Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent

Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy

(2014) Giles W Robinson et al.   BMC CANCER

Vemurafenib-Induced Neutrophilic Panniculitis in a Child with a Brainstem Glioma

(2014) Emily S. West et al.   PEDIATRIC DERMATOLOGY

Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells

(2013) Christian Koelsche et al.   ACTA NEUROPATHOLOGICA

BRAFV600E mutation is a negative prognosticator in pediatric ganglioglioma

(2013) Sonika Dahiya et al.   ACTA NEUROPATHOLOGICA

Dysembryoplastic Neuroepithelial Tumors Share with Pleomorphic Xanthoastrocytomas and Gangliogliomas BRAFV600EMutation and Expression

(2013) Céline Chappé et al.   BRAIN PATHOLOGY

Pediatric Brainstem Gangliogliomas ShowBRAFV600EMutation in a High Percentage of Cases

(2013) Andrew M. Donson et al.   BRAIN PATHOLOGY

Long-term outcome of centrally located low-grade glioma in children

(2013) Keita Terashima et al.   CANCER

Brainstem Ganglioglioma Successfully Treated With Vemurafenib

(2013) Sarah Rush et al.   JOURNAL OF CLINICAL ONCOLOGY

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

(2013)   NATURE GENETICS

A multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method

(2013) D. A. Walker et al.   NEURO-ONCOLOGY

Vemurafenib in pediatric patients withBRAFV600Emutated high-grade gliomas

(2013) Francisco Bautista et al.   PEDIATRIC BLOOD & CANCER

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

(2013) E. M. Van Allen et al.   Cancer Discovery

Randomized Study of Two Chemotherapy Regimens for Treatment of Low-Grade Glioma in Young Children: A Report From the Children's Oncology Group

(2012) Joann L. Ater et al.   JOURNAL OF CLINICAL ONCOLOGY

The molecular biology of WHO grade I astrocytomas

(2012) N. F. Marko et al.   NEURO-ONCOLOGY

Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas

(2012) C. Horbinski et al.   NEURO-ONCOLOGY

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

(2011) Huriye Cin et al.   ACTA NEUROPATHOLOGICA

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

(2011) Genevieve Schindler et al.   ACTA NEUROPATHOLOGICA

BRAF-KIAA1549 Fusion Predicts Better Clinical Outcome in Pediatric Low-Grade Astrocytoma

(2011) C. Hawkins et al.   CLINICAL CANCER RESEARCH

Targeted Therapy for BRAFV600E Malignant Astrocytoma

(2011) T. P. Nicolaides et al.   CLINICAL CANCER RESEARCH

BRAFAlterations in Primary Glial and Glioneuronal Neoplasms of the Central Nervous System With Identification of 2 Novel KIAA1549

(2011) Alex Lin et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

(2010) Jessie Villanueva et al.   CANCER CELL

Radiation Therapy for Pediatric Low-Grade Gliomas: Survival and Sequelae

(2010) Roger J. Packer   Current Neurology and Neuroscience Reports

MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential

(2010) Judith WM Jeuken et al.   JOURNAL OF PATHOLOGY

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Duplication of 7q34 in Pediatric Low-Grade Astrocytomas Detected by High-Density Single-Nucleotide Polymorphism-Based Genotype Arrays Results in a NovelBRAFFusion Gene

(2009) Angela J. Sievert et al.   BRAIN PATHOLOGY

Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours

(2009) K Jacob et al.   BRITISH JOURNAL OF CANCER

Late Effects of Conformal Radiation Therapy for Pediatric Patients With Low-Grade Glioma: Prospective Evaluation of Cognitive, Endocrine, and Hearing Deficits

(2009) Thomas E. Merchant et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Trial of Conformal Radiation Therapy for Pediatric Low-Grade Glioma

(2009) Thomas E. Merchant et al.   JOURNAL OF CLINICAL ONCOLOGY

MEK1 mutations confer resistance to MEK and B-RAF inhibition

(2009) C. M. Emery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tandem Duplication Producing a Novel OncogenicBRAFFusion Gene Defines the Majority of Pilocytic Astrocytomas

(2008) David T.W. Jones et al.   CANCER RESEARCH

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

(2008) Stefan Pfister et al.   JOURNAL OF CLINICAL INVESTIGATION

Frequent Gains at Chromosome 7q34 Involving BRAF in Pilocytic Astrocytoma

(2008) Eli E. Bar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas

(2008) H Deshmukh et al.   ONCOGENE