期刊
JOURNAL OF TROPICAL PEDIATRICS
卷 57, 期 4, 页码 245-250出版社
OXFORD UNIV PRESS
DOI: 10.1093/tropej/fmq091
关键词
magnesium sulfate; sildenafil; pulmonary hypertension; newborn
The aim of this prospective, randomized and controlled study was to compare the clinical efficacy of intravenous magnesium sulfate (MgSO4) and oral sildenafil therapies with persistent pulmonary hypertension of the newborn. A total of 34 infants in the MgSO4 group and 31 infants in the sildenafil group completed the study. The time to reach the adequate clinical response [defined as oxygen index (OI) level of < 15, a pulmonary artery pressure of < 20 mmHg) was significantly shorter in the sildenafil group ( p = 0.002). Duration of mechanical ventilation was longer and the number of the patients requiring inotropic support was higher in the MgSO4 group ( p = 0.001 and p = 0.002, respectively). Although among two groups the difference in OI > 5 as speculated in our hypothesis could only be found at 36 h of the treatment, sildenafil was more effective than MgSO4 in the treatment of persistent pulmonary hypertension of the newborns with regard to time to adequate clinical response, duration of mechanical ventilation and support requirement with inotropic agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据