Article
Cell Biology
Emilie Dinh, Thomas Rival, Alice Carrier, Noemi Asfogo, Olga Corti, Christophe Melon, Pascal Salin, Sylviane Lortet, Lydia Kerkerian-Le Goff
Summary: TP53INP1/dDOR plays a neuroprotective role in maintaining neuronal homeostasis, regulating autophagy and mitophagy in neurons. This has significant implications for neuroprotection and treatment of neurological disorders.
CELL DEATH & DISEASE
(2021)
Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Clinical Neurology
Tushar Kamath, Evan Z. Macosko
Summary: Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. Recent advances in genomic profiling have identified specific pathways and genetic variants involved in the susceptibility of dopaminergic neurons in Parkinson's disease. This provides new opportunities for understanding and developing therapies for this complex disorder.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Article
Cell & Tissue Engineering
Jinghua Piao, Susan Zabierowski, Brittany N. Dubose, Ellen J. Hill, Monalisa Navare, Nidia Claros, Siera Rosen, Kiran Ramnarine, Callie Horn, Craig Fredrickson, Karen Wong, Brent Safford, Sonja Kriks, Abderrahman El Maarouf, Urs Rutishauser, Claire Henchcliffe, Yongzeng Wang, Isabelle Riviere, Shannon Mann, Vladimir Bermudez, Stefan Irion, Lorenz Studer, Mark Tomishima, Viviane Tabar
Summary: The study successfully generated midbrain dopamine neurons from human embryonic stem cells and conducted extensive tests on animals to demonstrate the efficacy and safety of the cell product intended for potential human use, paving the way for future clinical trials.
Article
Multidisciplinary Sciences
Esther Gramage, Jorge Saiz, Rosalia Fernandez-Calle, Yasmina B. Martin, Maria Uribarri, Marcel Ferrer-Alcon, Coral Barbas, Gonzalo Herradon
Summary: This study found that overexpression of PTN has a neuroprotective effect in a mouse model of Parkinson's Disease and identified potential lipid-related drug candidates for Parkinson's Disease.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Frederique Depierreux, Eric Parmentier, Laurane Mackels, Katherine Baquero, Christian Degueldre, Evelyne Balteau, Eric Salmon, Christophe Phillips, Mohamed Ali Bahri, Pierre Maquet, Gaetan Garraux
Summary: This study found an increased accumulation of iron in the lateral substantia nigra in Parkinson's disease patients, while there was no specific regional specificity of NM signal within the substantia nigra in PD patients compared to healthy controls. Dopaminergic function impairment was positively correlated with iron accumulation and depigmentation in the substantia nigra, indicating a complex relationship between these factors in Parkinson's disease.
NPJ PARKINSONS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Neurosciences
Arnaud Pautrat, Racha Al Tannir, Karin Pernet-Gallay, Remi Soutrenon, Estelle Vendramini, Valerie Sinniger, Paul G. Overton, Olivier David, Veronique Coizet
Summary: The presence of central neuropathic pain in Parkinson's disease suggests that the brain circuits involved in pain processing may be dysfunctional. This study provides evidence that dysfunction in the subthalamic nucleus and/or substantia nigra pars reticulata may affect the processing of pain signals in the parabrachial nucleus (PBN) and lead to cellular and molecular adaptations in this structure. Rat models of Parkinson's disease with varying levels of dopaminergic lesions were used to demonstrate enhanced nociceptive responses in the substantia nigra reticulata and inhibited nociceptive responses and increased expression of GABA(A) receptors in the PBN following a total dopaminergic lesion. These findings suggest that molecular changes within the PBN, particularly increased GABA(A) expression, may contribute to the development of central neuropathic pain in Parkinson's disease.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Rahul Gaurav, Lydia Yahia-Cherif, Nadya Pyatigorskaya, Graziella Mangone, Emma Biondetti, Romain Valabregue, Claire Ewenczyk, R. Matthew Hutchison, Jesse M. Cedarbaum, Jean-Christophe Corvol, Marie Vidailhet, Stephane Lehericy
Summary: The study found a progressive decrease in neuromelanin-based substantia nigra signal and volume in PD patients, which could serve as a noninvasive assessment marker for disease progression.
MOVEMENT DISORDERS
(2021)
Article
Multidisciplinary Sciences
Lina A. Matschke, Marlene A. Komadowski, Annette Stoehr, Bolam Lee, Martin T. Henrich, Markus Griesbach, Susanne Rinne, Fanni F. Geibl, Wei-Hua Chiu, James B. Koprich, Jonathan M. Brotchie, Aytug K. Kiper, Amalia M. Dolga, Wolfgang H. Oertel, Niels Decher
Summary: This study characterizes the electrophysiological properties of neurons in Parkinson's disease (PD) models and suggests a role of Ca2+-activated K+ (SK) channels in PD by linking changes in LC firing rate to SK channel dysfunction.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Xishun Ma, Tongxia Li, Lizhen Du, Tongliang Han
Summary: Parkinson's disease is a common nervous system disease with motor retardation and resting tremor as its main manifestations. Early diagnosis of Parkinson's disease is difficult, but transcranial sonography has been widely used for its diagnosis and treatment. This article reviews the recent advances in the study of Parkinson's disease using transcranial sonography.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Sooyeon Ji, Eun-Jung Choi, Beomseok Sohn, Kyoungwon Baik, Na-Young Shin, Won-Jin Moon, Seongbeom Park, Soohwa Song, Phil Hyu Lee, Dong Hoon Shin, Se-Hong Oh, Eung Yeop Kim, Jongho Lee
Summary: This study proposes a new NM-sensitive imaging method called sandwichNM, which utilizes the incidental MT effects of spatial saturation RF pulses to generate high-quality NM images using product sequences. Compared to conventional NM-sensitive imaging methods, sandwichNM provides higher NM contrast and consistent contrasts across vendors in a multi-vendor experiment.
Article
Pharmacology & Pharmacy
Babita Singh, Shivani Pandey, Mohammad Rumman, Shashank Kumar, Prem Prakash Kushwaha, Rajesh Verma, Abbas Ali Mahdi
Summary: The study showed that Bacopa monnieri extract has neuroprotective and neurorescue effects against MPTP-induced degeneration of dopaminergic neurons, potentially slowing down disease progression and delaying neurodegeneration in Parkinson's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Argyrofthalmidou, Athanasios D. Spathis, Matina Maniati, Amalia Poula, Maira A. Katsianou, Evangelos Sotiriou, Maria Manousaki, Celine Perier, Ioanna Papapanagiotou, Zeta Papadopoulou-Daifoti, Pothitos M. Pitychoutis, Pavlos Alexakos, Miquel Vila, Leonidas Stefanis, Demetrios K. Vassilatis
Summary: Research shows that the impact of ASYN on the pathogenesis of PD, to some extent, is mediated by the down-regulation of Nurr1.
HUMAN MOLECULAR GENETICS
(2021)
Article
Anatomy & Morphology
Kosiek Wojciech, Rauk Zuzanna, Szulc Piotr, Cichy Anna, Rugiel Marzena, Chwiej Joanna, Janeczko Krzysztof, Setkowicz Zuzanna
Summary: The ketogenic diet affects the brain of pregnant females and impairs the somatic and neurological development of their offspring, but early postnatal withdrawal of this diet may initiate compensatory processes and considerable functional restitution of the nervous system based on still unrecognized mechanisms.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biochemistry & Molecular Biology
Karolina Planeta, Zuzanna Setkowicz, Mateusz Czyzycki, Natalia Janik-Olchawa, Damian Ryszawy, Krzysztof Janeczko, Rolf Simon, Tilo Baumbach, Joanna Chwiej
Summary: Glioblastoma multiforme (GBM) is a malignant brain tumor with limited treatment options. Animal models are commonly used to study the pathology of GBM and evaluate the efficacy and safety of therapies. In this study, synchrotron radiation-based X-ray fluorescence microscopy was used to investigate elemental changes in the rat brain with glioblastoma. The results showed that elemental changes were strongly correlated with the regions of tumor growth, providing insights into the pathogenesis and progression of GBM and potential biomarkers for its extension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microscopy
Artur D. Surowka, Mateusz Czyzycki, Agata Ziomber-Lisiak, Alessandro Migliori, Magdalena Szczerbowska-Boruchowska
Summary: The correlative Fourier Transform Infra-Red (FTIR) and hard X-Ray Fluorescence (XRF) microscopy studies provide valuable insights for investigating the mechanisms of neurological diseases and the associated mishandling of trace metals. These complementary methods offer new opportunities for analyzing and correlating molecular arrangements and chemical elements in thin biological samples, particularly in brain tissues.
Article
Multidisciplinary Sciences
Caroline Bissardon, Yadan Zhang, Helene Rouge Labriet, Sebastien Berujon, Laurent Charlet, Ilyas M. Khan, Emmanuel Brun, Sylvain Bohic
Summary: Understanding postnatal maturation of articular cartilage is crucial for tissue engineering strategies and cartilage repair. Changes in collagen structure and function occur over months to years, while tissue degeneration involves long-term dissolution of cartilage structure. Studying growth factors and imaging techniques can enhance our understanding of joint development and disease processes.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Correction
Anatomy & Morphology
Wojciech Kosiek, Zuzanna Rauk, Piotr Szulc, Anna Cichy, Marzena Rugiel, Joanna Chwiej, Krzysztof Janeczko, Zuzanna Setkowicz
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Energy & Fuels
Jagoda Worek, Xymena Badura, Anna Bialas, Joanna Chwiej, Kamil Kawon, Katarzyna Styszko
Summary: Transport is a significant source of environmental pollution, and microplastics released from tires are one of the most underestimated emissions. A study analyzing environmental samples found a large number of microplastic fragments in soil and road dust, with most of them originating from tires. The road dust samples contained more microplastics than the soil samples, and there was a noticeable difference in particle size between the two. This could be attributed to the distance of particle transportation and the degradation process in the soil.
Article
Biochemistry & Molecular Biology
Paula Kasprzyk, Pawel M. Wrobel, Joanna Dudala, Kalotina Geraki, Magdalena Szczerbowska-Boruchowska, Edyta Radwanska, Roger M. Krzyzewski, Dariusz Adamek, Marek Lankosz
Summary: This study analyzed the differences in elemental composition between myopathies, dystrophies, and reference muscle tissues. The results showed that Ca, Cu, K, Cl, and S had the greatest impact on these muscle disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Agata Ziomber-Lisiak, Katarzyna Talaga-Cwiertnia, Agnieszka Sroka-Oleksiak, Artur D. Surowka, Kajetan Juszczak, Magdalena Szczerbowska-Boruchowska
Summary: This study evaluated the effects of repetitive anodal tDCS on feeding behavior, metabolic status, and gut microbiota composition in rats with obesity induced by high-calorie diet. The results showed that AtDCS reduced appetite, body weight, and cholesterol levels, and modulated the ratio of Firmicutes to Bacteroidetes in the gut microbiome, suggesting its potential as a complementary treatment for obesity.
PHARMACOLOGICAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Szczerbowska-Boruchowska, Artur D. Surowka, Beata Ostachowicz, Kaja Piana, Anna Spaleniak, Pawel Wrobel, Joanna Dudala, Agata Ziomber-Lisiak
Summary: Early detection of subclinical obesity-driven changes is challenging. Existing measures like BMI often fail to provide accurate estimations. Whole-organ analysis of chemical elements shows promise as a new approach for identifying obesity markers.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Spectroscopy
Magdalena Szczerbowska-Boruchowska, Kaja Piana, Artur D. Surowka, Mateusz Czyzycki, Pawel Wrobel, Maciej Szymkowski, Agata Ziomber-Lisiak
Summary: The objective of this research was to investigate the brain changes associated with early-stage obesity at the molecular and elemental levels. Using Fourier transform infrared micro-spectroscopy (FTIR-MS) and synchrotron radiation induced X-ray fluorescence (SRXRF), the study evaluated brain macromolecular and elemental parameters in high-calorie diet-induced obese rats. The high-calorie diet was found to alter the structure and composition of lipids and proteins in specific brain areas important for energy homeostasis. The study also demonstrated the potential of combined X-ray and infrared spectroscopy in identifying brain biomolecular and elemental changes related to obesity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Magdalena Szczerbowska-Boruchowska, Patryk Stec, Mateusz Czyzycki, Zbigniew Szczerbowski, Rolf Simon, Tilo Baumbach, Agata Ziomber-Lisiak
Summary: The study proposes a method for using total absorbance under FTIR spectra as a mass surface correction procedure for XRF microimaging of tissues, and compares it with other correction methods. The results show that this method can effectively eliminate the surface mass effect and obtain surface mass-independent elemental quantities.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W. James, Caroline Bissardon, Salvatore Gazze, Franziska Knodel, Olivier Proux, Alexandra T. Gourlan, Philipp Rathert, Sylvain Bohic, Deyarina Gonzalez, Lewis W. Francis, Laurent Charlet, R. Steven Conlan
Summary: At physiological levels, selenium is involved in redox reactions and has potential anti-cancer effects. Selenium nanoparticles, coated with serum albumin or chitosan, enhance biocompatibility and bioavailability. In this study, selenium nanoparticles were found to regulate histone methylation in ovarian cancer cell models, leading to increased histone methylation at specific sites. This novel role of selenium in histone methylation is mediated by a decrease in S-adenosylhomocysteine, an endogenous inhibitor of lysine methyltransferases. These findings broaden our understanding of the action of selenium nanoparticles in cancer therapy and other applications.
Article
Biochemistry & Molecular Biology
Marzena Rugiel, Zuzanna Setkowicz-Janeczko, Wojciech Kosiek, Zuzanna Rauk, Kamil Kawon, Joanna Chwiej
Summary: Anti-seizure medications used during pregnancy may have an impact on the offspring's nervous system. The ketogenic diet (KD) may be an alternative therapy for pregnant women with seizures, but its risks during pregnancy are unknown and further investigation is needed. This study found that prenatal exposure to KD did not cause brain biochemical anomalies in 2 and 6-day-old rats, but abnormalities were observed in the 14-day-old rats, including increased levels of compounds containing carbonyl groups and decreased lipid content in the brain. These changes may be due to elevated exposure to ketone bodies and disturbance of lipid metabolism after prenatal exposure to KD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Matthieu Chourrout, Christophe Sandt, Timm Weitkamp, Tanja Ducic, David Meyronet, Thierry Baron, Jan Klohs, Nicolas Rama, Herve Boutin, Shifali Singh, Cecile Olivier, Marlene Wiart, Emmanuel Brun, Sylvain Bohic, Fabien Chauveau
Summary: Synchrotron X-ray phase-contrast tomography (XPCT) can visualize amyloid-beta (A beta) plaques from Alzheimer's Disease (AD) in label-free brain samples. This study suggests that the contrast of A beta in XPCT may be caused by A beta fibrils and/or metals trapped in the plaques. Analysis of brain samples from different types of AD patients and AD models reveals that a hyperdense contrast formation of A beta plaques in XPCT images is associated with biometal entrapment within plaques.
ACTA BIOMATERIALIA
(2023)
Article
Spectroscopy
Patryk Stec, Joanna Dudala, Aleksandra Wandzilak, Pawel Wrobel, Lukasz Chmura, Magdalena Szczerbowska-Boruchowska
Summary: Ovarian cancer is a deadly disease that is difficult to diagnose and treat, partly due to late diagnosis. In this study, infrared microspectroscopy was used to analyze the biomolecular composition of ovarian tissues. Paraffin-embedded preparations of tissues were used, but the paraffin absorbs infrared radiation, making it difficult to analyze the samples. Deparaffinization was performed before analysis, but the extent to which it affected the biomolecular composition was unclear. Results showed that deparaffinization led to changes in the composition, but classification of tissues based on FTIR measurements was still possible.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
