nambiar, Alexander Martin, Naiara Korta Martiartu, Thomas Frauenfelder, Marga B. Rominger, Lisa Ruby
Summary: This study examines the effect of breathing phase, liver lobe, and prandial state on noninvasive liver assessment using ultrasound measurements. The results show that breathing and prandial state do not significantly affect SWS, SWD, and ATI values.
Article
Gastroenterology & Hepatology
Maciej K. Janik, Beata Kruk, Benedykt Szczepankiewicz, Konrad Kostrzewa, Joanna Raszeja-Wyszomirska, Barbara Gornicka, Frank Lammert, Piotr Milkiewicz, Marcin Krawczyk
Summary: The study demonstrates that liver and spleen 2D-SWE are reliable complementary methods for diagnosing advanced fibrosis in patients with autoimmune hepatitis (AIH). Spleen 2D-SWE appears to be less influenced by inflammation and could aid in fibrosis assessment in therapy-naive patients or those with active hepatitis.
LIVER INTERNATIONAL
(2021)
Article
Acoustics
Hyoung-Ki Lee, James F. Greenleaf, Matthew W. Urban
Summary: Plane wave transmission has various applications in ultrasound imaging. Conventional PW compounding techniques suffer from displacement estimation errors. This study proposes a new scheme to improve the quality of PW compounding.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Acoustics
Yuqi Wang, Daniel S. Jacobson, Matthew W. Urban
Summary: A non-invasive method combining quasi-static and shear wave elastography was developed to estimate the localized stress-strain curve of materials. The method was tested on custom-made tissue-mimicking phantoms and showed good agreement with mechanical testing results.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Margherita Capriotti, Tuhin Roy, Nicholas R. Hugenberg, Hadiya Harrigan, Hon-Chi Lee, Wilkins Aquino, Murthy Guddati, James F. Greenleaf, Matthew W. Urban
Summary: This study investigated the effects of the shape and location of the acoustic radiation force (ARF) beam on the measurements of arterial dispersion ultrasound vibrometry (ADUV). Experimental evaluations on an arterial phantom and in vivo validation showed that the shape of the beam controls the selection and nature of the induced modes, while the location affects the measured dispersion curves.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Acoustics
Piotr Kijanka, Matthew W. Urban
Summary: In this study, an improved method for measuring shear wave attenuation, called two-point frequency shift power (2P-FSP), was proposed and tested using numerical and experimental data. The results showed that the 2P-FSP method provides improved results over the 2P-FS technique for lower signal-to-noise ratio (SNR) and locations farther from the push location considered, and can be used to measure attenuation of viscoelastic soft tissues.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tim Nordenfur, Kenneth Caidahl, Dmitry Grishenkov, Elira Maksuti, David Marlevi, Matthew W. Urban, Matilda Larsson
Summary: Shear wave elastography is a promising technique for assessing arterial stiffness. This study investigated the safety of SWE by examining the induced arterial strain and strain rate. The results showed that SWE does not expose the artery to higher strain rate than normal blood pressure variations and the induced strain is one order of magnitude higher than normal blood pressure variations.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christine U. Lee, Nicholas B. Larson, Matthew W. Urban, A. Lee Miller, Susheil Uthamaraj, Mara A. Piltin, James W. Jakub, Asha A. Bhatt, James F. Greenleaf, Gina K. Hesley
Summary: The study aimed to identify biopsy markers that show actionable twinkling in cadaveric breast and assess the association between actionable twinkling and marker surface roughness. Certain breast biopsy markers exhibited actionable twinkling in cadaveric breast, and this twinkling was associated with higher marker surface roughness.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Engineering, Biomedical
Hyoung-Ki Lee, Charles B. Capron, Hsiao-Chuan Liu, Tuhin Roy, Murthy N. Guddati, James F. Greenleaf, Matthew W. Urban
Summary: This study examines an artery-mimicking tube in water using three-dimensional measurements to provide a comprehensive understanding of the waves produced and their motion along the tube. The results categorize the motion into transient and steady state responses, with the waves propagating both axially and circumferentially. By successfully separating and visualizing the different waves, this study offers opportunities for improving the measurement of arterial mechanical properties.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eric E. Brost, Bradley J. Stish, Christine U. Lee, Matthew W. Urban, Christopher L. Deufel
Summary: This study aimed to improve the visibility of high-dose rate (HDR) brachytherapy needles under B-mode ultrasound imaging by applying an echogenic surface coating. The results showed that the echogenic coating reduced imaging artifacts, improved needle contrast, and the improvement increased with increasing coating thickness.
Article
Acoustics
Yuqi Wang, Shigeto Ono, Matthew P. Johnson, Nicholas B. Larson, Ted Lynch, Matthew W. Urban
Summary: This study aimed to investigate the mechanical property variability of two lots of CIRS Model 039 phantoms. Shear wave elastography measurements were conducted on each phantom and multilevel functional principal component analysis was performed. The results showed that the group velocity had low standard deviations and most individual phantoms had phase velocity curves within the 95% confidence interval. Therefore, MFPCA is an effective tool for analyzing the inter- and intra-phantom variability of phase velocity curves.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Hsiao-Chuan Liu, Bipin Gaihre, Piotr Kijanka, Lichun Lu, Matthew W. W. Urban
Summary: Hydrogel scaffolds have become an important platform for cellular therapy and tissue engineering in regenerative medicine. However, the current standard method to characterize mechanical properties of hydrogels, called dynamic mechanical analysis (DMA), has limitations. In this study, a novel technique called acoustic force elastography microscopy (AFEM) was proposed. AFEM can evaluate the elastic properties of tissue engineering scaffolds in a non-contact and non-destructive manner, providing a promising technique for quantifying elastic properties and exploring elastic changes in cell-laden scaffolds.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Proceedings Paper
Acoustics
Robert J. McGough, Matthew W. Urban
Summary: This paper introduces a fractional calculus model to describe the effects of propagation and attenuation in shear wave parameter estimation. Different power law exponents are evaluated in the model and it is found that using the Zolotarev fractional derivative leads to excellent agreement with measured data.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)
Proceedings Paper
Acoustics
Nicholas A. Bannon, Matthew W. Urban, Robert J. McGough
Summary: This study conducts rapid simulations of three-dimensional shear wave propagation in viscoelastic media using a Kelvin-Voigt model, accelerated by Green's functions with GPU parallelization and HPC resources. Shear wave speed estimates are obtained through cross-correlations from 3D waveforms, and a nonlinear least-squares approach is proposed to reduce the error in estimation by considering propagation, attenuation, and waveform spreading.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)
Article
Oncology
James W. Jakub, Gina K. Hesley, Nicholas B. Larson, Michael J. Yaszemski, A. Lee Miller, James F. Greenleaf, Matthew W. Urban, Christine U. Lee
Summary: This study evaluates the short-term safety and comparability of a nonmetallic twinkle marker to standard breast biopsy clips and radioactive seeds in terms of their visibility on color Doppler ultrasound. The results demonstrate that the twinkle marker is easily identifiable and has comparable safety and detection ease to the biopsy clip, suggesting its potential for clinical use.
RADIOLOGY-IMAGING CANCER
(2022)
Proceedings Paper
Materials Science, Characterization & Testing
Hsiao-Chuan Liu, Matthew W. Urban
Summary: Mechanical properties of tissues are important indicators for disease states. Acoustic radiation force (ARF) is commonly used as an excitation source in optical coherence elastography (OCE) to determine mechanical properties, but its use requires complicated focusing alignment. This study introduces a new technique, harmonic oscillation OCE, which allows for the evaluation of mechanical properties of samples placed in a cell culture plate without contacting the samples.
OPTICAL ELASTOGRAPHY AND TISSUE BIOMECHANICS VIV
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christine U. Lee, Matthew W. Urban, A. Lee Miller, Susheil Uthamaraj, James W. Jakub, Gina K. Hesley, Benjamin G. Wood, Nathan J. Brinkman, James L. Herrick, Nicholas B. Larson, Michael J. Yaszemski, James F. Greenleaf
Summary: Color Doppler twinkling is a valuable ultrasound feature in diagnosing urinary stones. This study investigates a polymeric material, PMMA, which twinkles and has measurable surface roughness and porosity. The comparison of different materials used for breast biopsy markers shows how twinkling can improve ultrasound detection.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2022)