Article
Biology
Rajendran Vijayakumar, Faiz Abdulaziz Alfaiz, Esam S. Al-Malki, Tim Sandle
Summary: The study utilized a novel design for passive sampling of sandstorm dust and found that the airborne endotoxin levels were generally high during sandstorm events, with levels increasing with the severity of the storms.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Veterinary Sciences
Jerine A. J. van der Eijk, Jorine M. Rommers, Theo van Hattum, Henk K. Parmentier, Norbert Stockhofe-Zurwieden, Andre J. A. Aarnink, Johanna M. J. Rebel
Summary: Chronic exposure to high concentrations of airborne endotoxins affects the immune system and respiratory tract of broilers, potentially influencing their disease susceptibility.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Elke Eriksen, Anani Komlavi Afanou, Anne Mette Madsen, Anne Straumfors, Pal Graff
Summary: Occupational exposure during waste sorting is associated with various health outcomes. This study compared the impact of work in fully automated waste sorting plants (AWSP) versus manual waste sorting plants (MWSP) on personal exposure to bioaerosols and related health effects. The results showed that workers at AWSP had lower exposure levels to inhalable dust, thoracic dust, and endotoxins compared to MWSP, but higher levels of fungal fragments, fungal spores, and actinobacterial spores. Microbial DNA exposure varied within and between types of waste sorting plants. Exposed workers also reported more common health symptoms compared to the unexposed control group.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Anne Mette Madsen, John Kerr White, Jeppe Lund Nielsen, Mehmet Emin Keskin, Kira Tendal, Margit Wagtberg Frederiksen
Summary: Breeding pigeons is associated with respiratory symptoms, as exposure to bacteria and endotoxin in pigeon coops may contribute to airway issues among breeders. The airborne dust in pigeon coops contained a diverse range of bacterial species, some of which could pose potential health risks.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Steffi Rocchi, Benoit Valot, Audrey Laboissiere, Audrey Guitton, Emeline Scherer, Laurence Millon, Gabriel Reboux
Summary: Cockroach allergens have a greater impact on asthma morbidity than those from dust mites, cats, and dogs. The American cockroach and the German cockroach are most frequently responsible for sensitization. The worldwide prevalence of allergic sensitization has been estimated at 2 to 26 % and is influenced by unfavorable socioeconomic conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Sophie Ndaw, Aurelie Remy, Daniele Jargot, Guillaume Antoine, Flavien Denis, Alain Robert
Summary: The study found that grain elevator workers are highly exposed to organic airborne dust containing multiple mycotoxins. Urinary biomarkers of mycotoxins showed significant concentrations post-shift, especially for DON. The data suggest the importance of multi-mycotoxin methods in evaluating occupational exposure to mycotoxins.
Article
Environmental Sciences
B. Paluchamy, Devi Prasad Mishra
Summary: This study assessed the exposure of airborne dust during remote LHD mucking and found that downcast airflow poses the greatest risk to remote LHD operators. It also emphasized the importance of adopting tele-remote-operated LHD and automated mucking operation in open stopes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Sophie Ndaw, Daniele Jargot, Guillaume Antoine, Flavien Denis, Sandrine Melin, Alain Robert
Summary: Investigating workplace exposure to mycotoxins is crucial for the implementation of preventive measures, and this study provides tools for measuring mycotoxins in urine and airborne samples. The developed multi-class mycotoxin method and validated analysis for both biomonitoring and airborne mycotoxin measurement show good analytical performances and suitability for investigating occupational exposure to mycotoxins.
Review
Public, Environmental & Occupational Health
Magne Bratveit, Samson Wakuma Abaya, Gloria Sakwari, Bente E. Moen
Summary: This study reviewed recent research on dust exposure and respiratory health among coffee factory workers in Tanzania and Ethiopia. The results indicate that male production workers in Ethiopia had higher dust exposure and prevalence of respiratory symptoms compared to those in Tanzania. Measures to reduce dust exposure should be implemented to protect the health of coffee production workers.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Allergy
Hideki Hasunuma, Yoshiko Yoda, Narumi Tokuda, Naoko Taniguchi, Yasuhiro Takeshima, Masayuki Shima
Summary: The study found that early-life exposure to house dust mite allergen and endotoxin in mattresses may be associated with the development of asthma. Significant increases in the incidence rates of asthma and wheezing were observed with higher levels of exposure.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Multidisciplinary Sciences
Hisao Okabe, Koichi Hashimoto, Mika Yamada, Takashi Ono, Kazufumi Yaginuma, Yohei Kume, Mina Chishiki, Akiko Sato, Yuka Ogata, Karin Imaizumi, Tsuyoshi Murata, Hyo Kyozuka, Kosei Shinoki, Seiji Yasumura, Hidekazu Nishigori, Keiya Fujimori, Mitsuaki Hosoya
Summary: The hygiene hypothesis suggests that pet exposure can prevent allergic disease, and this study aimed to explore the effect of exposure to various species of pets on the risk of food allergies. Dog and cat exposure during fetal development and early infancy was estimated to reduce the incidence risk of food allergies, while hamster exposure was estimated to increase the risk of nut allergy.
Article
Environmental Sciences
Reiji Kojima, Ryoji Shinohara, Megumi Kushima, Sayaka Horiuchi, Sanae Otawa, Kunio Miyake, Hiroshi Yokomichi, Yuka Akiyama, Tadao Ooka, Zentaro Yamagata
Summary: The association between endotoxin and allergic rhinitis is inconclusive. This study found that in a non-farming setting, both endotoxin and house dust mite allergens in dust were associated with an increased risk of house dust mite sensitization, but not with allergic rhinitis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Anne E. Rittscher, Abel A. Vlasblom, Birgitta Duim, Peter Scherpenisse, Isabella J. van Schothorst, Inge M. Wouters, Liese Van Gompel, Lidwien A. M. Smit
Summary: This study compares two sampling methods for measuring airborne MRSA in the farm environment and finds that both passive dust sampling with electrostatic dust fall collectors and active inhalable dust sampling using stationary air pumps with Teflon filters can detect MRSA. The study suggests that electrostatic dust fall collectors can be used as an affordable and easily standardized method for quantifying airborne MRSA levels in pig farms.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Engineering, Environmental
Marcin Cyprowski, Anna Lawniczek-Walczyk, Rafal L. Gorny
Summary: The study focused on exposure assessment to bacterial aerosols and organic dust in waste sorting plant. The waste reloading plant was found to be the most contaminated with anaerobic bacteria, while the control room had the lowest levels. The presence of anaerobic bacteria, including clostridia, was significantly affected by microclimate parameters.
JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
(2021)
Article
Environmental Sciences
Aleksandra Duda, Agata Piekut, Malgorzata Cwielag-Drabek
Summary: Breast cancer is the most frequently diagnosed cancer in women globally, with genetic predispositions, hormonal conditions, and lifestyle factors playing a role in the disease. Studies have shown a correlation between levels of airborne dust pollutants and the incidence of C50 in peri-and postmenopausal women in cities in the Silesia Province of Poland.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2022)
Article
Public, Environmental & Occupational Health
Jan Hovanec, Tobias Weiss, Holger Koch, Beate Pesch, Thomas Behrens, Benjamin Kendzia, Marina Arendt, Nico Dragano, Susanne Moebus, Boerge Schmidt, Thomas Bruening, Karl-Heinz Joeckel
Summary: The study findings show that there is a lack of accuracy in self-reported smoking intensity among individuals with lower socioeconomic status (SES) in both men and women. Although there is some correlation, the relationship between smoking intensity and urinary nicotine metabolites is weaker in the low SES group.
Article
Construction & Building Technology
Janin Maniscalco, Frank Hoffmeyer, Christian Monse, Birger Jettkant, Eike Marek, Thomas Bruening, Juergen Buenger, Kirsten Sucker
Summary: Exposure to high concentrations of CO2 affected blood pH and pCO2 levels, leading to increased respiratory rate, but all values remained within normal range. Cognitive performance, heart rate, CFF, and acute health did not show significant changes during the exposure.
Article
Oncology
T. Gambichler, J. Elfering, T. Meyer, S. Bruckmueller, E. Stockfleth, M. Skrygan, H. U. Kaefferlein, T. Bruening, K. Lang, D. Wagener, S. Schroeder, M. Nick, L. Susok
Summary: The study evaluated the protein expression characteristics of genes in a new prognostic gene expression assay for patients with cutaneous melanoma. Most markers showed relatively low protein expression, with some exceptions like COL6A6, GBP4, and KLHL41 which were enhanced in melanoma. While there were significant correlations between protein expression levels and clinical parameters, they did not completely align with the protective or risk-associated functions of the corresponding genes in the prognostic assay.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Nasim Mavaddat, Leila Dorling, Sara Carvalho, Jamie Allen, Anna Gonzalez-Neira, Renske Keeman, Manjeet K. Bolla, Joe Dennis, Qin Wang, Thomas U. Ahearn, Irene L. Andrulis, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Ignacio Briceno, Thomas Bruning, Nicola J. Camp, Archie Campbell, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Georgia Chenevix-Trench, Hans Christiansen, Kamila Czene, Thilo Dork, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Jurgen Geisler, Graham G. Giles, Pascal Guenel, Andreas Hadjisavvas, Eric Hahnen, Per Hall, Ute Hamann, Jaana M. Hartikainen, Mikael Hartman, Reiner Hoppe, Anthony Howell, Anna Jakubowska, Audrey Jung, Elza K. Khusnutdinova, Vessela N. Kristensen, Jingmei Li, Swee Ho Lim, Annika Lindblom, Maria A. Loizidou, Artitaya Lophatananon, Jan Lubinski, Michael J. Madsen, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Roger L. Milne, Nur Aishah Mohd Taib, Anna Morra, Kenneth Muir, Nadia Obi, Ana Osorio, Tjoung-Won Park-Simon, Paolo Peterlongo, Paolo Radice, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Mitul Shah, Xueling Sim, Melissa C. Southey, Heather Thorne, Ian Tomlinson, Diana Torres, Therese Truong, Cheng Har Yip, Amanda B. Spurdle, Maaike P. G. Vreeswijk, Alison M. Dunning, Montserrat Garcia-Closas, Paul D. P. Pharoah, Anders Kvist, Taru A. Muranen, Heli Nevanlinna, Soo Hwang Teo, Peter Devilee, Marjanka K. Schmidt, Douglas F. Easton
Summary: This case-control study analyzed breast cancer susceptibility genes and found that they are associated with different breast cancer subtypes and tumor characteristics. Understanding the age and subtype distributions associated with each gene can guide gene panel testing, risk prediction, and screening strategies.
Article
Oncology
T. Gambichler, C. Finis, N. Abu Rached, C. H. Scheel, J. C. Becker, K. Lang, H. U. Kafferlein, T. Bruning, N. Abolmaali, L. Susok
Summary: The study investigated the protein expression of DNA mismatch repair (MMR) proteins in patients with cutaneous melanoma (CM) receiving immune checkpoint inhibitor (ICI) therapy. Immunohistochemistry was performed on tumor tissue of 50 patients, and reduced MMR protein expression was observed in 16% of patients. Baseline neutrophil/lymphocyte ratio and reduced intratumoral MMR protein expression were significantly associated with favorable treatment response. However, further validation is required in larger patient cohorts.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jan Gleichenhagen, Christian Arndt, Swaantje Casjens, Carmen Toepfer, Holger Gerullis, Irina Raiko, Dirk Taeger, Thorsten Ecke, Thomas Bruening, Georg Johnen
Summary: Urine-based biomarkers are a promising approach for bladder cancer detection. A highly sensitive assay based on immuno-PCR technology was developed to detect small amounts of survivin protein. The assay showed a sensitivity of 30% and specificity of 89% for bladder cancer detection.
Article
Respiratory System
Christian Monse, Gotz Westphal, Monika Raulf, Birger Jettkant, Vera van Kampen, Benjamin Kendzia, Leonie Schurmeyer, Christoph Edzard Seifert, Eike-Maximilian Marek, Felicitas Wiegand, Nina Rosenkranz, Christopher Wegener, Rolf Merget, Thomas Bruning, Jurgen Buenger
Summary: This study investigates the inflammatory effects of barium sulfate particles in humans and finds that acute inhalation of barium sulfate particles does not induce inflammatory responses. In vitro data also support these findings.
BMC PULMONARY MEDICINE
(2022)
Article
Sport Sciences
Suzanne C. Dixon-Suen, Sarah J. Lewis, Richard M. Martin, Dallas R. English, Terry Boyle, Graham G. Giles, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Thomas U. Ahearn, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Paivi Auvinen, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Thomas Bruening, Saundra S. Buys, Nicola J. Camp, Daniele Campa, Federico Canzian, Jose E. Castelao, Melissa H. Cessna, Jenny Chang-Claude, Stephen J. Chanock, Christine L. Clarke, Don M. Conroy, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Doerk, Miriam Dwek, Diana M. Eccles, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Mark S. Goldberg, Pascal Guenel, Melanie Guendert, Eric Hahnen, Christopher A. Haiman, Lothar Haeberle, Niclas Hakansson, Per Hall, Ute Hamann, Steven N. Hart, Michelle Harvie, Peter Hillemanns, Antoinette Hollestelle, Maartje J. Hooning, Reiner Hoppe, John Hopper, Anthony Howell, David J. Hunter, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Jung, Rudolf Kaaks, Renske Keeman, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka-Sabit, Allison W. Kurian, James Lacey, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Sibylle Loibl, Jan Lubinski, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Dimitrios Mavroudis, Usha Menon, Anna Marie Mulligan, Rachel A. Murphy, Heli Nevanlinna, Ines Nevelsteen, William G. Newman, Kenneth Offit, Andrew F. Olshan, Hakan Olsson, Nick Orr, Alpa Patel, Julian Peto, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Erika Rees-Punia, Gad Rennert, Hedy S. Rennert, Atocha Romero, Emmanouil Saloustros, Dale P. Sandler, Marjanka K. Schmidt, Rita K. Schmutzler, Lukas Schwentner, Christopher Scott, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Melissa C. Southey, Jennifer Stone, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Mary Beth Terry, Rob A. E. M. Tollenaar, Melissa A. Troester, Therese Truong, Michael Untch, Celine M. Vachon, Vijai Joseph, Barbara Wappenschmidt, Clarice R. Weinberg, Alicja Wolk, Drakoulis Yannoukakos, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Roger L. Milne, Brigid M. Lynch
Summary: The study provides strong evidence that higher overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce the risk of breast cancer. The adoption of active lifestyles may help reduce the burden of the most common cancer in women.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Oncology
Thomas Behrens, Calvin Ge, Roel Vermeulen, Benjamin Kendzia, Ann Olsson, Joachim Schuez, Hans Kromhout, Beate Pesch, Susan Peters, Luetzen Portengen, Per Gustavsson, Dario Mirabelli, Pascal Guenel, Daniele Luce, Dario Consonni, Neil E. Caporaso, Maria Teresa Landi, John K. Field, Stefan Karrasch, Heinz-Erich Wichmann, Jack Siemiatycki, Marie-Elise Parent, Lorenzo Richiardi, Lorenzo Simonato, Karl-Heinz Joeckel, Wolfgang Ahrens, Hermann Pohlabeln, Guillermo Fernandez-Tardon, David Zaridze, John R. McLaughlin, Paul A. Demers, Beata Swiatkowska, Jolanta Lissowska, Tamas Pandics, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paolo Boffetta, Bas Bueno-de-Mesquita, Francesco Forastiere, Kurt Straif, Thomas Bruening
Summary: Limited evidence exists regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. This study found that occupational exposure to Cr(VI) and nickel was associated with lung-cancer risks, particularly in men. In men, the highest quartile of cumulative exposure to CR(VI) and nickel were both significantly associated with increased odds ratios for lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Mehdi Manoochehri, Nasim Borhani, Clarissa Gerhaeuser, Yassen Assenov, Maximilian Schoenung, Thomas Hielscher, Brock C. Christensen, Min Kyung Lee, Hermann-Josef Grone, Daniel B. Lipka, Thomas Bruening, Hiltrud Brauch, Yon-Dschun Ko, Ute Hamann
Summary: Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for earlier detection of triple-negative breast cancer (TNBC), aiding clinicians in easier and more efficient treatment options.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Analytical
Sonja A. Wrobel, Daniel Bury, Vladimir N. Belov, Jan M. Klenk, Bernhard Hauer, Heiko Hayen, Anderson J. Martino-Andrade, Holger M. Koch, Thomas Bruening, Heiko U. Kaefferlein
Summary: We have developed a specific and robust analytical method to analyze the most important neonicotinoids and their metabolites in human urine. The method was successfully validated and applied to quantify these compounds in individuals from the general population in Germany and pregnant women from Brazil with no known occupational exposures to neonicotinoids.
ANALYTICA CHIMICA ACTA
(2023)
Article
Allergy
Michal Gina, Katharina Wichert, Gerald Kutz, Thomas Bruening, Manige Fartasch
Summary: This study aimed to evaluate whether the use of protective creams prior to wearing liquid-proof gloves can mitigate the occlusion effect and skin sensitivity. The results showed that the use of protective creams did not alleviate the occlusion effect, and some creams may have negative effects on the skin barrier function and increase sensitivity.
CONTACT DERMATITIS
(2023)
Article
Allergy
Michal Gina, Katharina Wichert, Birgit Pieper, Thomas Behrens, Thomas Bruening, Manige Fartasch
Summary: This study compared the effects of using a shorter duration of a grit-containing cleanser and a longer duration of a mild cleanser on skin damage. The results showed that the shorter duration of the grit-containing cleanser resulted in more significant damage to the skin barrier, while the longer duration of the mild cleanser caused less damage.
CONTACT DERMATITIS
(2023)
Article
Environmental Sciences
Sonja A. Wrobel, Stephan Koslitz, Vladimir N. Belov, Daniel Bury, Heiko Hayen, Thomas Bruening, Holger M. Koch, Heiko U. Kaefferlein
Summary: This study developed and validated an analytical method to detect the metabolites of neonicotinoid insecticides in human urine. The results showed that the main metabolite in human urine was 6-chloronicotinic acid glycine, but the specific source of exposure remained unclear.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Dirk Taeger, Stephan Koslitz, Heiko U. Kaefferlein, Tim Pelzl, Birgit Heinrich, Dietmar Breuer, Tobias Weiss, Volker Harth, Thomas Behrens, Thomas Bruening
Summary: This study assessed the levels of polycyclic aromatic hydrocarbons (PAH) during firefighting operations in Germany using biomonitoring methods. The results showed that properly applied protective clothing and wearing of self-contained breathing apparatus (SCBA) can significantly reduce PAH exposure levels. However, there might still be individual situations in which PAH are increasingly incorporated, and the possibility of an individual increased cancer risk cannot be completely ruled out.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
