Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load

(2013) M. Yanina Pepino et al.   DIABETES CARE

Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements

(2013) Susan E. Swithers   TRENDS IN ENDOCRINOLOGY AND METABOLISM

When environmental chemicals act like uncontrolled medicine

(2013) Linda S. Birnbaum   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats

(2012) Susan E. Swithers et al.   BEHAVIOURAL BRAIN RESEARCH

Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters

(2012) Yakun Chen et al.   BIOCHEMICAL PHARMACOLOGY

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

Rationale for Further Medical and Health Research on High-Potency Sweeteners

(2012) Susan S. Schiffman   CHEMICAL SENSES

Effects of Diet Soda on Gut Hormones in Youths With Diabetes

(2012) R. J. Brown et al.   DIABETES CARE

Antibiotic resistance in triclosan tolerant fecal coliforms isolated from surface waters near wastewater treatment plant outflows (Morris County, NJ, USA)

(2012) June H. Middleton et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Formation of polychlorinated naphthalenes during the heating of cooking oil in the presence of high amounts of sucralose

(2012) Shujun Dong et al.   FOOD CONTROL

Non-Nutritive Sweeteners and their Role in the Gastrointestinal Tract

(2012) Rebecca J. Brown et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Randomized Trial of Sugar-Sweetened Beverages and Adolescent Body Weight

(2012) Cara B. Ebbeling et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Sugar-free or Sugar-Sweetened Beverages and Body Weight in Children

(2012) Janne C. de Ruyter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Altered processing of sweet taste in the brain of diet soda drinkers

(2012) Erin Green et al.   PHYSIOLOGY & BEHAVIOR

Endocrine Disruptor Regulation of MicroRNA Expression in Breast Carcinoma Cells

(2012) Syreeta L. Tilghman et al.   PLoS One

Sucralose revisited: Rebuttal of two papers about Splenda safety

(2012) Susan S. Schiffman et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Etiology of inflammatory bowel disease: A unified hypothesis

(2012) Xiaofa Qin   WORLD JOURNAL OF GASTROENTEROLOGY

Non-Caloric Sweeteners, Sweetness Modulators, and Sweetener Enhancers

(2012) Grant E. DuBois et al.   Annual Review of Food Science and Technology

Amygdala response to sucrose consumption is inversely related to artificial sweetener use

(2011) K.J. Rudenga et al.   APPETITE

Diet induced epigenetic changes and their implications for health

(2011) J. A. McKay et al.   Acta Physiologica

Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK

(2011) Tae-Il Jeon et al.   BIOCHEMICAL JOURNAL

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

(2011) Chibueze A. Ihunnah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides

(2011) Robert E. Steinert et al.   BRITISH JOURNAL OF NUTRITION

Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study

(2011) Keith T. Flaherty et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Sucralose – An ecotoxicological challenger?

(2011) Ann-Kristin Eriksson Wiklund et al.   CHEMOSPHERE

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects

(2011) H E Ford et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Validity of early indirect models of taste active sites and advances in new taste technologies enabled by improved models

(2011) Grant E DuBois   FLAVOUR AND FRAGRANCE JOURNAL

Unintentionally produced dioxin-like polychlorinated biphenyls during cooking

(2011) Shujun Dong et al.   FOOD CONTROL

What caused the recent worldwide increase of inflammatory bowel disease: Should sucralose be added as a suspect?

(2011) Xiaofa Qin   INFLAMMATORY BOWEL DISEASES

Environmental chemical exposures and human epigenetics

(2011) Lifang Hou et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cooking Process: A New Source of Unintentionally Produced Dioxins?

(2011) Jiajia Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Obesogen Hypothesis: A Shift of Focus from the Periphery to the Hypothalamus

(2011) Stéphanie Decherf et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Childhood Obesity and Environmental Chemicals

(2011) Michele La Merrill et al.   MOUNT SINAI JOURNAL OF MEDICINE

DNA damage induced by endogenous aldehydes: Current state of knowledge

(2011) Georgia-Persephoni Voulgaridou et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop

(2011) Stefan Pfuhler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in women

(2011) Andrew W. Brown et al.   NUTRITION RESEARCH

Prediction of Nonlinear Intestinal Absorption of CYP3A4 and P-Glycoprotein Substrates from their In Vitro Km Values

(2011) Tatsuhiko Tachibana et al.   PHARMACEUTICAL RESEARCH

The sweet taste of true synergy: positive allosteric modulation of the human sweet taste receptor

(2011) Guy Servant et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects

(2010) Jing Ma et al.   BRITISH JOURNAL OF NUTRITION

Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes

(2010) Zivjena Vucetic et al.   ENDOCRINOLOGY

Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren

(2010) Tuija Tapaninen et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Epigenetic effects of endocrine-disrupting chemicals on female reproduction: An ovarian perspective

(2010) Aparna Mahakali Zama et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Solubility of Sucralose in Different Solvents from (283.15 to 333.15) K

(2010) Xin Li et al.   JOURNAL OF CHEMICAL AND ENGINEERING DATA

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

High-intensity sweeteners and energy balance

(2010) Susan E. Swithers et al.   PHYSIOLOGY & BEHAVIOR

The effect of standardized Echinacea purpurea extract on rat cytochrome P450 expression level

(2010) P.M. Mrozikiewicz et al.   PHYTOMEDICINE

Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome

(2010) Carlos Guerrero-Bosagna et al.   PLoS One

Positive allosteric modulators of the human sweet taste receptor enhance sweet taste

(2010) G. Servant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of the sweet taste enhancers

(2010) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of cytochrome P450 3A4 and P-glycoprotein in first-pass intestinal extraction of omeprazole in rabbits

(2009) Hai-ming Fang et al.   ACTA PHARMACOLOGICA SINICA

Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects

(2009) Jing Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Model-Based Approach To Characterize Efavirenz Autoinduction and Concurrent Enzyme Induction with Carbamazepine

(2009) M. Zhu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.

(2009) Susan E. Swithers et al.   BEHAVIORAL NEUROSCIENCE

Qualitative Analysis of the Role of Metabolites in Inhibitory Drug−Drug Interactions: Literature Evaluation Based on the Metabolism and Transport Drug Interaction Database

(2009) Nina Isoherranen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus

(2009) J. S. FREEMAN   CLEVELAND CLINIC JOURNAL OF MEDICINE

Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

(2009) S. Hu et al.   CLINICAL CANCER RESEARCH

Effects of Dietary Factors on Drug Transport and Metabolism: The Impact on Dosage Guidelines in Transplant Patients

(2009) R Nowack et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Substrates, Inducers, Inhibitors and Structure-Activity Relationships of Human Cytochrome P450 2C9 and Implications in Drug Development

(2009) S.-F. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Ingestion of Diet Soda Before a Glucose Load Augments Glucagon-Like Peptide-1 Secretion

(2009) R. J. Brown et al.   DIABETES CARE

Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat

(2009) W. Meinl et al.   DRUG METABOLISM AND DISPOSITION

Polychlorinated Biphenyl-Mediated Decrease in Serum Thyroxine Level in Rodents

(2009) Y. Kato et al.   DRUG METABOLISM AND DISPOSITION

Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1

(2009) S. Tachibana et al.   DRUG METABOLISM AND DISPOSITION

Fetal and Neonatal Exposure to the Endocrine Disruptor Methoxychlor Causes Epigenetic Alterations in Adult Ovarian Genes

(2009) Aparna Mahakali Zama et al.   ENDOCRINOLOGY

Thermal degradation of sucralose and its potential in generating chloropropanols in the presence of glycerol

(2009) Anja Rahn et al.   FOOD CHEMISTRY

Specific metabolite production by gut microbiota as a basis for probiotic function

(2009) R.P. Ross et al.   INTERNATIONAL DAIRY JOURNAL

Gut microbiota: Changes throughout the lifespan from infancy to elderly

(2009) Paul W. O'Toole et al.   INTERNATIONAL DAIRY JOURNAL

The role and potential of probiotic bacteria in the gut, and the communication between gut microflora and gut/host

(2009) Sarah O'Flaherty et al.   INTERNATIONAL DAIRY JOURNAL

Probiotics and immunity

(2009) Andrea T. Borchers et al.   JOURNAL OF GASTROENTEROLOGY

The core gut microbiome, energy balance and obesity

(2009) Peter J. Turnbaugh et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Drug Transporter−Metabolism Alliance: Uncovering and Defining the Interplay

(2009) Leslie Z. Benet   MOLECULAR PHARMACEUTICS

What are the consequences of the disappearing human microbiota?

(2009) Martin J. Blaser et al.   NATURE REVIEWS MICROBIOLOGY

Suppression of the multidrug transporter P-glycoprotein using RNA interference in cultured rat astrocytes induced by coriaria lactone

(2009) Tian-Hua Yang et al.   NEUROLOGICAL RESEARCH

SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions

(2009) Saskia Preissner et al.   NUCLEIC ACIDS RESEARCH

Unraveling Mechanisms of Action of Probiotics

(2009) Philip M. Sherman et al.   NUTRITION IN CLINICAL PRACTICE

Change in diet, physical activity, and body weight among young-adults during the transition from high school to college

(2009) Heidi J Wengreen et al.   Nutrition Journal

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

(2009) Sarah Shugarts et al.   PHARMACEUTICAL RESEARCH

Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion

(2009) Yuko Nakagawa et al.   PLoS One

Intestinal Microbiota Regulate Xenobiotic Metabolism in the Liver

(2009) Britta Björkholm et al.   PLoS One

An overview of the safety of sucralose

(2009) V. Lee Grotz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm

(2009) Christelle Stouder et al.   REPRODUCTION

A New Kind of Drug Target

(2009) Melinda Wenner   SCIENTIFIC AMERICAN

Influence of Comedication on Serum Concentrations of Aripiprazole and Dehydroaripiprazole

(2009) Ragnhild Birkeland Waade et al.   THERAPEUTIC DRUG MONITORING

Octachlorostyrene Induces Cytochrome P450, UDP-glucuronosyltransferase, and Sulfotransferase via the Aryl Hydrocarbon Receptor and Constitutive Androstane Receptor

(2009) Yukie Yanagiba et al.   TOXICOLOGICAL SCIENCES

How important is intestinal cytochrome P450 3A metabolism?

(2009) Antonius E. van Herwaarden et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains

(2009) A. Bruyère et al.   XENOBIOTICA

Metabolites in safety testing

(2009) Timothy W Robison et al.   Bioanalysis

Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo

(2008) Yukihiro Fujita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition and induction of human cytochrome P450 enzymes: current status

(2008) Olavi Pelkonen et al.   ARCHIVES OF TOXICOLOGY

A role for sweet taste: Calorie predictive relations in energy regulation by rats.

(2008) Susan E. Swithers et al.   BEHAVIORAL NEUROSCIENCE

Sertraline and Its Metabolite Desmethylsertraline, but not Bupropion or Its Three Major Metabolites, Have High Affinity for P-Glycoprotein

(2008) Jun-Sheng Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The recovery time-course of CYP3A after induction by St John's wort administration

(2008) Hiromitsu Imai et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer

(2008) Irma Meijerman et al.   CANCER TREATMENT REVIEWS

Dietary Intake and the Development of the Metabolic Syndrome

(2008) Pamela L. Lutsey et al.   CIRCULATION

An Update on Clinical Drug Interactions with the Herbal Antidepressant St. Johns wort

(2008) Shu-Feng Zhou et al.   CURRENT DRUG METABOLISM

Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m-Chlorophenylpiperazine

(2008) B. Wen et al.   DRUG METABOLISM AND DISPOSITION

A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine

(2008) K. Yasuda et al.   DRUG METABOLISM AND DISPOSITION

Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel

(2008) Y. Nishiya et al.   DRUG METABOLISM AND DISPOSITION

Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats

(2008) D. Mitschke et al.   DRUG METABOLISM AND DISPOSITION

Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice

(2008) Wan-Seob Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4

(2008) Shingo Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacokinetics of Efavirenz When Co-administered With Rifampin in TB/HIV Co-infected Patients: Pharmacogenetic Effect ofCYP2B6Variation

(2008) Awewura Kwara et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Diagnosis and prevalence of enteropathogenic bacteria in children less than 5 years of age with acute diarrhea in Tehran children's hospitals

(2008) F. Jafari et al.   JOURNAL OF INFECTION

An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine

(2008) Oliver J. Mace et al.   JOURNAL OF PHYSIOLOGY-LONDON

Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats

(2008) Mohamed B. Abou-Donia et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes

(2008) Sandrine P Claus et al.   Molecular Systems Biology

The comet assay as an indicator test for germ cell genotoxicity

(2008) G SPEIT et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Gut microbiota: a potential new territory for drug targeting

(2008) Wei Jia et al.   NATURE REVIEWS DRUG DISCOVERY

Cortical activation in response to pure taste stimuli during the physiological states of hunger and satiety

(2008) Lori Haase et al.   NEUROIMAGE

Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment

(2008) Amandeep Mann et al.   NEUROPHARMACOLOGY

Fueling the Obesity Epidemic? Artificially Sweetened Beverage Use and Long-term Weight Gain

(2008) Sharon P. Fowler et al.   Obesity

Maternal levels of dichlorodiphenyl-dichloroethylene (DDE) may increase weight and body mass index in adult female offspring

(2008) W Karmaus et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

(2007) Joseph M. Custodio et al.   ADVANCED DRUG DELIVERY REVIEWS

Flurazepam inhibits the P-glycoprotein transport function: An insight to revert multidrug-resistance phenotype

(2007) Sofia A.C. Lima et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sucrose activates human taste pathways differently from artificial sweetener

(2007) Guido K.W. Frank et al.   NEUROIMAGE

The xenobiotic inhibitor profile of cytochrome P4502C8

(2003) Chin-Eng Ong et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine

(2003) Ole V. Olesen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY