Article
Environmental Sciences
Huan Chen, Wenxin Zhang, Yanqiu Zhou, Jiufeng Li, Hongzhi Zhao, Shunqing Xu, Wei Xia, Zongwei Cai, Yuanyuan Li
Summary: The study aimed to determine the patterns of exposure to environmental chemicals over three trimesters among pregnant women, identifying different exposure patterns and main chemical components. Various physiological, socio-demographic factors, and behavior patterns were found to be related to different exposure clusters and principal components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Yanying Ma, Camilla Taxvig, Andrea Rodriguez-Carrillo, Vicente Mustieles, Lena Reiber, Anja Kiesow, Nathalie Michelle Lobl, Mariana F. Fernandez, Tina Vicky Alstrup Hansen, Maria Joao Valente, Marike Kolossa-Gehring, Madlen David, Anne Marie Vinggaard
Summary: As part of the European Joint programme 'Human Biomonitoring for Europe', a new methodology for mixture risk assessment of chemicals affecting male reproductive function was explored. The study identified 231 chemicals that can interfere with human androgen receptor activity, and 61 of them were finally identified to have reliable data. The major drivers of the mixture effect were PCB 118, BBP, PFOS, DBP, and benzophenone-3, contributing to 75% of the total mixture effect.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Developmental Biology
Line Mathiesen, Tina Buerki-Thurnherr, Jana Pastuschek, Leonie Aengenheister, Lisbeth E. Knudsen
Summary: The burden of environmental chemicals in the human population, particularly during pregnancy, is a significant issue. Various groups of environmental chemicals have been studied in the ex vivo placental perfusion model, showing different transfer rates from fast to negligible. More standardized studies and quantitative structure-activity relationship analysis are needed to evaluate the risk of environmental toxicants on the human term placenta.
Review
Environmental Sciences
Da-Hye Kim, Yu Ait Bamai, Lidia Belova, Jos Bessems, Giulia Poma, Adrian Covaci
Summary: This review provides information on the occurrence of persistent and mobile chemicals (PMs) in human matrices and environmental samples, and discusses the current knowledge gaps and future research needs regarding human exposure to PMs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Pharmacology & Pharmacy
Melanie H. Jacobson, Akhgar Ghassabian, Andrea C. Gore, Leonardo Trasande
Summary: Women are more likely than men to develop mood disorders, especially during reproductive transitions. Exposure to environmental toxicants may impact maternal psychopathology during the perinatal period. Previous studies have shown that exposure to environmental tobacco smoke has a positive effect on antenatal depression, while persistent organic pollutants such as polybrominated diphenyl ethers have been associated with perinatal depression. The results for exposure to heavy metals and non-persistent chemicals are mixed, but studies in animal models support the association between bisphenols and phthalates and reduced maternal behavior and care after parturition.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Nina Lazarevic, Adrian G. Barnett, Peter D. Sly, Anna C. Callan, Ania Stasinska, Jane S. Heyworth, Andrea L. Hinwood, Luke D. Knibbs
Summary: The study did not find associations between mixtures of polybrominated diphenyl ethers, organochlorine pesticides, metals, and perfluorinated alkyl substances and fetal growth outcomes. Results suggested no meaningful associations between exposure to these chemicals and birth weight, length, and head circumference. Non-linear relationships with some chemicals were identified.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Review
Environmental Sciences
Mostafa Hadei, Abbas Shahsavani, Philip K. Hopke, Simin Naseri, Ahmadreza Yazdanbakhsh, Mohsen Sadani, Alireza Mesdaghinia, Maryam Yarahmadi, Masoumeh Rahmatinia, Sevda Fallah, Bahaaran Emam, Majid Kermani, Nemat Jaafarzadeh, Mohammadreza Alipour, Vajihe Hassanzadeh, Shahriyar Bazzazpour, Seyed Saeed Hashemi Nazari
Summary: This study systematically reviewed biomonitoring studies on carcinogen environmental pollutants in Iran, finding high concentrations of cadmium and arsenic in breast milk. The results highlighted the need for comprehensive action plans to reduce population exposure to these environmental contaminants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Robin P. Peeters, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: This study investigated the association between concentrations of endocrine disrupting chemicals (EDCs) in urine and blood during pregnancy and serum human chorionic gonadotropin (hCG) concentrations. The results showed that higher exposure to bisphenol A was associated with lower hCG concentrations, while higher triclosan exposure was associated with higher hCG concentrations. Higher exposure to certain phthalates and polychlorinated biphenyls (PCBs) was also associated with lower hCG concentrations. These findings suggest that EDC exposure may have negative effects on placental hCG production and secretion, warranting further experimental studies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Archita Mishra, Ghee Chuan Lai, Leong Jing Yao, Thet Tun Aung, Noam Shental, Aviva Rotter-Maskowitz, Edwin Shepherdson, Gurmit Singh Naranjan Singh, Rhea Pai, Adhika Shanti, Regina Men Men Wong, Andrea Lee, Costerwell Khyriem, Charles Antoine Dutertre, Svetoslav Chakarov, K. G. Srinivasan, Nurhidaya Binte Shadan, Xiao-Meng Zhang, Shabnam Khalilnezhad, Fabien Cottier, Alrina Shin Min Tan, Gillian Low, Phyllis Chen, Yiping Fan, Pei Xiang Hor, Avery Khoo May Lee, Mahesh Choolani, David Vermijlen, Ankur Sharma, Garold Fuks, Ravid Straussman, Norman Pavelka, Benoit Malleret, Naomi McGovern, Salvatore Albani, Jerry Kok Yen Chan, Florent Ginhoux
Summary: During the 2nd trimester of gestation, microbial signals were detected in fetal gut, skin, placenta, and lungs, contributing to fetal immune-priming. Live bacterial strains, including Staphylococcus and Lactobacillus, were identified in fetal tissues, activating memory T cells in the fetal mesenteric lymph node.
Article
Biochemistry & Molecular Biology
Sabrina Leverrier-Penna, Alain Michel, Laetitia L. Lecante, Nathalie Costet, Antonio Suglia, Christele Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M. Chemouny, Emmanuelle Becker, Vincent Lavoue, Antoine D. Rolland, Nathalie Dejucq-Rainsford, Cecile Vigneau, Severine Mazaud-Guittot
Summary: This study investigated the effects of analgesics on human fetal kidneys during early pregnancy, revealing a spectrum of abnormalities induced by these drugs, ranging from cell death to a decline in differentiating glomeruli density. Caution is warranted for the use of these medications during the first trimester of pregnancy.
Article
Environmental Sciences
L. Campo, L. Boniardi, E. Polledri, F. Longhi, C. Scuffi, S. Fustinoni
Summary: This study assessed ETS exposure in Milan schoolchildren, revealing a higher actual exposure rate than perceived by parents. Children living with smokers or vapers had higher COT-U levels, with partial smoking bans showing a slight mitigation effect on exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Analytical
Zhizhen Zhang, Shenghong Wang, Li Li
Summary: This review highlights the importance of understanding how chemical properties and human behavior interact to determine human exposure to environmental chemicals, emphasizing the variability in intake patterns among chemicals with different properties. Future research should focus on gaining more mechanistic insights into human exposure processes, improving techniques for characterizing and predicting chemical properties, expanding experimental data diversity, and describing interactions between chemical properties and human behavior.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2021)
Article
Environmental Sciences
Danielle R. Stevens, Emma M. Rosen, Kimi Van Wickle, Erin E. McNell, Paige A. Bommarito, Antonia M. Calafat, Julianne C. Botelho, Elena Sinkovskaya, Ann Przybylska, George Saade, Alfred Abuhamad, Kelly K. Ferguson
Summary: In early pregnancy, exposure to phthalates and replacement chemicals may have adverse effects on fetal growth. Phthalate biomarkers in urine were found to be associated with reduced fetal growth, while replacement biomarkers showed no such association.
ENVIRONMENTAL RESEARCH
(2023)
Review
Food Science & Technology
Kristina Habschied, Gabriella Kanizai Saric, Vinko Krstanovic, Kresimir Mastanjevic
Summary: Mycotoxins are secondary metabolites produced by fungi that have a toxic effect on human and animal health. Biomonitoring of mycotoxins in plasma, serum, urine, and blood samples has become a common method for determining exposure, with novel techniques aiming toward simultaneous determination of multiple mycotoxins. Liquid chromatography (LC) methodologies coupled with tandem mass spectrometry (MS/MS) or high-resolution mass spectrometry (HRMS) are now the most reliable method for determining mycotoxin exposure.
Article
Environmental Sciences
Giehae Choi, Jordan R. Kuiper, Deborah H. Bennett, Emily S. Barrett, Theresa M. Bastain, Carrie Breton, Sridhar Chinthakindi, Anne L. Dunlop, Shohreh F. Farzan, Julie B. Herbstman, Margaret R. Karagas, Carmen J. Marsit, John D. Meeker, Rachel Morello-Frosch, Thomas G. O'Connor, Edo D. Pellizzari, Megan E. Romano, Sheela Sathyanarayana, Susan Schantz, Rebecca J. Schmidt, Deborah J. Watkins, Hongkai Zhu, Kurunthachalam Kannan, Jessie P. Buckley, Tracey J. Woodruff
Summary: This study aimed to investigate the exposure of melamine, melamine derivatives, and aromatic amines in pregnant women in the United States and explore the associations with participant and urine sample collection characteristics. The results revealed that the exposure to these chemicals was ubiquitous in pregnant women and was associated with factors such as race/ethnicity, urinary cotinine, and sample collection time.