Article
Gastroenterology & Hepatology
Xin Quan, Xiuling Ye, Shuaijie Qian, Bo Wei, Huan Tong, Zhidong Wang, Yang Tai, Xu Guo, Jinhang Gao, Hao Wu
Summary: In this retrospective study, we investigated the association between platelet-fibrin clot strength, platelet activation, and portal vein thrombosis in decompensated cirrhosis. The results showed that patients with portal vein thrombosis had significantly lower platelet counts, and higher platelet-fibrin clot strength was independently associated with portal vein thrombosis. Additionally, collagen-induced platelet aggregation and plasma concentration of soluble p-selectin were significantly higher in patients with portal vein thrombosis.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Cell Biology
Wayne T. Muraoka, Prajeeda M. Nair, Daniel N. Darlington, Xiaowu Wu, James A. Bynum, Andrew P. Cap
Summary: This study describes a 96-well-based clot retraction assay that allows for rapid measurement of platelet function and provides quantitative information. The assay is robust to different calcium concentrations and can predict factors affecting platelet function.
Article
Pharmacology & Pharmacy
Gi Suk Nam, Soyoung Kim, Yun-Suk Kwon, Min-Kyung Kim, Kyung-Soo Nam
Summary: MAP4K4 inhibitors reduce thrombus formation by regulating platelet activation, showing potential for the treatment of thrombosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Anesthesiology
Andrew Maslow, Tracey Cheves, Maurice Frankie Joyce, Patricia Apruzzese, Joseph Sweeney
Summary: This study aimed to explore the relationship between platelet concentration (PLT) and clot strength measured by thromboelastography maximum amplitude (TEG-MA) in healthy volunteers. The results showed a positive correlation between PLT and TEG-MA, with a linear relationship below 90x10^9/L and a plateau above 90x10^9/L. There was also a positive correlation between fibrinogen concentration and TEG-MA.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Hematology
Cecilia Karlstrom, Gunilla Gryfelt, Laurent Schmied, Stephan Meinke, Petter Hoglund
Summary: Prophylactic platelet transfusion is common in severely thrombocytopenic patients, but responses are variable and difficult to predict. This study found that corrected count increment (CCI) varied greatly among patients, and factors like time since last transfusion and storage time of PLT products affected transfusion response. Furthermore, the study suggests that the thrombocytopenic environment or disease-associated factors may hinder platelet responsiveness.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Yueyi Sun, Oluwamayokun Oshinowo, David R. Myers, Wilbur A. Lam, Alexander Alexeev
Summary: Blood clot contraction plays a crucial role in wound healing and hemostasis. This study investigates the relationship between single platelet forces and macroscopic clot forces, providing insights into blood disorders associated with bleeding and thrombosis. The findings contribute to the development of platelet-based biomaterials and facilitate the understanding of clotting mechanisms.
Article
Biochemistry & Molecular Biology
Daniel Gao, Caroline W. Sun, Angela B. Woodley, Jing-fei Dong
Summary: Clot retraction, which requires the functional platelet alpha(IIb)beta(3) integrin, is an important measure of platelet function and can be used to detect functional changes in platelets. Platelet counts and the surface density of the integrin alpha(IIb)beta(3) affect clot retraction.
Article
Chemistry, Multidisciplinary
Bin Liu, Francesca Victorelli, Yu Yuan, Yi Shen, Hui Hong, Guohua Hou, Shuang Liang, Zekun Li, Xin Li, Xindi Yin, Fazheng Ren, Yuan Li
Summary: Thrombotic diseases pose a serious threat to public health, and current thrombolytic drugs have low efficiency. Therefore, a modified platelet membrane-cloaked nanotube system is developed to enhance thrombolytic efficiency. The system demonstrates excellent clot-penetration properties and reduces drug side effects.
Review
Biochemistry & Molecular Biology
Vance G. Nielsen, Tanner Goff, Brent D. Hunsaker, Coulter D. Neves
Summary: This narrative review highlights the importance of the processes of blood coagulation and fibrinolysis in maintaining the integrity of the circulatory system and fluidity of its contents, and sheds light on the underappreciated impact of metals on these processes. Through in vitro and in vivo investigations, the authors identify twenty-five metals that can modulate platelet activity, plasmatic coagulation, and fibrinolysis, and provide detailed insights into the molecular interactions between these metals and key cells and proteins of the hemostatic system. The review aims to serve as a comprehensive evaluation of the current understanding of metal interactions with the hemostatic system, and as a guide for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Yueyi Sun, David R. Myers, Svetoslav V. Nikolov, Oluwamayokun Oshinowo, John Baek, Samuel M. Bowie, Tamara P. Lambert, Eric Woods, Yumiko Sakurai, Wilbur A. Lam, Alexander Alexeev
Summary: Researchers discovered that platelets utilize a new emergent behavior, asynchrono-mechanical amplification, to enhance material contraction and magnify contractile forces. This behavior, triggered by the heterogeneity in the timing of a population of actuators, indicates that cell heterogeneity plays an essential biophysical function in cell-matrix biomaterials.
Article
Hematology
Karen P. Fong, Kathleen S. Molnar, Nicholas Agard, Rustem Litvinov, Oleg Kim, James A. Wells, John W. Weisel, William F. DeGrado, Joel S. Bennett
Summary: Blood clot contraction is driven by traction forces generated by the platelet cytoskeleton and regulated by integrin alpha IIb beta 3. Proteolytically cleaved platelet proteins, particularly talin and vinculin, play crucial roles in clot contraction. Calpain-mediated cleavage of these proteins occurs independent of cytoskeletal-generated tensile forces, suggesting calpain's involvement in later stages of clot retraction through focal adhesion disassembly.
Article
Thermodynamics
Hakon Selvnes, Yosr Allouche, Armin Hafner, Christian Schlemminger, Ignat Tolstorebrov
Summary: This paper presents the design and performance of a cold thermal energy storage (CTES) unit integrated into a refrigeration system. The experimental results show that using CO2 as the refrigerant and a commercial PCM as the storage medium in a plate heat exchanger achieves high charging and discharging performance.
APPLIED THERMAL ENGINEERING
(2022)
Article
Environmental Sciences
Kristian Svane, Peter Enevoldsen, George Xydis
Summary: The industrial cold stores can store thermal energy as passive thermal energy. They can contribute with flexible consumption by cooling further in periods of low-cost electricity. To fulfill the potential, data measurement is necessary to control the cold stores and ensure food safety. A case study showed that cooling further in periods of low-cost electricity could result in 30% savings, which could reach up to 40% with proper price forecasting. The full capacity of cold stores in Denmark can potentially use 2% of the average wind electricity production for thermal energy storage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Qi Yang, Angel Enriquez, Dillon Devathasan, Craig A. Thompson, Dillan Nayee, Ryan Harris, Douglas Satoski, Barnabas Obeng-Gyasi, Albert Lee, R. Timothy Bentley, Hyowon Lee
Summary: Maintaining the patency of indwelling drainage devices is crucial for preventing complications. Researchers have created a self-clearing catheter that can remove obstructive blood clots using magnetic fields. Experimental models and animal studies showed that these catheters have longer functionality, lower pressure, and better survival rates.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Konstanze Aurich, Jan Wesche, Martin Ulbricht, Oliver Otto, Andreas Greinacher, Raghavendra Palankar
Summary: The addition of 2-10 mM Mg2+ in platelet concentrates can prevent cytoskeleton changes caused by Ca2+ release and maintain the deformability of platelets. Furthermore, increasing Mg2+ concentration up to 10 mM can preserve the cytoskeletal integrity and biomechanical properties of platelets stored at low temperatures.
SCIENTIFIC REPORTS
(2022)
