Article
Oncology
Yufei Yang, Xuebing Yan, Xinxiang Li, Yanlei Ma, Ajay Goel
Summary: Colorectal cancer is a common malignancy with challenges in diagnosis and treatment, and recent research suggests that long non-coding RNAs play important roles in the progression of the disease.
Review
Biochemistry & Molecular Biology
Matteo Lulli, Cristina Napoli, Ida Landini, Enrico Mini, Andrea Lapucci
Summary: Non-coding RNAs, especially long non-coding RNAs, have been shown to play critical roles in the initiation, progression, and drug resistance of colorectal cancer. They are emerging as potential therapeutic targets and predictive biomarkers for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nikolay K. Shakhpazyan, Liudmila M. Mikhaleva, Arcady L. Bedzhanyan, Nikolay K. Sadykhov, Konstantin Y. Midiber, Alexandra K. Konyukova, Andrey S. Kontorschikov, Ksenia S. Maslenkina, Alexander N. Orekhov
Summary: This comprehensive review explores the intricate roles of long non-coding RNAs (lncRNAs) within the microenvironment of colorectal cancer (CRC), particularly in relation to immunity, intercellular communication, and therapeutic potential. The review highlights the significance of lncRNAs in influencing inflammation, immune evasion, and treatment response in CRC, and proposes them as potential candidates for novel therapeutic strategies and biomarkers. The review also examines the complex interplay of lncRNAs with CRC tumor subtypes, their impact on immunity and inflammation within the tumor stroma, and their transportation through extracellular vesicles, specifically exosomes. Additionally, the review delves into the intricate relationship between lncRNAs and other non-coding RNAs, such as microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Finally, potential strategies to manipulate lncRNAs to enhance anti-tumor immunity are proposed, highlighting the importance of lncRNAs in innovative therapeutic interventions in CRC.
Review
Oncology
Ru Sun, Xiao-Yun He, Cheng Mei, Chun-Lin Ou
Summary: Exosomes, small extracellular vesicles ranging from 30-150 nm, are crucial in cell-to-cell communication by transferring biological information like DNA, RNA, and proteins. Recent findings indicate that exosomes can carry long non-coding RNAs (lncRNAs), impacting the progression of colorectal cancer significantly.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jiaying Li, Rundong Chai, Yinxiao Chen, Shuwu Zhao, Yuhong Bian, Xiangling Wang
Summary: Colorectal cancer is a common gastrointestinal malignancy with complex pathogenesis. Curcumin has shown potent anti-tumor and anti-inflammatory effects. Recent studies have revealed that curcumin can regulate non-coding RNA expression levels to suppress tumor development in colorectal cancer. This review provides a scientific basis for the clinical application of non-coding RNAs in colorectal cancer.
Review
Biology
Massimiliano Agostini, Mara Mancini, Eleonora Candi
Summary: Metabolic reprogramming is a hallmark of cancers and long non-coding RNAs play a role in regulating cancer-specific metabolic alterations. This overview focuses on breast cancer metabolic reprogramming and the involvement of long non-coding RNAs in driving these alterations.
Article
Oncology
Saeed Ashrafizaveh, Milad Ashrafizadeh, Ali Zarrabi, Kiavash Husmandi, Amirhossein Zabolian, Md Shahinozzaman, Amir Reza Aref, Michael R. Hamblin, Noushin Nabavi, Francesco Crea, Yuzhuo Wang, Kwang Seok Ahn
Summary: Studies have shown that long non-coding RNAs play a significant role in DOX resistance, both activating resistance pathways and increasing sensitivity of cancer cells to DOX.
Article
Medical Laboratory Technology
Yong-Qiang Gong, Tai-Liang Lu, Fu-Tao Hou, Chao -Wu Chen
Summary: Gastric cancer is a global health problem with high mortality, and its incidence varies significantly across different regions. The interaction between Helicobacter pylori infection and epigenetics plays a crucial role in the occurrence of gastric cancer. Antisense long non-coding RNAs (lncRNAs) have been found to be closely associated with various aspects of gastric cancer. However, a comprehensive compilation and discussion of diverse antisense lncRNAs in gastric cancer is lacking. This review focuses on summarizing the predisposing factors, the interaction between H. pylori and epigenetics in gastric cancer, and the underlying molecular mechanisms and regulatory roles of each antisense lncRNA. Additionally, new insights into the potential diagnosis and treatment of antisense lncRNAs in gastric cancer are provided.
CLINICA CHIMICA ACTA
(2022)
Review
Biochemistry & Molecular Biology
Dimitra Ioanna Lampropoulou, Evangelia Pliakou, Gerasimos Aravantinos, Dimitrios Filippou, Maria Gazouli
Summary: Exosomal ncRNAs play a significant role in CRC drug resistance, and this field has great research potential for discovering new biomarkers for therapy monitoring or reversing drug desensitization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Abdolmajid Ghasemian, Hadeel A. Omear, Yaser Mansoori, Pardis Mansouri, Xinpei Deng, Farzaneh Darbeheshti, Elham Zarenezhad, Maryam Kohansal, Babak Pezeshki, Zhangling Wang, Hailin Tang
Summary: Colorectal cancer is a fatal cancer, and lncRNAs play regulatory roles in cell proliferation and immune responses via the JAK/STAT signaling pathway, making them potential biomarkers and therapeutic targets.
FRONTIERS IN GENETICS
(2023)
Review
Pathology
Mohammad Mahdi Khanifar, Zahra Zafari, Mohsen Sheykhhasan
Summary: Colorectal cancer is a prevalent malignancy and a leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) are dysregulated in colorectal cancer and have been found to modulate the expression of the p53 gene, a crucial tumor suppressor gene involved in various cellular processes. Understanding the interaction between lncRNAs and the p53 pathway in colorectal cancer has important implications for carcinogenesis, tumor progression, and therapeutic resistance.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Vilma Maldonado, Jorge Melendez-Zajgla
Summary: Breast cancer is the leading cause of cancer-related deaths in women worldwide, with mortality rates in the United States stagnant in recent years despite earlier diagnosis and treatment improvements. Long non-coding RNAs (lncRNAs) play a significant role in breast cancer, particularly in the hypoxic response of cancer cells, which may contribute to tumoral progression. This review summarizes the role of hypoxia-associated lncRNAs in cancer hallmarks, their effects on hypoxia signaling pathway, and their potential as diagnostic and prognostic tools.
Article
Oncology
Jiafeng Chen, Xinrong Li, Shuixin Yan, Jiadi Li, Yuxin Zhou, Minhua Wu, Jinhua Ding, Jiahui Yang, Yijie Yuan, Ye Zhu, Weizhu Wu
Summary: By constructing an ARlncRNA prognostic model, the prognosis of breast cancer can be accurately assessed, providing guidance for individualized treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Hui-Jin Li, Xue Gong, Zheng-Kun Li, Wei Qin, Chun-Xia He, Lu Xing, Xin Zhou, Dong Zhao, Hui-Ling Cao
Summary: Bladder cancer is characterized by dysregulated lncRNAs, which play key roles in tumorigenesis, progression, and prognosis. These lncRNAs can serve as potential diagnostic and prognostic biomarkers for bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Wei Nie, Min-juan Hu, Qin Zhang, Jun Lu, Fang-fei Qian, Le-le Zhang, Fang Hu, Chang-hui Li, Shu-hui Cao, Jing-wen Li, Yue Wang, Xue-yan Zhang, Mi-die Xu, Bao-hui Han
Summary: In lung adenocarcinoma (LUAD), the expression of DUBR is significantly downregulated and associated with poor prognosis. DUBR suppresses migration and invasion of LUAD cells by attenuating oxidative phosphorylation.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Jingquan Li, Zihao Zhang, Xu Feng, Zhuqing Shen, Ji Sun, Xiuwen Zhang, Fengjiao Bu, Midie Xu, Cong Tan, Ziliang Wang
Summary: STC2 plays a role in regulating cell growth, invasion, and glycolysis in nasopharyngeal carcinoma (NPC) and its expression is associated with clinical progression. The interaction of STC2 with ITGB2 and its involvement in the ITGB2/FAK/SOX6 axis suggest a potential therapeutic target for NPC.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Meeting Abstract
Oncology
Wenhua Li, Jinjia Chang, Midie Xu, Xiaodong Zhu
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Tianqi Li, Jiquan Chen, Jun Liu, Qingjie Chen, Wei Nie, Mi-Die Xu
Summary: In this study, a prognostic prediction model for patients with LUAD was developed based on the expression profiles of lipid metabolism-related genes. Three molecular subtypes were identified in LUAD, and a seven-gene signature was confirmed as an independent prognostic factor. The established gene signature can be used as a new prognostic marker for predicting survival in patients with LUAD.
JOURNAL OF ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhen-Xiong Zhao, Yan-Qiu Zhang, Hui Sun, Zi-Qi Chen, Jin-Jia Chang, Xin Wang, Xu Wang, Cong Tan, Shu-Juan Ni, Wei-Wei Weng, Meng Zhang, Lei Wang, Dan Huang, Yun Feng, Wei-Qi Sheng, Mi-Die Xu
Summary: This study confirms the specific localization of VDR in gastric cancer tissues and demonstrates that activation of VDR can suppress CAF-induced chemotherapy resistance in gastric cancer. The study also reveals that CAF-derived IL-8 induces oxaliplatin resistance through activating the PI3K/AKT pathway, and treatment with vitamin D can attenuate the tumor-supportive effect of IL-8 on gastric cancer cells.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Immunology
Midie Xu, Jinjia Chang, Wenfeng Wang, Xin Wang, Xu Wang, Weiwei Weng, Cong Tan, Meng Zhang, Shujuan Ni, Lei Wang, Zhaohui Huang, Zhenzhong Deng, Wenhua Li, Dan Huang, Weiqi Sheng
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Weiwei Weng, Meng Zhang, Shujuan Ni, Cong Tan, Midie Xu, Xin Wang, Hui Sun, Lei Wang, Dan Huang, Weiqi Sheng
Summary: This study found that alpha-fetoprotein-producing gastric cancer is a subtype of gastric cancer with aggressive biological behavior, and the expression of CLDN18.2 is decreased and negatively correlated with prognosis. CLDN18.2 may serve as a target for special treatment strategies in alpha-fetoprotein-producing gastric cancer.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Immunology
Weiwei Weng, Lin Yu, Zhang Li, Cong Tan, Jiaojie Lv, I. Weng Lao, Wenhuo Hu, Zhenzhong Deng, Zebing Liu, Jian Wang, Midie Xu
Summary: This study identified three immune subtypes of sarcomas based on gene expression profiles, characterized by different immune cell features, gene mutations, and clinical outcomes. The study also found differences in expression levels of immunogenic cell death modulators and immune checkpoints among the subtypes. Additionally, an immune gene signature with good prognostic performance was developed.
Review
Cell Biology
Hui Sun, Xu Wang, Xin Wang, Midie Xu, Weiqi Sheng
Summary: Despite progress in cancer treatment, gastric cancer (GC) still has a poor prognosis. Recent research has shown that the malignant behavior of cancer is not only caused by tumor cells, but also mediated by the activity of cancer stroma and regulated by molecular networks in the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundant in the stroma and play a significant role in the malignant development of GC. CAFs can modulate the biological properties of tumor cells through various mechanisms, affecting the initiation and progression of GC. However, there is heterogeneity in the cellular origins, phenotypes, and functions of CAFs in the TME of GC, and the molecular mechanisms are not well understood.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Midie Xu, Jiuliang Yan, Beiyuan Hu, Chuntao Wu, Haitao Gu, Zihao Qi, Tao Chen, Wenting Yang, Yan Zheng, Hanguang Dong, Weiqi Sheng, Jiang Long
Summary: This study analyzed the genomic variations between primary and metastatic tumors in PanNETs patients, finding low genomic heterogeneity and evidence of polyclonal seeding during metastatic progression. Copy number variations of BRCA1/BRCA2 were associated with better prognosis. Pathways in cancer, DNA repair, and cell cycle regulation were significantly enriched. The study provides novel insight into genetic changes in metastatic tumors of PanNETs.
Article
Oncology
Hui Sun, Xin Wang, Xiaoyan Zhang, Xu Wang, Cong Tan, Weiwei Weng, Meng Zhang, Shujuan Ni, Lei Wang, Dan Huang, Midie Xu, Weiqi Sheng
Summary: This study explored the expression and clinical relevance of CAF-associated markers EZH2 and FOXM1 in gastric samples. The results showed that EZH2 and FOXM1 expression were positively associated with CAFs abundance and correlated with clinicopathological parameters and prognosis.
Article
Oncology
Jianpeng Gao, Zhenxiong Zhao, Hena Zhang, Shenglin Huang, Midie Xu, Hongda Pan
Summary: Transcriptomic sequencing and follow-up analyses revealed unique molecular and immune features of paired normal mucosae, primary and ovarian metastatic tumors. A novel OM- and M2 macrophage-related signature, M2GO, was established and served as a promising prognostic and immunotherapeutic biomarker in gastric cancer patients. The M2GO score was significantly associated with clinical outcomes, molecular and immune features, and differential responses to immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Lu Gan, Qingguo Li, Wei Nie, Yi Zhang, Hesheng Jiang, Cong Tan, Long Zhang, Jieyun Zhang, Qian Li, Pengcong Hou, Yitao Yuan, Xun Sun, Dongmei Liu, Weiqi Sheng, Tianshu Liu, Midie Xu, Weijian Guo
Summary: PROX1 is a transcription factor that promotes malignant transformation and stemness in colorectal cancer (CRC). It has been found that PROX1 is associated with cell glucose metabolism and regulates cell proliferation and glucose metabolism through interaction with SIRT3. High PROX1 expression combined with low SIRT3 expression predicts poor prognosis in CRC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Lin Qian, Na Li, Xiao-Chen Lu, Midie Xu, Ying Liu, Kaiyue Li, Yi Zhang, Kewen Hu, Yu-Ting Qi, Jun Yao, Ying-Li Wu, Wenyu Wen, Shenglin Huang, Zheng-Jun Chen, Miao Yin, Qun-Ying Lei
Summary: In this study, the researchers identified a relationship between branched-chain amino acid metabolism and cell growth and motility through RhoC signaling. They found that enhanced BCAT1 activity, caused by a mutation enriched in gastric cancer, leads to increased production of a metabolite that activates RhoC signaling. The study also found that the BCAA-derived metabolite can directly bind to the small GTPase protein RhoC and enhance its activity. The researchers also discovered that the drug candesartan can inhibit BCAT1 activity, leading to decreased RhoC activity and cancer cell motility.
Article
Cell Biology
Xiaoqi Ma, Midie Xu, Xing Zhang, Xin Wang, Kexin Su, Zihang Xu, Xiaoyu Wang, Yifu Yang
Summary: The present study investigates the mechanism of gambogenic acid (GNA), a natural compound, on apoptosis and ferroptosis in colorectal cancer (CRC). The results show that GNA inhibits tumor growth by suppressing the proliferation of CRC cell lines and induces ferroptosis by activating endoplasmic reticulum stress and ROS production. Furthermore, GNA regulates iron metabolism to further induce ferroptosis.
CELL BIOLOGY INTERNATIONAL
(2023)
