Review
Biochemistry & Molecular Biology
Thembaninkosi G. Gaule, Ramzi A. Ajjan
Summary: Fibrinogen plays a crucial role in blood clotting, with alterations in its structure or incorporation of antifibrinolytic proteins potentially leading to unstable or persistent clots, increasing the risk of bleeding or thrombosis. Understanding fibrinogen function can help in developing effective therapies to modulate clotting and bleeding risk while maintaining the delicate balance between clot formation and lysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Margot DeBot, Andrew P. Eitel, Ernest E. Moore, Angela Sauaia, Patrick Lutz, Terry R. Schaid, Jamie B. Hadley, Daniel J. Kissau, Mitchell J. Cohen, Marguerite R. Kelher, Christopher C. Silliman
Summary: The study found that patients with blood type O have an increased risk of bleeding and coagulation disorders after trauma, which is associated with lower von Willebrand factor activity.
Article
Biochemistry & Molecular Biology
Oriol Bosch-Sanz, Yvette Rabada, Xevi Biarnes, Javier Pedreno, Luis Caveda, Mercedes Balcells, Jordi Martorell, David Sanchez-Garcia
Summary: Fibrinolysis is a natural process that removes fibrin deposits to ensure blood fluidity. Excessive fibrinolytic activity can cause complications in surgery or trauma. Current antifibrinolytic drugs require high doses and have side effects, limiting their use in patients with renal impairment. This study synthesized a series of compounds and identified a candidate with higher specificity and lower dosage. Molecular docking and dynamics analysis revealed the importance of 1,2,3-triazole in the activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Julia R. Coleman, Ernest E. Moore, Marguerite R. Kelher, Kenneth Jones, Mitchell J. Cohen, Anirban Banerjee, Christopher C. Silliman
Summary: This study revealed that thrombin-activatable fibrinolysis inhibitor (TAFI) plays a major role in fibrinolysis shutdown after trauma-induced coagulopathy.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Critical Care Medicine
Michael A. Lawson, Lori A. Holle, Nathan E. Dow, Grant Hennig, Bas de Laat, Hunter B. Moore, Ernest E. Moore, Mitchell J. Cohen, Beth A. Bouchard, Kalev Freeman, Alisa S. Wolberg
Summary: Dehydration therapy can dissolve solid substances in water and selectively absorb drug and dye substances using the suction force of colloidal particles on paper.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Surgery
Gregory R. Stettler, Ernest E. Moore, Geoffrey R. Nunns, Marguerite Kelher, Anirban Banerjee, Christopher C. Silliman
Summary: The study found that no single blood component or volume of whole blood led to attenuation of tPA-mediated fibrinolysis in an in vitro model of TIC. Cryoprecipitate was the most effective at improving coagulation function.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Veterinary Sciences
N. E. Sigrist, L. Langenegger, R. Jud Schefer, K. Kluge, A. P. N. Kutter
Summary: This retrospective study investigated the effect of tranexamic acid on ongoing bleeding in dogs with non surgically treated haemoabdomen. The results showed that antifibrinolytic therapy did not have a significant effect on stopping bleeding, suggesting the involvement of other mechanisms.
SCHWEIZER ARCHIV FUR TIERHEILKUNDE
(2022)
Article
Critical Care Medicine
Christina Creel-Bulos, Sara C. Auld, Mark Caridi-Scheible, Nicholas A. Barker, Sarah Friend, Manila Gaddh, Christine L. Kempton, Cheryl L. Maier, Fadi Nahab, Roman Sniecinski
Summary: The COVID-19 pandemic has led to serious complications including systemic inflammation, organ dysfunction, and thromboembolic disease. Within the institution, a study on critically ill patients found a high prevalence of fibrinolysis shutdown among those who experienced thrombotic events. This suggests the potential benefit of using viscoelastic testing to identify patients who may benefit from fibrinolytic therapy.
Article
Medicine, General & Internal
Yan Wang, Jinwei Xie, Fuxing Pei
Summary: Perioperative bleeding in total hip and knee arthroplasty is associated with postoperative hyperfibrinolysis caused by surgical trauma. D-dimer and fibrin (ogen) degradation products are effective and practical markers for predicting acute postoperative fibrinolytic activity, which peaks at 6 hours after surgery and lasts for at least 24 hours.
Article
Medicine, General & Internal
Satoshi Gando, Atsushi Shiraishi, Takeshi Wada, Kazuma Yamakawa, Seitaro Fujishima, Daizoh Saitoh, Shigeki Kushimoto, Hiroshi Ogura, Toshikazu Abe, Toshihiko Mayumi, Junichi Sasaki, Joji Kotani, Naoshi Takeyama, Ryosuke Tsuruta, Kiyotsugu Takuma, Shin-ichiro Shiraishi, Yasukazu Shiino, Taka-aki Nakada, Kohji Okamoto, Yuichiro Sakamoto, Akiyoshi Hagiwara, Satoshi Fujimi, Yutaka Umemura, Yasuhiro Otomo
Summary: Tranexamic acid (TXA) reduces the risk of bleeding trauma death without altering the need for blood transfusion. In the early stage of trauma, TXA inhibit fibrin(ogen)olysis, but it's not associated with a reduction in the transfusion volume.
Article
Emergency Medicine
Gregory R. Stettler, Ernest E. Moore, Geoffrey R. Nunns, Hunter B. Moore, Benjamin R. Huebner, Christopher C. Silliman, Anirban Banerjee, Angela Sauaia
Summary: This study investigated the association between blood alcohol levels and fibrinolysis in trauma patients, finding that high alcohol consumption is linked to an increased incidence of fibrinolysis shutdown, which may impact post-injury hemostatic resuscitation strategies.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Akriti Rastogi, Ellis Ferguson, Michela Donnarumma, Nicola J. Mutch
Summary: This study compared the efficacy of cryoprecipitate and two fibrinogen concentrates in restoring clot integrity in a trauma-induced coagulopathy (TIC) model. Results showed that FibCLOT(R) was superior in normalizing clot structure and stabilizing clots against mechanical and fibrinolytic degradation compared to the other treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Stanislas Grassin-Delyle, Haleema Shakur-Still, Roberto Picetti, Lauren Frimley, Heather Jarman, Ross Davenport, William McGuinness, Phil Moss, Jason Pott, Nigel Tai, Elodie Lamy, Saik Urien, Danielle Prowse, Andrew Thayne, Catherine Gilliam, Harvey Pynn, Ian Roberts
Summary: The study demonstrates that intramuscular TXA is well tolerated and rapidly absorbed in bleeding trauma patients. A two-compartment open model best describes the pharmacokinetic characteristics of TXA, with therapeutic concentrations reached within 4 to 11 minutes for a 70-kg patient.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Hematology
Hunter B. Moore
Summary: Low fibrinolytic activity is associated with pathological thrombosis and multiple-organ failure. There are two commonly associated terms, hypofibrinolysis and fibrinolysis shutdown, to describe this condition. However, these terms are often used interchangeably in describing critically ill patients, leading to confusion in understanding the underlying disease processes. The lack of research on the cellular mediators of these processes further complicates the issue. This article aims to review the mechanisms of fibrinolysis in the context of low fibrinolytic states and emphasize the importance of differentiating hypofibrinolysis from fibrinolysis shutdown.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Anesthesiology
Christian Fenger-Eriksen, Mads Rasmussen, Niels Juul, Jan Krog, Anne-Mette Hvas
Summary: TXA administration with low-dose regimen during craniosynostosis surgery did not change any of the 92 inflammatory markers compared with placebo. However, significant changes reflecting immune activation were observed during surgical stress.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2021)