Article
Construction & Building Technology
Huan Wang, Guijin Wang, Xianting Li
Summary: The paper proposes a novel image-based occupancy positioning system that utilizes multiple cameras for image capture and digital image processing to achieve real-time provision of occupant positioning and orientation information in different scenarios.
JOURNAL OF BUILDING ENGINEERING
(2021)
Article
Nutrition & Dietetics
Miori Tanaka, Shungo Fujii, Hirofumi Inoue, Nobuyuki Takahashi, Yoshiko Ishimi, Mariko Uehara
Summary: In vitro studies have shown that (S)-equol is more effective than (R)-equol in inhibiting osteoclast formation and enhancing osteoclast apoptosis. Experimental results in OVX mice showed that (S)-equol improved bone density, while (R)-equol did not have this effect.
JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Federica Saponaro, Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Alessandro Saba, Clementina Manera, Grazia Chiellini
Summary: Bone is a complex and dynamic tissue involved in various functions, with bone remodeling requiring the coordinated action of osteoblasts and osteoclasts and the involvement of numerous hormones and messenger molecules. The endocannabinoid system, a new player in skeletal health, shows potential for treating bone diseases associated with accelerated osteoclastic bone resorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Shannon Thoonen, Hui Min Tay, Carol Hua
Summary: A fluorescent, chiral coordination polymer (CP) with a unique topology has been synthesized using a dipyridyl ligand derived from 1,1'-bi-2-naphthol (BINOL). High enantioselectivity ratios up to 2.61 were achieved in fluorescence sensing studies with chiral analytes.
CHEMICAL COMMUNICATIONS
(2022)
Article
Computer Science, Information Systems
Jing Sun, Yi-Mu Ji, Shang-Dong Liu
Summary: In this paper, a vehicle pose estimation method with heuristic L-shape fitting and grid-based particle filter is proposed, which achieves significant improvements in both the runtime efficiency and pose estimation accuracy of incomplete point clouds.
Article
Rehabilitation
Ozge Solakoglu, Bilinc Dogruoz Karatekin, Yasemin Yumusakhuylu, Erkan Mesci, Afitap Icagasioglu
Summary: Adding the Tree Pose (Vrksasana) to conventional exercises can improve the static and dynamic balance of postmenopausal osteoporotic patients.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Chemistry, Physical
Chong Ye, Yifan Sun, Yong Li, Xiangdong Zhang
Summary: We propose a single-shot nondestructive quantum sensing method for efficient detection of tiny amounts of chiral substances, especially at the single-molecule level. Our scheme involves two steps: first, the two enantiomers are prepared in different rotational states via microwave enantio-specific state transfer. Then, chiral discrimination is transferred to quantum hypothesis testing. By introducing a nondestructive quantum-state detection technique assisted with a microwave resonator, the molecular chirality is determined by the sign of the output signals.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Review
Thermodynamics
Yan Ding, Shuxue Han, Zhe Tian, Jian Yao, Wanyue Chen, Qiang Zhang
Summary: The study focuses on the deviation of energy simulation results for buildings from actual consumption, attributing it mainly to inaccurate estimation of occupancy. Improving the accuracy level of occupancy prediction can notably reduce the error between reality and prediction. Despite various studies on occupancy, differences in detection, prediction, and validation methods still exist.
BUILDING SIMULATION
(2022)
Article
Chemistry, Analytical
Demet Dincel, Hernando Rosales-Solano, Shakiba Zeinali, Janusz Pawliszyn
Summary: The study introduces a new in-vial standard water generating system for stable preparation of hydrophobic compounds in an aquatic environment. The system consists of a vial with an aqueous solution and a polydimethylsiloxane thin film spiked with target compounds, allowing for stable analyte concentration.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Rui Du, Xiao-Yan Tang, Cheng Yang, Wen-Hong Gao, Shun-Ji Gao, Hui-Juan Xiang, Li Yang
Summary: This study aimed to assess the association between marijuana use and liver steatosis and fibrosis in the general US population. The results showed that past and current marijuana users had a lower prevalence of liver steatosis compared to never users. However, there was no significant association between marijuana use and liver fibrosis.
Article
Endocrinology & Metabolism
L. Mattia, S. Davis, C. Mark-Wagstaff, B. Abrahamsen, N. Peel, R. Eastell, M. Schini
Summary: This study evaluated the impact of the PINP monitoring algorithm on the effectiveness and cost-effectiveness of osteoporosis treatment in Sheffield, UK. The results showed that patients monitored with PINP had better outcomes in terms of oral bisphosphonate treatment, bone density monitoring, and improvement in hip bone density. The PINP monitoring algorithm has the potential to be cost-effective in the UK NHS setting.
Article
Chemistry, Multidisciplinary
Haruna Mizutani, Ryouta Kawanishi, Kazutaka Shibatomi
Summary: Enantioselective decarboxylative protonation of tetralone-derived beta-ketocarboxylic acids was achieved with up to 89% enantiomeric excess (ee) in the presence of a chiral primary amine catalyst. Furthermore, this method was applied to enantioselective deuteration to afford the corresponding alpha-deuterioketones with up to 88% ee.
CHEMICAL COMMUNICATIONS
(2021)
Article
Automation & Control Systems
Yongqiang Mou, Zhiyi Huang, Lingfan Lin, Yishi Guo, Zhen Yang
Summary: The article discusses the impact of image quality on final analysis results in the smart retail industry and proposes a novel geometry-supervised pose network to estimate shelf poses. Additionally, a new retail shelf pose dataset (RSPD) is introduced, along with a complete 3-D shelf posture for training end-to-end networks. Experimental results show that the proposed GSPN achieves state-of-the-art performance on RSPD.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2021)
Review
Biochemistry & Molecular Biology
Federica Armeli, Alessio Bonucci, Elisa Maggi, Alessandro Pinto, Rita Businaro
Summary: The Mediterranean diet has broad-spectrum neuroprotective activity, potentially counteracting neurodegeneration by modulating the endocannabinoid system. The co-evolution of the human endocannabinoid system and dietary habits in the Mediterranean lifestyle may play a key role in pro-homeostatic activity.
Article
Computer Science, Artificial Intelligence
Lele Wu, Zhenbo Yu, Yijiang Liu, Qingshan Liu
Summary: In this study, we propose a limb pose aware framework consisting of a kinematic constraint aware network and a trajectory aware temporal module to improve the 3D prediction accuracy of limb joint positions. By introducing relative bone angles and absolute bone angles as kinematic constraints, and incorporating a hierarchical Transformer network for trajectory estimation, we successfully alleviate the problem of errors accumulated along limbs and achieve promising results.
IEEE TRANSACTIONS ON IMAGE PROCESSING
(2022)
Article
Biochemistry & Molecular Biology
Andrew R. McEwan, Connor Davidson, Elizabeth Hay, Yvonne Turnbull, Johanna Celene Erickson, Pietro Marini, Dana Wilson, Andrew M. McIntosh, Mark J. Adams, Chris Murgatroyd, Perry Barrett, Mirela Delibegovic, Toni-Kim Clarke, Alasdair MacKenzie
Summary: This study identified a significant interaction between allelic variation of the human GAL5.1 gene, alcohol intake, and anxiety in men, using human association analysis. Disruption of GAL5.1 in mice resulted in reduced ethanol intake and anxiety-like behavior in male animals. The EGR1 transcription factor was found to be important in the activity of the GG genotype of GAL5.1 in amygdala and hypothalamus.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Natalya M. Kogan, Maximilian Peters, Raphael Mechoulam
Summary: The cannabinoid anticancer para-quinone HU-331, synthesized by the group fifty years ago, has shown high efficacy against human cancer cells mainly through topoisomerase II alpha catalytic inhibition. Researchers reviewed compounds synthesized based on HU-331, summarizing their activities and mechanisms, and reported the synthesis and action of novel quinones to further explore the structure-activity relationship in this series.
Article
Biochemistry & Molecular Biology
Reem Smoum, Christeene Haj, Shira Hirsch, Alina Nemirovski, Zhannah Yekhtin, Benny Bogoslavsky, Gaganjyot Kaur Bakshi, Mukesh Chourasia, Ruth Gallily, Joseph Tam, Raphael Mechoulam
Summary: A series of novel cannabinoid derivatives were synthesized and found to have high affinity and selectivity for the CB2 receptor. One of the synthesized derivatives showed high affinity and selectivity for the human CB2 receptor.
Article
Biology
Bitya Raphael-Mizrahi, Malka Attar-Namdar, Mukesh Chourasia, Maria G. Cascio, Avital Shurki, Joseph Tam, Moshe Neuman, Neta Rimmerman, Zvi Vogel, Arie Shteyer, Roger G. Pertwee, Andreas Zimmer, Natalya M. Kogan, Itai Bab, Yankel Gabet, Mone Zaidi
Summary: The endocannabinoid system, consisting of OGP and CB2, plays an important role in maintaining bone health and preventing age-related bone loss. OGP acts as an agonist and positive allosteric modulator of CB2, and its decrease in circulation with age is associated with bone loss in premenopausal women and adult mice.
Article
Immunology
Sadiq Umar, Anil K. Singh, Mukesh Chourasia, Stephanie M. Rasmussen, Jeffrey H. Ruth, Salahuddin Ahmed
Summary: This study investigates the role of O-GlcNAcylation in rheumatoid arthritis (RA) and its regulation using human RA patient-derived synovial fibroblasts (RASFs). The results suggest that O-GlcNAcylation could be a potential therapeutic target and PGG has the potential to inhibit inflammatory processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Surendra Rajit Prasad, Prakash Kumar, Saptarshi Mandal, Anu Mohan, Radhika Chaurasia, Ashish Shrivastava, Pallaprolu Nikhil, Dande Aishwarya, P. Ramalingam, Rahul Gajbhiye, Shriya Singh, Arunava Dasgupta, Mukesh Chourasia, V. Ravichandiran, Prolay Das, Debabrata Mandal
Summary: In this study, we evaluated the effectiveness of different types of saturated medium-chain fatty acids against Leishmania. We found that caprylic acid (CA) showed the most potent anti-leishmanial effect. Further investigation revealed that CA mediates cell death by depleting ergosterol through inhibiting the enzyme mevalonate kinase (MevK) in the ergosterol biosynthesis pathway. This study provides insights into the mechanism of CA against visceral leishmaniasis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Pietro Marini, Philip Cowie, Ahmet Ayar, Guy S. S. Bewick, John Barrow, Roger G. G. Pertwee, Alasdair MacKenzie, Paolo Tucci
Summary: In this study, the researchers investigated the mechanism of CB1/M-3 receptor cross-talk using SH-SY5Y cells as a model system. They found that M-3 receptor activation upregulates the CNR1 gene, leading to a more potent CB1 receptor response. Calcium homeostasis plays a crucial role in this cross-talk. The co-expression of M-3 and CB1 receptors in specific brain areas suggests their involvement in altered synaptic plasticity after exposure to cannabinoids, and highlights the potential of targeting the M-3 receptor in drug development and understanding response variation to cannabinoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Mukesh Chourasia, Todd Cowen, Aviva Friedman-Ezra, Eden Rubanovich, Avital Shurki
Summary: The ability to design catalysis depends on understanding the electrostatic effect of the surrounding on the participating chemical bonds. A simplistic model of point charges (PCs) was used to determine a set of rules for constructing PC-bond arrangements that can strengthen or weaken different chemical bonds. The strongest bond strengthening and weakening effects occur when the PC is placed along the bond axis, close to the more and less polarizable atom/fragment, respectively. Overall, bond strengthening is easier to achieve compared to bond weakening.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Cell Biology
Chanchal Thomas Mannully, Reut Bruck-Haimson, Anish Zacharia, Paul Orih, Alaa Shehadeh, Daniel Saidemberg, Natalya M. Kogan, Sivan Alfandary, Raphael Serruya, Arie Dagan, Isabelle Petit, Arieh Moussaieff
Summary: Stem cell self-renewal and differentiation are regulated by metabolism, specifically lipid desaturation. Inhibiting specific metabolic enzymes can maintain stem cell characteristics and reduce cell apoptosis. Monounsaturated fatty acids are beneficial for stem cells but detrimental to trophoblast cells.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M. Kogan, Aron Weller
Summary: This study explored the anti-depressant effects of Cannabidiolic Acid-Methyl Ester (CBDA-ME) in female Wistar-Kyoto (WKY) rats and found that females require higher doses of CBDA-ME to induce anti-depressant effects. Furthermore, the anti-depressant effects of CBDA-ME in females may be related to serum Brain-Derived Neurotrophic Factor (BDNF), endocannabinoid levels, and hippocampal expression of Fatty Acid Amide Hydrolase (FAAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Paolo Tucci, Iain Brown, Guy S. S. Bewick, Roger G. G. Pertwee, Pietro Marini
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Yarden Lavi, Natalya M. Kogan, Louise M. Topping, Caojie Liu, Fiona E. McCann, Richard O. Williams, Aviva Breuer, Zhanna Yekhtin, Aviva Friedman Ezra, Ruth Gallily, Marc Feldmann, Raphael Mechoulam
Summary: There is growing interest in non-psychoactive phytocannabinoids, such as CBD, CBG, and CBC, as potential therapeutic agents. This study developed new derivatives by methylating positions of olivetol and evaluated their anti-inflammatory effects. The CBD derivative, 2, and the CBG derivative, 11, showed significant reduction in cytokine levels and were as potent as dexamethasone in inhibiting IL-1 beta. These new derivatives have potential as novel drug candidates for inflammatory conditions.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zamzam Awida, Sahar Hiram-Bab, Almog Bachar, Hussam Saed, Dan Zyc, Anton Gorodov, Nathalie Ben-Califa, Sewar Omari, Jana Omar, Liana Younis, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Ida Gluzman, Tamar Liron, Bitya Raphael-Mizrahi, Albert Kolomansky, Martina Rauner, Ben Wielockx, Yankel Gabet, Drorit Neumann
Summary: This study demonstrates that EPOR in the monocytic lineage is at least partially responsible for the effect of EPO on bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)