Article
Biochemistry & Molecular Biology
Seonguk Yang, Seulah Lee, Yujeong Lee, Jung-Hyun Cho, Sou Hyun Kim, Eun-Sol Ha, Young-Suk Jung, Hae Young Chung, Min-Soo Kim, Hyung Sik Kim, Seung-Cheol Chang, Kyung-Jin Min, Jaewon Lee
Summary: This study investigated the neurotoxicity of polystyrene nanoparticles on neural progenitor cells and hippocampal neurogenesis. The results showed that cationic amine-modified polystyrene had cytotoxic effects, while anionic carboxylate-modified polystyrene and neutral nanoparticles did not. Cationic polystyrene nanoparticles caused mitochondrial dysfunction, energy depletion, and cellular senescence. In vivo studies on mice demonstrated impaired hippocampal neurogenesis and memory retention after exposure to cationic polystyrene nanoparticles.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tong Zheng, Donna F. Bielinski, Derek R. Fisher, Jianyi Zhang, Barbara Shukitt-Hale
Summary: Blueberry extract has a positive effect on the viability and proliferation rates of adult hippocampal progenitor cells, potentially reversing decreases caused by dopamine, possibly due to its anti-inflammatory, antioxidant, and calcium-buffering properties.
Article
Neurosciences
Brittany A. Mayweather, Sean M. Buchanan, Lee L. Rubin
Summary: GDF11 functions differently in embryonic development and adult neurogenesis, regulating the proliferation of neural progenitors and the number of newborn neurons. This indicates that circulating systemic GDF11 and endogenously expressed GDF11 in the adult brain may have different target cells or mechanisms of action.
Article
Environmental Sciences
Hao Wang, Glen M. Abel, Daniel R. Storm, Zhengui Xia
Summary: Cadmium (Cd) is a toxic heavy metal that is a significant public health concern due to its potential neurotoxic effects on cognition in both humans and animals. Exposure to Cd during adolescence can impair short-term spatial memory and contextual fear memory in mice, while also affecting key processes of hippocampal neurogenesis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Prasanna Kandel, Fatih Semerci, Rachana Mishra, William Choi, Aleksandar Bajic, Dodge Baluya, LiHua Ma, Kevin Chen, Austin C. Cao, Tipwarin Phongmekhin, Nick Matinyan, Alba Jimenez-Panizo, Srinivas Chamakuri, Idris O. Raji, Lyra Chang, Pablo Fuentes-Prior, Kevin R. MacKenzie, Caroline L. Benn, Eva Estebanez-Perpina, Koen Venken, David D. Moore, Damian W. Young, Mirjana Maletic-Savatic
Summary: Oleic acid is identified as the endogenous ligand for the orphan nuclear receptor TLX, which converts it from a repressor to an activator, increasing neural stem cell mitotic activity and promoting hippocampal neurogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Ting-Hsuan Yu, Yi-Jen Wu, Miao-Er Chien, Kuei-Sen Hsu
Summary: Multisession anodal transcranial direct current stimulation (tDCS) enhances adult hippocampal neurogenesis (AHN) and improves cognitive functions related to it. The modulation of AHN plays a crucial role in the beneficial effects of tDCS on cognitive functions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Microbiology
Veronica Anaya-Martinez, Jhony Anacleto-Santos, Ricardo Mondragon-Flores, Armando Zepeda-Rodriguez, Brenda Casarrubias-Tabarez, Teresa de Jesus Lopez-Perez, Mariana Citlalli de Alba-Alvarado, Cintli Martinez-Ortiz-de-Montellano, Elba Carrasco-Ramirez, Norma Rivera-Fernandez
Summary: The study found that chronic infection with Toxoplasma gondii can increase the proliferation of neural progenitor cells (NPCs). Histological brain sections from infected mice showed a significant increase in NPCs proliferation in the evaluated zones.
Review
Medicine, Research & Experimental
Vahideh Zalouli, Hosnieh Rajavand, Mahdi Bayat, Jalil Khaleghnia, Fariborz Sharifianjazi, Farzad Jafarinazhad, Nima Beheshtizadeh
Summary: Physical exercise has positive effects on adult hippocampal neurogenesis (AHN) and cognitive processes. The effects of anaerobic resistance training and high-intensity interval training on AHN are not clear. Individual genetic diversity may play a role in the response to exercise on AHN. Exercise can improve health on average, but the benefits may vary due to genetic differences. This review discusses the capability of AHN for peripheral nervous system regeneration and central nervous system control through physical exercise, as well as the genes and factors involved.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Anuradha Yadav, Ankit Tandon, Brashket Seth, Shweta Goyal, Sangh Jyoti Singh, Shashi Kant Tiwari, Swati Agarwal, Saumya Nair, Rajnish Kumar Chaturvedi
Summary: Exposure to cypermethrin reduces neural stem cell proliferation, decreases the generation of mature neurons, and increases the number of glial cells and apoptotic cells in the hippocampus, leading to neurogenic imbalance and neurodegeneration, ultimately causing cognitive dysfunction in rats.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell & Tissue Engineering
Kristi Dietert, Swetha Mahesula, Sheetal Hegde, John Verschelde, Pamela Reed, Shane Sprague, Erzsebet Kokovay, Naomi L. Sayre
Summary: After ischemia, SDF1 upregulates in brain parenchyma cells, promoting the migration of adult neural stem cells to the injury site through the CXCR4 receptor. We identified LRP1 as a novel regulator of CXCR4 in neural stem cells and observed disrupted neural stem cell migration in vitro and reduced localization to the lesion in LRP1 knockout mice. Our findings suggest that the interaction between LRP1 and CXCR4 could have significant implications for neural stem cell physiology.
Article
Cell Biology
Koji Shimozaki
Summary: The synthetic REV-ERB agonist SR9009 was found to regulate neurite outgrowth in cultured rat AHPs in a concentration-dependent manner, while also modulating the expression of downstream target genes and inhibiting cell growth through various pathways. This study provides insight into the multifunctional mechanisms of action associated with SR9009 in proliferation and neuronal maturation of cultured rat AHPs.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Muhammad M. Hossain, Abdelmadjid Belkadi, Xiaofeng Zhou, Emanuel DiCicco-Bloom
Summary: In addition to age and traumatic brain injury, environmental exposure to pesticides, such as deltamethrin, may be a potential risk factor for neurodegenerative diseases and cognitive impairments. This study found that acute exposure to low doses of deltamethrin can cause endoplasmic reticulum stress and activation of apoptotic pathways, leading to impaired neurogenesis in the hippocampus.
Article
Cell Biology
Wen Chen, Nana Liu, Shijun Shen, Wei Zhu, Jing Qiao, Shujuan Chang, Jianfeng Dong, Mingliang Bai, Li Ma, Shanshan Wang, Wenwen Jia, Xudong Guo, Ang Li, Jiajie Xi, Cizhong Jiang, Jiuhong Kang
Summary: Fetal growth restriction impairs cognitive function in later life by decreasing hippocampal neurogenesis through reduced proliferation of neural stem cells. The long-term decrease in Tet1/Notch signaling in hippocampal NSCs contributes to impaired neurogenesis following FGR, suggesting potential targets for intervention of FGR-related cognitive disorders.
Article
Chemistry, Medicinal
Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Lee
Summary: In a mouse study, low-dose curcumin was found to promote hippocampal neurogenesis and enhance memory retention, suggesting its potential role in preventing age and neurodegenerative disease-related cognitive deficits.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Correction
Multidisciplinary Sciences
Lu Wang, Zhen Li, David Sievert, Desiree E. C. Smith, Marisa I. Mendes, Dillon Y. Chen, Valentina Stanley, Shereen Ghosh, Yulu Wang, Majdi Kara, Ayca Dilruba Aslanger, Rasim O. Rosti, Henry Houlden, Gajja S. Salomons, Joseph G. Gleeson
Summary: A correction to the paper has been published.
NATURE COMMUNICATIONS
(2021)
Article
Psychiatry
Hyunkyu Kim, Wonjeong Jeong, Seung Hoon Kim, Jun Ho Seo, Jin Sun Ryu, You-seok Kim, Jeong-Ho Seok, Sung-In Jang, Eun-Cheol Park
Summary: This study aimed to investigate the association between social phobia and the risk of arrhythmia. The results showed a significant association between social phobia history and elevated risks of arrhythmia.
Article
Biochemistry & Molecular Biology
Seulah Lee, Dong Geun Hong, Seonguk Yang, Jaehoon Kim, Minwoo Baek, Seoyeong Kim, Dinakaran Thirumalai, Hae Young Chung, Seung-Cheol Chang, Jaewon Lee
Summary: Parkinson's disease is a progressive movement disorder caused by neurodegeneration. Modulating chronic neuroinflammatory response, specifically through GSK-3 beta inhibitory peptide (IAGIP), has been shown to prevent neurodegeneration and motor dysfunction in PD models. These findings provide new therapeutic possibilities for targeting PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Wonjeong Jeong, Jae Hong Joo, Hyunkyu Kim, Sung-In Jang, Eun-Cheol Park
Summary: There is a significant association between statin adherence and the risk of ischemic and hemorrhagic stroke, highlighting the importance of adherence to statin treatment for patients with hyperlipidemia to reduce stroke risk.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biology
Soo Jeong Kim, Youngsik Woo, Hyun Jin Kim, Bon Seong Goo, Truong Thi My Nhung, Seol-Ae Lee, Bo Kyoung Suh, Dong Jin Mun, Joung-Hun Kim, Sang Ki Park
Summary: This study identifies the role of the protein Rai14 in the regulation of dendritic spine dynamics and its association with stress-induced depressive-like behaviors. Rai14-deficient neurons exhibit reduced dendritic spine density and impaired synaptic activity. Rai14 forms a complex with Tara, preventing its degradation and accumulating in the dendritic spine neck, enhancing spine maintenance. Rai14 deficiency also alters gene expression relevant to depression and increases depressive-like behaviors.
Article
Chemistry, Multidisciplinary
Donggyu Lee, Youngsik Woo, Ji-seon Lim, Ikbum Park, Sang Ki Park, Joon Won Park
Summary: In this study, a neurological protein was quantified in a single cell using atomic force microscopy (AFM). The captured DISC1 protein was visualized through force mapping with AFM. The average number of DISC1 in a cell was found to be 4.38 x 10(3), consistent with the ensemble-averaged value. This AFM approach can be useful for studying protein behavior and tracking physiological changes in individual cells.
Article
Medicine, General & Internal
Seung Hoon Kim, Sung Hoon Jeong, Hyunkyu Kim, Eun-Cheol Park, Suk-Yong Jang
Summary: This study suggests that RA is associated with a higher risk of developing POAG, especially within 2 years after diagnosis or among patients aged 75 years or older.
Article
Biochemistry & Molecular Biology
Bon Seong Goo, Dong Jin Mun, Seunghyun Kim, Truong Thi My Nhung, Su Been Lee, Youngsik Woo, Soo Jeong Kim, Bo Kyoung Suh, Sung Jin Park, Hee-Eun Lee, Kunyou Park, Hyunsoo Jang, Jong-Cheol Rah, Ki-Jun Yoon, Seung Tae Baek, Seung-Yeol Park, Sang Ki Park
Summary: This study investigates the association between MAD1L1 and schizophrenia and identifies the molecular mechanisms underlying this association. The researchers found that MAD1 plays a crucial role in neuronal development and is involved in neuronal migration and neurite outgrowth. MAD1 also regulates vesicular trafficking from the Golgi apparatus to the plasma membrane, which is essential for neuronal polarity. The findings suggest that alterations in MAD1 may contribute to the pathobiology of schizophrenia.
MOLECULAR PSYCHIATRY
(2023)
Article
Chemistry, Medicinal
Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Lee
Summary: In a mouse study, low-dose curcumin was found to promote hippocampal neurogenesis and enhance memory retention, suggesting its potential role in preventing age and neurodegenerative disease-related cognitive deficits.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Eunbyul Cho, Youngsik Woo, Yeongjun Suh, Bo Kyoung Suh, Soo Jeong Kim, Truong Thi My Nhung, Jin Yeong Yoo, Tran Diem Nghi, Su Been Lee, Dong Jin Mun, Sang Ki Park
Summary: The authors developed a MAM-specific BRET-based Ca2+ indicator called MAM-Calflux, which serves as both a Ca2+ indicator and a structural marker. It can estimate steady-state MAM Ca2+ levels and visualize abnormally accumulated MAM Ca2+ in Parkinson's disease mouse model. MAM-Calflux can be a versatile tool for ratiometric measurement of dynamic inter-organellar Ca2+ communication.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Ramalingam Manikandan, Jaehoon Kim, Akihito Ishigami, Joon Young Cho, Jung Hoon Kim, Joon Tark Han, Jaewon Lee, Seung-Cheol Chang
Summary: This study presents a simple sensing methodology using a novel supra single-walled carbon nanotube-coated glassy carbon electrode for rapid detection of multiple biomolecules in human health diagnostics. The developed sensor showed simultaneous sensing of ascorbic acid, dopamine, and uric acid with high selectivity and excellent reproducibility in real samples. The sensor is rapid, low cost, scalable, and suitable for real-world applications.
Article
Multidisciplinary Sciences
Hyunkyu Kim, Yu Shin Park, Seung Hoon Kim, Kyungduk Hurh, Jinhyun Kim, Eun-Cheol Park, Sung-In Jang
Summary: This study investigated the association between stress-related disorders and the risk of dementia in a Korean population. The results showed that individuals with stress-related disorders, particularly those with post-traumatic stress disorder, had a higher risk of developing dementia. Patients with stress-related disorders also showed the highest risk for Alzheimer's dementia.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Sivaguru Jayaraman, Thenmozhi Rajarathinam, Hyeon-Geun Jang, Dinakaran Thirumalai, Jaewon Lee, Hyun-Jong Paik, Seung-Cheol Chang
Summary: This study developed a method for detecting melatonin using a ruthenium-incorporated carbon sphere sensor, which exhibited excellent electrocatalytic properties and selectivity, making it suitable for pharmaceutical quality control.
Article
Multidisciplinary Sciences
Dong Jin Mun, Bon Seong Goo, Bo Kyoung Suh, Ji-Ho Hong, Youngsik Woo, Soo Jeong Kim, Seunghyun Kim, Su Been Lee, Yubin Won, Jin Yeong Yoo, Eunbyul Cho, Eun Jin Jang, Truong Thi My Nhung, Hong Minh Triet, Hongyul An, Haeryun Lee, Minh Dang Nguyen, Seung-Yeol Park, Seung Tae Baek, Sang Ki Park
Summary: In this study, the Gcap14-Ndel1 complex is identified as a fundamental regulator of cytoskeletal remodeling during neurodevelopment, including neuronal process elongation and migration. Deficiency of Gcap14 leads to impaired cortical lamination and defective neuronal migration. The interaction between Gcap14 and Ndel1 effectively corrects the downregulation of microtubule dynamics and the defects in neuronal migration caused by Gcap14 deficiency.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychiatry
H. Kim, S. H. Kim, W. Jeong, Y. S. Park, J. Kim, E. C. Park, S. I. Jang
Summary: This study investigated the risk of schizophrenia in patients newly diagnosed with OCD using a nationally representative sample cohort in South Korea. The results found that patients with OCD had a higher risk of schizophrenia compared to the control group.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Lee
Summary: The present study found that a diet containing morin can prevent motor dysfunction and dopaminergic neuronal damage in a mouse model of Parkinson's disease. It can also significantly reduce neuroinflammation. In vitro studies showed that morin exerts its anti-inflammatory effects by blocking the ERK-p65 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)