Article
Biochemistry & Molecular Biology
Kristina Lossow, Maria Schwarz, Anna P. Kipp
Summary: Cancer remains a major cause of death worldwide, and early diagnosis is critical for improved survival rates and treatment success. Studies have shown that cancer patients generally have elevated serum copper levels and diminished zinc levels, with inconsistent changes in selenium and iron levels depending on the type of cancer. Further research is needed to investigate whether these element concentrations can predict the survival probability of cancer patients.
Review
Medicine, General & Internal
Nai-Wen Su, Yu-Jen Chen
Summary: Metronomic therapy is a low-dose, repeated treatment approach for cancer that targets antiangiogenesis and immunomodulation mechanisms, showing comparative efficacy to traditional chemotherapy but with reduced side effects. In the treatment of oral cavity squamous cell carcinoma and other cancers, metronomic therapy has demonstrated promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Article
Nutrition & Dietetics
Adam Darago, Michal Klimczak, Joanna Stragierowicz, Mateusz Jobczyk, Anna Kilanowicz
Summary: The concentrations of zinc, copper, and selenium in different parts of the prostate gland are associated with men's age and the nature of pathological changes. Zinc levels increase with age in the central part of the prostate, while lower zinc levels in the peripheral part may be linked to the development of prostate adenocarcinoma and benign prostatic hyperplasia. These results suggest a disruption in the homeostasis of essential elements in the etiology of BPH and PCa.
Review
Oncology
Leonardo Di Gennaro, Raimondo De Cristofaro, Antonietta Ferretti, Maria Basso, Claudia Riccio, Massimo Cordaro, Carlo Lajolo
Summary: This review discusses the relationship between oral squamous cell carcinoma (OSCC) and venous thromboembolism (VTE). VTE has a significant impact on the mortality rate of cancer patients, and the thrombotic risk in OSCC patients has not been extensively studied, leading to insufficient prevention measures and affecting the effectiveness of oncologic treatment.
Review
Oncology
Leonardo de Oliveira Siquara da Rocha, Bruno Solano de Freitas Souza, Daniel W. Lambert, Clarissa de Araujo Gurgel Rocha
Summary: Cell-in-cell structures are common in tumors, including oral squamous cell carcinoma. Cell-in-cell events in oral squamous cell carcinoma are associated with tumor aggressiveness, metastasis, and therapeutic resistance. The lack of standard terminology makes it difficult to classify and understand the behavior and impacts of these structures. Understanding the link between cell-in-cell structures and more aggressive behavior in oral squamous cell carcinoma is crucial for developing effective therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Heinrich Botha, Camile S. Farah, Kendrick Koo, Nicola Cirillo, Michael McCullough, Rita Paolini, Antonio Celentano
Summary: Research shows that in oral squamous cell carcinoma, glucose transporter 1 (GLUT-1) and GLUT-3 expression levels are correlated with tumor stage, treatment resistance, and poor prognosis. Other glucose transporters (GLUTs) are relatively understudied and may have the potential to improve patient care with further analysis.
Article
Microbiology
Wei Wei, Jia Li, Xin Shen, Jinglu Lyu, Caixia Yan, Boyu Tang, Wenjuan Ma, Huixu Xie, Lei Zhao, Lei Cheng, Ye Deng, Yan Li
Summary: Periodontitis promotes the development of OSCC by altering the oral bacterial community and tumor immune microenvironment.
Review
Biochemistry & Molecular Biology
Agnieszka Kaminska, Giovanni Luca Romano, Robert Rejdak, Sandrine Zweifel, Michal Fiedorowicz, Magdalena Rejdak, Anahita Bajka, Rosario Amato, Claudio Bucolo, Teresio Avitabile, Filippo Drago, Mario Damiano Toro
Summary: This review summarizes the role of trace elements in the pathogenesis and prevention of glaucomatous diseases, emphasizing the genetic background associated with glaucoma-related abnormalities in physiological processes involving necessary trace elements for cell functioning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chia-Huei Lee, Yu-Hsin Tsao, Yui-Ping Weng, I-Ching Wang, Yao-Ping Chen, Pin-Feng Hung
Summary: The herbal medicine perilla leaf extract (PLE) has been found to inhibit the viability of oral squamous cell carcinoma (OSCC) cells. The main phenols in PLE, caffeic acid (CA) and rosmarinic acid (RA), were shown to reduce OSCC cell viability in a dose-dependent manner. In addition, chronic treatment with CA and RA increased the sensitivity of OSCC cells to the EGFR tyrosine kinase inhibitor gefitinib and effectively suppressed interleukin-1 beta secretion. These findings suggest that perilla phenols can be used as adjuvant therapies to improve the efficacy of chemotherapy and EGFR-targeted therapy in OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Branly Kilola Mbunga, Ingunn M. S. Engebretsen, Tor A. Strand, Elin L. F. Gjengdal, Pierre Z. Akilimali, Mina M. Langfjord, Pierrot L. Tugirimana, Mala Ali Mapatano
Summary: Prevalence of zinc and selenium deficiencies is high among children under five in Popokabaka, Democratic Republic of Congo. These deficiencies may be associated with inflammation and linear growth.
Article
Oncology
Purandar Sarkar, Samaresh Malik, Sayantan Laha, Shantanab Das, Soumya Bunk, Jay Gopal Ray, Raghunath Chatterjee, Abhik Saha
Summary: This study identified significant changes in the oral microbial community of Indian oral squamous cell carcinoma (OSCC) patients, with significantly lower bacterial diversity in malignant samples compared to normal counterparts. Genera such as Prevotella, Corynebacterium were enriched in OSCC lesions, while Actinomyces, Sutterella were notably decreased. HPV-16 was significantly associated with OSCC development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Ecology
Manolito G. Torralba, Gajender Aleti, Weizhong Li, Kelvin Jens Moncera, Yi-Han Lin, Yanbao Yu, Michal M. Masternak, Wojciech Golusinski, Pawel Golusinski, Katarzyna Lamperska, Anna Edlund, Marcelo Freire, Karen E. Nelson
Summary: The study found a higher number of Fusobacteria, Bacteroidetes, and Firmicutes in oral squamous cell carcinoma (OSCC) tumor tissue, with an increase of Prevotella in saliva from OSCC patients and a prevalence of Corynebacterium in healthy subjects. Additionally, adhesion and virulence factors associated with Streptococcus gordonii and Fusobacterium genera were detected in OSCC tissues, suggesting potential biomarkers for disease progression.
Article
Medical Laboratory Technology
Meng Yang, Jieying Ding, Qingqiong Luo, Xu Chen, Fuxiang Chen
Summary: By using saponin to disrupt the membranes of serum EVs, the diagnostic efficacy of SCCA for oral squamous cell carcinoma can be improved. This provides a simple and rapid method with great potential for clinical application.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Lorenzo Fernandes Moca Trevisani, Isabelle Fernandes Kulcsar, Marco Aurelio Vamondes Kulcsar, Rogerio Aparecido Dedivitis, Luiz Paulo Kowalski, Leandro Luongo Matos
Summary: Oral squamous cell carcinoma (OSCC) is a significant public health concern, but there is a lack of well-established indices that specifically relate to the patient and indicate a worse prognosis. This study assessed the prognostic impact of hematological indices in OSCC patients and found that the red cell distribution width (RDW) is a reliable parameter for assessing overall survival.
Article
Chemistry, Analytical
J. Datta, S. Dasgupta, R. Guin, M. Venkatesh, S. Suvarna, D. P. Chowdhury
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2016)
Article
Spectroscopy
P. S. Remya Devi, S. Suvarna, M. Ghosh, G. Kiran Kumar, R. Verma, A. V. R. Reddy
X-RAY SPECTROMETRY
(2016)
Article
Engineering, Marine
Praveen S. Suvarna, Arunakumar Hunasanahally Sathyanarayana, Pruthviraj Umesh, Kiran G. Shirlal
Article
Engineering, Marine
Arunakumar Hunasanahally Sathyanarayana, Praveen S. Suvarna, Pruthviraj Umesh, Kiran G. Shirlal
Summary: This study modified conventional pile breakwater by widening the pile's cross-sectional area at the surface level in a conical shape to improve wave energy absorption. Experimental results demonstrated that the introduction of pile head on conventional pile breakwater is beneficial in improving wave attenuation and the overall performance of the CPHB as a coastal protection structure is promising. Empirical equations were developed for quick prediction of transmission and reflection coefficients with high accuracy.
Proceedings Paper
Engineering, Electrical & Electronic
Sohan Suvarna, Hoam Chung, Rajkumar S. Pant
2019 INTERNATIONAL CONFERENCE ON UNMANNED AIRCRAFT SYSTEMS (ICUAS' 19)
(2019)
Proceedings Paper
Automation & Control Systems
Sohan Suvarna, Dibyayan Sengupta, Pavankumar Koratikere, Rajkumar S. Pant
2019 FIFTH INDIAN CONTROL CONFERENCE (ICC)
(2019)
Article
Biochemistry & Molecular Biology
Mehul Jariwala, S. Suvarna, G. Kiran Kumar, Alpa Amin, A. C. Udas
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2014)
Proceedings Paper
Materials Science, Multidisciplinary
Kripa M. Suvarna, K. Rajendra Udupa, A. O. Surendranathan
CENTURY OF STAINLESS STEELS
(2013)
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)