Article
Biochemistry & Molecular Biology
Tokumitsu Wakabayashi, Yui Nojiri, Miwa Takahashi-Watanabe
Summary: The study demonstrates that the soil nematode Caenorhabditis elegans can avoid toxic RE ions through its chemosensory system, which may share similarities with its avoidance behavior towards heavy metal ions.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Physics, Multidisciplinary
Tosif Ahamed, Antonio C. Costa, Greg J. Stephens
Summary: The authors use a data-driven framework based on the theory of dynamical systems to characterize nematode behavior and explain its complexity through deterministic chaotic dynamics. They find both basic stereotyped movements and locally unstable dynamics with signatures of deterministic chaos in the behavior of the roundworm. The presence of positive Lyapunov exponents and a symmetric Lyapunov spectrum suggests that the worm's movement control is driven by damped-driven Hamiltonian dynamics.
Review
Medical Laboratory Technology
Sumanpreet Kaur, Sheemona Chowdhary, Deepak Kumar, Rajasri Bhattacharyya, Dibyajyoti Banerjee
Summary: Population and food requirements are increasing, leading to an increase in pesticide use. Organophosphorous and organocarbamate compounds are commonly used pesticides, but distinguishing between them is important for the diagnosis and management of poisoning cases.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Alexandra R. Willis, Ronesh Sukhdeo, Aaron W. Reinke
Summary: Research has shown that innate immune priming can protect hosts from secondary infections and may even be passed on to future generations. Models like Caenorhabditis elegans have provided insights into the mechanisms behind innate immune priming and its implications for health and evolution.
Review
Biochemistry & Molecular Biology
Jogender Singh
Summary: Forward genetics is a powerful tool for unraveling molecular mechanisms of biological processes, with C. elegans being a favored model due to ease of genetic manipulation and availability of tools. Recent advancements have accelerated mutation identification, making forward genetic screens the method of choice for understanding biological functions.
MOLECULAR GENETICS AND GENOMICS
(2021)
Article
Chemistry, Analytical
Liwei Xu, Xinxin Xu, Hua Kuang, Ye Liu, Chuanlai Xu, Xiaoling Wu
Summary: Transcriptomics and metabolomics were used to investigate the effects of exposure to a cocktail of neonicotinoids (Neo) and a synergist piperonyl butoxide (PBO). The results showed that Neo and PBO disrupted mRNA and metabolite levels in a dose-dependent manner. Co-exposure enhanced Neo-induced liver steatosis, focal necrosis, and oxidative stress, while metabolic biomarkers indicated that insulin signaling activation and restricted oxidative phosphorylation (OXPHOS) were associated with the development of non-alcoholic fatty liver disease (NAFLD) and Alzheimer's disease (AD).
ANALYTICAL CHEMISTRY
(2023)
Review
Environmental Sciences
Vahulabaranan Rajagopalan, Swethaa Venkataraman, Devi Sri Rajendran, Vaidyanathan Vinoth Kumar, Vaithyanathan Vasanth Kumar, Gayathri Rangasamy
Summary: Neurotoxic pesticides pose a severe threat to humans and the environment, accumulating in the food chain and persisting in the environment to cause long-term exposure and adverse effects on non-target organisms. Accurate and reliable detection of these pesticides and associated neurotransmitters is crucial for clinical applications. Acetylcholinesterase (AchE) biosensors have emerged as a sensitive tool for electrochemical detection, showcasing tremendous potential in various fields.
ENVIRONMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Suresh Chandra Phulara, Swapnil Pandey, Anubhuti Jha, Puneet Singh Chauhan, Pratima Gupta, Virendra Shukla
Summary: The study demonstrated that Prenol could significantly extend the lifespan of C. elegans and alleviate protein aggregation. By activating specific genes and transcription factors, Prenol improved stress tolerance and health-span of the worms. These findings suggest that small molecules like Prenol could be explored as potential therapeutics against aging and age-related conditions.
Article
Limnology
Zhang Zhongshan, Wang Xiaomei, Pan Yongliang, Wang Zhanqi, Wen Zhengshun, Liu Feng, Mao Genxiang
Summary: Research has shown that Pyropia haitanensis polysaccharide (LP) has anti-aging properties, extending the lifespan of nematodes and reducing protein aggregation through nuclear DAF-16 pathway.
JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qianqian Sun, Cen Liu, Kunxiu Jiang, Yongsheng Fang, Chuchu Kong, Jin Fu, Yonggang Liu
Summary: Harmine exhibits dosage-dependent toxic effects on Caenorhabditis elegans, including growth inhibition, egg laying defects, shortened lifespan, and increased mortality, possibly through the inhibition of acetylcholinesterase activity leading to foraging disorders in the worms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biodiversity Conservation
Marilyn Silva
Summary: This study examined the activities, chemical-target specificity, and in vitro to in vivo extrapolation of several neurotoxic pesticides using new approach methodologies. The results showed consistent toxicity between in vitro and in vivo assays, and the Integrated Chemical Environment models were highly predictive of in vivo neurotoxicity points of departure.
HUMAN AND ECOLOGICAL RISK ASSESSMENT
(2023)
Article
Multidisciplinary Sciences
Yuxia Wei, Qingqing Liu, Jian Zhao
Summary: This study addresses the issue of unclear control requirements for particular wastewater pollutants in China's pesticide industry's wastewater discharge standards. It establishes a method for deriving discharge limits based on water quality criteria for pesticides to protect nonsensitive species. The study determines the discharge limit for malathion and shows that it is technically feasible and economically rational.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Fabian Schmitt, Lukas Babylon, Fabian Dieter, Gunter P. Eckert
Summary: This study investigated the impact of environmentally hazardous substances on the healthspan and mitochondrial functions of invertebrates, finding that pesticides can decrease heat stress resistance but can be improved by polyphenolic metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Jose G. Dorea
Summary: Exposure to neurotoxic substances poses a significant threat to children's neurodevelopment in Latin American and Caribbean countries, especially impacting children from laboring families. Studies indicate that prenatal exposure has more lasting effects than exposure through human milk, underscoring the urgent need to reduce neurotoxicant exposure to protect children's neurodevelopment.
ENVIRONMENTAL RESEARCH
(2021)
Article
Agronomy
Jin Yang, Yiming Chang, Yanning Zhang, Lizhen Zhu, Liangang Mao, Lan Zhang, Xingang Liu, Hongyun Jiang
Summary: This study found that the mixture of commonly used pesticides imidacloprid, acetochlor, and tebuconazole in rice fields had a more pronounced effect on the reproductive outcomes of zebrafish, resulting in reduced number of F1 embryos, increased developmental defects, and disruption in reproductive hormones and gene expression.