Article
Oncology
Magdalena Rausch, Adriano Rutz, Pierre-Marie Allard, Celine Delucinge-Vivier, Mylene Docquier, Olivier Dormond, Paul J. Dyson, Jean-Luc Wolfender, Patrycja Nowak-Sliwinska
Summary: Drug combination screening was used to design a multidrug combination for treating sunitinib-resistant clear cell renal cell carcinoma, resulting in significant alterations in gene transcription related to apoptosis and metabolic pathways. The optimized multidrug combination showed strong upregulation of sphingolipids and demonstrated significant anti-cancer efficacy in ex vivo organoid-like cultures. The combination treatment maintained an efficacy of over 70%, indicating a promising mechanism of action for selectively targeting cancer cells in ccRCC.
Article
Medicine, General & Internal
Nikhil K. Khankari, Jacob M. Keaton, Venexia M. Walker, Kyung Min Lee, Megan M. Shuey, Shoa L. Clarke, Kent R. Heberer, Donald R. Miller, Peter D. Reaven, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Summary: This study evaluated several lipid control medications as potential therapeutic options for the prevention of type 2 diabetes (T2D), using tissue-specific predicted gene expression summary statistics in a two-sample Mendelian randomisation (MR) design. The results suggest that icosapent ethyl (IPE) may lower triglycerides and reduce the risk of T2D, while statins and PCSK-9 inhibitors (PCSK-9i) may lower LDL-C levels but are not associated with T2D susceptibility. Experimental validation and randomized control trials are needed to confirm these findings.
Article
Computer Science, Information Systems
Sothornin Mam, Duangdao Wichadakul, Peerapon Vateekul
Summary: Type 2 diabetes is a prevalent disease with no cure. Drug repurposing can discover new drugs by repositioning existing ones. Previous attempts were limited in performance, but a deep learning approach using graph neural networks shows promising results for link prediction.
Article
Multidisciplinary Sciences
Irati Macaya, Marta Roman, Connor Welch, Rodrigo Entrialgo-Cadierno, Marina Salmon, Alba Santos, Iker Feliu, Joanna Kovalski, Ines Lopez, Maria Rodriguez-Remirez, Sara Palomino-Echeverria, Shane M. Lonfgren, Macarena Ferrero, Silvia Calabuig, Iziar A. Ludwig, David Lara-Astiaso, Eloisa Jantus-Lewintre, Elizabeth Guruceaga, Shruthi Narayanan, Mariano Ponz-Sarvise, Antonio Pineda-Lucena, Fernando Lecanda, Davide Ruggero, Purvesh Khatri, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Irene Ferrer, Luis Paz-Ares, Matthias Drosten, Mariano Barbacid, Ignacio Gil-Bazo, Silve Vicent
Summary: Drug combinations are essential for overcoming resistance to targeted therapies in cancer treatment. By utilizing a gene signature-driven drug repurposing approach and a pairwise pharmacological screen, the authors identified a synergistic drug combination for KRAS-mutated lung adenocarcinoma. The combination treatment shows cytotoxic response and involves inhibition of the PKC inhibitor target AURKB.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Takeshi Tanaka, Takaharu Asano, Takehito Okui, Shiori Kuraoka, Sasha A. Singh, Masanori Aikawa, Elena Aikawa
Summary: Vascular calcification is a cardiovascular disorder with no therapeutic options. A recent study discovered that the existing drug niclosamide can inhibit vascular calcification by suppressing the CROT pathway, indicating its potential as a non-invasive treatment option for this condition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Rebwar Saeed M. Rashid, Selin Temurlu, Arwa Abourajab, Pelin Karsili, Meltem Dinleyici, Basma Al-Khateeb, Huriye Icil
Summary: Type 2 diabetes can be controlled by inhibiting alpha-glucosidase, but current drugs have limitations. This study explored repurposing FDA-approved drugs and identified Trabectedin and Demeclocycline as potential inhibitors for alpha-glucosidase, showing promise for repurposing against type 2 diabetes.
Article
Biochemistry & Molecular Biology
Jisu Oh, Hyeon Hae Lee, Yunhui Jeong, Siyeong Yoon, Hyun-Ju An, Minjung Baek, Do Kyung Kim, Soonchul Lee
Summary: Inadequate vessel maintenance or growth can lead to ischemia in diseases like myocardial infarction and stroke. Developing new compounds to salvage ischemic tissues is urgent, with drug repurposing and computational virtual screening playing key roles in efficient and cost-effective drug discovery. This study successfully identified ellipticine as a pro-angiogenic substance through virtual computational methods and demonstrated its efficacy at a sublethal dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Yuan Liu, Ziwen Tong, Jingru Shi, Ruichao Li, Mathew Upton, Zhiqiang Wang
Summary: Antimicrobial resistance poses a global health challenge, but a combination of antibiotics and non-antibiotic compounds offers an effective strategy. A pathogen-by-pathogen approach highlights the critical value of drug repurposing.
Article
Chemistry, Medicinal
Henry R. O'Donnell, Tia A. Tummino, Conner Bardine, Charles S. Craik, Brian K. Shoichet
Summary: This study reveals that many drugs repurposed for combating COVID-19 in biochemical assays are actually artifacts, and suggests that even drugs can act artifactually via colloidal aggregation at screening-relevant concentrations.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Biochemistry & Molecular Biology
Abbas Khan, Syed Shujait Ali, Muhammad Tahir Khan, Shoaib Saleem, Arif Ali, Muhammad Suleman, Zainib Babar, Athar Shafiq, Mazhar Khan, Dong-Qing Wei
Summary: The current coronavirus pandemic has raised concerns about the modern public health care system, with a total of 4,434,653 confirmed cases and 302,169 deaths reported. A study combining drug repurposing and virtual drug screening strategies identified potential inhibitors targeting 3CLpro, including Saquinavir and five drugs from the Traditional Chinese Medicine database. Molecular dynamics simulation and total binding free energy results showed promising hits that should be tested experimentally against SARS-COV-2.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Pharmacology & Pharmacy
Daniel P. Smith, Olly Oechsle, Michael J. Rawling, Ed Savory, Alix M. B. Lacoste, Peter John Richardson
Summary: The study utilized a visual analytics workflow that combined computational tools and human expertise to quickly screen for drugs suitable for treating COVID-19, identifying the rheumatoid arthritis drug baricitinib as an effective treatment. This finding was supported by data from randomized trials and emergency approval by the FDA.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
Marco Greco, Anas Munir, Debora Musaro, Chiara Coppola, Michele Maffia
Summary: Parkinson's disease is a pathological condition characterized by protein aggregation, and type 2 diabetes may be one of its etiological factors as it alters biological processes such as autophagy and mitochondrial homeostasis.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Linong Ji, Juliana C. N. Chan, Miao Yu, Kun Ho Yoon, Sin Gon Kim, Sung Hee Choi, Chien-Ning Huang, Shih Te Tu, Chih-Yuan Wang, Paivi Maria Paldanius, Wayne H. H. Sheu
Summary: Type 2 diabetes in the East Asian population is characterized by low BMI, beta-cell dysfunction, and high body fat percentage, leading to early onset of the disease and increased risk of stroke and renal disease. Early combination therapy is recommended for better glycemic control in East Asian patients with T2D.
DIABETES OBESITY & METABOLISM
(2021)
Review
Multidisciplinary Sciences
Ana Salome Correia, Fatima Gartner, Nuno Vale
Summary: Cancer is a highly complex set of diseases, with breast cancer being particularly prevalent among women. Despite recent advancements, treatment for cancer remains challenging, leading to costly and intensive research. Drug repurposing and combinations are emerging strategies that show promise in improving therapy outcomes and reducing associated costs.
Article
Biochemistry & Molecular Biology
Ling Jin, Tingting Guo, Zhixin Li, Zhen Lei, Hui Li, Yiqing Mao, Xi Wang, Na Zhou, Yizhuang Zhang, Ruobi Hu, Xuehui Zhang, Gang Niu, David M. Irwin, Huanran Tan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2015)
Article
Peripheral Vascular Disease
Ling Jin, Xianjuan Lin, Lei Yang, Xiaofang Fan, Wenjie Wang, Shuangyue Li, Jing Li, Xiaoyan Liu, Minghui Bao, Xiao Cui, Jichun Yang, Qinghua Cui, Bin Geng, Jun Cai
Article
Multidisciplinary Sciences
Xiao Cui, Lei Ye, Jing Li, Ling Jin, Wenjie Wang, Shuangyue Li, Minghui Bao, Shouling Wu, Lifeng Li, Bin Geng, Xin Zhou, Jian Zhang, Jun Cai
SCIENTIFIC REPORTS
(2018)
Review
Biochemistry & Molecular Biology
Ling Jin, Qirui Song, Weili Zhang, Bin Geng, Jun Cai
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Cardiac & Cardiovascular Systems
Hui Li, Xi Wang, Yiqing Mao, Ruobi Hu, Wei Xu, Zhen Lei, Na Zhou, Ling Jin, Tingting Guo, Zhixin Li, David M. Irwin, Gang Niu, Huanran Tan
CARDIOVASCULAR DIABETOLOGY
(2014)
Article
Genetics & Heredity
Rongjing Song, Xi Wang, Yiqing Mao, Hui Li, Zhixin Li, Wei Xu, Rong Wang, Tingting Guo, Ling Jin, Xiaojing Zhang, Yizhuang Zhang, Na Zhou, Ruobi Hu, Jianwei Jia, Zhen Lei, David M. Irwin, Gang Niu, Huanran Tan
Article
Biochemistry & Molecular Biology
Wei Xu, Hui Li, Rong Wang, Zhen Lei, Yiqing Mao, Xi Wang, Yizhuang Zhang, Tingting Guo, Rongjing Song, Xiaojing Zhang, Ling Jin, Zhixin Li, David M. Irwin, Gang Niu, Huanran Tan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Article
Multidisciplinary Sciences
Yi Wang, Tingting Guo, Shuyong Zhao, Zhixin Li, Yiqing Mao, Hui Li, Xi Wang, Rong Wang, Wei Xu, Rongjing Song, Ling Jin, Xiuli Li, David M. Irwin, Gang Niu, Huanran Tan
Article
Multidisciplinary Sciences
Xiaojing Zhang, Hui Li, Yiqing Mao, Zhixin Li, Rong Wang, Tingting Guo, Ling Jin, Rongjing Song, Wei Xu, Na Zhou, Yizhuang Zhang, Ruobi Hu, Xi Wang, Huakang Huang, Zhen Lei, Gang Niu, David M. Irwin, Huanran Tan
Article
Biochemistry & Molecular Biology
Yuanxu Gao, Weili Yang, Ling Jin, Lixiang Xue, Jichun Yang, Qinghua Cui
Article
Cardiac & Cardiovascular Systems
Xiaomin Song, Xuan Zou, Weipeng Ge, Cuiliu Hou, Zhujie Cao, Hongmei Zhao, Tiantian Zhang, Ling Jin, Yi Fu, Wei Kong, Chen Yan, Jun Cai, Jing Wang
Summary: The study revealed the significant role of IgG and its receptor in hypertension, suggesting a potential mechanism involving the suppression of AT1R internalization in smooth muscle cells. Fc gamma RIIB could be an innovative therapeutic target for hypertension, particularly for patients with autoimmune diseases.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Xiao Cui, Fang Qin, Lei Song, Tian Wang, Bin Geng, Weili Zhang, Ling Tin, Wenjie Wang, Shuangyue Li, Xinping Tian, Huimin Zhang, Jun Cai
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Na Wu, Ling Jin, Jun Cai
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2017)
