Article
Multidisciplinary Sciences
Jeth WeiQuan Chng, Tamilsalvan Parvathi, Junxiong Pang
Summary: This study compared the knowledge, attitudes, and practices scores between dengue sustained hotspots (SHS) and non-sustained hotspots (NSHS), and identified factors associated with dengue prevention among SHS residents in Singapore. The findings showed that there were no significant differences in the mean scores for knowledge, attitudes, and practices between SHS and NSHS. However, certain factors such as age, ethnicity, education level, housing type, and healthcare-seeking behavior were associated with SHS and may influence the risk of dengue transmission in residential areas.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Ruixue Hou, Lewis E. Tomalin, Jessica Pintado Silva, Seunghee Kim-Schulze, Stephen S. Whitehead, Ana Fernandez-Sesma, Anna P. Durbin, Mayte Suarez-Farinas
Summary: Understanding the immune response to dengue virus is crucial for dengue vaccine development. This study showed that the tetravalent vaccine has better protective effects against DENV compared to the trivalent admixture. Additionally, differences in immune responses between Black and White participants were observed.
Article
Chemistry, Analytical
Pei-Shan Tsai, Pin-Xian Du, Batuhan Birol Keskin, Nan-Yao Lee, Shu-Wen Wan, Ya-Lan Lin, Wen-Yu Su, Pei-Chun Lin, Wei-Hsun Lin, Hsi-Chang Shih, Tzong-Shiann Ho, Guan-Da Syu
Summary: This study aims to analyze the humoral immunity and cross-reactivity in dengue patients using a multiplexed protein microarray. The results show that patients with severe dengue have higher levels of IgG antibodies against multiple Flavivirus antigens. Logistic regression analysis identifies groups of markers that can effectively distinguish dengue patients from healthy controls and hospitalized patients from mild cases.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Felipe Dzul-Manzanilla, Fabian Correa-Morales, Azael Che-Mendoza, Jorge Palacio-Vargas, Gustavo Sanchez-Tejeda, Jesus F. Gonzalez-Roldan, Hugo Lopez-Gatell, Adriana E. Flores-Suarez, Hector Gomez-Dantes, Giovanini E. Coelho, Haroldo S. da Silva Bezerra, Norma Pavia-Ruz, Audrey Lenhart, Pablo Manrique-Saide, Gonzalo M. Vazquez-Prokopec
Summary: The study identified persistent Aedes-borne disease hotspots in cities across southern Mexico, accounting for 17.6% of the total area, 25.6% of the population, and 32.1% of all Aedes-borne disease cases. There was an overlap of 61.7% for dengue and Zika hotspots, and 53.3% for dengue and chikungunya hotspots. Significant associations were found between dengue hotspots in 2008-2016 and those in 2017-20 in five of the nine cities.
LANCET PLANETARY HEALTH
(2021)
Article
Multidisciplinary Sciences
Aloisio S. Nascimento Filho, Thiago B. Murari, Paulo Ferreira, Hugo Saba, Marcelo A. Moret
Summary: The study investigated the spread of dengue in the Brazilian dry climate region of Bahia from 2000 to 2009 through a multiscale statistical analysis. Results showed significant and persistent cross-correlation between most economic regions, suggesting that economic regions or climatic conditions are not statistically significant in the spread of dengue in Bahia. The study's main contribution lies in revealing multiple aspects related to the propagation of dengue in dry climate regions through cross-correlation analysis.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Jaime E. Castellanos, Nayeli Jaimes, Carolina Coronel-Ruiza, Juan Pablo Rojas, Luis F. Mejia, Victor H. Villarreal, Luz E. Maya, Luz M. Claros, Cielo Orjuela, Eliana Calvo, Maria Victoria Munoz, Myriam L. Velandia-Romero
Summary: A study conducted in a pediatric clinic in Cali, Colombia, identified CHIKV as the arbovirus causing febrile cases in children, potentially leading to double infections. The results emphasize the importance of clinical tests to determine the arbovirus involved in infectious diseases for better treatment and surveillance.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Yihong Wan, Wenyu Wu, Jiawen Zhang, Liren Li, Yuanda Wan, Xiaodong Tang, Xiaoguang Chen, Shuwen Liu, Xingang Yao
Summary: The new drug tenovin-1 shows promising potential in treating dengue virus infection by significantly inhibiting viral replication and inflammatory response. By targeting SIRT2, tenovin-1 exerts its antiviral effects with specificity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Muhammad Bilal Khan, Zih-Syuan Yang, Chih-Yen Lin, Ming-Cheng Hsu, Aspiro Nayim Urbina, Wanchai Assavalapsakul, Wen-Hung Wang, Yen-Hsu Chen, Sheng-Fan Wang
Summary: Dengue is a disease caused by dengue virus infection, and its clinical manifestations vary. Currently, there is a lack of effective antiviral drugs and vaccines, so it is necessary to study the virus characteristics, epidemiology, and develop treatment and control strategies.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Immunology
Andrew G. Letizia, Catherine B. Pratt, Michael R. Wiley, Anne T. Fox, Mba Mosore, Bright Agbodzi, Clara Yeboah, Selassie Kumordjie, Nicholas Di Paola, Kone Cisse Assana, David Coulidiaty, Casimir Ouedraogo, Joseph H. Kofi Bonney, William Ampofo, Zekiba Tarnagda, Lassana Sangare
Summary: Through next-generation sequencing of samples from the 2017 DENV outbreak in Burkina Faso, 29 DENV genomes were isolated, showing the endemic nature of DENV-2 in the region. Discordant diagnostic results were observed, likely due to genetic divergence between these genomes.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Chathurani Sigera, Chaturaka Rodrigo, Nipun L. de Silva, Praveen Weeratunga, Deepika Fernando, Senaka Rajapakse
Summary: This study aimed to characterize the direct costs of managing hospitalized patients with suspected dengue infection in Sri Lanka. The findings suggest that confirming dengue diagnosis using subsidized tests for patients presenting in the first three days of fever may be cost-efficient, as non-dengue patients incur a similar cost per day as dengue patients.
Article
Infectious Diseases
Olivier Maillard, Jeanne Belot, Thibault Adenis, Olivier Rollot, Antoine Adenis, Bertrand Guihard, Patrick Gerardin, Antoine Bertolotti
Summary: This study aimed to evaluate the performance of the SD Bioline Dengue Duo rapid diagnostic test in adults consulting at an emergency department during the 2019 epidemic. The results showed that the test had a sensitivity of 42% and a specificity of 15%, indicating that it did not achieve sufficient performance levels for early dengue diagnosis in this setting.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Medicine, General & Internal
Ralph Huits, Kristina M. Angelo, Bhawana Amatya, Sapha Barkati, Elizabeth D. Barnett, Emmanuel Bottieau, Hannah Emetulu, Loic Epelboin, Gilles Eperon, Line Medebb, Federico Gobbi, Martin P. Grobusch, Oula Itani, Sabine Jordan, Paul Kelly, Karin Leder, Marta Diaz-Menendez, Nobumasa Okumura, Aisha Rizwan, Camilla Rothe, Mauro Saio, Jesse Waggoner, Yukihiro Yoshimura, Michael Libman, Davidson H. Hamer, Eli Schwartz
Summary: This study retrospectively analyzed the cases of severe dengue or dengue with warning signs among international travelers reported to GeoSentinel from 2007 to 2022. The incidence of complicated dengue was relatively low in travelers. Clinicians should closely monitor patients with dengue for warning signs of severe disease.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Lina Tian, Chumin Liang, Xiaorong Huang, Zhe Liu, Juan Su, Chuan Guo, Guanghu Zhu, Jiufeng Sun
Summary: In this study, the genomic epidemiology of a dengue outbreak in Shantou, China in 2019 was investigated using whole-genome sequencing. The outbreak lasted from July to December, with a total of 944 confirmed cases and no gender bias or fatalities. Multiple introductions and internal transmission were observed, highlighting the importance of genomic epidemiology in real-time monitoring of disease outbreaks.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Endocrinology & Metabolism
Alexandre Giannecchini Romagnolo, Karina Inacio Carvalho
Summary: Dengue virus causes dengue fever, transmitted by Aedes aegypti mosquito, with severe symptoms that can disable individuals for weeks. Due to global warming, the vector mosquito will spread to new areas, exposing more people to the disease in the coming decades. Despite the severity of the disease, there are currently no treatments or efficient vaccines available. Metabolomic studies provide a new perspective to understand dengue fever at a molecular level, showing significant changes in metabolites but with some conflicting results. Overall, metabolomic approaches prove to be an excellent and viable way to expand knowledge about dengue fever.
Article
Environmental Sciences
Jessica B. Oliveira, Thiago B. Murari, Aloisio S. Nascimento Filho, Hugo Saba, Marcelo A. Moret, Claudia Andrea L. Cardoso
Summary: This study evaluated the effect of sanitation on the cross-correlation between rainfall and the first symptoms of dengue fever. Results showed that the cross-correlation between rain and dengue increased as the city implemented actions to improve basic sanitation. The study suggests that cities with improved sanitation have a high correlation between dengue fever and annual precipitation, and prevention and control policies can be targeted accordingly.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Critical Care Medicine
Damon P. Eisen, Karin Leder, Robyn L. Woods, Jessica E. Lockery, Sarah L. McGuinness, Rory Wolfe, David Pilcher, Elizabeth M. Moore, Adithya Shastry, Mark R. Nelson, Christopher M. Reid, John J. McNeil, Emma S. McBryde
Summary: The study found that daily low-dose aspirin treatment did not reduce deaths associated with sepsis in community dwelling older adults. The findings do not support the use of aspirin as a primary prevention strategy to reduce the burden of sepsis in this population.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Virology
Naomi Komadina, Sheena G. Sullivan, Karin Leder, Jodie McVernon
Summary: Swine flu outbreaks pose potential threats to human public health, with documented cases of swine-origin influenza infecting humans since the emergence of swine-origin H1N1 in 2009. An analysis of historical influenza viruses revealed evidence of prior circulation of H3N2v NP and M1 immunogenic peptides, which could provide insight into the emergence of influenza viruses and inform immunogenic peptide selection for vaccines inducing cytotoxic T-cell-mediated immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Daniel P. Forster, Karin Leder
Summary: Typhoid fever risk is significant for Australian travelers to endemic regions, with immigrants returning to their country of birth at higher risk. These findings aid clinicians and public health officials in planning pre-travel vaccination strategies for at-risk individuals and groups.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Donna M. Urquhart, Jeffrey Rosenfeld, Maurits van Tulder, Anita E. Wluka, Karin Leder, Allen C. Cheng, Andrew B. Forbes, Patrick Chan, Richard O'Sullivan, Susan Liew, Flavia M. Cicuttini
Summary: This study aims to investigate the efficacy of antibiotic treatment for chronic low back pain and determine which patient subgroup is most likely to benefit. One hundred and seventy individuals with chronic low back pain will be recruited and randomly allocated to receive antibiotics or placebo, with outcomes assessed at 12 months.
Article
Environmental Sciences
Sarah L. McGuinness, Josphin Johnson, Owen Eades, Peter A. Cameron, Andrew Forbes, Jane Fisher, Kelsey Grantham, Carol Hodgson, Peter Hunter, Jessica Kasza, Helen L. Kelsall, Maggie Kirkman, Grant Russell, Philip L. Russo, Malcolm R. Sim, Kasha P. Singh, Helen Skouteris, Karen L. Smith, Rhonda L. Stuart, Helena J. Teede, James M. Trauer, Andrew Udy, Sophia Zoungas, Karin Leder
Summary: The study found that Australian healthcare workers employed in 2021 experienced poor mental health outcomes, with prevalence differences observed according to occupation. Longitudinal evidence is needed to guide the implementation of effective measures to support the physical and mental wellbeing of healthcare workers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Bethany Cooper, Erica Donner, Lin Crase, Hamish Robertson, David Carter, Michael Short, Barbara Drigo, Karin Leder, Anne Roiko, Kelly Fielding
Summary: This paper systematically reviews the processes of building and maintaining the social license to operate wastewater monitoring. It explores the relationship between different stakeholder communities and offers a dynamic model to guide researchers and practitioners.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Public, Environmental & Occupational Health
Jordan Akritidis, Sarah L. McGuinness, Karin Leder
Summary: This study aimed to describe the factors influencing risk-taking willingness, risk perceptions, and future health-seeking intention among student travelers. The study found that willingness to take risks was influenced by factors such as age, nationality, travel experience, and perception of COVID-19 risk. Risk perception was influenced by factors such as age, perception of COVID-19 risk, and intention to seek travel advice in the future.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Sarah L. McGuinness, Johnson Josphin, Owen Eades, Sharon Clifford, Jane Fisher, Maggie Kirkman, Grant Russell, Carol L. Hodgson, Helen L. Kelsall, Riki Lane, Helen Skouteris, Karen L. Smith, Karin Leder
Summary: This study provides in-depth insights into the challenges and successes of organizational responses across four healthcare settings in Melbourne, Australia during the COVID-19 pandemic. Future efforts should focus on bidirectional communication, strengthening and sustaining the healthcare workforce, and investing in flexible and meaningful psychological support and wellbeing initiatives for HCWs.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Watcharapong Piyaphane, Rhett J. Stoney, Hilmir Asgeirsson, Grace D. Appiah, Marta Diaz-Menendez, Elizabeth D. Barnett, Philippe Gautret, Michael Libman, Patricia Schlagenhauf, Karin Leder, Katherine Plewes, Martin P. Grobusch, Ralph Huits, Kunjana Mavunda, Davidson H. Hamer, Lin H. Chen
Summary: International travellers may seek healthcare during their trip or plan healthcare abroad. The study indicates that many travellers encounter health problems during travel that could be prevented and managed through pre-travel consultations.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Medicine, General & Internal
Stacey L. Rowe, Karin Leder, Kylie Dyson, Lalitha Sundaresan, Dennis Wollersheim, Brigid Lynch, Ifrah Abdullahi, Benjamin C. Cowie, Nicola Stephens, Terence M. Nolan, Sheena G. Sullivan, Brett Sutton, Allen C. Cheng
Summary: This study aimed to assess the associations between SARS-CoV-2 infection and the increased hospitalisation rates for respiratory and non-respiratory conditions. The results showed that SARS-CoV-2 infection was associated with higher hospitalisation rates for conditions such as myocarditis, thrombocytopenia, pulmonary embolism, acute myocardial infarction, and cerebral infarction.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Editorial Material
Public, Environmental & Occupational Health
Sarah L. McGuinness, Colleen L. Lau, Karin Leder
Summary: The recent outbreak of Japanese encephalitis in southeastern Australia highlights the changing epidemiology of this disease and the importance of integrated surveillance to inform risk-based discussions and vaccination recommendations for travelers and local populations.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Asma Sohail, Jordan Akritidis, Sarah McGuinness, Karin Leder
Summary: This study investigates the impact of the COVID-19 pandemic on travel risk perceptions and pre-travel healthcare attendance among university students. The results show that students' risk perceptions regarding travel-related illnesses are influenced by past experiences, travel destination, vaccination status, and knowledge. Barriers to seeking pre-travel advice include a lack of perceived need and concerns about accessibility/availability, while potential benefits include reduced health risks, vaccine-induced protection, and knowledge gain. Recommendations are provided to improve students' engagement in pre-travel advice.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Helen Louise Kelsall, Michael F. Di Donato, Sarah Mcguinness, Alex Collie, Shannon Zhong, Owen Eades, Malcolm Ross Sim, Karin Leder
Summary: This study aims to analyze and describe workers' compensation claims of healthcare and other industries during the COVID-19 pandemic in Victoria, Australia. By comparing COVID-19 infection claims and rates by industry and occupation, and considering the epidemiology of COVID-19 in Victoria, the study found that industry, occupation, severity, and timing have an impact on COVID-19 infection claims.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Environmental Sciences
Rachael Lappan, Rebekah Henry, Steven L. Chown, Stephen P. Luby, Ellen E. Higginson, Lamiya Bata, Thanavit Jirapanjawat, Christelle Schang, John J. Openshaw, Joanne O'Toole, Audrie Lin, Autiko Tela, Amelia Turagabeci, Tony H. F. Wong, Matthew A. French, Rebekah R. Brown, Karin Leder, Chris Greening, David McCarthy
Summary: Both TAC and qPCR methods showed similar performance in detecting and quantifying enteropathogens in non-inhibited samples, but PCR inhibitors could substantially affect detection via TAC.
LANCET PLANETARY HEALTH
(2021)
Letter
Public, Environmental & Occupational Health
Daniel Griffiths, Karin Leder, Alex Collie
HEALTH PROMOTION JOURNAL OF AUSTRALIA
(2021)
