☆ 4.3 Article

The use of cluster and discriminant analysis in the investigations of the role of trace metals in the pathogenesis of Parkinson's disease

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2010)

期刊

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

卷 24, 期 2, 页码 78-88

出版社

ELSEVIER GMBH

DOI: 10.1016/j.jtemb.2009.11.002

关键词

Parkinson's disease; Metals; X-ray fluorescence microscopy; Synchrotron radiation; Multivariate methods

类别

Biochemistry & Molecular Biology Endocrinology & Metabolism

资金

Polish Ministry of Knowledge and Higher Education
European Commission [HPRI-CT-1999-00040/2001-00140]
European Community
HASYLAB [II-02-092, II-20060029]
ESRF [MD32, MD60]
Foundation for Polish Science

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摘要

X-ray fluorescence microscopy was applied for two-dimensional elemental analysis of substantia nigra (SN) tissue. The samples representing Parkinson's disease (PD) and control cases were examined at HASYLAB beamline L and at ESRF beamline ID22. Two-dimensional mapping of P. S. Cl. K, Ca, Fe, Cu, Zn, Se and Br was done with the spatial resolution of 15 and 5 mu m. The masses per unit area of elements in neuromelanin reach nerve cells of SN were determined. The elemental data were processed using two multivariate techniques, namely cluster and discriminant analysis. The statistical methods were used for data reduction, both unsupervised and supervised classification as well as for the creation of a model that would simplify case identification based on the elemental analysis of SN tissue. The results of cluster analysis confirmed the statistical significance of the differences in elemental composition of PD and control SN nerve cells. Based on the results of discriminant analysis, the elements (P, Cl, Fe, Cu and Zn) that played the greatest role in the process of differentiation between neurons from examined groups were determined. (c) 2009 Elsevier GmbH. All rights reserved.

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Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Neurological study on the effect of CeNPs and/or La Cl3 on adult male albino rats

Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk

Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

The protective impact of curcumin, vitamin D and E along with manganese oxide and Iron (III) oxide nanoparticles in rats with scrotal hyperthermia: Role of apoptotic genes, miRNA and circRNA

Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian

Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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