Article
Plant Sciences
Lidia Lopez-Serrano, Mary-Rus Martinez-Cuenca, Salvador Lopez-Galarza, Angeles Calatayud
Summary: This study reveals the different tolerance mechanisms employed by pepper plants to cope with salt stress, including the accumulation of Na+ in vacuoles and endosomes, compartmentalization of Na+ ions in root and leaf vacuoles and xylem parenchyma cells, and the movement and accumulation of Na+ ions in xylem and xylem parenchyma cells by the activation of specific genes.
PHYSIOLOGIA PLANTARUM
(2023)
Review
Oncology
Erik H. Knelson, Shetal A. Patel, Jacob M. Sands
Summary: Small-cell lung cancer has a poor prognosis with limited treatment options. PARP inhibitors have shown promise as a therapeutic target, especially when used in combination therapies that contribute to DNA damage, inhibit the DNA damage response, or activate the immune system. Identifying biomarkers and developing treatment combinations based on the evolving classification of small-cell lung cancer subtypes and gene expression patterns will be crucial for improving outcomes in this challenging cancer.
Article
Physics, Fluids & Plasmas
Simone Pigolotti
Summary: The study investigates the fluctuation of cell division times in microbial populations and finds that population growth is significantly impacted. Depending on whether fluctuations are correlated among different cells, either the Euler-Lotka equation or a similar equation that accounts for correlations is used to predict population growth rates.
Article
Multidisciplinary Sciences
A. Kaidow, N. Ishii, S. Suzuki, T. Shiina, K. Endoh, Y. Murakami, H. Kasahara
Summary: It has been discovered that cells with chromosome damage and defective recombinase activity can survive under appropriate oxidative stress levels. By reducing intracellular reactive oxygen species (ROS) levels, cells become sensitive to ROS rather than chronic chromosome damage. Additionally, expression of the Hsp33 protein enhances cell survival and maintains an appropriate oxidative stress level in cells with oxidative damage, rescuing cell growth.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Environmental
Muhammad Irfan, Amir Shafeeq, Umair Siddiq, Farzana Bashir, Tausif Ahmad, Muhammad Athar, Muhammad Tahir Butt, Sami Ullah, Ahmad Mukhtar, Mohamed Hussien, Su Shiung Lam
Summary: The demand and importance of fairness creams have increased, but some of these products contain harmful substances such as heavy metals, hydroquinone and microorganisms. This study aims to determine and evaluate the concentration of these substances in different fairness creams and assess the health risks to consumers. The findings showed that many of the tested creams exceeded the permissible limits and it is recommended to reduce the use of these products to ensure human safety and skin health.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Civil
Diqi Zeng, Hao Zhang, Hongzhe Dai, Michael Beer
Summary: Risk assessment of spatially distributed infrastructure systems under natural hazards should consider the performance of individual components as stochastically correlated due to similarities in engineering practices. This study addresses the scalability issue of risk analysis by developing an interpolation technique that accurately evaluates damages of sampled components and interpolates damages of remaining components. The method is applicable to both linear systems and systems with complex connectivity. Two examples demonstrate its effectiveness in cyclone loss assessment and connectivity analysis of infrastructure systems.
Article
Multidisciplinary Sciences
Yuelong Yan, Hongqi Teng, Qinglei Hang, Lavanya Kondiparthi, Guang Lei, Amber Horbath, Xiaoguang Liu, Chao Mao, Shiqi Wu, Li Zhuang, M. James You, Masha V. Poyurovsky, Li Ma, Kellen Olszewski, Boyi Gan
Summary: SLC7A11 protects cancer cells from oxidative stress by supporting glutathione synthesis. High expression promotes primary tumor growth but induces disulfide stress and impairs metastasis under oxidative stress conditions.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Federico H. Larrosa, Lucas Borras
Summary: This study investigates the effect of altered stand density on maize yields and whether short shading treatments during different stages around flowering can help distinguish genotypic differences in relevant eco-physiological parameters. The results show that kernel number per plant is the yield component most related to yield changes, and that specific shading treatments soon after anthesis cause the greatest yield reductions. Hybrids that are less sensitive to shading stress have a lower reduction in plant growth rate and accumulate more ear biomass during flowering.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Oncology
Juyeun Lee, Michael Nicosia, Ellen S. Hong, Daniel J. Silver, Cathy Li, Defne Bayik, Dionysios C. Watson, Adam Lauko, Kristen E. Kay, Sabrina Z. Wang, Sadie Johnson, Mary McGraw, Matthew M. Grabowski, Danielle D. Kish, Amar B. Desai, Wendy A. Goodman, Scott J. Cameron, Hideho Okada, Anna Valujskikh, Robert L. Fairchild, Manmeet S. Ahluwalia, Justin D. Lathia
Summary: This study demonstrates the crucial role of T cells in driving sex differences in glioblastoma (GBM) progression. Male mice exhibited accelerated tumor growth with decreased frequency and increased exhaustion of CD8+ T cells in the tumor. Furthermore, a higher frequency of progenitor exhausted T cells was found in males, with improved responsiveness to anti-PD-1 treatment. These findings highlight the importance of sex-biased predetermined behavior of T cells in GBM.
Article
Biochemistry & Molecular Biology
Yue Zhang, Bei Liu, Jiaqi Zhai, Qinglei Wang, Susheng Song
Summary: This study investigated the functions of JAZs in JA responses by analyzing various jaz mutants and found that these mutants differentially affect JA responses, indicating the complexity of the JA pathway in these multiple jaz mutants.
PLANT SIGNALING & BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Ella Katz, Anna Knapp, Mariele Lensink, Caroline Kaley Keller, Jordan Stefani, Jia-Jie Li, Emily Shane, Kaelyn Tuermer-Lee, Arnold J. Bloom, Daniel J. Kliebenstein
Summary: This study investigated the natural genetic variation in nitrogen use in plants by growing a large population of Arabidopsis thaliana genotypes under different nitrogen sources. The results showed a wide range of nitrogen responses associated with different genes and traits. Moreover, unique nitrogen responses, such as preference for ammonium or nitrate, were found to be generated by combinations of loci rather than single large-effect loci.
Article
Dermatology
Ryota Tanaka, Yuki Ichimura, Noriko Kubota, Akimasa Saito, Yoshiyuki Nakamura, Yosuke Ishitsuka, Rei Watanabe, Yasuhiro Fujisawa, Seiya Mizuno, Satoru Takahashi, Manabu Fujimoto, Naoko Okiyama
Summary: The study revealed that PD-L1 plays a predominant role in Th1 and Th17 type immunity, while PD-L2 is involved in Th2 type immunity. Experimental validation supported this conclusion.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Environmental Sciences
Carolina Rodrigues dos Santos, Gemima Santos Arcanjo, Lucilaine Valeria de Souza Santos, Konrad Koch, Miriam Cristina Santos Amaral
Summary: Pharmaceutically active compounds are increasingly found in water bodies worldwide, posing potential risks to ecosystems and human health. Some pharmaceuticals have been identified to have high environmental and human health risks, calling for removal using advanced technologies.
ENVIRONMENTAL POLLUTION
(2021)
Article
Construction & Building Technology
Jeong-In Jeon, Hye-Won Lee, Si-Hyun Park, Dan-Ki Yoon, Jeong-Il Lee, Cheol-Min Lee
Summary: This study proposes an organic film-based method to assess semivolatile organic compound (SVOC) exposure in indoor environments. Various phthalate exposure pathways were examined in children and adults, and the findings provide important baseline data for future research in health risk assessments and SVOC exposure utilizing organic films.
Article
Geosciences, Multidisciplinary
Tingting Ji, Hsi-Hsien Wei, Igal M. Shohet, Feng Xiong
Summary: Risk and resilience assessments are commonly used separately to guide policymakers in disaster-risk reduction policies, however, an integrated approach accounting for both seems to be lacking in current research due to the challenge of integrating their distinct measurement metrics. Risk assessment estimates disaster risk in terms of operational metrics such as monetary or casualties' loss, while most resilience analysis represents community resilience as an index without specific unit metric.
Article
Environmental Sciences
Sonja Christensen, Zeina Jaffar, Elizabeth Cole, Virginia Porter, Maria Ferrini, Britten Postma, Kent E. Pinkerton, Mihi Yang, Yang Jee Kim, Luke Montrose, Kevan Roberts, Andrij Holian, Yoon Hee Cho
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2017)
Article
Toxicology
Elizabeth Cole, Traci A. Brown, Kent E. Pinkerton, Britten Postma, Keegan Malany, Mihi Yang, Yang Jee Kim, Raymond F. Hamilton, Andrij Holian, Yoon Hee Cho
INHALATION TOXICOLOGY
(2017)
Article
Toxicology
Maria Ferrini, Sophia Carvalho, Yoon Hee Cho, Britten Postma, Lucas Miranda Marques, Kent Pinkerton, Kevan Roberts, Zeina Jaffar
PARTICLE AND FIBRE TOXICOLOGY
(2017)
Correction
Nutrition & Dietetics
So Young Kim, Gyung-Ah Wie, Yeong-Ah Cho, Hyun-hee Kang, Kyoung-A. Ryu, Min-Kyong Yoo, Shinyoung Jun, Seong-Ah Kim, Kyungho Ha, Jeongseon Kim, Yoon Hee Cho, Sangah Shin, Hyojee Joung
Article
Environmental Sciences
Sujin Kim, Yoon Hee Cho, Inae Lee, Wonji Kim, Sungho Won, Ja-Lok Ku, Hyo-Bang Moon, Jeongim Park, Sungkyoon Kim, Gyuyeon Choi, Kyungho Choi
ENVIRONMENT INTERNATIONAL
(2018)
Article
Oncology
Ho-Sun Lee, Yunkyeong Kang, Kyung Tae, Gyu-Un Bae, Jong Y. Park, Yoon Hee Cho, Mihi Yang
CANCER RESEARCH AND TREATMENT
(2018)
Article
Environmental Sciences
Yoon Hee Cho, Yoonhee Jang, Hae Dong Woo, Yang Jee Kim, Su Young Kim, Sonja Christensen, Elizabeth Cole, Soo Yong Choi, Hai Won Chung
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2019)
Article
Multidisciplinary Sciences
Lindsay J. Collin, Lauren E. McCullough, Kathleen Conway, Alexandra J. White, Xinran Xu, Yoon Hee Cho, Sumitra Shantakumar, Susan L. Teitelbaum, Alfred I. Neugut, Regina M. Santella, Jia Chen, Marilie D. Gammon
Article
Public, Environmental & Occupational Health
Young Ah Kim, Yeong Sook Yoon, Hee Sun Kim, Se Jeong Jeon, Elizabeth Cole, Jeongsun Lee, Younglim Kho, Yoon Hee Cho
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2019)
Article
Chemistry, Medicinal
Elizabeth Cole, Jessica L. Ray, Shannon Bolten, Raymond F. Hamilton, Pamela K. Shaw, Britten Postma, Mary Buford, Andrij Holian, Yoon Hee Cho
CHEMICAL RESEARCH IN TOXICOLOGY
(2019)
Article
Environmental Sciences
Na-Youn Park, Yoon Hee Cho, Kyungho Choi, Eun-Hee Lee, Yang Jee Kim, Jung Hoan Kim, Younglim Kho
ENVIRONMENTAL POLLUTION
(2019)
Article
Biochemistry & Molecular Biology
Eunbee Kim, Joon Seok Lee, Eunjae Kim, Myung-Ah Lee, Alfred N. Fonteh, Michael Kwong, Yoon Hee Cho, Un Jae Lee, Mihi Yang
Summary: The study found a potential correlation between the increase in colorectal cancer incidence in Korea and the consumption of red and processed meat; urinary MeIQx and PhIP were associated with red meat intake and urinary 1-OHP; multiple fatty acids were higher in cases than controls.
Article
Environmental Sciences
Yang Jee Kim, Joong Won Lee, Yoon Hee Cho, Young Joo Choi, Younghyun Lee, Hai Won Chung
Summary: This study aimed to assess chromosomal instability in power plant workers exposed to occupational radiation at low doses in South Korea. The results showed that the frequency of chromosomal aberrations was significantly higher in workers exposed to low doses of radiation.
Article
Oncology
Lauren E. McCullough, Jia Chen, Yoon Hee Cho, Nikhil K. Khankari, Patrick T. Bradshaw, Alexandra J. White, Susan L. Teitelbaum, Mary Beth Terry, Alfred I. Neugut, Hanina Hibshoosh, Regina M. Santella, Marilie D. Gammon
BREAST CANCER RESEARCH
(2017)
Article
Allergy
L. Montrose, T. J. Ward, E. O. Semmens, Y. H. Cho, B. Brown, C. W. Noonan
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2017)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)