Review
Gastroenterology & Hepatology
Linnea Haggard, Ida Glimberg, Benjamin Lebwohl, Rajani Sharma, Elizabeth C. Verna, Peter H. R. Green, Jonas F. Ludvigsson
Summary: This study found a higher prevalence of CD in individuals with AIH compared to the general population through a systematic review. Screening for CD may be considered in patients with AIH.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Maya Aharoni Golan, Becca Feldman, Jacob E. Ollech, Moshe Hoshen, Raanan Shamir, Rachel-Gingold Belfer, Zohar Levi
Summary: In this retrospective study, persistent-positive celiac serology was found to be potentially associated with an increased risk of hypothyroidism among the pediatric population. Further prospective cohorts are needed to confirm these findings.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Daniel Vasile Balaban, Iulia Enache, Marina Ciochina, Alina Popp, Mariana Jinga
Summary: Celiac disease is a chronic autoimmune disease that primarily affects the intestines but can also impact the pancreas. While the endocrine changes in the pancreas, such as type 1 diabetes, have been extensively studied in relation to celiac disease, there has been less focus on the exocrine alterations. This review examines the available evidence on the risk of pancreatitis, autoimmune pancreatitis, prevalence and outcomes of exocrine insufficiency, and the link with cystic fibrosis in celiac disease patients. The mechanisms behind the associated exocrine impairment in celiac disease are also discussed, along with recommendations for clinical practice.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Analytical
Nicole M. Ralbovsky, Igor K. Lednev
Summary: This study utilized Raman hyperspectroscopy to identify celiac disease in red blood cells, aiming to develop a noninvasive, cost-effective, accurate, and reliable diagnostic method. Through partial least squares discriminant analysis (PLS-DA) and ROC curve analysis, the method achieved 100% successful external validation at the individual donor level.
Article
Pediatrics
Pier-Angelo Tovo, Anna Opramolla, Antonio Pizzol, Giulia Calosso, Valentina Dapra, Ilaria Galliano, Cristina Calvi, Michele Pinon, Fabio Cisaro, Caterina Rigazio, Pier Luigi Calvo, Massimiliano Bergallo
Summary: This study found that the transcription levels of pol genes of HERV-H, -K, and -W in WBCs from celiac patients were significantly higher than those in the control group, suggesting that these HERVs may play a role in the development of celiac disease.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Constantin Schmidt, Julian Stuerznickel, Andre Strahl, Ralf Oheim, Christina Weiler-Normann, Marcial Sebode, Florian Barvencik, Ansgar W. Lohse, Thorsten Schinke, Michael Amling, Christoph Schramm, Tim Rolvien
Summary: In patients with autoimmune hepatitis, there is a significant age-dependent deterioration of cortical bone microarchitecture, which may contribute to the increased fracture risk observed in these patients. Specifically, these patients showed a predominant reduction in cortical thickness at the distal radius and tibia, with no significant differences in trabecular parameters.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Jaimy Villavicencio Kim, George Y. Wu
Summary: Elevated aminotransferases in celiac disease patients can normalize with a strict gluten-free diet, especially in those with cryptogenic liver disease. The relationship between liver damage and intestinal permeability may play a role in the elevation of aminotransferases in celiac disease. Routine monitoring of liver enzymes and adherence to a gluten-free diet is recommended for celiac disease patients, with further investigation needed if there is no improvement despite strict compliance with the diet.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Cumali Efe, Anand V. Kulkarni, Benedetta Terziroli Beretta-Piccoli, Bianca Magro, Albert Friedrich Staettermayer, Mustafa Cengiz, Daniel Clayton-Chubb, Craig Lammert, Christine Bernsmeier, Ozlem Gul, Fatima Higuera-de la Tijera, Margarita Anders, Ellina Lytvyak, Mete Akin, Tugrul Purnak, Rodrigo Liberal, Mirta Peralta, Berat Ebik, Serkan Duman, Nurhan Demir, Yasemin Balaban, Alvaro Urzua, Fernando Contreras, Maria Grazia Venturelli, Yilmaz Bilgic, Adriana Medina, Marcos Girala, Fulya Guensar, Maria-Carlota Londono, Theodoros Androutsakos, Ayelen Kisch, Alper Yurci, Fatih Guezelbult, Yasir Furkan Cagin, Enver Avci, Murat Guezelbulut, Emine Kubra Dindar-Demiray, Murat Harputluoglu, Rahul Kumar, Sanjaya K. Satapathy, Manuel Mendizabal, Marcelo Silva, Stefano Fagiuoli, Stuart K. Roberts, Nese Karadag Soylu, Ramazan Idilman, Eric M. Yoshida, Aldo J. Montano-Loza, George N. Dalekos, Ezequiel Ridruejo, Thomas D. Schiano, Staffan Wahlin
Summary: This study evaluated the clinical features, treatment response, and outcomes of liver injury following SARS-CoV-2 vaccination. The liver injury was predominantly hepatocellular and some patients showed features of immune-mediated hepatitis. Corticosteroid therapy may be beneficial for patients with immune-mediated features or severe hepatitis. The overall outcome was generally favorable, but a few patients experienced vaccine-associated liver failure.
Article
Immunology
Nishtha Ahuja, Jagdeep Singh, Ranjana Walker Minz, Shashi Anand, Ashim Das, Sunil Taneja
Summary: Autoimmune hepatitis (AIH) is a chronic and progressive liver disease with both environmental and genetic factors playing a role in its development. This study aimed to investigate the distribution of HLA-DRB1, PTPN22, and CTLA-4 polymorphisms in North Indian AIH patients and their associations with clinical and pathological characteristics. The results showed a significant association between HLA-DRB1*03 and AIH in the North Indian population. Additionally, the GG genotype of CTLA-4 CT 60 was found to be more frequent in AIH patients compared to controls, and it was identified as an independent predictor for AIH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Maria Pina Dore, Giuseppe Fanciulli, Malik Rouatbi, Sandro Mereu, Giovanni Mario Pes
Summary: This retrospective case-control study aimed to explore the prevalence of thyroid disorders (TDs) in adult celiac patients from Northern Sardinia. The results showed a significantly higher incidence of autoimmune thyroid disorders in celiac patients compared to non-autoimmune thyroid disorders. These results suggest the need for surveillance for thyroid disorders in patients with celiac disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Xiaoying Kang, Alexander Ploner, Bjorn Roelstraete, Jonas F. Ludvigsson, Karin Wirdefeldt
Summary: Using a population-based matched cohort design, this study found no overall association between celiac disease (CeD) and risk of Parkinson's disease (PD). However, CeD diagnosed before age 60 was positively associated with incident diagnosis of PD, particularly after 10-15 years since biopsy. These findings suggest that patients with CeD diagnosed before 60 may have an increased vulnerability to long-term development of PD.
ANNALS OF NEUROLOGY
(2023)
Review
Immunology
Sara Molaaghaee-Rouzbahani, Nastaran Asri, Somayeh Jahani-Sherafat, Davar Amani, Andrea Masotti, Kaveh Baghaei, Abbas Yadegar, Hamed Mirjalali, Mohammad Rostami-Nejad
Summary: This study highlights the importance of Macrophages (MQs) in the development of celiac disease and suggests that balancing the polarization of MQs may be a potential therapeutic target for this disease.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Gastroenterology & Hepatology
Aldo J. Montano-Loza, Vincenzo Ronca, Maryam Ebadi, Bettina E. Hansen, Gideon Hirschfield, Saleh Elwir, Mohamad Alsaed, Piotr Milkiewicz, Maciej K. Janik, Hanns-Ulrich Marschall, Maria Antonella Burza, Cumali Efe, Ali Riza Caliskan, Murat Harputluoglu, Gokhan Kabacam, Debora Terrabuio, Fernanda de Quadros Onofrio, Nazia Selzner, Alan Bonder, Albert Pares, Laura Llovet, Murat Akyildiz, Cigdem Arikan, Michael P. Manns, Richard Taubert, Anna-Lena Weber, Thomas D. Schiano, Brandy Haydel, Piotr Czubkowski, Piotr Socha, Natalia Oldak, Nobuhisa Akamatsu, Atsushi Tanaka, Cynthia Levy, Eric F. Martin, Aparna Goel, Mai Sedki, Irena Jankowska, Toru Ikegami, Maria Rodriguez, Martina Sterneck, Christina Weiler-Normann, Christoph Schramm, Maria Francesca Donato, Ansgar Lohse, Raul J. Andrade, Vilas R. Patwardhan, Bart van Hoek, Maaike Biewenga, Andreas E. Kremer, Yoshihide Ueda, Mark Deneau, Mark Pedersen, Marlyn J. Mayo, Annarosa Floreani, Patrizia Burra, Maria Francesca Secchi, Benedetta Terziroli Beretta-Piccoli, Marco Sciveres, Giuseppe Maggiore, Syed-Mohammed Jafri, Dominique Debray, Muriel Girard, Florence Lacaille, Ellina Lytvyak, Andrew L. Mason, Michael Heneghan, Ye Htun Oo
Summary: Recurrence of autoimmune hepatitis (AIH) is common after liver transplantation, and it is associated with younger age at transplantation, the use of mycophenolate mofetil post-transplant, sex mismatch, and high pre-transplant IgG levels. Recurrent AIH is associated with impaired graft and overall survival. Better characterization, prevention, and treatment strategies are needed for the management of recurrent AIH.
JOURNAL OF HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Aaron Lerner, Jozelio Freire de Carvalho, Anna Kotrova, Yehuda Shoenfeld
Summary: A gluten-free diet may serve as a novel therapeutic strategy for classical non-gluten-dependent autoimmune conditions, with symptom relief observed in most patients.
Article
Immunology
Javier Sanchez-Solares, Luis Sanchez, Carmela Pablo-Torres, Celso Diaz-Fernandez, Poul Sorensen, Domingo Barber, Cristina Gomez-Casado
Summary: The study found that CD patients have significantly decreased expression of epithelial junction proteins in their oral mucosa, suggesting compromised barrier integrity. The increase in FoxP3+ cells in CD patients indicates recruitment of Tregs to the damaged mucosa. Amphiregulin mRNA levels in PBMCs and epithelial damage in the oral mucosa correlated with Treg infiltration, suggesting a potential repair phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Mohammed Al-Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy, Yasser El-Sawaf
Summary: The COVID-19 pandemic poses a threat to individuals of all ages worldwide, including children. Gastrointestinal manifestations are common in patients, particularly those with severe disease, with symptoms like diarrhea, vomiting, and abdominal pain frequently observed in children. Atypical manifestations can also occur, such as appendicitis or liver injury, especially in the presence of multisystem inflammatory disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Mortada El-Shabrawi, Iqbal Memon, Dina Attia, Nehal M. El-Koofy
JOURNAL OF HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Nermin Kamal Saeed, Mohammed Al-Beltagi, Adel Salah Bediwy, Yasser El-Sawaf, Osama Toema
Summary: Gut microbiota plays a significant role in the development and immune system differentiation in children, and dysbiosis is associated with various childhood disorders.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Endocrinology & Metabolism
Mohammed Al-Beltagi, Adel Salah Bediwy, Nermin Kamal Saeed
Summary: Insulin resistance is increasingly common in children and adolescents, with a strong link to obesity and metabolic syndrome. Genetic mutations, environmental factors, and abnormal energy pathways all contribute to the development of insulin resistance, which is a crucial risk factor for developing type-II diabetes mellitus in children.
WORLD JOURNAL OF DIABETES
(2022)
Article
Gastroenterology & Hepatology
Hasan M. Isa, Asma Z. Hasan, Sara Khalifa, Sana S. Alhewaizem, Abdulrahman D. Mahroofi, Fatema N. Alkhan, Mohammed Al-Beltagi
Summary: This study found a low prevalence of liver enzyme elevation in children with acute bronchiolitis, with most patients showing normalized liver function during follow-up. However, elevated liver enzymes were associated with prolonged hospital stay and positive urine cultures.
WORLD JOURNAL OF HEPATOLOGY
(2022)
Article
Allergy
Mohamad Miqdady, Saif AlMutaeri, Najwa Alsawi, Loie Goronfolah, Christos Tzivinikos, Hamad Al Hameli, David Cremonesini, Mohammed Al-Enezi, Ahmad Hussain, Zainab Al Damerdash, Mohammed Al-Biltagi
Summary: This study estimates the budgetary impact of introducing AAF as the first-line management for infants with suspected CMPA in Saudi Arabia, Kuwait, and the UAE. The results show that the early introduction of AAF can result in cost savings in these countries.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Review
Medicine, General & Internal
Adel Salah Bediwy, Mohammed Al-Biltagi, Nermin Kamal Saeed, Hosameldin A. Bediwy, Reem Elbeltagi
Summary: Pleural effusion is common in ICU patients and its diagnosis and management are important. There are difficulties in diagnosing pleural effusion in ICU patients due to clinical, radiological, and laboratory challenges. Pleural effusion can impact patient prognosis and outcome, and pleural effusion drainage can modify clinical outcomes.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Endocrinology & Metabolism
Reem Elbeltagi, Mohammed Al-Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy
Summary: Breast milk is the best nutritional source for neonates and infants, providing protection against metabolic diseases and promoting intelligence and mental development. It also benefits mothers by preventing obesity and type 2 diabetes. However, further research is needed to fully understand the effects of breastfeeding on infants of diabetic mothers.
WORLD JOURNAL OF DIABETES
(2023)
Review
Gastroenterology & Hepatology
Reem Elbeltagi, Mohammed Al-Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy, Osama Toema
Summary: Since March 31, 2022, there has been an increasing number of previously healthy children experiencing acute hepatitis of unknown origin. This syndrome is characterized by jaundice and significantly elevated liver enzymes. A literature review revealed that the median age is 4 years with a male predominance. Common symptoms include jaundice, vomiting, anorexia, diarrhea, abdominal pain, pyrexia, pale stool, and dark urine. Adenoviruses and SARS-CoV-2 were detected in many patients, suggesting a possible underlying mechanism.
WORLD JOURNAL OF HEPATOLOGY
(2023)
Article
Pediatrics
Sanaa Shaaban, Mohammed Al-Beltagi, Omnia El Rashidy, May Nassar, Yasmin El Gendy
Summary: This article presents a ketogenic diet algorithm developed by experts at Children's Hospital, Ain Shams University, Egypt, for the treatment of drug-resistant epilepsy in children. The algorithm has been proven to be highly influential in facilitating the implementation of the ketogenic diet and resulted in significant health benefits for pediatric patients.
FRONTIERS IN PEDIATRICS
(2023)
Editorial Material
Pediatrics
Zoi Dorothea Pana, Mortada El-Shabrawi, Muhammad Ashraf Sultan, Thomas Murray, Anggraini Alam, Vijay Yewale, Dhanya Dharmapalan, Jonanthan D. Klein, Joseph Haddad, Naveen Thacker, Aman B. Pulungan, Adamos Hadjipanayis
BMJ PAEDIATRICS OPEN
(2023)
Article
Pediatrics
Shaimaa Sayed, Mortada H. F. El-Shabrawi, Eman Abdelmonaem, Nehal El Koofy, Sara Tarek
Summary: This study compared four nutritional screening tools and anthropometry measurements, and found that STRONGkids had the highest sensitivity for detecting malnutrition, followed by STAMP, PYMS had the lowest sensitivity but highest specificity, and SGNA had higher sensitivity but lower specificity. The study concluded that nutritional screening tools are valuable and recommended for assessing the nutritional status of children.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Article
Medicine, General & Internal
Aysha Fakhroo, Marya Al-Hammadi, Latifa Fakhroo, Fatima Al -Ali, Rania Snobar, Mohammed Al- Beltagi, Amer Kamal
Summary: This study aimed to evaluate the neuroprotective effects of vitamin B12 injection on PTZ-induced rats. The results showed that vitamin B12 pre-treatment alleviates the seizure occurrence among PTZ-kindled rat models, suggesting that vitamin B12 is a potential strategy and treatment for epilepsy and other related epileptogenesis activities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Pediatrics
Gihan Ahmed Sobhy, Mortada El-Shabrawi, Heba Safar
Summary: This study aimed to assess the quality of life of children with GSD and their parents and determine the impact of myopathies. The results showed that GSDs alter children and their parents' mental and physical abilities, with lower QoL scores detected in children with myopathies.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2022)
Review
Nutrition & Dietetics
Mohammed Al-Biltagi, Wafaa Faysal, Fatoumah Alabdulrazzaq, Hassan Alsabea, Ziad Bassil, Fadi Chamseddine, Imad Chokr, Ahmed El-Beleidy, Mostafa Ezzat, Antoine Farrah, Mohammad Mizyed, Ashraf Othman Saleh Sayed, Hussam Abu Talib, Yasser Wali
Summary: The transition of foods and suboptimal diets during toddlerhood in the Middle East lead to malnutrition and micronutrient deficiencies in children. A group of fourteen experts from the region reached a consensus on improving the nutritional status of toddlers, highlighting the relevance of young child formula (YCF) and other strategies such as fortified cow's milk, cereals, and vitamin supplements. This consensus aims to serve as a guide to healthcare professionals and parents in addressing the nutritional balance in young children.
JOURNAL OF NUTRITIONAL SCIENCE
(2022)
